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Sian M Noble - One of the best experts on this subject based on the ideXlab platform.
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clinical and patient reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms baseline results and diagnostic findings of the urodynamics for prostate surgery trial randomised Evaluation of assessme
European urology focus, 2019Co-Authors: Amanda L Lewis, Grace J Young, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, Sian M Noble, Gordon T TaylorAbstract:Abstract Background Clinical Evaluation of male lower urinary tract symptoms (MLUTS) in secondary care uses a range of Assessments. It is unknown how MLUTS Evaluation influences outcome of therapy recommendations and choice, notably urodynamics (UDS; filling cystometry and pressure flow studies). Objective To report participants’ sociodemographic and clinical characteristics, and initial diagnostic findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM). UPSTREAM is a randomised controlled trial evaluating whether symptoms are noninferior and surgery rates are lower if UDS is included. Design, setting, and participants A total of 820 men (≥18 yr of age) seeking treatment for bothersome LUTS were recruited from 26 National Health Service hospital urology departments. Intervention Care pathway based on routine, noninvasive tests (control) or routine care plus UDS (intervention arm). Outcome measurements and statistical analysis The primary outcome is International Prostate Symptom Score (IPSS) and the key secondary outcome is surgery rates 18 mo after randomisation. International Consultation on Incontinence Questionnaires were captured for MLUTS, sexual function, and UDS satisfaction. Baseline clinical and patient-reported outcome measures (PROMs), and UDS findings were informally compared between arms. Trends across age groups for urinary and sexual PROMs were evaluated with a Cuzick’s test, and questionnaire items were compared using Pearson’s correlation coefficient. Results and limitations Storage LUTS, notably nocturia, and impaired sexual function are prominent in men being assessed for surgery. Sociodemographic and clinical Evaluations were similar between arms. Overall mean IPSS and quality of life scores were 18.94 and 4.13, respectively. Trends were found across age groups, with older men suffering from higher rates of incontinence, nocturia, and erectile dysfunction, and younger men suffering from increased daytime frequency and voiding symptoms. Men undergoing UDS testing expressed high satisfaction with the procedure. Conclusions Men being considered for surgery have additional clinical features that may affect treatment decision making and outcomes, notably storage LUTS and impaired sexual function. Patient summary We describe initial Assessment findings from a large clinical study of the treatment pathway for men suffering with bothersome urinary symptoms who were referred to hospital for further treatment, potentially including surgery. We report the patient characteristics and diagnostic test results, including symptom questionnaires, bladder diaries, flow rate tests, and urodynamics.
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urodynamics for prostate surgery trial randomised Evaluation of Assessment methods upstream for diagnosis and management of bladder outlet obstruction in men study protocol for a randomised controlled trial
Trials, 2015Co-Authors: K Bailey, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, J A Lane, Sian M NobleAbstract:Background Lower urinary tract symptoms (LUTS) comprise storage symptoms, voiding symptoms and post-voiding symptoms. Prevalence and severity of LUTS increase with age and the progressive increase in the aged population group has emphasised the importance to our society of appropriate and effective management of male LUTS. Identification of causal mechanisms is needed to optimise treatment and uroflowmetry is the simplest non-invasive test of voiding function. Invasive urodynamics can evaluate storage function and voiding function; however, there is currently insufficient evidence to support urodynamics becoming part of routine practice in the clinical Evaluation of male LUTS.
Peter S Blair - One of the best experts on this subject based on the ideXlab platform.
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clinical and patient reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms baseline results and diagnostic findings of the urodynamics for prostate surgery trial randomised Evaluation of assessme
European urology focus, 2019Co-Authors: Amanda L Lewis, Grace J Young, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, Sian M Noble, Gordon T TaylorAbstract:Abstract Background Clinical Evaluation of male lower urinary tract symptoms (MLUTS) in secondary care uses a range of Assessments. It is unknown how MLUTS Evaluation influences outcome of therapy recommendations and choice, notably urodynamics (UDS; filling cystometry and pressure flow studies). Objective To report participants’ sociodemographic and clinical characteristics, and initial diagnostic findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM). UPSTREAM is a randomised controlled trial evaluating whether symptoms are noninferior and surgery rates are lower if UDS is included. Design, setting, and participants A total of 820 men (≥18 yr of age) seeking treatment for bothersome LUTS were recruited from 26 National Health Service hospital urology departments. Intervention Care pathway based on routine, noninvasive tests (control) or routine care plus UDS (intervention arm). Outcome measurements and statistical analysis The primary outcome is International Prostate Symptom Score (IPSS) and the key secondary outcome is surgery rates 18 mo after randomisation. International Consultation on Incontinence Questionnaires were captured for MLUTS, sexual function, and UDS satisfaction. Baseline clinical and patient-reported outcome measures (PROMs), and UDS findings were informally compared between arms. Trends across age groups for urinary and sexual PROMs were evaluated with a Cuzick’s test, and questionnaire items were compared using Pearson’s correlation coefficient. Results and limitations Storage LUTS, notably nocturia, and impaired sexual function are prominent in men being assessed for surgery. Sociodemographic and clinical Evaluations were similar between arms. Overall mean IPSS and quality of life scores were 18.94 and 4.13, respectively. Trends were found across age groups, with older men suffering from higher rates of incontinence, nocturia, and erectile dysfunction, and younger men suffering from increased daytime frequency and voiding symptoms. Men undergoing UDS testing expressed high satisfaction with the procedure. Conclusions Men being considered for surgery have additional clinical features that may affect treatment decision making and outcomes, notably storage LUTS and impaired sexual function. Patient summary We describe initial Assessment findings from a large clinical study of the treatment pathway for men suffering with bothersome urinary symptoms who were referred to hospital for further treatment, potentially including surgery. We report the patient characteristics and diagnostic test results, including symptom questionnaires, bladder diaries, flow rate tests, and urodynamics.
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urodynamics for prostate surgery trial randomised Evaluation of Assessment methods upstream for diagnosis and management of bladder outlet obstruction in men study protocol for a randomised controlled trial
Trials, 2015Co-Authors: K Bailey, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, J A Lane, Sian M NobleAbstract:Background Lower urinary tract symptoms (LUTS) comprise storage symptoms, voiding symptoms and post-voiding symptoms. Prevalence and severity of LUTS increase with age and the progressive increase in the aged population group has emphasised the importance to our society of appropriate and effective management of male LUTS. Identification of causal mechanisms is needed to optimise treatment and uroflowmetry is the simplest non-invasive test of voiding function. Invasive urodynamics can evaluate storage function and voiding function; however, there is currently insufficient evidence to support urodynamics becoming part of routine practice in the clinical Evaluation of male LUTS.
Martin J. Van Den Bent - One of the best experts on this subject based on the ideXlab platform.
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Fatigue in patients with low grade glioma: systematic Evaluation of Assessment and prevalence
Journal of Neuro-Oncology, 2017Co-Authors: Ellen M. P. Van Coevorden-van Loon, Marijke B. Coomans, Majanka H. Heijenbrok-kal, Gerard M. Ribbers, Martin J. Van Den BentAbstract:Fatigue is the most prevalent and disabling symptom in cancer patients. Yet, scientific literature on this topic is scarce and reports disparate results. This study systematically reviews how fatigue is assessed in patients with low-grade glioma and evaluates its prevalence in LGG patients. A systematic literature search was performed in PubMed, Embase and PsychINFO for articles reporting on fatigue in patients with LGG. Two reviewers independently extracted data from selected articles. Inclusion criteria were: (1) patients with suspected or confirmed LGG; (2) fatigue was assessed as primary or secondary outcome measure; (3) age≥ 18 years; (4) full-length article written in English or Dutch. In total, 19 articles were selected, including 971 patients. Seven self-Assessment instruments were identified. Prevalence rates ranged from 39 to 77%. Fatigue was found to be a common side effect of treatment. The prevalence rates ranged from 20 to 76% when fatigue was reported as a mild or moderate side effect and fatigue was prevalent in 4% when reported as a severe side effect. Fatigue is a common problem in LGG patients that warrants more therapeutic and scientific attention. Gaining deeper insight in the underlying mechanisms of fatigue is essential in targeting therapy to individual patients.
Paul Abrams - One of the best experts on this subject based on the ideXlab platform.
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clinical and patient reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms baseline results and diagnostic findings of the urodynamics for prostate surgery trial randomised Evaluation of assessme
European urology focus, 2019Co-Authors: Amanda L Lewis, Grace J Young, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, Sian M Noble, Gordon T TaylorAbstract:Abstract Background Clinical Evaluation of male lower urinary tract symptoms (MLUTS) in secondary care uses a range of Assessments. It is unknown how MLUTS Evaluation influences outcome of therapy recommendations and choice, notably urodynamics (UDS; filling cystometry and pressure flow studies). Objective To report participants’ sociodemographic and clinical characteristics, and initial diagnostic findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM). UPSTREAM is a randomised controlled trial evaluating whether symptoms are noninferior and surgery rates are lower if UDS is included. Design, setting, and participants A total of 820 men (≥18 yr of age) seeking treatment for bothersome LUTS were recruited from 26 National Health Service hospital urology departments. Intervention Care pathway based on routine, noninvasive tests (control) or routine care plus UDS (intervention arm). Outcome measurements and statistical analysis The primary outcome is International Prostate Symptom Score (IPSS) and the key secondary outcome is surgery rates 18 mo after randomisation. International Consultation on Incontinence Questionnaires were captured for MLUTS, sexual function, and UDS satisfaction. Baseline clinical and patient-reported outcome measures (PROMs), and UDS findings were informally compared between arms. Trends across age groups for urinary and sexual PROMs were evaluated with a Cuzick’s test, and questionnaire items were compared using Pearson’s correlation coefficient. Results and limitations Storage LUTS, notably nocturia, and impaired sexual function are prominent in men being assessed for surgery. Sociodemographic and clinical Evaluations were similar between arms. Overall mean IPSS and quality of life scores were 18.94 and 4.13, respectively. Trends were found across age groups, with older men suffering from higher rates of incontinence, nocturia, and erectile dysfunction, and younger men suffering from increased daytime frequency and voiding symptoms. Men undergoing UDS testing expressed high satisfaction with the procedure. Conclusions Men being considered for surgery have additional clinical features that may affect treatment decision making and outcomes, notably storage LUTS and impaired sexual function. Patient summary We describe initial Assessment findings from a large clinical study of the treatment pathway for men suffering with bothersome urinary symptoms who were referred to hospital for further treatment, potentially including surgery. We report the patient characteristics and diagnostic test results, including symptom questionnaires, bladder diaries, flow rate tests, and urodynamics.
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urodynamics for prostate surgery trial randomised Evaluation of Assessment methods upstream for diagnosis and management of bladder outlet obstruction in men study protocol for a randomised controlled trial
Trials, 2015Co-Authors: K Bailey, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, J A Lane, Sian M NobleAbstract:Background Lower urinary tract symptoms (LUTS) comprise storage symptoms, voiding symptoms and post-voiding symptoms. Prevalence and severity of LUTS increase with age and the progressive increase in the aged population group has emphasised the importance to our society of appropriate and effective management of male LUTS. Identification of causal mechanisms is needed to optimise treatment and uroflowmetry is the simplest non-invasive test of voiding function. Invasive urodynamics can evaluate storage function and voiding function; however, there is currently insufficient evidence to support urodynamics becoming part of routine practice in the clinical Evaluation of male LUTS.
John S Mcgrath - One of the best experts on this subject based on the ideXlab platform.
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clinical and patient reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms baseline results and diagnostic findings of the urodynamics for prostate surgery trial randomised Evaluation of assessme
European urology focus, 2019Co-Authors: Amanda L Lewis, Grace J Young, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, Sian M Noble, Gordon T TaylorAbstract:Abstract Background Clinical Evaluation of male lower urinary tract symptoms (MLUTS) in secondary care uses a range of Assessments. It is unknown how MLUTS Evaluation influences outcome of therapy recommendations and choice, notably urodynamics (UDS; filling cystometry and pressure flow studies). Objective To report participants’ sociodemographic and clinical characteristics, and initial diagnostic findings of the Urodynamics for Prostate Surgery Trial; Randomised Evaluation of Assessment Methods (UPSTREAM). UPSTREAM is a randomised controlled trial evaluating whether symptoms are noninferior and surgery rates are lower if UDS is included. Design, setting, and participants A total of 820 men (≥18 yr of age) seeking treatment for bothersome LUTS were recruited from 26 National Health Service hospital urology departments. Intervention Care pathway based on routine, noninvasive tests (control) or routine care plus UDS (intervention arm). Outcome measurements and statistical analysis The primary outcome is International Prostate Symptom Score (IPSS) and the key secondary outcome is surgery rates 18 mo after randomisation. International Consultation on Incontinence Questionnaires were captured for MLUTS, sexual function, and UDS satisfaction. Baseline clinical and patient-reported outcome measures (PROMs), and UDS findings were informally compared between arms. Trends across age groups for urinary and sexual PROMs were evaluated with a Cuzick’s test, and questionnaire items were compared using Pearson’s correlation coefficient. Results and limitations Storage LUTS, notably nocturia, and impaired sexual function are prominent in men being assessed for surgery. Sociodemographic and clinical Evaluations were similar between arms. Overall mean IPSS and quality of life scores were 18.94 and 4.13, respectively. Trends were found across age groups, with older men suffering from higher rates of incontinence, nocturia, and erectile dysfunction, and younger men suffering from increased daytime frequency and voiding symptoms. Men undergoing UDS testing expressed high satisfaction with the procedure. Conclusions Men being considered for surgery have additional clinical features that may affect treatment decision making and outcomes, notably storage LUTS and impaired sexual function. Patient summary We describe initial Assessment findings from a large clinical study of the treatment pathway for men suffering with bothersome urinary symptoms who were referred to hospital for further treatment, potentially including surgery. We report the patient characteristics and diagnostic test results, including symptom questionnaires, bladder diaries, flow rate tests, and urodynamics.
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urodynamics for prostate surgery trial randomised Evaluation of Assessment methods upstream for diagnosis and management of bladder outlet obstruction in men study protocol for a randomised controlled trial
Trials, 2015Co-Authors: K Bailey, Paul Abrams, Peter S Blair, Christopher R Chapple, Cathryn Glazener, Jeremy Horwood, John S Mcgrath, J A Lane, Sian M NobleAbstract:Background Lower urinary tract symptoms (LUTS) comprise storage symptoms, voiding symptoms and post-voiding symptoms. Prevalence and severity of LUTS increase with age and the progressive increase in the aged population group has emphasised the importance to our society of appropriate and effective management of male LUTS. Identification of causal mechanisms is needed to optimise treatment and uroflowmetry is the simplest non-invasive test of voiding function. Invasive urodynamics can evaluate storage function and voiding function; however, there is currently insufficient evidence to support urodynamics becoming part of routine practice in the clinical Evaluation of male LUTS.
