The Experts below are selected from a list of 138 Experts worldwide ranked by ideXlab platform

Yuichiro Yano - One of the best experts on this subject based on the ideXlab platform.

  • blood pressure reactivity to psychological stress in young adults and cognition in midlife the coronary artery risk development in young adults cardia study
    Journal of the American Heart Association, 2016
    Co-Authors: Yuichiro Yano, Hongyan Ning, Jared P. Reis, Lenore J. Launer, Kristine Yaffe, Cora E Lewis, Nick R Bryan, Stephen Sidney, Emiliano Albanese, Philip Greenland
    Abstract:

    Background The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress‐induced BP reactivity in young adults is associated with midlife cognitive Function is sparse. Methods and Results We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty‐three years later, cognitive Function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed Test), the Rey Auditory Verbal Learning Test (a verbal memory Test), and the modified Stroop Test (an Executive Function Test). At the time of follow‐up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow‐up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop Test (β [SE]: −0.06 [0.02] and −0.05 [0.02]; all P <0.01). SBP reactivity was more consistently associated than diastolic BP reactivity with cognitive Function scores. The associations between SBP reactivity and cognitive Function were mostly similar between blacks and whites. Conclusions Lower psychological stress‐induced SBP reactivity in younger adults was associated with lower cognitive Function in midlife. BP reactivity to psychological stressors may have different associations with target organs in hypertension.

  • Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study: Blood Pressure Variability and Cognition
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-jones
    Abstract:

    Whether long-term blood pressure variability (BPV) throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults ages 18 to 30 years (mean age 25 years) at baseline (Year 0), we assessed BPV by standard deviation (SD) and average real variability (ARV) over 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (DSST, psychomotor speed Test), the Rey Auditory Verbal Learning Test (RAVLT, verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Year 25). At the Year 25 examination, participants (n=2,326) with a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARVSBP, ARVDBP, and SDDBP were significantly associated with lower scores of DSST (β [standard error: SE]: −.025[.006], −.029[.007], and −.029[.007] respectively; all P

  • long term blood pressure variability throughout young adulthood and cognitive Function in midlife the coronary artery risk development in young adults cardia study
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M Lloydjones
    Abstract:

    Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y(0)), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (psychomotor speed Test), the Rey Auditory Verbal Learning Test (verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Y(25)). At the Y(25) examination, participants (n=2326) had a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARV(SBP), ARV(DBP), and SD(DBP) were significantly associated with lower scores of Digit Symbol Substitution Test (β [SE]: -0.025 [0.006], -0.029 [0.007], and -0.029 [0.007], respectively; all P<0.001) and Rey Auditory Verbal Learning Test (β [SE]: -0.016 [0.006], -0.021 [0.007], and -0.019 [0.007], respectively; all P<0.05) after adjustment for demographic and clinical characteristics and with cumulative exposure to BP through Y(0) to Y(25). Neither SDBP nor ARV(BP) was associated with the Stroop score. The associations between ARV(BP) or SD(BP) and each cognitive Function Test were similar between blacks and whites except for 1 significant interaction between race and SDS(BP) on the Digit Symbol Substitution Test (P<0.05). Long-term BP variability for 25 years beginning in young adulthood was associated with worse psychomotor speed and verbal memory Tests in midlife, independent of cumulative exposure to BP during follow-up.

Philip Greenland - One of the best experts on this subject based on the ideXlab platform.

  • blood pressure reactivity to psychological stress in young adults and cognition in midlife the coronary artery risk development in young adults cardia study
    Journal of the American Heart Association, 2016
    Co-Authors: Yuichiro Yano, Hongyan Ning, Jared P. Reis, Lenore J. Launer, Kristine Yaffe, Cora E Lewis, Nick R Bryan, Stephen Sidney, Emiliano Albanese, Philip Greenland
    Abstract:

    Background The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress‐induced BP reactivity in young adults is associated with midlife cognitive Function is sparse. Methods and Results We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty‐three years later, cognitive Function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed Test), the Rey Auditory Verbal Learning Test (a verbal memory Test), and the modified Stroop Test (an Executive Function Test). At the time of follow‐up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow‐up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop Test (β [SE]: −0.06 [0.02] and −0.05 [0.02]; all P <0.01). SBP reactivity was more consistently associated than diastolic BP reactivity with cognitive Function scores. The associations between SBP reactivity and cognitive Function were mostly similar between blacks and whites. Conclusions Lower psychological stress‐induced SBP reactivity in younger adults was associated with lower cognitive Function in midlife. BP reactivity to psychological stressors may have different associations with target organs in hypertension.

  • Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study: Blood Pressure Variability and Cognition
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-jones
    Abstract:

    Whether long-term blood pressure variability (BPV) throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults ages 18 to 30 years (mean age 25 years) at baseline (Year 0), we assessed BPV by standard deviation (SD) and average real variability (ARV) over 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (DSST, psychomotor speed Test), the Rey Auditory Verbal Learning Test (RAVLT, verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Year 25). At the Year 25 examination, participants (n=2,326) with a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARVSBP, ARVDBP, and SDDBP were significantly associated with lower scores of DSST (β [standard error: SE]: −.025[.006], −.029[.007], and −.029[.007] respectively; all P

  • long term blood pressure variability throughout young adulthood and cognitive Function in midlife the coronary artery risk development in young adults cardia study
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M Lloydjones
    Abstract:

    Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y(0)), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (psychomotor speed Test), the Rey Auditory Verbal Learning Test (verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Y(25)). At the Y(25) examination, participants (n=2326) had a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARV(SBP), ARV(DBP), and SD(DBP) were significantly associated with lower scores of Digit Symbol Substitution Test (β [SE]: -0.025 [0.006], -0.029 [0.007], and -0.029 [0.007], respectively; all P<0.001) and Rey Auditory Verbal Learning Test (β [SE]: -0.016 [0.006], -0.021 [0.007], and -0.019 [0.007], respectively; all P<0.05) after adjustment for demographic and clinical characteristics and with cumulative exposure to BP through Y(0) to Y(25). Neither SDBP nor ARV(BP) was associated with the Stroop score. The associations between ARV(BP) or SD(BP) and each cognitive Function Test were similar between blacks and whites except for 1 significant interaction between race and SDS(BP) on the Digit Symbol Substitution Test (P<0.05). Long-term BP variability for 25 years beginning in young adulthood was associated with worse psychomotor speed and verbal memory Tests in midlife, independent of cumulative exposure to BP during follow-up.

Hongyan Ning - One of the best experts on this subject based on the ideXlab platform.

  • blood pressure reactivity to psychological stress in young adults and cognition in midlife the coronary artery risk development in young adults cardia study
    Journal of the American Heart Association, 2016
    Co-Authors: Yuichiro Yano, Hongyan Ning, Jared P. Reis, Lenore J. Launer, Kristine Yaffe, Cora E Lewis, Nick R Bryan, Stephen Sidney, Emiliano Albanese, Philip Greenland
    Abstract:

    Background The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress‐induced BP reactivity in young adults is associated with midlife cognitive Function is sparse. Methods and Results We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty‐three years later, cognitive Function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed Test), the Rey Auditory Verbal Learning Test (a verbal memory Test), and the modified Stroop Test (an Executive Function Test). At the time of follow‐up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow‐up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop Test (β [SE]: −0.06 [0.02] and −0.05 [0.02]; all P <0.01). SBP reactivity was more consistently associated than diastolic BP reactivity with cognitive Function scores. The associations between SBP reactivity and cognitive Function were mostly similar between blacks and whites. Conclusions Lower psychological stress‐induced SBP reactivity in younger adults was associated with lower cognitive Function in midlife. BP reactivity to psychological stressors may have different associations with target organs in hypertension.

  • Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study: Blood Pressure Variability and Cognition
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-jones
    Abstract:

    Whether long-term blood pressure variability (BPV) throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults ages 18 to 30 years (mean age 25 years) at baseline (Year 0), we assessed BPV by standard deviation (SD) and average real variability (ARV) over 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (DSST, psychomotor speed Test), the Rey Auditory Verbal Learning Test (RAVLT, verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Year 25). At the Year 25 examination, participants (n=2,326) with a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARVSBP, ARVDBP, and SDDBP were significantly associated with lower scores of DSST (β [standard error: SE]: −.025[.006], −.029[.007], and −.029[.007] respectively; all P

  • long term blood pressure variability throughout young adulthood and cognitive Function in midlife the coronary artery risk development in young adults cardia study
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M Lloydjones
    Abstract:

    Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y(0)), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (psychomotor speed Test), the Rey Auditory Verbal Learning Test (verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Y(25)). At the Y(25) examination, participants (n=2326) had a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARV(SBP), ARV(DBP), and SD(DBP) were significantly associated with lower scores of Digit Symbol Substitution Test (β [SE]: -0.025 [0.006], -0.029 [0.007], and -0.029 [0.007], respectively; all P<0.001) and Rey Auditory Verbal Learning Test (β [SE]: -0.016 [0.006], -0.021 [0.007], and -0.019 [0.007], respectively; all P<0.05) after adjustment for demographic and clinical characteristics and with cumulative exposure to BP through Y(0) to Y(25). Neither SDBP nor ARV(BP) was associated with the Stroop score. The associations between ARV(BP) or SD(BP) and each cognitive Function Test were similar between blacks and whites except for 1 significant interaction between race and SDS(BP) on the Digit Symbol Substitution Test (P<0.05). Long-term BP variability for 25 years beginning in young adulthood was associated with worse psychomotor speed and verbal memory Tests in midlife, independent of cumulative exposure to BP during follow-up.

Jared P. Reis - One of the best experts on this subject based on the ideXlab platform.

  • blood pressure reactivity to psychological stress in young adults and cognition in midlife the coronary artery risk development in young adults cardia study
    Journal of the American Heart Association, 2016
    Co-Authors: Yuichiro Yano, Hongyan Ning, Jared P. Reis, Lenore J. Launer, Kristine Yaffe, Cora E Lewis, Nick R Bryan, Stephen Sidney, Emiliano Albanese, Philip Greenland
    Abstract:

    Background The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress‐induced BP reactivity in young adults is associated with midlife cognitive Function is sparse. Methods and Results We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty‐three years later, cognitive Function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed Test), the Rey Auditory Verbal Learning Test (a verbal memory Test), and the modified Stroop Test (an Executive Function Test). At the time of follow‐up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow‐up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop Test (β [SE]: −0.06 [0.02] and −0.05 [0.02]; all P <0.01). SBP reactivity was more consistently associated than diastolic BP reactivity with cognitive Function scores. The associations between SBP reactivity and cognitive Function were mostly similar between blacks and whites. Conclusions Lower psychological stress‐induced SBP reactivity in younger adults was associated with lower cognitive Function in midlife. BP reactivity to psychological stressors may have different associations with target organs in hypertension.

  • Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study: Blood Pressure Variability and Cognition
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-jones
    Abstract:

    Whether long-term blood pressure variability (BPV) throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults ages 18 to 30 years (mean age 25 years) at baseline (Year 0), we assessed BPV by standard deviation (SD) and average real variability (ARV) over 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (DSST, psychomotor speed Test), the Rey Auditory Verbal Learning Test (RAVLT, verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Year 25). At the Year 25 examination, participants (n=2,326) with a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARVSBP, ARVDBP, and SDDBP were significantly associated with lower scores of DSST (β [standard error: SE]: −.025[.006], −.029[.007], and −.029[.007] respectively; all P

  • long term blood pressure variability throughout young adulthood and cognitive Function in midlife the coronary artery risk development in young adults cardia study
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M Lloydjones
    Abstract:

    Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y(0)), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (psychomotor speed Test), the Rey Auditory Verbal Learning Test (verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Y(25)). At the Y(25) examination, participants (n=2326) had a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARV(SBP), ARV(DBP), and SD(DBP) were significantly associated with lower scores of Digit Symbol Substitution Test (β [SE]: -0.025 [0.006], -0.029 [0.007], and -0.029 [0.007], respectively; all P<0.001) and Rey Auditory Verbal Learning Test (β [SE]: -0.016 [0.006], -0.021 [0.007], and -0.019 [0.007], respectively; all P<0.05) after adjustment for demographic and clinical characteristics and with cumulative exposure to BP through Y(0) to Y(25). Neither SDBP nor ARV(BP) was associated with the Stroop score. The associations between ARV(BP) or SD(BP) and each cognitive Function Test were similar between blacks and whites except for 1 significant interaction between race and SDS(BP) on the Digit Symbol Substitution Test (P<0.05). Long-term BP variability for 25 years beginning in young adulthood was associated with worse psychomotor speed and verbal memory Tests in midlife, independent of cumulative exposure to BP during follow-up.

Lenore J. Launer - One of the best experts on this subject based on the ideXlab platform.

  • blood pressure reactivity to psychological stress in young adults and cognition in midlife the coronary artery risk development in young adults cardia study
    Journal of the American Heart Association, 2016
    Co-Authors: Yuichiro Yano, Hongyan Ning, Jared P. Reis, Lenore J. Launer, Kristine Yaffe, Cora E Lewis, Nick R Bryan, Stephen Sidney, Emiliano Albanese, Philip Greenland
    Abstract:

    Background The classic view of blood pressure (BP) reactivity to psychological stress in relation to cardiovascular risks assumes that excess reactivity is worse and lower reactivity is better. Evidence addressing how stress‐induced BP reactivity in young adults is associated with midlife cognitive Function is sparse. Methods and Results We assessed BP reactivity during a star tracing task and a video game in adults aged 20 to 32 years. Twenty‐three years later, cognitive Function was assessed with use of the Digit Symbol Substitution Test (a psychomotor speed Test), the Rey Auditory Verbal Learning Test (a verbal memory Test), and the modified Stroop Test (an Executive Function Test). At the time of follow‐up, participants (n=3021) had a mean age of 50.2 years; 56% were women, and 44% were black. In linear regression models adjusted for demographic and clinical characteristics including baseline and follow‐up resting BP, lower systolic BP (SBP) reactivity during the star tracing and video game was associated with worse Digit Symbol Substitution Test scores (β [SE]: 0.11 [0.02] and 0.05 [0.02], respectively) and worse performance on the Stroop Test (β [SE]: −0.06 [0.02] and −0.05 [0.02]; all P <0.01). SBP reactivity was more consistently associated than diastolic BP reactivity with cognitive Function scores. The associations between SBP reactivity and cognitive Function were mostly similar between blacks and whites. Conclusions Lower psychological stress‐induced SBP reactivity in younger adults was associated with lower cognitive Function in midlife. BP reactivity to psychological stressors may have different associations with target organs in hypertension.

  • Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) study: Blood Pressure Variability and Cognition
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M. Lloyd-jones
    Abstract:

    Whether long-term blood pressure variability (BPV) throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults ages 18 to 30 years (mean age 25 years) at baseline (Year 0), we assessed BPV by standard deviation (SD) and average real variability (ARV) over 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (DSST, psychomotor speed Test), the Rey Auditory Verbal Learning Test (RAVLT, verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Year 25). At the Year 25 examination, participants (n=2,326) with a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARVSBP, ARVDBP, and SDDBP were significantly associated with lower scores of DSST (β [standard error: SE]: −.025[.006], −.029[.007], and −.029[.007] respectively; all P

  • long term blood pressure variability throughout young adulthood and cognitive Function in midlife the coronary artery risk development in young adults cardia study
    Hypertension, 2014
    Co-Authors: Yuichiro Yano, Hongyan Ning, Norrina B. Allen, Jared P. Reis, Lenore J. Launer, Kiang Liu, Kristine Yaffe, Philip Greenland, Donald M Lloydjones
    Abstract:

    Whether long-term blood pressure (BP) variability throughout young adulthood is associated with cognitive Function in midlife remains uncertain. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA), which recruited healthy young adults aged 18 to 30 years (mean age, 25 years) at baseline (Y(0)), we assessed BP variability by SD and average real variability (ARV) for 25 years (8 visits). Cognitive Function was assessed with the Digit Symbol Substitution Test (psychomotor speed Test), the Rey Auditory Verbal Learning Test (verbal memory Test), and the modified Stroop Test (Executive Function Test) at follow-up (Y(25)). At the Y(25) examination, participants (n=2326) had a mean age of 50.4 years, 43% were men, and 40% were black. In multivariable-adjusted linear regression models, higher ARV(SBP), ARV(DBP), and SD(DBP) were significantly associated with lower scores of Digit Symbol Substitution Test (β [SE]: -0.025 [0.006], -0.029 [0.007], and -0.029 [0.007], respectively; all P<0.001) and Rey Auditory Verbal Learning Test (β [SE]: -0.016 [0.006], -0.021 [0.007], and -0.019 [0.007], respectively; all P<0.05) after adjustment for demographic and clinical characteristics and with cumulative exposure to BP through Y(0) to Y(25). Neither SDBP nor ARV(BP) was associated with the Stroop score. The associations between ARV(BP) or SD(BP) and each cognitive Function Test were similar between blacks and whites except for 1 significant interaction between race and SDS(BP) on the Digit Symbol Substitution Test (P<0.05). Long-term BP variability for 25 years beginning in young adulthood was associated with worse psychomotor speed and verbal memory Tests in midlife, independent of cumulative exposure to BP during follow-up.