The Experts below are selected from a list of 186 Experts worldwide ranked by ideXlab platform
Teresa Liu-ambrose - One of the best experts on this subject based on the ideXlab platform.
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An Economic Evaluation of Resistance Training and Aerobic Training versus Balance and Toning Exercises in Older Adults with Mild Cognitive Impairment
PloS one, 2013Co-Authors: Jennifer C. Davis, Stirling Bryan, Carlo A. Marra, Devika Sharma, Alison Chan, B. Lynn Beattie, Peter Graf, Teresa Liu-ambroseAbstract:Background Mild Cognitive impairment (MCI) represents a critical window to intervene against dementia. Exercise training is a promising intervention strategy, but the efficiency (i.e., relationship of costs and consequences) of such types of training remains unknown. Thus, we estimated the incremental cost-effectiveness of resistance training or aerobic training compared with balance and tone exercises in terms of changes in Executive Cognitive Function among senior women with probable MCI.
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Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Archives of internal medicine, 2010Co-Authors: Teresa Liu-ambrose, B. Lynn Beattie, Peter Graf, Lindsay S. Nagamatsu, Maureen C. Ashe, Todd C. HandyAbstract:Background Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat Cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of Executive Cognitive Functions in senior women. Methods In this single-blinded randomized trial, 155 community-dwelling women aged 65 to 75 years living in Vancouver were randomly allocated to once-weekly (n = 54) or twice-weekly (n = 52) resistance training or twice-weekly balance and tone training (control group) (n = 49). The primary outcome measure was performance on the Stroop test, an Executive Cognitive test of selective attention and conflict resolution. Secondary outcomes of Executive Cognitive Functions included set shifting as measured by the Trail Making Tests (parts A and B) and working memory as assessed by verbal digit span forward and backward tests. Gait speed, muscular Function, and whole-brain volume were also secondary outcome measures. Results Both resistance training groups significantly improved their performance on the Stroop test compared with those in the balance and tone group ( P ≤ .03). Task performance improved by 12.6% and 10.9% in the once-weekly and twice-weekly resistance training groups, respectively; it deteriorated by 0.5% in the balance and tone group. Enhanced selective attention and conflict resolution was significantly associated with increased gait speed. Both resistance training groups demonstrated reductions in whole-brain volume compared with the balance and tone group at the end of the study ( P ≤ .03). Conclusion Twelve months of once-weekly or twice-weekly resistance training benefited the Executive Cognitive Function of selective attention and conflict resolution among senior women. Trial Registration clinicaltrials.gov Identifier:NCT00426881
Todd C. Handy - One of the best experts on this subject based on the ideXlab platform.
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Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Archives of internal medicine, 2010Co-Authors: Teresa Liu-ambrose, B. Lynn Beattie, Peter Graf, Lindsay S. Nagamatsu, Maureen C. Ashe, Todd C. HandyAbstract:Background Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat Cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of Executive Cognitive Functions in senior women. Methods In this single-blinded randomized trial, 155 community-dwelling women aged 65 to 75 years living in Vancouver were randomly allocated to once-weekly (n = 54) or twice-weekly (n = 52) resistance training or twice-weekly balance and tone training (control group) (n = 49). The primary outcome measure was performance on the Stroop test, an Executive Cognitive test of selective attention and conflict resolution. Secondary outcomes of Executive Cognitive Functions included set shifting as measured by the Trail Making Tests (parts A and B) and working memory as assessed by verbal digit span forward and backward tests. Gait speed, muscular Function, and whole-brain volume were also secondary outcome measures. Results Both resistance training groups significantly improved their performance on the Stroop test compared with those in the balance and tone group ( P ≤ .03). Task performance improved by 12.6% and 10.9% in the once-weekly and twice-weekly resistance training groups, respectively; it deteriorated by 0.5% in the balance and tone group. Enhanced selective attention and conflict resolution was significantly associated with increased gait speed. Both resistance training groups demonstrated reductions in whole-brain volume compared with the balance and tone group at the end of the study ( P ≤ .03). Conclusion Twelve months of once-weekly or twice-weekly resistance training benefited the Executive Cognitive Function of selective attention and conflict resolution among senior women. Trial Registration clinicaltrials.gov Identifier:NCT00426881
Peter Graf - One of the best experts on this subject based on the ideXlab platform.
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An Economic Evaluation of Resistance Training and Aerobic Training versus Balance and Toning Exercises in Older Adults with Mild Cognitive Impairment
PloS one, 2013Co-Authors: Jennifer C. Davis, Stirling Bryan, Carlo A. Marra, Devika Sharma, Alison Chan, B. Lynn Beattie, Peter Graf, Teresa Liu-ambroseAbstract:Background Mild Cognitive impairment (MCI) represents a critical window to intervene against dementia. Exercise training is a promising intervention strategy, but the efficiency (i.e., relationship of costs and consequences) of such types of training remains unknown. Thus, we estimated the incremental cost-effectiveness of resistance training or aerobic training compared with balance and tone exercises in terms of changes in Executive Cognitive Function among senior women with probable MCI.
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Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Archives of internal medicine, 2010Co-Authors: Teresa Liu-ambrose, B. Lynn Beattie, Peter Graf, Lindsay S. Nagamatsu, Maureen C. Ashe, Todd C. HandyAbstract:Background Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat Cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of Executive Cognitive Functions in senior women. Methods In this single-blinded randomized trial, 155 community-dwelling women aged 65 to 75 years living in Vancouver were randomly allocated to once-weekly (n = 54) or twice-weekly (n = 52) resistance training or twice-weekly balance and tone training (control group) (n = 49). The primary outcome measure was performance on the Stroop test, an Executive Cognitive test of selective attention and conflict resolution. Secondary outcomes of Executive Cognitive Functions included set shifting as measured by the Trail Making Tests (parts A and B) and working memory as assessed by verbal digit span forward and backward tests. Gait speed, muscular Function, and whole-brain volume were also secondary outcome measures. Results Both resistance training groups significantly improved their performance on the Stroop test compared with those in the balance and tone group ( P ≤ .03). Task performance improved by 12.6% and 10.9% in the once-weekly and twice-weekly resistance training groups, respectively; it deteriorated by 0.5% in the balance and tone group. Enhanced selective attention and conflict resolution was significantly associated with increased gait speed. Both resistance training groups demonstrated reductions in whole-brain volume compared with the balance and tone group at the end of the study ( P ≤ .03). Conclusion Twelve months of once-weekly or twice-weekly resistance training benefited the Executive Cognitive Function of selective attention and conflict resolution among senior women. Trial Registration clinicaltrials.gov Identifier:NCT00426881
B. Lynn Beattie - One of the best experts on this subject based on the ideXlab platform.
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An Economic Evaluation of Resistance Training and Aerobic Training versus Balance and Toning Exercises in Older Adults with Mild Cognitive Impairment
PloS one, 2013Co-Authors: Jennifer C. Davis, Stirling Bryan, Carlo A. Marra, Devika Sharma, Alison Chan, B. Lynn Beattie, Peter Graf, Teresa Liu-ambroseAbstract:Background Mild Cognitive impairment (MCI) represents a critical window to intervene against dementia. Exercise training is a promising intervention strategy, but the efficiency (i.e., relationship of costs and consequences) of such types of training remains unknown. Thus, we estimated the incremental cost-effectiveness of resistance training or aerobic training compared with balance and tone exercises in terms of changes in Executive Cognitive Function among senior women with probable MCI.
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Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Archives of internal medicine, 2010Co-Authors: Teresa Liu-ambrose, B. Lynn Beattie, Peter Graf, Lindsay S. Nagamatsu, Maureen C. Ashe, Todd C. HandyAbstract:Background Cognitive decline among seniors is a pressing health care issue. Specific exercise training may combat Cognitive decline. We compared the effect of once-weekly and twice-weekly resistance training with that of twice-weekly balance and tone exercise training on the performance of Executive Cognitive Functions in senior women. Methods In this single-blinded randomized trial, 155 community-dwelling women aged 65 to 75 years living in Vancouver were randomly allocated to once-weekly (n = 54) or twice-weekly (n = 52) resistance training or twice-weekly balance and tone training (control group) (n = 49). The primary outcome measure was performance on the Stroop test, an Executive Cognitive test of selective attention and conflict resolution. Secondary outcomes of Executive Cognitive Functions included set shifting as measured by the Trail Making Tests (parts A and B) and working memory as assessed by verbal digit span forward and backward tests. Gait speed, muscular Function, and whole-brain volume were also secondary outcome measures. Results Both resistance training groups significantly improved their performance on the Stroop test compared with those in the balance and tone group ( P ≤ .03). Task performance improved by 12.6% and 10.9% in the once-weekly and twice-weekly resistance training groups, respectively; it deteriorated by 0.5% in the balance and tone group. Enhanced selective attention and conflict resolution was significantly associated with increased gait speed. Both resistance training groups demonstrated reductions in whole-brain volume compared with the balance and tone group at the end of the study ( P ≤ .03). Conclusion Twelve months of once-weekly or twice-weekly resistance training benefited the Executive Cognitive Function of selective attention and conflict resolution among senior women. Trial Registration clinicaltrials.gov Identifier:NCT00426881
Jørn Arnt - One of the best experts on this subject based on the ideXlab platform.
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Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved
Psychopharmacology, 2009Co-Authors: Arne Mørk, Louise M. Witten, Jørn ArntAbstract:Rationale Second-generation antipsychotics have some beneficial effect on cognition. Recent studies, furthermore, indicate differential effects of second-generation antipsychotics on impairment in Executive Cognitive Function. Objective We evaluated the effect of the second-generation antipsychotic drug, sertindole, on extracellular levels of dopamine (DA), acetylcholine (ACh), and glutamate (Glu) in the rat medial prefrontal cortex (mPFC). Risperidone was studied for comparison. Moreover, selective serotonin 5-HT_2A, 5-HT_2C, and 5-HT_6 receptor antagonists were used, given alone and in combination with the preferential DA D_2 receptor antagonist, haloperidol, to further clarify the action of the two drugs. Materials and methods Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals. Results Sertindole and risperidone significantly increased extracellular levels of DA. Haloperidol; the 5-HT_2A receptor antagonist, M100907; the 5-HT_2C receptor antagonist, SB242084; and the 5-HT_6 receptor antagonist, GSK-742457, induced minor increases in levels of DA, but the three latter compounds raised the DA levels notably in combination with haloperidol. Sertindole and risperidone significantly increased the extracellular levels of ACh but only sertindole raised the extracellular levels of Glu. The selective 5-HT_6 receptor antagonist, SB-271046, significantly increased the extracellular levels of Glu. Conclusion Sertindole and risperidone markedly increased extracellular levels of DA in mPFC. The built-in 5-HT_2A/5-HT_2C/D_2 receptor antagonism of the two drugs might be involved in this action. Both drugs increased the extracellular levels of ACh but only sertindole enhanced Glu levels. The high affinity of sertindole for the 5-HT_6 receptor compared to risperidone may differentiate sertindole from risperidone.
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Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved
Psychopharmacology, 2009Co-Authors: Arne Mørk, Louise Witten, Jørn ArntAbstract:Rationale Second-generation antipsychotics have some beneficial effect on cognition. Recent studies, furthermore, indicate differential effects of second-generation antipsychotics on impairment in Executive Cognitive Function.