The Experts below are selected from a list of 1383 Experts worldwide ranked by ideXlab platform
Ping Hu - One of the best experts on this subject based on the ideXlab platform.
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combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the direct extraction and purification of pseudohypericin and hypericin from st john s wort hypericum perforatum l
IEEE Journal of Solid-state Circuits, 2015Co-Authors: Yang Li, Min Zhang, Hongyang Zhang, Yuerong Wang, Ping HuAbstract:St. John's wort has attracted particular attention because of its beneficial effects as an antidepressant, antiviral, and anticancer agent. A method for the combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the simultaneous extraction and purification of pseudohypericin and hypericin from the herb is presented in this paper. Firstly, the constituents were extracted and directly adsorBed by Expanded Bed Adsorption chromatography under optimal conditions. The stepwise elution was then performed by Expanded Bed Adsorption chromatography that enriched the targets with higher purities and recoveries compared to other methods. Secondly, the eluent fractions from Expanded Bed Adsorption chromatography were further separated by two-step high-speed countercurrent chromatography. A two-step high-speed countercurrent chromatography method with a biphasic solvent system composed of n-hexane/ethyl acetate/methanol/water with a volume ratio of 1:2:1:2 was performed by stepwise changing the flow rate of the mobile phase. Consequently, 5.6 mg of pseudohypericin and 2.2 mg of hypericin with purities of 95.5 and 95.0%, respectively, were successfully obtained from 40 mg of crude sample.
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coupling of ultrasound assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model extraction and enrichment of ginsenosides from radix ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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Coupling of ultrasound‐assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model: Extraction and enrichment of ginsenosides from Radix Ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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direct process integration of extraction and Expanded Bed Adsorption in the recovery of crocetin derivatives from fructus gardenia
Journal of Chromatography B, 2007Co-Authors: Min Zhang, Ping Hu, Qionglin Liang, Huihua Yang, Yiming WangAbstract:A process that integrated an extraction tank (EXT) and an Expanded Bed Adsorption (EBA) into a new system EXT-EBA for direct purifying crocetin derivatives from Fructus Gardenia was descriBed. Conditions were set to allow the extraction and purification in a single step. A comparison between the integrated process and the conventional process to purify crocetin derivatives was presented. The integrated process resulted in 52.79% recovery of crocin compared to 24.12% in the conventional process. The process time and solvent used were decreased in the integrated process. The result suggests that the EXT-EBA integrates extraction, clarification, and purification in a single step, greatly simplifying the process flow and reducing the cost and time of extraction and purification of crocetin derivatives from Fructus Gardenia.
Everaldo Silvino Dos Santos - One of the best experts on this subject based on the ideXlab platform.
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Recurrent neural network modeling applied to Expanded Bed Adsorption chromatography of chitosanases produced by Paenibacillus ehimensis
Chemical Engineering Research & Design, 2016Co-Authors: Carlos Eduardo De Araujo Padilha, Jackson Araújo De Oliveira, Gorete Ribeiro De Macedo, Carlos Alberto De Araújo Padilha, Domingos Fabiano De Santana Souza, Everaldo Silvino Dos SantosAbstract:Abstract Nonlinear autoregressive networks with external input (NARX) and multilayer perceptron (MLP) has been used to predict the activity and protein content for flow-through, washing and elution steps during Expanded Bed Adsorption chromatography of chitosanases produced by Paenibacillus ehimensis. Bed expansion as well as the influence of particulate-containing feedstock study showed a stable Bed operation without significant impact on the yield as well as purification factor when the cells were fed to the column. Also, NARXs showed a better performance to predict the chitosanolytic activity as well as total protein than MLPs.
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modeling and simulation of breakthrough curves of recombinant 503 antigen using immobilized metal affinity Expanded Bed Adsorption chromatography
Separation and Purification Technology, 2016Co-Authors: Francisco Caninde De Sousa, Jackson Araújo De Oliveira, Gorete Ribeiro De Macedo, Carlos Eduardo De Araujo Padilha, Abimaelle Silva Chiberio, Daniella Regina Arantes Martins, Vitor Troccoli Ribeiro, Everaldo Silvino Dos SantosAbstract:Abstract In this study a mathematical model was used to simulate the breakthrough curves of the recombinant 503 antigen of Leishmania infantum chagasi using immobilized metal affinity Expanded Bed Adsorption chromatography. Initially, experimental curves were carried out in different conditions such as superficial liquid velocity, settled Bed height as well as the initial 503 antigen concentration. The particle swarm optimization (PSO) algorithm was used for global parameter estimation by a general rate model, which proved to be an efficient tool for parameter estimation in chromatographic processes. Modeling and simulation of the 503 antigen breakthrough curves displayed a good performance during the estimation and validation stages. The highest global process efficiencies obtained was 88.8%. Finally, the validated model was used in the optimization stage, showing the process and column efficiencies of 89.2% and 75.9%, respectively. The results showed the applicability of this approach for modeling and optimization of chromatographic processes.
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recovery and purification of chitosanase produced by bacillus cereus using Expanded Bed Adsorption and central composite design
IEEE Journal of Solid-state Circuits, 2016Co-Authors: Nathalia Kelly De Araujo, Gorete Ribeiro De Macedo, Vanessa Carvalho Pimentel, Nayane Macedo Portela Da Silva, Carlos Eduardo De Araujo Padilha, Everaldo Silvino Dos SantosAbstract:This study presents a system for Expanded Bed Adsorption for the purification of chitosanase from broth extract in a single step. A chitosanase-producing strain was isolated and identified as Bacillus cereus C-01 and used to produce chitosanases. The Expanded Bed Adsorption conditions for chitosanase purification were optimized statistically using STREAMLINE(TM) DEAE and a homemade column (2.6 × 30.0 cm). Dependent variables were defined by the quality criteria purification factor (P) and enzyme yield to optimize the chromatographic process. Statistical analyses showed that the optimum conditions for the maximum P were 150 cm/h load flow velocity, 6.0 cm settled Bed height, and 7.36 cm distributor height. Distributor height had a strong influence on the process, considerably affecting both the P and enzyme yield. Optimizing the purification variables resulted in an approximately 3.66-fold increase in the P compared with the value under nonoptimized conditions. This system is promising for the recovery of chitosanase from B. cereus C-01 and is economically viable because it promotes the reduction steps.
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Enhancing purification of chitosanase from Metarhizium anisopliae by Expanded Bed Adsorption chromatography using Doehlert design
Biocatalysis and agricultural biotechnology, 2015Co-Authors: Sergio Carvalho De Santana, Raimundo Cosme Da Silva Filho, Jackson Araújo De Oliveira, Gorete Ribeiro De Macedo, Francine Ferreira Padilha, Everaldo Silvino Dos SantosAbstract:Abstract The use of Expanded Bed Adsorption with three different adsorbents Streamline (SP XL, DEAE and PHENYL) to purify the chitosanase from Metarhizium anisopliae strain with and without clarification using Doehlert design for the optimization of the experiments has been investigated. Chitosanases are enzymes that hydrolyze chitosan, a carbohydrate, resulting oligosaccharides that have many biological remarkable activities, such as anti-cancer, anti-HIV and anti-oxidants activities. The superficial velocity was evaluated in five levels, from 40 to 260 cm h−1, while the type of adsorbent, a qualitative variable, was assessed at three levels, saving materials and time according to the Doehlert design. The results showed that it is possible to purify chitosanase from M. anisopliae by Expanded Bed Adsorption. Chitosanase purification factor ranged from 2 to 3.1-fold and yield ranged from 27.7 to 45.3%. The highest enzyme activity in the elution was 0.06 U/mL values which were higher than or close to those reported. The molecular mass of chitosanase was about 45 kDa using SDS-PAGE.
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recovery and purification of recombinant 503 antigen of leishmania infantum chagasi using Expanded Bed Adsorption chromatography
Journal of Chromatography B, 2015Co-Authors: Francisco Caninde De Sousa, Gorete Ribeiro De Macedo, Carlos Eduardo De Araujo Padilha, Abimaelle Silva Chiberio, Daniella Regina Arantes Martins, Everaldo Silvino Dos SantosAbstract:Abstract Visceral leishmaniasis, a disease caused by Leishmania infantum chagasi , represents a major public health problem in many areas of the world. However, there is currently no vaccine for human use. The aim of this work was to purify the 503 antigen of Leishmania i. chagasi directly from unclarified Escherichia coli feedstock through Expanded Bed Adsorption (EBA) chromatography. Batch experiments were performed to optimize the Adsorption and elution conditions of the antigen onto a STREAMLINE™ Chelating resin using two central composite rotatable designs (CCRD). The results showed that the optimal binding conditions of the 503 antigen were pH 8.0 in the presence of 2.4 M NaCl. For the elution of the target protein, the optimized conditions included the presence of 600.0 mM imidazole. The Adsorption isothermal data of the 503 antigen were fitted to the Langmuir Adsorption isotherm. The EBA experiment successfully recovered 59.2% of the 503 antigen from the unclarified E. coli homogenate with a purification factor of 6.0.
Min Zhang - One of the best experts on this subject based on the ideXlab platform.
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combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the direct extraction and purification of pseudohypericin and hypericin from st john s wort hypericum perforatum l
IEEE Journal of Solid-state Circuits, 2015Co-Authors: Yang Li, Min Zhang, Hongyang Zhang, Yuerong Wang, Ping HuAbstract:St. John's wort has attracted particular attention because of its beneficial effects as an antidepressant, antiviral, and anticancer agent. A method for the combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the simultaneous extraction and purification of pseudohypericin and hypericin from the herb is presented in this paper. Firstly, the constituents were extracted and directly adsorBed by Expanded Bed Adsorption chromatography under optimal conditions. The stepwise elution was then performed by Expanded Bed Adsorption chromatography that enriched the targets with higher purities and recoveries compared to other methods. Secondly, the eluent fractions from Expanded Bed Adsorption chromatography were further separated by two-step high-speed countercurrent chromatography. A two-step high-speed countercurrent chromatography method with a biphasic solvent system composed of n-hexane/ethyl acetate/methanol/water with a volume ratio of 1:2:1:2 was performed by stepwise changing the flow rate of the mobile phase. Consequently, 5.6 mg of pseudohypericin and 2.2 mg of hypericin with purities of 95.5 and 95.0%, respectively, were successfully obtained from 40 mg of crude sample.
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coupling of ultrasound assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model extraction and enrichment of ginsenosides from radix ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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Coupling of ultrasound‐assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model: Extraction and enrichment of ginsenosides from Radix Ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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direct process integration of extraction and Expanded Bed Adsorption in the recovery of crocetin derivatives from fructus gardenia
Journal of Chromatography B, 2007Co-Authors: Min Zhang, Ping Hu, Qionglin Liang, Huihua Yang, Yiming WangAbstract:A process that integrated an extraction tank (EXT) and an Expanded Bed Adsorption (EBA) into a new system EXT-EBA for direct purifying crocetin derivatives from Fructus Gardenia was descriBed. Conditions were set to allow the extraction and purification in a single step. A comparison between the integrated process and the conventional process to purify crocetin derivatives was presented. The integrated process resulted in 52.79% recovery of crocin compared to 24.12% in the conventional process. The process time and solvent used were decreased in the integrated process. The result suggests that the EXT-EBA integrates extraction, clarification, and purification in a single step, greatly simplifying the process flow and reducing the cost and time of extraction and purification of crocetin derivatives from Fructus Gardenia.
Hongyang Zhang - One of the best experts on this subject based on the ideXlab platform.
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combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the direct extraction and purification of pseudohypericin and hypericin from st john s wort hypericum perforatum l
IEEE Journal of Solid-state Circuits, 2015Co-Authors: Yang Li, Min Zhang, Hongyang Zhang, Yuerong Wang, Ping HuAbstract:St. John's wort has attracted particular attention because of its beneficial effects as an antidepressant, antiviral, and anticancer agent. A method for the combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the simultaneous extraction and purification of pseudohypericin and hypericin from the herb is presented in this paper. Firstly, the constituents were extracted and directly adsorBed by Expanded Bed Adsorption chromatography under optimal conditions. The stepwise elution was then performed by Expanded Bed Adsorption chromatography that enriched the targets with higher purities and recoveries compared to other methods. Secondly, the eluent fractions from Expanded Bed Adsorption chromatography were further separated by two-step high-speed countercurrent chromatography. A two-step high-speed countercurrent chromatography method with a biphasic solvent system composed of n-hexane/ethyl acetate/methanol/water with a volume ratio of 1:2:1:2 was performed by stepwise changing the flow rate of the mobile phase. Consequently, 5.6 mg of pseudohypericin and 2.2 mg of hypericin with purities of 95.5 and 95.0%, respectively, were successfully obtained from 40 mg of crude sample.
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coupling of ultrasound assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model extraction and enrichment of ginsenosides from radix ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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Coupling of ultrasound‐assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model: Extraction and enrichment of ginsenosides from Radix Ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
Yuerong Wang - One of the best experts on this subject based on the ideXlab platform.
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combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the direct extraction and purification of pseudohypericin and hypericin from st john s wort hypericum perforatum l
IEEE Journal of Solid-state Circuits, 2015Co-Authors: Yang Li, Min Zhang, Hongyang Zhang, Yuerong Wang, Ping HuAbstract:St. John's wort has attracted particular attention because of its beneficial effects as an antidepressant, antiviral, and anticancer agent. A method for the combination of integrated Expanded Bed Adsorption chromatography and countercurrent chromatography for the simultaneous extraction and purification of pseudohypericin and hypericin from the herb is presented in this paper. Firstly, the constituents were extracted and directly adsorBed by Expanded Bed Adsorption chromatography under optimal conditions. The stepwise elution was then performed by Expanded Bed Adsorption chromatography that enriched the targets with higher purities and recoveries compared to other methods. Secondly, the eluent fractions from Expanded Bed Adsorption chromatography were further separated by two-step high-speed countercurrent chromatography. A two-step high-speed countercurrent chromatography method with a biphasic solvent system composed of n-hexane/ethyl acetate/methanol/water with a volume ratio of 1:2:1:2 was performed by stepwise changing the flow rate of the mobile phase. Consequently, 5.6 mg of pseudohypericin and 2.2 mg of hypericin with purities of 95.5 and 95.0%, respectively, were successfully obtained from 40 mg of crude sample.
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coupling of ultrasound assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model extraction and enrichment of ginsenosides from radix ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
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Coupling of ultrasound‐assisted extraction and Expanded Bed Adsorption for simplified medicinal plant processing and its theoretical model: Extraction and enrichment of ginsenosides from Radix Ginseng as a case study
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Jianing Mi, Min Zhang, Hongyang Zhang, Yuerong Wang, Shikun Wu, Ping HuAbstract:: A high-efficient and environmental-friendly method for the preparation of ginsenosides from Radix Ginseng using the method of coupling of ultrasound-assisted extraction with Expanded Bed Adsorption is descriBed. Based on the optimal extraction conditions screened by surface response methodology, ginsenosides were extracted and adsorBed, then eluted by the two-step elution protocol. The comparison results between the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method and conventional method showed that the former was better than the latter in both process efficiency and greenness. The process efficiency and energy efficiency of the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption method rapidly increased by 1.4-fold and 18.5-fold of the conventional method, while the environmental cost and CO(2) emission of the conventional method were 12.9-fold and 17.0-fold of the new method. Furthermore, the theoretical model for the extraction of targets was derived. The results revealed that the theoretical model suitably descriBed the process of preparing ginsenosides by the coupling of ultrasound-assisted extraction with Expanded Bed Adsorption system.
