Exchange Transfusion

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform

Praveen Kumar - One of the best experts on this subject based on the ideXlab platform.

  • adverse events following blood Exchange Transfusion for neonatal hyperbilirubinemia a prospective study
    Journal of clinical neonatology, 2019
    Co-Authors: Swathi Chacham, Jogender Kumar, Sourabh Dutta, Praveen Kumar
    Abstract:

    Background: Exchange Transfusion (ET) for hyperbilirubinemia is associated with many complications. The complications are underreported as most of the published studies are retrospective, used varying definitions of adverse events (AEs) and variable follow-up periods. Aim: We evaluated the incidence of clinical, biochemical, hematological, and radiological AEs, including serious AEs, within 2 weeks of ET for hyperbilirubinemia in neonates, using standard definitions. Materials and Methods: This prospective observational study was conducted in level III newborn unit of north India from February 2008 to February 2009. We enrolled consecutive inborn and outborn neonates admitted with hyperbilirubinemia and required ET. Babies requiring partial Exchange for anemia/polycythemia or ET for indications other than hyperbilirubinemia were excluded. They were prospectively monitored for clinical, biochemical, hematological, and radiological AEs up to 2 weeks following the procedure. We calculated the incidence/AE rate (AER) as the rate of events per 100 ET and compared them among various groups using the Chi-square test. The SPSS v20 was used for the analysis, and value of P

  • blood Exchange Transfusion for infants with severe neonatal hyperbilirubinemia
    Seminars in Perinatology, 2011
    Co-Authors: Srinivas Murki, Praveen Kumar
    Abstract:

    Blood Exchange Transfusion has become a rare event in most developed countries. As a result, many pediatricians may not have performed or even seen one. However, it remains a frequent emergency rescue procedure for severe neonatal hyperbilirubinemia in many underdeveloped regions of the world. Conventionally, Exchange Transfusion has been performed via a central umbilical venous catheter by pull-push cycle method and recently peripheral artery/peripheral vein has emerged as an alternative, isovolumetric route. Continuous arterio-venous Exchange is possibly more effective though its automation has not been successful. Concerns for procedural and operator related adverse events have been raised in the context of declining indications. A required continued expertise for this life-saving intervention, in the face of rare but critical hyperbilirubinemia and/or unrecognized hemolytic diseases, deserves adaptation of newer technologies to make neonatal Exchange Transfusion a safer and more effective procedure. Technological innovations and simulation technologies are urgently needed.

  • donor blood glucose 6 phosphate dehydrogenase deficiency reduces the efficacy of Exchange Transfusion in neonatal hyperbilirubinemia
    Pediatrics, 2009
    Co-Authors: Sandip Samanta, Praveen Kumar, Sai Sunil Kishore, Gurjeewan Garewal, Anil Narang
    Abstract:

    OBJECTIVES: Acute intravascular hemolysis after Exchange Transfusion with glucose 6-phosphate dehydrogenase-deficient blood has been reported; however, it is not routine to screen donor blood for glucose 6-phosphate dehydrogenase deficiency while performing Exchange Transfusion. We hypothesized that Exchange Transfusion with glucose 6-phosphate dehydrogenase-deficient blood would lead to a less-than-expected decrease in total serum bilirubin. The objective of this study was to evaluate the effect of Exchange Transfusion with glucose 6-phosphate dehydrogenase-deficient blood in neonates with idiopathic hyperbilirubinemia on postExchange total serum bilirubin levels, duration of phototherapy, and need for repeat Exchange Transfusions. METHODS: All neonates who were undergoing Exchange Transfusion for idiopathic hyperbilirubinemia were enrolled. A sample of donor blood was collected at the time of Exchange Transfusion for a glucose 6-phosphate dehydrogenase assay. The standard criteria for starting and stopping phototherapy and Exchange Transfusion were applied. RESULTS: During the 1-year study period, 21 infants underwent Exchange with glucose 6-phosphate dehydrogenase-deficient blood, and 114 neonates with similar baseline characteristics underwent Exchange Transfusion with glucose 6-phosphate dehydrogenase-normal blood. From 6 to 60 hours after Exchange Transfusion, there was a significantly lesser drop in total serum bilirubin in the recipients of glucose 6-phosphate dehydrogenase-deficient donor blood compared with recipients of glucose 6-phosphate dehydrogenase-normal blood. The mean duration of phototherapy in the postExchange period and number of infants who underwent repeat Exchange Transfusions were significantly higher in recipients of glucose 6-phosphate dehydrogenase-deficient donor blood in comparison with control subjects. Concurrently, there was a significantly higher drop in hematocrit and rise in plasma hemoglobin in the glucose 6-phosphate dehydrogenase-deficient donor group. CONCLUSIONS: Exchange Transfusion with glucose 6-phosphate dehydrogenase-deficient donor blood leads to a lesser drop in postExchange total serum bilirubin. It prolongs the duration of phototherapy and increases the need for repeat Exchange Transfusions.

  • acute intravascular haemolysis following Exchange Transfusion with g 6 pd deficient blood
    European Journal of Pediatrics, 1994
    Co-Authors: Praveen Kumar, Subrata Sarkar, Anil Narang
    Abstract:

    A neonate with hyperbilirubinaemia who developed massive intravascular haemolysis following Exchange Transfusion with glucose-6-phosphate dehydrogenase deficient blood is described. It is recommended that in areas endemic for this enzyme deficiency the donor blood should be screened before being used for Exchange Transfusion.

Thomas B Newman - One of the best experts on this subject based on the ideXlab platform.

  • total serum bilirubin exceeding Exchange Transfusion thresholds in the setting of universal screening
    The Journal of Pediatrics, 2012
    Co-Authors: Valerie J Flaherman, Michael W Kuzniewicz, Gabriel J Escobar, Thomas B Newman
    Abstract:

    Objective To describe the incidence and predictors of total serum bilirubin (TSB) levels that meet or exceed American Academy of Pediatrics (AAP) Exchange Transfusion (ET) thresholds in the setting of universal screening. Study design We conducted a retrospective cohort analysis of electronic data on 18 089 newborns ≥35 weeks gestation born at Northern California Kaiser Permanente Medical Care Program hospitals implementing universal TSB screening in 2005 to 2007, with chart review for subjects with TSB levels reaching the AAP threshold for ET. Results The outcome developed in 22 infants (0.12%); 14 (63.6%) were Conclusion Screening was sensitive but not specific for predicting Exchange threshold.

Bolajoko O Olusanya - One of the best experts on this subject based on the ideXlab platform.

Y Suputtamongkol - One of the best experts on this subject based on the ideXlab platform.

  • Exchange Transfusion as an adjunct to the treatment of severe falciparum malaria
    Tropical Medicine & International Health, 1998
    Co-Authors: S Hoontrakoon, Y Suputtamongkol
    Abstract:

    Summary objective  To compare the efficacy of Exchange Transfusion as the adjunct to quinine treatment (21 patients) with quinine therapy alone (29 patients). method  A retrospective study of 50 patients with severe falciparum malaria was conducted at Chumphorn Hospital, Southern Thailand. results  Clinical characteristics in both treatment groups were not significantly different although in the Exchange Transfusion group, the admission geometric mean parasitaemia (18 (5%), and the proportion of patients with more than 10% parasitaemia was higher (76%, P= 0.03) than in the group who received quinine alone (10 ± 4%; 38%, P = 0.1). The mortality rate of patients who received Exchange Transfusion was 48%; that of the remainder, 69%. (P= 0.3). ARDS (P= 0.01) and oliguric renal failure (P= 0.04) were significant risk factors for death in these patients. conclusion  Exchange Transfusion was safe and well tolerated. Results of our study revealed a 20% reduction in mortality when Exchange Transfusion was used as an adjunct to quinine treatment. It should therefore be considered in patients with severe falciparum malaria when possible.

Robert N Davidson - One of the best experts on this subject based on the ideXlab platform.

  • severe falciparum malaria predicting the effect of Exchange Transfusion
    QJM: An International Journal of Medicine, 1994
    Co-Authors: Robert J Wilkinson, J L Brown, Geoffrey Pasvol, P L Chiodini, Robert N Davidson
    Abstract:

    The rationale for Exchange Transfusion (ET) in severe Plasmodium falciparum malaria is to lower the parasite burden rapidly, to replenish unparasitized cells and to correct severe anaemia. In addition, parasite antigens or ‘toxins’ may be removed. Despite reports of successful ET in the treatment of malaria since 1974, it remains controversial and its role and technique have been poorly defined. We present a mathematical model of ET which relates volume of Exchange to reduction in parasitaemia and change in haemoglobin concentration. This model fits published and unpublished clinical data well, and should facilitate standardization of ET in future.

Related terms

Exchange Transfusion - 15 days free trial to Access Experts & Abstracts