The Experts below are selected from a list of 213 Experts worldwide ranked by ideXlab platform
Massimo Bonacchi - One of the best experts on this subject based on the ideXlab platform.
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a new formula for determining arterial oxygen saturation during venovenous Extracorporeal Oxygenation
Intensive Care Medicine, 2013Co-Authors: Elmi Messai, Abdesselam Bouguerra, Guy Harmelin, Gabriella Di Lascio, Giovanni Cianchi, Massimo BonacchiAbstract:Purpose Venovenous Extracorporeal membrane Oxygenation (VV-ECMO) is used to treat severe forms of acute respiratory distress syndrome (ARDS). VV-ECMO management may be confusing due to the lack of information about the interplay between the determinant parameters and their impact on Oxygenation. We found a relationship between arterial oxygen saturation (SaO2) and its relevant parameters. The aim of this study was to assess the validity of this model.
Steffen Leonhardt - One of the best experts on this subject based on the ideXlab platform.
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In Vivo Validation of an Automatic Controlled Extracorporeal Membrane Oxygenator
IFMBE Proceedings, 2020Co-Authors: Tobias Wartzek, Marian Walter, Thomas Schmitz-rode, Stefan Kowalewski, Rolf Rossaint, Steffen LeonhardtAbstract:In cases where vital gas exchange can’t be provided by the human lung, Extracorporeal membrane Oxygenation therapy is used as an ‘ultima ratio’. Up to now, the operating parameters of this long term therapy are adjusted only heuristically at infrequent and discrete time intervals during the day. In order to provide an individually and continuously adapting therapy, an automatic blood gas controller was developed. This approach allows to preset a specific oxygen and carbon dioxide partial pressure at the output of the oxygenator. The automated Extracorporeal Oxygenation setup then continuously monitors the status of the patient and can trigger an alarm in cases of any abnormal system behavior. Thus, the therapy is improved and the medical staff is relieved in addition. This paper describes the development of the controlled Extracorporeal Oxygenation system including modeling of the whole system and controller design. First results of in-vitro- and in-vivo-experiments are shown.
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A physiological model for Extracorporeal Oxygenation controller design
2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010Co-Authors: Marian Walter, Andre Stollenwerk, Sören Weyer, Rüdger Kopp, Jutta Arens, Steffen LeonhardtAbstract:Long term Extracorporeal membrane Oxygenation can be used in cases of severe lung failure to maintain sufficient gas exchange without the need to apply higher ventilation pressures which damage the lung additionally. The use of cardiopulmonary bypass devices is well established inside the operating room. The usage of such devices as long-term support in the intensive care unit is still experimental and limited to few cases. This is because neither machine architecture nor staff situation provides for the long term application scenario. In the joint research Project “smart ECLA” we target an advanced ECMO device featuring an automation system capable of maintaining gas concentrations automatically. One key requirement for systematic controller design is the availability of a process model, which will be presented in this article.
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ECC - Automation of long term Extracorporeal Oxygenation systems
2009 European Control Conference (ECC), 2009Co-Authors: Marian Walter, Tobias Wartzek, Ruedger Kopp, Andre Stollenwerk, Ali Kashefi, Steffen LeonhardtAbstract:In case of severe lung malfunction (ARDS), conventional artificial ventilation strategies may not be able to maintain physiological gas exchange. In these life threatening situations, Extracorporeal gas exchange is one of the last available options to keep the patient alive. Until now, most centers use modified cardiopulmonary bypass devices (heart-lung machines). These devices were designed and built for permanent supervision by a trained perfusionist while in operation. In particular, control and safety concepts are tailored to constant attention of an operator. As this can not be achieved in an intensive care unit, more advanced concepts for control and patient safety are necessary. This paper describes an automation concept for advanced Extracorporeal lung assist systems for long term use in the intensive care unit. A main focus will be on the modelling of the gas exchange module (oxygenator) and the derivation of controllers for oxygen and carbon dioxide concentration at the oxygenator output.
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Automation of long term Extracorporeal Oxygenation systems
2009 European Control Conference (ECC), 2009Co-Authors: Marian Walter, Tobias Wartzek, Ruedger Kopp, Andre Stollenwerk, Ali Kashefi, Steffen LeonhardtAbstract:In case of severe lung malfunction (ARDS), conventional artificial ventilation strategies may not be able to maintain physiological gas exchange. In these life threatening situations, Extracorporeal gas exchange is one of the last available options to keep the patient alive. Until now, most centers use modified cardiopulmonary bypass devices (heart-lung machines). These devices were designed and built for permanent supervision by a trained perfusionist while in operation. In particular, control and safety concepts are tailored to constant attention of an operator. As this can not be achieved in an intensive care unit, more advanced concepts for control and patient safety are necessary. This paper describes an automation concept for advanced Extracorporeal lung assist systems for long term use in the intensive care unit. A main focus will be on the modelling of the gas exchange module (oxygenator) and the derivation of controllers for oxygen and carbon dioxide concentration at the oxygenator output.
Elmi Messai - One of the best experts on this subject based on the ideXlab platform.
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a new formula for determining arterial oxygen saturation during venovenous Extracorporeal Oxygenation
Intensive Care Medicine, 2013Co-Authors: Elmi Messai, Abdesselam Bouguerra, Guy Harmelin, Gabriella Di Lascio, Giovanni Cianchi, Massimo BonacchiAbstract:Purpose Venovenous Extracorporeal membrane Oxygenation (VV-ECMO) is used to treat severe forms of acute respiratory distress syndrome (ARDS). VV-ECMO management may be confusing due to the lack of information about the interplay between the determinant parameters and their impact on Oxygenation. We found a relationship between arterial oxygen saturation (SaO2) and its relevant parameters. The aim of this study was to assess the validity of this model.
Arthur J Boujoukos - One of the best experts on this subject based on the ideXlab platform.
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initial experience with single cannulation for venovenous Extracorporeal Oxygenation in adults
The Annals of Thoracic Surgery, 2010Co-Authors: C Bermudez, Rodolfo V Rocha, Penny L Sappington, Yoshiya Toyoda, Holt N Murray, Arthur J BoujoukosAbstract:Purpose Historically, venovenous Extracorporeal membrane Oxygenation has required dual cannulation. A single-venous cannulation strategy may facilitate implantation and patient mobilization. Here we present our early experience with a single cannulation technique. Description Review of venovenous Extracorporeal membrane Oxygenation support using internal jugular vein insertion of the Avalon elite bicaval dual lumen catheter (Avalon Laboratories, Rancho Dominguez, CA) in 11 consecutive patients with severe respiratory failure. Evaluation Adequate Oxygenation was obtained in all patients: 115 mm Hg Pa0 2 (median), 53 to 401 mm Hg (range). Median time of support was 78 hours (range, 3 to 267 hours). No mortality was directly related to the cannulation strategy. There were three nonfatal cannulation-related events. Two patients had proximal cannula displacement requiring repositioning. One patient suffered an acute thrombosis of the cannula. Conclusions Our series supports single-venous cannulation in venovenous Extracorporeal membrane Oxygenation as a promising technique. It may be an excellent alternative to current cannulation strategies in patients requiring prolonged support and specifically for those considered for a bridge-to-lung transplantation.
Giovanni Cianchi - One of the best experts on this subject based on the ideXlab platform.
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a new formula for determining arterial oxygen saturation during venovenous Extracorporeal Oxygenation
Intensive Care Medicine, 2013Co-Authors: Elmi Messai, Abdesselam Bouguerra, Guy Harmelin, Gabriella Di Lascio, Giovanni Cianchi, Massimo BonacchiAbstract:Purpose Venovenous Extracorporeal membrane Oxygenation (VV-ECMO) is used to treat severe forms of acute respiratory distress syndrome (ARDS). VV-ECMO management may be confusing due to the lack of information about the interplay between the determinant parameters and their impact on Oxygenation. We found a relationship between arterial oxygen saturation (SaO2) and its relevant parameters. The aim of this study was to assess the validity of this model.
