The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Duoqiang Pan - One of the best experts on this subject based on the ideXlab platform.
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Removal of Nickel(II) from Aqueous Solutions Using Synthesized β-Zeolite and Its Ethylenediamine Derivative
Industrial & Engineering Chemistry Research, 2017Co-Authors: Peng Liu, Ni Yuan, Wei Xiong, Duoqiang PanAbstract:β-Zeolite was synthesized and modified with Ethylenediamine (EDA). The synthesized materials were characterized and used for the removal of nickel(II) from aqueous solutions. The influences of the pH, contact time, and temperature on nickel(II) adsorption onto synthesized β-zeolite and β-zeolite modified with Ethylenediamine (β-zeolite–EDA) were studied by a batch technique, and X-ray photoelectron spectroscopy was employed to analyze the experimental data and identify the formation of coordination bonds between the adsorbents and nickel(II). The dynamic process showed that the adsorption of nickel(II) onto β-zeolite and β-zeolite–EDA matched the pseudo-second-order kinetics model, and the adsorption of nickel(II) was significantly dependent on the pH values. Through simulation of the adsorption isotherms by the Langmuir, Freundlich, and Dubinin–Radushkevich models, it could be seen that the adsorption patterns of nickel(II) onto β-zeolite and β-zeolite–EDA were mainly controlled by surface complexation a...
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Removal of U(VI) from aqueous solution using synthesized β-zeolite and its Ethylenediamine Derivative
Journal of Molecular Liquids, 2017Co-Authors: Peng Liu, Ni Yuan, Yanqi Liu, Duoqiang PanAbstract:Abstract β-Zeolite was synthesized and modified with Ethylenediamine (EDA).The synthesized materials were characterized and used for removal of U(VI) from aqueous solutions. The influences of pH, contact time and temperature on U(VI) adsorption onto synthesized β-zeolite and modified β-zeolite by Ethylenediamine (β-zeolite-EDA) were studied by batch technique, and XPS was employed to analysed the experimental data. The dynamic process showed that the adsorption of U(VI) onto β-zeolite and β-zeolite-EDA matched the pseudo-second-order kinetics model, and the adsorption of U(VI) were significantly dependent on pH values. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich (D-R) models, it could be seen respectively that the adsorption patterns of U(VI) onto β-zeolite and β-zeolite-EDA were mainly controlled by surface complexation, and the adsorption processes were endothermic and spontaneous. XPS analysis considered the formation of different complexes at different experimental conditions. The modification of β-zeolite by Ethylenediamine improved the adsorption capacity of U(VI) significantly, it shows a novel material for the removing of U(VI) from water environment for industrialized application.
Zhiyuan Zhong - One of the best experts on this subject based on the ideXlab platform.
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Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles
Biomacromolecules, 2016Co-Authors: Jian Zhang, Chao Deng, Fenghua Meng, Zhiyuan ZhongAbstract:Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles have attracted an enormous interest for controlled drug delivery. Their clinical applications are, however, partly hindered by lack of biocompatible, biodegradable and functional surfactants. Here, we designed and developed a novel biocompatible surfactant based on amphiphilic vitamin E-oligo(methyl diglycol l-glutamate) (VEOEG) for facile fabrication of robust and tumor-targeting PLGA-based nanomedicines. VEOEG was prepared with controlled Mn of 1.7–2.6 kg/mol and low molecular weight distribution (Đ = 1.04–1.16) via polymerization of methyl diglycol l-glutamate N-carboxyanhydride using vitamin E-Ethylenediamine Derivative (VE-NH2) as an initiator. VEOEG had a hydrophile–lipophile balance data of 13.8–16.1 and critical micellar concentration of 189.3–203.8 mg/L depending on lengths of oligopeptide. Using VEOEG as a surfactant, PLGA nanoparticles could be obtained via nanoprecipitation method with a small and uniform hydrodynamic size of 135 nm and posit...
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Vitamin E‑Oligo(methyl diglycol l‑glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles
2016Co-Authors: Jian Zhang, Chao Deng, Fenghua Meng, Zhiyuan ZhongAbstract:Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles have attracted an enormous interest for controlled drug delivery. Their clinical applications are, however, partly hindered by lack of biocompatible, biodegradable and functional surfactants. Here, we designed and developed a novel biocompatible surfactant based on amphiphilic vitamin E-oligo(methyl diglycol l-glutamate) (VEOEG) for facile fabrication of robust and tumor-targeting PLGA-based nanomedicines. VEOEG was prepared with controlled Mn of 1.7–2.6 kg/mol and low molecular weight distribution (Đ = 1.04–1.16) via polymerization of methyl diglycol l-glutamate N-carboxyanhydride using vitamin E-Ethylenediamine Derivative (VE-NH2) as an initiator. VEOEG had a hydrophile–lipophile balance data of 13.8–16.1 and critical micellar concentration of 189.3–203.8 mg/L depending on lengths of oligopeptide. Using VEOEG as a surfactant, PLGA nanoparticles could be obtained via nanoprecipitation method with a small and uniform hydrodynamic size of 135 nm and positive surface charge of +26.6 mV, in accordance with presence of amino groups at the surface. The resulting PLGA nanoparticles could be readily coated with hyaluronic acid (HA) to form highly stable, small-sized (143 nm), monodisperse, and negatively charged nanoparticles (HA-PLGA NPs). Notably, paclitaxel-loaded HA-PLGA NPs (PTX-HA-PLGA NPs) exhibited better antitumor effects in CD44-positive MCF-7 breast tumor cells than Taxol (a clinical paclitaxel formulation). The in vivo pharmacokinetics assay in nude mice displayed that PTX-HA-PLGA NPs possessed a long plasma half-life of 3.14 h. The in vivo biodistribution studies revealed that PTX-HA-PLGA NPs had a high tumor PTX level of 8.4% ID/g, about 6 times better than that of Taxol. Interestingly, therapeutic studies showed that PTX-HA-PLGA NPs caused significantly more effective tumor growth inhibition, better survival rate and lower adverse effect than Taxol. VEOEG has emerged as a versatile and functional surfactant for the fabrication of advanced anticancer nanomedicines
Peng Liu - One of the best experts on this subject based on the ideXlab platform.
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Removal of Nickel(II) from Aqueous Solutions Using Synthesized β-Zeolite and Its Ethylenediamine Derivative
Industrial & Engineering Chemistry Research, 2017Co-Authors: Peng Liu, Ni Yuan, Wei Xiong, Duoqiang PanAbstract:β-Zeolite was synthesized and modified with Ethylenediamine (EDA). The synthesized materials were characterized and used for the removal of nickel(II) from aqueous solutions. The influences of the pH, contact time, and temperature on nickel(II) adsorption onto synthesized β-zeolite and β-zeolite modified with Ethylenediamine (β-zeolite–EDA) were studied by a batch technique, and X-ray photoelectron spectroscopy was employed to analyze the experimental data and identify the formation of coordination bonds between the adsorbents and nickel(II). The dynamic process showed that the adsorption of nickel(II) onto β-zeolite and β-zeolite–EDA matched the pseudo-second-order kinetics model, and the adsorption of nickel(II) was significantly dependent on the pH values. Through simulation of the adsorption isotherms by the Langmuir, Freundlich, and Dubinin–Radushkevich models, it could be seen that the adsorption patterns of nickel(II) onto β-zeolite and β-zeolite–EDA were mainly controlled by surface complexation a...
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Removal of U(VI) from aqueous solution using synthesized β-zeolite and its Ethylenediamine Derivative
Journal of Molecular Liquids, 2017Co-Authors: Peng Liu, Ni Yuan, Yanqi Liu, Duoqiang PanAbstract:Abstract β-Zeolite was synthesized and modified with Ethylenediamine (EDA).The synthesized materials were characterized and used for removal of U(VI) from aqueous solutions. The influences of pH, contact time and temperature on U(VI) adsorption onto synthesized β-zeolite and modified β-zeolite by Ethylenediamine (β-zeolite-EDA) were studied by batch technique, and XPS was employed to analysed the experimental data. The dynamic process showed that the adsorption of U(VI) onto β-zeolite and β-zeolite-EDA matched the pseudo-second-order kinetics model, and the adsorption of U(VI) were significantly dependent on pH values. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich (D-R) models, it could be seen respectively that the adsorption patterns of U(VI) onto β-zeolite and β-zeolite-EDA were mainly controlled by surface complexation, and the adsorption processes were endothermic and spontaneous. XPS analysis considered the formation of different complexes at different experimental conditions. The modification of β-zeolite by Ethylenediamine improved the adsorption capacity of U(VI) significantly, it shows a novel material for the removing of U(VI) from water environment for industrialized application.
Jian Zhang - One of the best experts on this subject based on the ideXlab platform.
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Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles
Biomacromolecules, 2016Co-Authors: Jian Zhang, Chao Deng, Fenghua Meng, Zhiyuan ZhongAbstract:Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles have attracted an enormous interest for controlled drug delivery. Their clinical applications are, however, partly hindered by lack of biocompatible, biodegradable and functional surfactants. Here, we designed and developed a novel biocompatible surfactant based on amphiphilic vitamin E-oligo(methyl diglycol l-glutamate) (VEOEG) for facile fabrication of robust and tumor-targeting PLGA-based nanomedicines. VEOEG was prepared with controlled Mn of 1.7–2.6 kg/mol and low molecular weight distribution (Đ = 1.04–1.16) via polymerization of methyl diglycol l-glutamate N-carboxyanhydride using vitamin E-Ethylenediamine Derivative (VE-NH2) as an initiator. VEOEG had a hydrophile–lipophile balance data of 13.8–16.1 and critical micellar concentration of 189.3–203.8 mg/L depending on lengths of oligopeptide. Using VEOEG as a surfactant, PLGA nanoparticles could be obtained via nanoprecipitation method with a small and uniform hydrodynamic size of 135 nm and posit...
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Vitamin E‑Oligo(methyl diglycol l‑glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles
2016Co-Authors: Jian Zhang, Chao Deng, Fenghua Meng, Zhiyuan ZhongAbstract:Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles have attracted an enormous interest for controlled drug delivery. Their clinical applications are, however, partly hindered by lack of biocompatible, biodegradable and functional surfactants. Here, we designed and developed a novel biocompatible surfactant based on amphiphilic vitamin E-oligo(methyl diglycol l-glutamate) (VEOEG) for facile fabrication of robust and tumor-targeting PLGA-based nanomedicines. VEOEG was prepared with controlled Mn of 1.7–2.6 kg/mol and low molecular weight distribution (Đ = 1.04–1.16) via polymerization of methyl diglycol l-glutamate N-carboxyanhydride using vitamin E-Ethylenediamine Derivative (VE-NH2) as an initiator. VEOEG had a hydrophile–lipophile balance data of 13.8–16.1 and critical micellar concentration of 189.3–203.8 mg/L depending on lengths of oligopeptide. Using VEOEG as a surfactant, PLGA nanoparticles could be obtained via nanoprecipitation method with a small and uniform hydrodynamic size of 135 nm and positive surface charge of +26.6 mV, in accordance with presence of amino groups at the surface. The resulting PLGA nanoparticles could be readily coated with hyaluronic acid (HA) to form highly stable, small-sized (143 nm), monodisperse, and negatively charged nanoparticles (HA-PLGA NPs). Notably, paclitaxel-loaded HA-PLGA NPs (PTX-HA-PLGA NPs) exhibited better antitumor effects in CD44-positive MCF-7 breast tumor cells than Taxol (a clinical paclitaxel formulation). The in vivo pharmacokinetics assay in nude mice displayed that PTX-HA-PLGA NPs possessed a long plasma half-life of 3.14 h. The in vivo biodistribution studies revealed that PTX-HA-PLGA NPs had a high tumor PTX level of 8.4% ID/g, about 6 times better than that of Taxol. Interestingly, therapeutic studies showed that PTX-HA-PLGA NPs caused significantly more effective tumor growth inhibition, better survival rate and lower adverse effect than Taxol. VEOEG has emerged as a versatile and functional surfactant for the fabrication of advanced anticancer nanomedicines
Ni Yuan - One of the best experts on this subject based on the ideXlab platform.
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Removal of Nickel(II) from Aqueous Solutions Using Synthesized β-Zeolite and Its Ethylenediamine Derivative
Industrial & Engineering Chemistry Research, 2017Co-Authors: Peng Liu, Ni Yuan, Wei Xiong, Duoqiang PanAbstract:β-Zeolite was synthesized and modified with Ethylenediamine (EDA). The synthesized materials were characterized and used for the removal of nickel(II) from aqueous solutions. The influences of the pH, contact time, and temperature on nickel(II) adsorption onto synthesized β-zeolite and β-zeolite modified with Ethylenediamine (β-zeolite–EDA) were studied by a batch technique, and X-ray photoelectron spectroscopy was employed to analyze the experimental data and identify the formation of coordination bonds between the adsorbents and nickel(II). The dynamic process showed that the adsorption of nickel(II) onto β-zeolite and β-zeolite–EDA matched the pseudo-second-order kinetics model, and the adsorption of nickel(II) was significantly dependent on the pH values. Through simulation of the adsorption isotherms by the Langmuir, Freundlich, and Dubinin–Radushkevich models, it could be seen that the adsorption patterns of nickel(II) onto β-zeolite and β-zeolite–EDA were mainly controlled by surface complexation a...
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Removal of U(VI) from aqueous solution using synthesized β-zeolite and its Ethylenediamine Derivative
Journal of Molecular Liquids, 2017Co-Authors: Peng Liu, Ni Yuan, Yanqi Liu, Duoqiang PanAbstract:Abstract β-Zeolite was synthesized and modified with Ethylenediamine (EDA).The synthesized materials were characterized and used for removal of U(VI) from aqueous solutions. The influences of pH, contact time and temperature on U(VI) adsorption onto synthesized β-zeolite and modified β-zeolite by Ethylenediamine (β-zeolite-EDA) were studied by batch technique, and XPS was employed to analysed the experimental data. The dynamic process showed that the adsorption of U(VI) onto β-zeolite and β-zeolite-EDA matched the pseudo-second-order kinetics model, and the adsorption of U(VI) were significantly dependent on pH values. Through simulating the adsorption isotherms by Langmuir, Freundlich and Dubini-Radushkevich (D-R) models, it could be seen respectively that the adsorption patterns of U(VI) onto β-zeolite and β-zeolite-EDA were mainly controlled by surface complexation, and the adsorption processes were endothermic and spontaneous. XPS analysis considered the formation of different complexes at different experimental conditions. The modification of β-zeolite by Ethylenediamine improved the adsorption capacity of U(VI) significantly, it shows a novel material for the removing of U(VI) from water environment for industrialized application.