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Juha Toyras - One of the best experts on this subject based on the ideXlab platform.

  • severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea
    Sleep and Breathing, 2017
    Co-Authors: Antti Kulkas, Brett Duce, Timo Leppanen, Craig Hukins, Juha Toyras
    Abstract:

    Frequency of apnea and hypopnea events is used to estimate the severity of obstructive sleep apnea (OSA). However, comprehensive information on whether apneas and hypopneas cause an equal biological effect is not available. The purpose of the present work was to evaluate the effect of the breathing cessation event type (i.e., obstructive apnea or hypopnea) and duration on the severity of related SpO2 desaturation events. Type 1 polysomnographies of 395 patients (220 males and 175 females) examined for suspected OSA were analyzed. Desaturation severity related to hypopnea and obstructive apnea events were compared and comparison was controlled for gender, sleep stage, sleeping position, age, and body mass index. Hypopneas and obstructive apneas were further divided into eight different durational categories and related desaturation event characteristics were compared between the categories. SpO2 desaturation events caused by obstructive apneas were statistically significantly (p ≤ 0.004) longer, greater in area, and deeper compared to the SpO2 desaturations caused by hypopneas. The increase in the duration of hypopnea and obstructive apnea events led to increase in the duration and area of related SpO2 desaturations. The increase in the obstructive apnea event duration also led to increase in the depth of related desaturation event. Obstructive apneas led to more severe SpO2 desaturation compared to hypopneas. Increased event duration led to increase in the severity of the related SpO2 desaturation. In addition to considering event duration, obstructive apneas should have more weight than hypopneas when estimating severity of OSA and associated long-term cardiovascular risk.

Brett Duce - One of the best experts on this subject based on the ideXlab platform.

  • severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea
    Sleep and Breathing, 2017
    Co-Authors: Antti Kulkas, Brett Duce, Timo Leppanen, Craig Hukins, Juha Toyras
    Abstract:

    Frequency of apnea and hypopnea events is used to estimate the severity of obstructive sleep apnea (OSA). However, comprehensive information on whether apneas and hypopneas cause an equal biological effect is not available. The purpose of the present work was to evaluate the effect of the breathing cessation event type (i.e., obstructive apnea or hypopnea) and duration on the severity of related SpO2 desaturation events. Type 1 polysomnographies of 395 patients (220 males and 175 females) examined for suspected OSA were analyzed. Desaturation severity related to hypopnea and obstructive apnea events were compared and comparison was controlled for gender, sleep stage, sleeping position, age, and body mass index. Hypopneas and obstructive apneas were further divided into eight different durational categories and related desaturation event characteristics were compared between the categories. SpO2 desaturation events caused by obstructive apneas were statistically significantly (p ≤ 0.004) longer, greater in area, and deeper compared to the SpO2 desaturations caused by hypopneas. The increase in the duration of hypopnea and obstructive apnea events led to increase in the duration and area of related SpO2 desaturations. The increase in the obstructive apnea event duration also led to increase in the depth of related desaturation event. Obstructive apneas led to more severe SpO2 desaturation compared to hypopneas. Increased event duration led to increase in the severity of the related SpO2 desaturation. In addition to considering event duration, obstructive apneas should have more weight than hypopneas when estimating severity of OSA and associated long-term cardiovascular risk.

Wei Luo - One of the best experts on this subject based on the ideXlab platform.

  • CCL - Improving Event Detection via Information Sharing among Related Event Types
    Lecture Notes in Computer Science, 2017
    Co-Authors: Shulin Liu, Yubo Chen, Kang Liu, Jun Zhao, Zhunchen Luo, Wei Luo
    Abstract:

    Event detection suffers from data sparseness and label imbalance problem due to the expensive cost of manual annotations of events. To address this problem, we propose a novel approach that allows for information sharing among related event types. Specifically, we employ a fully connected three-layer artificial neural network as our basic model and propose a type-group regularization term to achieve the goal of information sharing. We conduct experiments with different configurations of type groups, and the experimental results show that information sharing among related event types remarkably improves the detecting performance. Compared with state-of-the-art methods, our proposed approach achieves a better \(F_1\) score on the widely used ACE 2005 event evaluation dataset.

Antti Kulkas - One of the best experts on this subject based on the ideXlab platform.

  • severity of desaturation events differs between hypopnea and obstructive apnea events and is modulated by their duration in obstructive sleep apnea
    Sleep and Breathing, 2017
    Co-Authors: Antti Kulkas, Brett Duce, Timo Leppanen, Craig Hukins, Juha Toyras
    Abstract:

    Frequency of apnea and hypopnea events is used to estimate the severity of obstructive sleep apnea (OSA). However, comprehensive information on whether apneas and hypopneas cause an equal biological effect is not available. The purpose of the present work was to evaluate the effect of the breathing cessation event type (i.e., obstructive apnea or hypopnea) and duration on the severity of related SpO2 desaturation events. Type 1 polysomnographies of 395 patients (220 males and 175 females) examined for suspected OSA were analyzed. Desaturation severity related to hypopnea and obstructive apnea events were compared and comparison was controlled for gender, sleep stage, sleeping position, age, and body mass index. Hypopneas and obstructive apneas were further divided into eight different durational categories and related desaturation event characteristics were compared between the categories. SpO2 desaturation events caused by obstructive apneas were statistically significantly (p ≤ 0.004) longer, greater in area, and deeper compared to the SpO2 desaturations caused by hypopneas. The increase in the duration of hypopnea and obstructive apnea events led to increase in the duration and area of related SpO2 desaturations. The increase in the obstructive apnea event duration also led to increase in the depth of related desaturation event. Obstructive apneas led to more severe SpO2 desaturation compared to hypopneas. Increased event duration led to increase in the severity of the related SpO2 desaturation. In addition to considering event duration, obstructive apneas should have more weight than hypopneas when estimating severity of OSA and associated long-term cardiovascular risk.

André Scheen - One of the best experts on this subject based on the ideXlab platform.

  • Type 2 Diabetes and Thiazide Diuretics
    Current Diabetes Reports, 2018
    Co-Authors: André Scheen
    Abstract:

    Purpose of Review In patients with prediabetes or type 2 diabetes, the use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset diabetes. Recent Findings These metabolic disturbances are less marked with low-dose thiazides and, in most but not all studies, with thiazide-like diuretics (chlorthalidone, indapamide) than with thiazide-type diuretics (hydrochlorothiazide). In post hoc analyses of subgroups of patients with hypertension and type 2 diabetes, thiazides resulted in a significant reduction in cardiovascular events, all-cause mortality, and hospitalization for heart failure compared to placebo and generally were shown to be non-inferior to other antihypertensive agents. Summary Benefits attributed to thiazide diuretics in terms of cardiovascular event reduction outweigh the risk of worsening glucose control in type 2 diabetes and of new-onset diabetes in non-diabetic patients. Thiazides still play a key role in the management of patients with type 2 diabetes and hypertension.