The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform
Jason Bramwell - One of the best experts on this subject based on the ideXlab platform.
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Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results.
Journal of General Virology, 2009Co-Authors: Michael J Stack, Lorenzo González, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason BramwellAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrPd). This study compares the WB and IHC characteristics of PrPd from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
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Short Communication Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results
2009Co-Authors: Michael J Stack, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason Bramwell, Steve GrimmerAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrP d ). This study compares the WB and IHC characteristics of PrP d from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
Michael J Stack - One of the best experts on this subject based on the ideXlab platform.
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Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results.
Journal of General Virology, 2009Co-Authors: Michael J Stack, Lorenzo González, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason BramwellAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrPd). This study compares the WB and IHC characteristics of PrPd from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
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Short Communication Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results
2009Co-Authors: Michael J Stack, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason Bramwell, Steve GrimmerAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrP d ). This study compares the WB and IHC characteristics of PrP d from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
Romolo Nonno - One of the best experts on this subject based on the ideXlab platform.
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Molecular discrimination of Sheep bovine spongiform encephalopathy from scrapie.
Emerging Infectious Diseases, 2011Co-Authors: Laura Pirisinu, Sergio Migliore, Michele Angelo Di Bari, Elena Esposito, Thierry Baron, Claudia D’agostino, Luigi De Grossi, Umberto Agrimi, Gabriele Vaccari, Romolo NonnoAbstract:Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from Sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and Experimental Sheep BSE.
Jemma Thorne - One of the best experts on this subject based on the ideXlab platform.
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Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results.
Journal of General Virology, 2009Co-Authors: Michael J Stack, Lorenzo González, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason BramwellAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrPd). This study compares the WB and IHC characteristics of PrPd from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
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Short Communication Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results
2009Co-Authors: Michael J Stack, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason Bramwell, Steve GrimmerAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrP d ). This study compares the WB and IHC characteristics of PrP d from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
Martin Jeffrey - One of the best experts on this subject based on the ideXlab platform.
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Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results.
Journal of General Virology, 2009Co-Authors: Michael J Stack, Lorenzo González, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason BramwellAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrPd). This study compares the WB and IHC characteristics of PrPd from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
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Short Communication Three serial passages of bovine spongiform encephalopathy in Sheep do not significantly affect discriminatory test results
2009Co-Authors: Michael J Stack, Martin Jeffrey, Stuart Martin, Colin Macaldowie, Melanie J. Chaplin, Jemma Thorne, Robin Sayers, L.a. Davis, Jason Bramwell, Steve GrimmerAbstract:During the 1980s, bovine spongiform encephalopathy (BSE)-contaminated meat and bonemeal were probably fed to Sheep, raising concerns that BSE may have been transmitted to Sheep in the UK. The human disease, variant Creutzfeldt–Jakob disease, arose during the BSE epidemic, and oral exposure of humans to BSE-infected tissues has been implicated in its aetiology. The concern is that Sheep BSE could provide another source of BSE exposure to humans via Sheep products. Two immunological techniques, Western immunoblotting (WB) and immunohistochemistry (IHC), have been developed to distinguish scrapie from cases of Experimental Sheep BSE by the characteristics of their respective abnormal, disease-associated prion proteins (PrP d ). This study compares the WB and IHC characteristics of PrP d from brains of primary, secondary and tertiary Experimental ovine BSE cases with those of cattle BSE and natural Sheep scrapie. Discrimination between Experimental Sheep BSE and scrapie remained possible by both methods, regardless of the route of challenge.
