The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Eleonora P M Corssmit - One of the best experts on this subject based on the ideXlab platform.
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autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring Euthyroidism
The Journal of Clinical Endocrinology and Metabolism, 2008Co-Authors: C F A Eustatiarutten, Karen A Heemstra, Johannes A Romijn, Eleonora P M Corssmit, Johannes W A Smit, Rik C Schoemaker, Jacobus BurggraafAbstract:Context: Knowledge on the relationship between the autonomic nervous system and subclinical hyperthyroidism is mainly based upon cross-sectional studies in heterogeneous patient populations, and the effect of restoration to Euthyroidism in subclinical hyperthyroidism has not been studied. Objective:We investigated the long-term effects of exogenous subclinical hyperthyroidism on the autonomic nervous system and the potential effects of restoration of Euthyroidism. Design: This was a prospective single-blinded, placebo-controlled, randomized trial. Setting: The study was performed at a university hospital. Patients: A total of 25 patients who were on more than 10-yr TSH suppressive therapy after thyroidectomy was examined. Intervention:Patientswerestudiedatbaselineandsubsequentlyrandomizedtoa6-monththyroid hormone substitution regimen to obtain either Euthyroidism or maintenance of the subclinical hyperthyroid state. Main Outcome Measures: Urinary excretion of catecholamines and heart rate variability were measured. Baseline data of the subclinical hyperthyroidism patients were compared with data obtained in patients with hyperthyroidism and controls. Results:Urinaryexcretionofnorepinephrineandvanillylmandelicacidwashigherinthesubclinical hyperthyroidism patients compared with controls and lower compared with patients with overt hyperthyroidism. Heart rate variability was lower in patients with hyperthyroidism, intermediate in subclinical hyperthyroidism patients, and highest in the healthy controls. No differences were observed after restoration of Euthyroidism.
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glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomised controlled trial
Clinical Endocrinology, 2006Co-Authors: Karen A Heemstra, J W A Smit, C F A Eustatiarutten, A C Heijboer, Marijke Frolich, Johannes A Romijn, Eleonora P M CorssmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on glucose and lipid metabolism is unclear. Therefore, we evaluated glucose and lipid metabolism in patients with differentiated thyroid carcinoma (DTC) on TSH suppressive thyroxine therapy as a model for subclinical hyperthyroidism and investigated whether restoration to Euthyroidism affects metabolism. Design We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. Patients Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and Euthyroidism (Euthyroidism group, 12 patients). Measurements We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. Results At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and Euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. Conclusion In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of Euthyroidism in general does not affect glucose and lipid metabolism.
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quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomized controlled trial
Clinical Endocrinology, 2006Co-Authors: C F A Eustatiarutten, Marijke Frolich, Johannes A Romijn, Eleonora P M Corssmit, Alberto M Pereira, J W A SmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on quality of life is unclear. Therefore, we evaluated quality of life in patients with differentiated thyroid carcinoma (DTC) on TSH-suppressive thyroxine therapy as a model for subclinical hyperthyroidism and we investigated whether restoration to Euthyroidism affects quality of life. Design We performed a prospective, single-blinded, placebo-controlled, randomized trial of 6 months’ duration with two parallel groups. Patients and methods Twenty-four subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with L-thyroxine completed the study. L-thyroxine dose was replaced by study medication containing L-thyroxine or L-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group) and Euthyroidism (euthyroid group). Both groups consisted of 12 patients. We evaluated quality of life using five validated questionnaires. Results At baseline, the somatic disorder questionnaire (SDQ) indicated more somatic dysfunction in patients as compared with reference values, whereas the depression score (HADS) revealed a better score than the reference group. All other quality of life parameters were normal. At baseline, no significant differences between the low-TSH and the Euthyroidism groups were observed. After 6 months, none of the quality of life parameters in the low-TSH group was different from baseline values. In the euthyroid group, motivation was significantly improved (Multidimensional Fatigue Index-20, P = 0·003), although this parameter did not differ from the reference group at baseline. A probable worsening in role limitations as a result of physical problems (Short Form-36; P = 0·050) was observed. No improvement in the SDQ score was observed. Conclusion In summary, quality of life in patients with DTC and long-term subclinical hyperthyroidism in general is preserved. Restoration of Euthyroidism in general does not affect quality of life.
C F A Eustatiarutten - One of the best experts on this subject based on the ideXlab platform.
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autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring Euthyroidism
The Journal of Clinical Endocrinology and Metabolism, 2008Co-Authors: C F A Eustatiarutten, Karen A Heemstra, Johannes A Romijn, Eleonora P M Corssmit, Johannes W A Smit, Rik C Schoemaker, Jacobus BurggraafAbstract:Context: Knowledge on the relationship between the autonomic nervous system and subclinical hyperthyroidism is mainly based upon cross-sectional studies in heterogeneous patient populations, and the effect of restoration to Euthyroidism in subclinical hyperthyroidism has not been studied. Objective:We investigated the long-term effects of exogenous subclinical hyperthyroidism on the autonomic nervous system and the potential effects of restoration of Euthyroidism. Design: This was a prospective single-blinded, placebo-controlled, randomized trial. Setting: The study was performed at a university hospital. Patients: A total of 25 patients who were on more than 10-yr TSH suppressive therapy after thyroidectomy was examined. Intervention:Patientswerestudiedatbaselineandsubsequentlyrandomizedtoa6-monththyroid hormone substitution regimen to obtain either Euthyroidism or maintenance of the subclinical hyperthyroid state. Main Outcome Measures: Urinary excretion of catecholamines and heart rate variability were measured. Baseline data of the subclinical hyperthyroidism patients were compared with data obtained in patients with hyperthyroidism and controls. Results:Urinaryexcretionofnorepinephrineandvanillylmandelicacidwashigherinthesubclinical hyperthyroidism patients compared with controls and lower compared with patients with overt hyperthyroidism. Heart rate variability was lower in patients with hyperthyroidism, intermediate in subclinical hyperthyroidism patients, and highest in the healthy controls. No differences were observed after restoration of Euthyroidism.
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glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomised controlled trial
Clinical Endocrinology, 2006Co-Authors: Karen A Heemstra, J W A Smit, C F A Eustatiarutten, A C Heijboer, Marijke Frolich, Johannes A Romijn, Eleonora P M CorssmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on glucose and lipid metabolism is unclear. Therefore, we evaluated glucose and lipid metabolism in patients with differentiated thyroid carcinoma (DTC) on TSH suppressive thyroxine therapy as a model for subclinical hyperthyroidism and investigated whether restoration to Euthyroidism affects metabolism. Design We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. Patients Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and Euthyroidism (Euthyroidism group, 12 patients). Measurements We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. Results At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and Euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. Conclusion In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of Euthyroidism in general does not affect glucose and lipid metabolism.
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quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomized controlled trial
Clinical Endocrinology, 2006Co-Authors: C F A Eustatiarutten, Marijke Frolich, Johannes A Romijn, Eleonora P M Corssmit, Alberto M Pereira, J W A SmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on quality of life is unclear. Therefore, we evaluated quality of life in patients with differentiated thyroid carcinoma (DTC) on TSH-suppressive thyroxine therapy as a model for subclinical hyperthyroidism and we investigated whether restoration to Euthyroidism affects quality of life. Design We performed a prospective, single-blinded, placebo-controlled, randomized trial of 6 months’ duration with two parallel groups. Patients and methods Twenty-four subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with L-thyroxine completed the study. L-thyroxine dose was replaced by study medication containing L-thyroxine or L-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group) and Euthyroidism (euthyroid group). Both groups consisted of 12 patients. We evaluated quality of life using five validated questionnaires. Results At baseline, the somatic disorder questionnaire (SDQ) indicated more somatic dysfunction in patients as compared with reference values, whereas the depression score (HADS) revealed a better score than the reference group. All other quality of life parameters were normal. At baseline, no significant differences between the low-TSH and the Euthyroidism groups were observed. After 6 months, none of the quality of life parameters in the low-TSH group was different from baseline values. In the euthyroid group, motivation was significantly improved (Multidimensional Fatigue Index-20, P = 0·003), although this parameter did not differ from the reference group at baseline. A probable worsening in role limitations as a result of physical problems (Short Form-36; P = 0·050) was observed. No improvement in the SDQ score was observed. Conclusion In summary, quality of life in patients with DTC and long-term subclinical hyperthyroidism in general is preserved. Restoration of Euthyroidism in general does not affect quality of life.
Johannes A Romijn - One of the best experts on this subject based on the ideXlab platform.
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autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring Euthyroidism
The Journal of Clinical Endocrinology and Metabolism, 2008Co-Authors: C F A Eustatiarutten, Karen A Heemstra, Johannes A Romijn, Eleonora P M Corssmit, Johannes W A Smit, Rik C Schoemaker, Jacobus BurggraafAbstract:Context: Knowledge on the relationship between the autonomic nervous system and subclinical hyperthyroidism is mainly based upon cross-sectional studies in heterogeneous patient populations, and the effect of restoration to Euthyroidism in subclinical hyperthyroidism has not been studied. Objective:We investigated the long-term effects of exogenous subclinical hyperthyroidism on the autonomic nervous system and the potential effects of restoration of Euthyroidism. Design: This was a prospective single-blinded, placebo-controlled, randomized trial. Setting: The study was performed at a university hospital. Patients: A total of 25 patients who were on more than 10-yr TSH suppressive therapy after thyroidectomy was examined. Intervention:Patientswerestudiedatbaselineandsubsequentlyrandomizedtoa6-monththyroid hormone substitution regimen to obtain either Euthyroidism or maintenance of the subclinical hyperthyroid state. Main Outcome Measures: Urinary excretion of catecholamines and heart rate variability were measured. Baseline data of the subclinical hyperthyroidism patients were compared with data obtained in patients with hyperthyroidism and controls. Results:Urinaryexcretionofnorepinephrineandvanillylmandelicacidwashigherinthesubclinical hyperthyroidism patients compared with controls and lower compared with patients with overt hyperthyroidism. Heart rate variability was lower in patients with hyperthyroidism, intermediate in subclinical hyperthyroidism patients, and highest in the healthy controls. No differences were observed after restoration of Euthyroidism.
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glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomised controlled trial
Clinical Endocrinology, 2006Co-Authors: Karen A Heemstra, J W A Smit, C F A Eustatiarutten, A C Heijboer, Marijke Frolich, Johannes A Romijn, Eleonora P M CorssmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on glucose and lipid metabolism is unclear. Therefore, we evaluated glucose and lipid metabolism in patients with differentiated thyroid carcinoma (DTC) on TSH suppressive thyroxine therapy as a model for subclinical hyperthyroidism and investigated whether restoration to Euthyroidism affects metabolism. Design We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. Patients Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and Euthyroidism (Euthyroidism group, 12 patients). Measurements We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. Results At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and Euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. Conclusion In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of Euthyroidism in general does not affect glucose and lipid metabolism.
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quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomized controlled trial
Clinical Endocrinology, 2006Co-Authors: C F A Eustatiarutten, Marijke Frolich, Johannes A Romijn, Eleonora P M Corssmit, Alberto M Pereira, J W A SmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on quality of life is unclear. Therefore, we evaluated quality of life in patients with differentiated thyroid carcinoma (DTC) on TSH-suppressive thyroxine therapy as a model for subclinical hyperthyroidism and we investigated whether restoration to Euthyroidism affects quality of life. Design We performed a prospective, single-blinded, placebo-controlled, randomized trial of 6 months’ duration with two parallel groups. Patients and methods Twenty-four subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with L-thyroxine completed the study. L-thyroxine dose was replaced by study medication containing L-thyroxine or L-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group) and Euthyroidism (euthyroid group). Both groups consisted of 12 patients. We evaluated quality of life using five validated questionnaires. Results At baseline, the somatic disorder questionnaire (SDQ) indicated more somatic dysfunction in patients as compared with reference values, whereas the depression score (HADS) revealed a better score than the reference group. All other quality of life parameters were normal. At baseline, no significant differences between the low-TSH and the Euthyroidism groups were observed. After 6 months, none of the quality of life parameters in the low-TSH group was different from baseline values. In the euthyroid group, motivation was significantly improved (Multidimensional Fatigue Index-20, P = 0·003), although this parameter did not differ from the reference group at baseline. A probable worsening in role limitations as a result of physical problems (Short Form-36; P = 0·050) was observed. No improvement in the SDQ score was observed. Conclusion In summary, quality of life in patients with DTC and long-term subclinical hyperthyroidism in general is preserved. Restoration of Euthyroidism in general does not affect quality of life.
J W A Smit - One of the best experts on this subject based on the ideXlab platform.
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glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomised controlled trial
Clinical Endocrinology, 2006Co-Authors: Karen A Heemstra, J W A Smit, C F A Eustatiarutten, A C Heijboer, Marijke Frolich, Johannes A Romijn, Eleonora P M CorssmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on glucose and lipid metabolism is unclear. Therefore, we evaluated glucose and lipid metabolism in patients with differentiated thyroid carcinoma (DTC) on TSH suppressive thyroxine therapy as a model for subclinical hyperthyroidism and investigated whether restoration to Euthyroidism affects metabolism. Design We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. Patients Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and Euthyroidism (Euthyroidism group, 12 patients). Measurements We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. Results At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and Euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. Conclusion In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of Euthyroidism in general does not affect glucose and lipid metabolism.
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quality of life in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomized controlled trial
Clinical Endocrinology, 2006Co-Authors: C F A Eustatiarutten, Marijke Frolich, Johannes A Romijn, Eleonora P M Corssmit, Alberto M Pereira, J W A SmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on quality of life is unclear. Therefore, we evaluated quality of life in patients with differentiated thyroid carcinoma (DTC) on TSH-suppressive thyroxine therapy as a model for subclinical hyperthyroidism and we investigated whether restoration to Euthyroidism affects quality of life. Design We performed a prospective, single-blinded, placebo-controlled, randomized trial of 6 months’ duration with two parallel groups. Patients and methods Twenty-four subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with L-thyroxine completed the study. L-thyroxine dose was replaced by study medication containing L-thyroxine or L-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group) and Euthyroidism (euthyroid group). Both groups consisted of 12 patients. We evaluated quality of life using five validated questionnaires. Results At baseline, the somatic disorder questionnaire (SDQ) indicated more somatic dysfunction in patients as compared with reference values, whereas the depression score (HADS) revealed a better score than the reference group. All other quality of life parameters were normal. At baseline, no significant differences between the low-TSH and the Euthyroidism groups were observed. After 6 months, none of the quality of life parameters in the low-TSH group was different from baseline values. In the euthyroid group, motivation was significantly improved (Multidimensional Fatigue Index-20, P = 0·003), although this parameter did not differ from the reference group at baseline. A probable worsening in role limitations as a result of physical problems (Short Form-36; P = 0·050) was observed. No improvement in the SDQ score was observed. Conclusion In summary, quality of life in patients with DTC and long-term subclinical hyperthyroidism in general is preserved. Restoration of Euthyroidism in general does not affect quality of life.
Karen A Heemstra - One of the best experts on this subject based on the ideXlab platform.
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autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring Euthyroidism
The Journal of Clinical Endocrinology and Metabolism, 2008Co-Authors: C F A Eustatiarutten, Karen A Heemstra, Johannes A Romijn, Eleonora P M Corssmit, Johannes W A Smit, Rik C Schoemaker, Jacobus BurggraafAbstract:Context: Knowledge on the relationship between the autonomic nervous system and subclinical hyperthyroidism is mainly based upon cross-sectional studies in heterogeneous patient populations, and the effect of restoration to Euthyroidism in subclinical hyperthyroidism has not been studied. Objective:We investigated the long-term effects of exogenous subclinical hyperthyroidism on the autonomic nervous system and the potential effects of restoration of Euthyroidism. Design: This was a prospective single-blinded, placebo-controlled, randomized trial. Setting: The study was performed at a university hospital. Patients: A total of 25 patients who were on more than 10-yr TSH suppressive therapy after thyroidectomy was examined. Intervention:Patientswerestudiedatbaselineandsubsequentlyrandomizedtoa6-monththyroid hormone substitution regimen to obtain either Euthyroidism or maintenance of the subclinical hyperthyroid state. Main Outcome Measures: Urinary excretion of catecholamines and heart rate variability were measured. Baseline data of the subclinical hyperthyroidism patients were compared with data obtained in patients with hyperthyroidism and controls. Results:Urinaryexcretionofnorepinephrineandvanillylmandelicacidwashigherinthesubclinical hyperthyroidism patients compared with controls and lower compared with patients with overt hyperthyroidism. Heart rate variability was lower in patients with hyperthyroidism, intermediate in subclinical hyperthyroidism patients, and highest in the healthy controls. No differences were observed after restoration of Euthyroidism.
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glucose tolerance and lipid profile in longterm exogenous subclinical hyperthyroidism and the effects of restoration of Euthyroidism a randomised controlled trial
Clinical Endocrinology, 2006Co-Authors: Karen A Heemstra, J W A Smit, C F A Eustatiarutten, A C Heijboer, Marijke Frolich, Johannes A Romijn, Eleonora P M CorssmitAbstract:Summary Objective The impact of prolonged subclinical hyperthyroidism on glucose and lipid metabolism is unclear. Therefore, we evaluated glucose and lipid metabolism in patients with differentiated thyroid carcinoma (DTC) on TSH suppressive thyroxine therapy as a model for subclinical hyperthyroidism and investigated whether restoration to Euthyroidism affects metabolism. Design We performed a prospective, single-blinded, placebo-controlled, randomised trial of 6 months duration with 2 parallel groups. Patients Twenty-five subjects with a history of differentiated thyroid carcinoma with > 10 years TSH-suppressive therapy with l-thyroxine completed the study. l-thyroxine dose was replaced by study medication containing l-thyroxine or l-thyroxine plus placebo. Medication was titrated to establish continuation of TSH suppression (low-TSH group, 13 patients) and Euthyroidism (Euthyroidism group, 12 patients). Measurements We evaluated glucose metabolism by glucose tolerance test and HOMA (IR) and lipid metabolism by lipid profile. In addition, we measured plasma concentrations of glucoregulatory hormones. Results At baseline, glucose tolerance, HOMA (IR), lipid profile and plasma concentrations of glucoregulatory hormones were within the normal range. No significant differences between the low TSH and Euthyroidism group were observed. After 6 months, neither glucose nor lipid metabolism in the low TSH group were different from baseline values. Conclusion In summary, glucose and lipid metabolism in patients with DTC and long-term subclinical hyperthyroidism in general are not affected. Restoration of Euthyroidism in general does not affect glucose and lipid metabolism.
