The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Paul K Witting - One of the best experts on this subject based on the ideXlab platform.
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pre treatment with the synthetic antioxidant t butyl bisphenol protects cerebral tissues from Experimental Ischemia reperfusion injury
Journal of Neurochemistry, 2014Co-Authors: Thi Thuy Hong Duong, Belal Chami, Aisling C Mcmahon, Genevieve Fong, Joanne M Dennis, Saul Benedict Freedman, Paul K WittingAbstract:Treatments to inhibit or repair neuronal cell damage sustained during focal Ischemia/reperfusion injury in stroke are largely unavailable. We demonstrate that dietary supplementation with the antioxidant di-tert-butyl-bisphenol (BP) before injury decreases infarction and vascular complications in Experimental stroke in an animal model. We confirm that BP, a synthetic polyphenol with superior radical-scavenging activity than vitamin E, crosses the blood–brain barrier and accumulates in rat brain. Supplementation with BP did not affect blood pressure or endogenous vitamin E levels in plasma or cerebral tissue. Pre-treatment with BP significantly lowered lipid, protein and thiol oxidation and decreased infarct size in animals subjected to middle cerebral artery occlusion (2 h) and reperfusion (24 h) injury. This neuroprotective action was accompanied by down-regulation of hypoxia inducible factor-1α and glucose transporter-1 mRNA levels, maintenance of neuronal tissue ATP concentration and inhibition of pro-apoptotic factors that together enhanced cerebral tissue viability after injury. That pre-treatment with BP ameliorates oxidative damage and preserves cerebral tissue during focal ischemic insult indicates that oxidative stress plays at least some causal role in promoting tissue damage in Experimental stroke. The data strongly suggest that inhibition of oxidative stress through BP scavenging free radicals in vivo contributes significantly to neuroprotection. We demonstrate that pre-treatment with ditert-butyl bisphenol(Di-t-Bu-BP) inhibits lipid, protein, and total thiol oxidation and decreases caspase activation and infarct size in rats subjected to middle cerebral artery occlusion (2 h) and reperfusion (24 h) injury. These data suggest that inhibition of oxidative stress contributes significantly to neuroprotection.
Torukameya - One of the best experts on this subject based on the ideXlab platform.
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Basic Fibroblast Growth Factor Increases Regional Cerebral Blood Flow and Reduces Infarct Size After Experimental Ischemia in a Rat Model
Stroke, 1995Co-Authors: Ryusuitanaka, Yoshiomiyasaka, Kenzohyada, Takashiohwada, TorukameyaAbstract:Background and Purpose The aim of this study was to ascertain whether basic fibroblast growth factors (bFGF) caused reduction in size of cerebral infarcts in Sprague-Dawley rats with Experimental Ischemia. Methods In the first experiment we induced permanent occlusion of the left middle cerebral artery (MCA). Within 5 minutes after MCA occlusion, we infused bFGF (100 ng in 0.1 mL of saline) in the bFGF-treated group (n=14) and 0.1 mL of saline alone in the control group (n=7) into the common carotid artery ipsilateral to MCA occlusion. We harvested the brains 24 hours after MCA occlusion and determined infarct size planimetrically as a percentage of hemisphere size. In the second experiment cerebral blood flow (CBF) was continuously measured for 120 minutes after MCA occlusion in the bFGF-treated group (n=9) and in the control group (n=8) with the use of laser-Doppler flowmetry. Results Infarct size in the bFGF-treated group decreased significantly in comparison with that in the control group (repeated-me...
Toru Kameya - One of the best experts on this subject based on the ideXlab platform.
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Basic Fibroblast Growth Factor Increases Regional Cerebral Blood Flow and Reduces Infarct Size After Experimental Ischemia in a Rat Model
Stroke, 1995Co-Authors: Ryusui Tanaka, Yoshio Miyasaka, Kenzoh Yada, Takashi Ohwada, Toru KameyaAbstract:Background and Purpose The aim of this study was to ascertain whether basic fibroblast growth factors (bFGF) caused reduction in size of cerebral infarcts in Sprague-Dawley rats with Experimental Ischemia. Methods In the first experiment we induced permanent occlusion of the left middle cerebral artery (MCA). Within 5 minutes after MCA occlusion, we infused bFGF (100 ng in 0.1 mL of saline) in the bFGF-treated group (n=14) and 0.1 mL of saline alone in the control group (n=7) into the common carotid artery ipsilateral to MCA occlusion. We harvested the brains 24 hours after MCA occlusion and determined infarct size planimetrically as a percentage of hemisphere size. In the second experiment cerebral blood flow (CBF) was continuously measured for 120 minutes after MCA occlusion in the bFGF-treated group (n=9) and in the control group (n=8) with the use of laser-Doppler flowmetry. Results Infarct size in the bFGF-treated group decreased significantly in comparison with that in the control group (repeated-measures ANOVA, P
Talip Gül - One of the best experts on this subject based on the ideXlab platform.
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Protective effects of honokiol on Ischemia/reperfusion injury of rat ovary: an Experimental study.
Drug design development and therapy, 2016Co-Authors: Senem Yaman Tunç, Elif Ağaçayak, Neval Yaman Görük, Mehmet Sait İçen, Abdulkadir Turgut, Ulaş Alabalık, Cihan Togrul, Cenap Ekinci, Aysun Ekinci, Talip GülAbstract:Aim The purpose of this study was to investigate the protective effect of honokiol on Experimental Ischemia/reperfusion injury of rat ovary.
Ryusuitanaka - One of the best experts on this subject based on the ideXlab platform.
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Basic Fibroblast Growth Factor Increases Regional Cerebral Blood Flow and Reduces Infarct Size After Experimental Ischemia in a Rat Model
Stroke, 1995Co-Authors: Ryusuitanaka, Yoshiomiyasaka, Kenzohyada, Takashiohwada, TorukameyaAbstract:Background and Purpose The aim of this study was to ascertain whether basic fibroblast growth factors (bFGF) caused reduction in size of cerebral infarcts in Sprague-Dawley rats with Experimental Ischemia. Methods In the first experiment we induced permanent occlusion of the left middle cerebral artery (MCA). Within 5 minutes after MCA occlusion, we infused bFGF (100 ng in 0.1 mL of saline) in the bFGF-treated group (n=14) and 0.1 mL of saline alone in the control group (n=7) into the common carotid artery ipsilateral to MCA occlusion. We harvested the brains 24 hours after MCA occlusion and determined infarct size planimetrically as a percentage of hemisphere size. In the second experiment cerebral blood flow (CBF) was continuously measured for 120 minutes after MCA occlusion in the bFGF-treated group (n=9) and in the control group (n=8) with the use of laser-Doppler flowmetry. Results Infarct size in the bFGF-treated group decreased significantly in comparison with that in the control group (repeated-me...
