The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Mark G Lesage - One of the best experts on this subject based on the ideXlab platform.
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Prevalence, magnitude, and correlates of an Extinction Burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively. Objective The objective of the study was to examine the prevalence, magnitude, and correlates of an Extinction Burst in nicotine-seeking behavior using data from a previously published study and recently trained animals. Materials and methods Rats were trained to self-administer nicotine (0.03 mg/kg per infusion) during daily 23-h sessions. Saline Extinction was subsequently arranged, followed by reacquisition of NSA for some animals. Results There was no increase in the daily infusion rate on the first day of Extinction. However, a significant increase (35%) in mean peak 2-h infusion rates was observed within the first Extinction session, indicative of an Extinction Burst. Greater Extinction Burst magnitude was correlated with higher infusion rates during the first 2 h of baseline sessions and smaller decreases in infusion rate at the end of Extinction. In addition, animals with the slowest initial rates of Extinction exhibited the fastest rates of reacquisition when unlimited access to nicotine was restored. Conclusions A modest increase in drug-seeking behavior occurred early within the first Extinction session in rats trained to self-administer nicotine in unlimited access sessions. The presence of an Extinction Burst in nicotine-seeking behavior suggests similar mechanisms underlying Extinction of NSA and self-administration of other drugs of abuse in animals and also parallels a similar phenomenon sometimes observed in smokers.
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prevalence magnitude and correlates of an Extinction Burst in drug seeking behavior in rats trained to self administer nicotine during unlimited access 23 h day sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively.
Andrew C Harris - One of the best experts on this subject based on the ideXlab platform.
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Prevalence, magnitude, and correlates of an Extinction Burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively. Objective The objective of the study was to examine the prevalence, magnitude, and correlates of an Extinction Burst in nicotine-seeking behavior using data from a previously published study and recently trained animals. Materials and methods Rats were trained to self-administer nicotine (0.03 mg/kg per infusion) during daily 23-h sessions. Saline Extinction was subsequently arranged, followed by reacquisition of NSA for some animals. Results There was no increase in the daily infusion rate on the first day of Extinction. However, a significant increase (35%) in mean peak 2-h infusion rates was observed within the first Extinction session, indicative of an Extinction Burst. Greater Extinction Burst magnitude was correlated with higher infusion rates during the first 2 h of baseline sessions and smaller decreases in infusion rate at the end of Extinction. In addition, animals with the slowest initial rates of Extinction exhibited the fastest rates of reacquisition when unlimited access to nicotine was restored. Conclusions A modest increase in drug-seeking behavior occurred early within the first Extinction session in rats trained to self-administer nicotine in unlimited access sessions. The presence of an Extinction Burst in nicotine-seeking behavior suggests similar mechanisms underlying Extinction of NSA and self-administration of other drugs of abuse in animals and also parallels a similar phenomenon sometimes observed in smokers.
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prevalence magnitude and correlates of an Extinction Burst in drug seeking behavior in rats trained to self administer nicotine during unlimited access 23 h day sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively.
Matthew M. Ford - One of the best experts on this subject based on the ideXlab platform.
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Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice
Psychopharmacology, 2008Co-Authors: Deborah A. Finn, Gregory P. Mark, Andrea M. Fretwell, Katherine R. Gililland-kaufman, Moriah N. Strong, Matthew M. FordAbstract:Rationale Recent work in our laboratory documented that the “sipper” method of operant ethanol self-administration produced high ethanol intake and blood ethanol concentrations as well as the typical Extinction “Burst” in responding under nonreinforced conditions in male C57BL/6 mice. However, the neurochemical basis for reinstatement of responding following Extinction has not been examined in mice with this model. Objectives Based on findings that the GABAergic neurosteroid allopregnanolone (ALLO) significantly increased the consummatory phase of ethanol self-administration, the present study determined the effect of ALLO on the reinstatement of extinguished ethanol-seeking behavior and compared this effect to the reinstatement of responding for sucrose reward. Materials and methods Separate groups of male C57BL/6 mice were trained to lever press for access to a 10% ethanol (10E) or a 5% sucrose (5S) solution. A single response requirement of 16 presses (RR16) on an active lever resulted in 30 min of continuous access to the 10E or 5S solution. After the animals responded on the RR16 schedule for 14 weeks, mice were exposed to 30 min Extinction sessions where responding had no scheduled consequence. Once responding stabilized below the preExtinction baseline, mice received an intraperitoneal injection of ALLO (0, 3.2, 5.6, 10, or 17 mg/kg) 15 min prior to the Extinction session in a within-subjects design. Results ALLO produced a dose-dependent increase in responding under nonreinforced conditions in both the 10E and 5S groups. Additional work documented the ability of a conditioned cue light or a compound cue (light+lever retraction) to reinstate nonreinforced responding on the previously active lever. Conclusions These findings definitively show that conditioned cues and priming with ALLO are potent stimuli for reinstating both ethanol- and sucrose-seeking behavior in C57BL/6 mice.
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Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice.
Psychopharmacology, 2008Co-Authors: Deborah A. Finn, Gregory P. Mark, Andrea M. Fretwell, Katherine R. Gililland-kaufman, Moriah N. Strong, Matthew M. FordAbstract:Rationale Recent work in our laboratory documented that the “sipper” method of operant ethanol self-administration produced high ethanol intake and blood ethanol concentrations as well as the typical Extinction “Burst” in responding under nonreinforced conditions in male C57BL/6 mice. However, the neurochemical basis for reinstatement of responding following Extinction has not been examined in mice with this model.
Paul R Pentel - One of the best experts on this subject based on the ideXlab platform.
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Prevalence, magnitude, and correlates of an Extinction Burst in drug-seeking behavior in rats trained to self-administer nicotine during unlimited access (23 h/day) sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively. Objective The objective of the study was to examine the prevalence, magnitude, and correlates of an Extinction Burst in nicotine-seeking behavior using data from a previously published study and recently trained animals. Materials and methods Rats were trained to self-administer nicotine (0.03 mg/kg per infusion) during daily 23-h sessions. Saline Extinction was subsequently arranged, followed by reacquisition of NSA for some animals. Results There was no increase in the daily infusion rate on the first day of Extinction. However, a significant increase (35%) in mean peak 2-h infusion rates was observed within the first Extinction session, indicative of an Extinction Burst. Greater Extinction Burst magnitude was correlated with higher infusion rates during the first 2 h of baseline sessions and smaller decreases in infusion rate at the end of Extinction. In addition, animals with the slowest initial rates of Extinction exhibited the fastest rates of reacquisition when unlimited access to nicotine was restored. Conclusions A modest increase in drug-seeking behavior occurred early within the first Extinction session in rats trained to self-administer nicotine in unlimited access sessions. The presence of an Extinction Burst in nicotine-seeking behavior suggests similar mechanisms underlying Extinction of NSA and self-administration of other drugs of abuse in animals and also parallels a similar phenomenon sometimes observed in smokers.
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prevalence magnitude and correlates of an Extinction Burst in drug seeking behavior in rats trained to self administer nicotine during unlimited access 23 h day sessions
Psychopharmacology, 2007Co-Authors: Andrew C Harris, Paul R Pentel, Mark G LesageAbstract:Rationale Animals trained to self-administer a variety of addictive drugs exhibit a temporary increase in response rate when saline is substituted for the drug (i.e., an “Extinction Burst”). However, the presence of an Extinction Burst in animal models of nicotine self-administration (NSA) has not been studied extensively.
Deborah A. Finn - One of the best experts on this subject based on the ideXlab platform.
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Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice
Psychopharmacology, 2008Co-Authors: Deborah A. Finn, Gregory P. Mark, Andrea M. Fretwell, Katherine R. Gililland-kaufman, Moriah N. Strong, Matthew M. FordAbstract:Rationale Recent work in our laboratory documented that the “sipper” method of operant ethanol self-administration produced high ethanol intake and blood ethanol concentrations as well as the typical Extinction “Burst” in responding under nonreinforced conditions in male C57BL/6 mice. However, the neurochemical basis for reinstatement of responding following Extinction has not been examined in mice with this model. Objectives Based on findings that the GABAergic neurosteroid allopregnanolone (ALLO) significantly increased the consummatory phase of ethanol self-administration, the present study determined the effect of ALLO on the reinstatement of extinguished ethanol-seeking behavior and compared this effect to the reinstatement of responding for sucrose reward. Materials and methods Separate groups of male C57BL/6 mice were trained to lever press for access to a 10% ethanol (10E) or a 5% sucrose (5S) solution. A single response requirement of 16 presses (RR16) on an active lever resulted in 30 min of continuous access to the 10E or 5S solution. After the animals responded on the RR16 schedule for 14 weeks, mice were exposed to 30 min Extinction sessions where responding had no scheduled consequence. Once responding stabilized below the preExtinction baseline, mice received an intraperitoneal injection of ALLO (0, 3.2, 5.6, 10, or 17 mg/kg) 15 min prior to the Extinction session in a within-subjects design. Results ALLO produced a dose-dependent increase in responding under nonreinforced conditions in both the 10E and 5S groups. Additional work documented the ability of a conditioned cue light or a compound cue (light+lever retraction) to reinstate nonreinforced responding on the previously active lever. Conclusions These findings definitively show that conditioned cues and priming with ALLO are potent stimuli for reinstating both ethanol- and sucrose-seeking behavior in C57BL/6 mice.
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Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice.
Psychopharmacology, 2008Co-Authors: Deborah A. Finn, Gregory P. Mark, Andrea M. Fretwell, Katherine R. Gililland-kaufman, Moriah N. Strong, Matthew M. FordAbstract:Rationale Recent work in our laboratory documented that the “sipper” method of operant ethanol self-administration produced high ethanol intake and blood ethanol concentrations as well as the typical Extinction “Burst” in responding under nonreinforced conditions in male C57BL/6 mice. However, the neurochemical basis for reinstatement of responding following Extinction has not been examined in mice with this model.
