The Experts below are selected from a list of 102 Experts worldwide ranked by ideXlab platform
Jer-yuarn Wu - One of the best experts on this subject based on the ideXlab platform.
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Identification of susceptibility gene associated with female primary Sjögren’s syndrome in Han Chinese by genome-wide association study
Human Genetics, 2016Co-Authors: I-wen Song, Hsiang-cheng Chen, Jenn-hwai Yang, Chi-ching Chang, Chung-tei Chou, Yi-chun Chou, Chien-hsiun Chen, Yuan-tsong Chen, Chen-hung Chen, Jer-yuarn WuAbstract:Primary Sjögren’s syndrome (PSS) is an autoimmune disease targeting Exocrine glands. It ten times more dominantly affects women than men with an onset peak at menopause. The genetic factor predisposing women to PSS remains unclear. Therefore, we aimed to identify susceptibility loci for PSS in women. We performed genome-wide association study (GWAS) using 242 female PSS patients and 1444 female control in Han Chinese population residing in Taiwan. Replication was conducted in an independent cohort of 178 female PSS and 14,432 control subjects. We identified rs117026326 on GTF2I with GWAS significance ( P = 1.10 × 10^−15) and rs13079920 on RBMS3 with suggestive significance ( P = 2.90 × 10^−5) associating with PSS in women. The association of RBMS3 was further evidenced by imputation in which rs13072846 ( P = 4.89 × 10^−5) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. PSS pathogenesis involves both immune (effector) and Exocrine (target) System. We suggested that while GTF2I is a previously reported associating gene which may function in immune System, RBMS3 is a novel susceptibility gene that predisposes women to PSS potentially through modulating acinar apoptosis and TGF-β signaling in target Exocrine System.
Wanjin Hong - One of the best experts on this subject based on the ideXlab platform.
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vamp8 endobrevin as a general vesicular snare for regulated exocytosis of the Exocrine System
Molecular Biology of the Cell, 2007Co-Authors: Chengchun Wang, Chee Peng Ng, Jie Li, Hwee Chien Liew, Jukka Leinonen, Hannu Rajaniemi, Zhi Hong Zhou, Qi Zeng, Wanjin HongAbstract:The molecular mechanism governing the regulated secretion of most Exocrine tissues remains elusive, although VAMP8/endobrevin has recently been shown to be the major vesicular SNARE (v-SNARE) of zymogen granules of pancreatic Exocrine acinar cells. In this article, we have characterized the role of VAMP8 in the entire Exocrine System. Immunohistochemical studies showed that VAMP8 is expressed in all examined Exocrine tissues such as salivary glands, lacrimal (tear) glands, sweat glands, sebaceous glands, mammary glands, and the prostate. Severe anomalies were observed in the salivary and lacrimal glands of VAMP8-null mice. Mutant salivary glands accumulated amylase and carbonic anhydrase VI. Electron microscopy revealed an accumulation of secretory granules in the acinar cells of mutant parotid and lacrimal glands. Pilocarpine-stimulated secretion of saliva proteins was compromised in the absence of VAMP8. Protein aggregates were observed in mutant lacrimal glands. VAMP8 may interact with syntaxin 4 and SNAP-23. These results suggest that VAMP8 may act as a v-SNARE for regulated secretion of the entire Exocrine System.
I-wen Song - One of the best experts on this subject based on the ideXlab platform.
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Identification of susceptibility gene associated with female primary Sjögren’s syndrome in Han Chinese by genome-wide association study
Human Genetics, 2016Co-Authors: I-wen Song, Hsiang-cheng Chen, Jenn-hwai Yang, Chi-ching Chang, Chung-tei Chou, Yi-chun Chou, Chien-hsiun Chen, Yuan-tsong Chen, Chen-hung Chen, Jer-yuarn WuAbstract:Primary Sjögren’s syndrome (PSS) is an autoimmune disease targeting Exocrine glands. It ten times more dominantly affects women than men with an onset peak at menopause. The genetic factor predisposing women to PSS remains unclear. Therefore, we aimed to identify susceptibility loci for PSS in women. We performed genome-wide association study (GWAS) using 242 female PSS patients and 1444 female control in Han Chinese population residing in Taiwan. Replication was conducted in an independent cohort of 178 female PSS and 14,432 control subjects. We identified rs117026326 on GTF2I with GWAS significance ( P = 1.10 × 10^−15) and rs13079920 on RBMS3 with suggestive significance ( P = 2.90 × 10^−5) associating with PSS in women. The association of RBMS3 was further evidenced by imputation in which rs13072846 ( P = 4.89 × 10^−5) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. PSS pathogenesis involves both immune (effector) and Exocrine (target) System. We suggested that while GTF2I is a previously reported associating gene which may function in immune System, RBMS3 is a novel susceptibility gene that predisposes women to PSS potentially through modulating acinar apoptosis and TGF-β signaling in target Exocrine System.
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Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.
Human Genetics, 2016Co-Authors: I-wen Song, Hsiang-cheng Chen, Jenn-hwai Yang, Chi-ching Chang, Chung-tei Chou, Yi-chun Chou, Chien-hsiun Chen, Yuan-tsong ChenAbstract:Primary Sjogren’s syndrome (PSS) is an autoimmune disease targeting Exocrine glands. It ten times more dominantly affects women than men with an onset peak at menopause. The genetic factor predisposing women to PSS remains unclear. Therefore, we aimed to identify susceptibility loci for PSS in women. We performed genome-wide association study (GWAS) using 242 female PSS patients and 1444 female control in Han Chinese population residing in Taiwan. Replication was conducted in an independent cohort of 178 female PSS and 14,432 control subjects. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 × 10−15) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 × 10−5) associating with PSS in women. The association of RBMS3 was further evidenced by imputation in which rs13072846 (P = 4.89 × 10−5) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. PSS pathogenesis involves both immune (effector) and Exocrine (target) System. We suggested that while GTF2I is a previously reported associating gene which may function in immune System, RBMS3 is a novel susceptibility gene that predisposes women to PSS potentially through modulating acinar apoptosis and TGF-β signaling in target Exocrine System.
Chengchun Wang - One of the best experts on this subject based on the ideXlab platform.
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vamp8 endobrevin as a general vesicular snare for regulated exocytosis of the Exocrine System
Molecular Biology of the Cell, 2007Co-Authors: Chengchun Wang, Chee Peng Ng, Jie Li, Hwee Chien Liew, Jukka Leinonen, Hannu Rajaniemi, Zhi Hong Zhou, Qi Zeng, Wanjin HongAbstract:The molecular mechanism governing the regulated secretion of most Exocrine tissues remains elusive, although VAMP8/endobrevin has recently been shown to be the major vesicular SNARE (v-SNARE) of zymogen granules of pancreatic Exocrine acinar cells. In this article, we have characterized the role of VAMP8 in the entire Exocrine System. Immunohistochemical studies showed that VAMP8 is expressed in all examined Exocrine tissues such as salivary glands, lacrimal (tear) glands, sweat glands, sebaceous glands, mammary glands, and the prostate. Severe anomalies were observed in the salivary and lacrimal glands of VAMP8-null mice. Mutant salivary glands accumulated amylase and carbonic anhydrase VI. Electron microscopy revealed an accumulation of secretory granules in the acinar cells of mutant parotid and lacrimal glands. Pilocarpine-stimulated secretion of saliva proteins was compromised in the absence of VAMP8. Protein aggregates were observed in mutant lacrimal glands. VAMP8 may interact with syntaxin 4 and SNAP-23. These results suggest that VAMP8 may act as a v-SNARE for regulated secretion of the entire Exocrine System.
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VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the Exocrine System.
Molecular Biology of the Cell, 2007Co-Authors: Chengchun Wang, Chee Peng Ng, Jie Li, Hwee Chien Liew, Jukka Leinonen, Hannu Rajaniemi, Zhi Hong ZhouAbstract:The molecular mechanism governing the regulated secretion of most Exocrine tissues remains elusive, although VAMP8/endobrevin has recently been shown to be the major vesicular SNARE (v-SNARE) of zymogen granules of pancreatic Exocrine acinar cells. In this article, we have characterized the role of VAMP8 in the entire Exocrine System. Immunohistochemical studies showed that VAMP8 is expressed in all examined Exocrine tissues such as salivary glands, lacrimal (tear) glands, sweat glands, sebaceous glands, mammary glands, and the prostate. Severe anomalies were observed in the salivary and lacrimal glands of VAMP8-null mice. Mutant salivary glands accumulated amylase and carbonic anhydrase VI. Electron microscopy revealed an accumulation of secretory granules in the acinar cells of mutant parotid and lacrimal glands. Pilocarpine-stimulated secretion of saliva proteins was compromised in the absence of VAMP8. Protein aggregates were observed in mutant lacrimal glands. VAMP8 may interact with syntaxin 4 and SNAP-23. These results suggest that VAMP8 may act as a v-SNARE for regulated secretion of the entire Exocrine System.
Yuan-tsong Chen - One of the best experts on this subject based on the ideXlab platform.
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Identification of susceptibility gene associated with female primary Sjögren’s syndrome in Han Chinese by genome-wide association study
Human Genetics, 2016Co-Authors: I-wen Song, Hsiang-cheng Chen, Jenn-hwai Yang, Chi-ching Chang, Chung-tei Chou, Yi-chun Chou, Chien-hsiun Chen, Yuan-tsong Chen, Chen-hung Chen, Jer-yuarn WuAbstract:Primary Sjögren’s syndrome (PSS) is an autoimmune disease targeting Exocrine glands. It ten times more dominantly affects women than men with an onset peak at menopause. The genetic factor predisposing women to PSS remains unclear. Therefore, we aimed to identify susceptibility loci for PSS in women. We performed genome-wide association study (GWAS) using 242 female PSS patients and 1444 female control in Han Chinese population residing in Taiwan. Replication was conducted in an independent cohort of 178 female PSS and 14,432 control subjects. We identified rs117026326 on GTF2I with GWAS significance ( P = 1.10 × 10^−15) and rs13079920 on RBMS3 with suggestive significance ( P = 2.90 × 10^−5) associating with PSS in women. The association of RBMS3 was further evidenced by imputation in which rs13072846 ( P = 4.89 × 10^−5) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. PSS pathogenesis involves both immune (effector) and Exocrine (target) System. We suggested that while GTF2I is a previously reported associating gene which may function in immune System, RBMS3 is a novel susceptibility gene that predisposes women to PSS potentially through modulating acinar apoptosis and TGF-β signaling in target Exocrine System.
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Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.
Human Genetics, 2016Co-Authors: I-wen Song, Hsiang-cheng Chen, Jenn-hwai Yang, Chi-ching Chang, Chung-tei Chou, Yi-chun Chou, Chien-hsiun Chen, Yuan-tsong ChenAbstract:Primary Sjogren’s syndrome (PSS) is an autoimmune disease targeting Exocrine glands. It ten times more dominantly affects women than men with an onset peak at menopause. The genetic factor predisposing women to PSS remains unclear. Therefore, we aimed to identify susceptibility loci for PSS in women. We performed genome-wide association study (GWAS) using 242 female PSS patients and 1444 female control in Han Chinese population residing in Taiwan. Replication was conducted in an independent cohort of 178 female PSS and 14,432 control subjects. We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 × 10−15) and rs13079920 on RBMS3 with suggestive significance (P = 2.90 × 10−5) associating with PSS in women. The association of RBMS3 was further evidenced by imputation in which rs13072846 (P = 4.89 × 10−5) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. PSS pathogenesis involves both immune (effector) and Exocrine (target) System. We suggested that while GTF2I is a previously reported associating gene which may function in immune System, RBMS3 is a novel susceptibility gene that predisposes women to PSS potentially through modulating acinar apoptosis and TGF-β signaling in target Exocrine System.