The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
Mahmut Odabası - One of the best experts on this subject based on the ideXlab platform.
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Comparison of fixed combinations of dorzolamide/timolol and brimonidine/timolol in patients with primary open-angle glaucoma
International Ophthalmology, 2011Co-Authors: Gokhan Gulkilik, Mahmut OdabasıAbstract:To compare the short-term effectiveness and ocular side-effects of fixed combinations of dorzolamide/timolol (DTFC) and brimonidine/timolol (BTFC) in patients with primary open-angle glaucoma (POAG). Forty-two Eyes of 42 patients newly diagnosed with primary open-angle glaucoma were assessed prospectively. One of the two Eyes was chosen randomly and treated with DTFC (2 × 1) for 4 weeks. The treatment was then stopped to allow a 4-week wash-out period. Following the wash-out period, the same Eye was treated with BTFC (2 × 1) for 4 weeks. Intraocular pressure (IOP) values were measured before and after each treatment at 0800, 1,200 and 1,600 h. Tear function test results and ocular side-effects were also recorded. The mean baseline IOP values for DTFC and BTFC were 24.1 ± 1.8 and 24.6 ± 2.4 mmHg, respectively. The mean IOP values after 4 weeks of treatment with DTFC or BTFC were 17.1 ± 2.9 and 16.9 ± 2.5 mmHg, respectively. Both medications reduced IOP values significantly ( P = 0.0000). The effectiveness of both medications was similar ( P = 0.7363). Both combinations significantly reduced the amount of tear secretion and tear break-up time ( P = 0.0000). Eye Burning was more common with DTFC than with BTFC ( P = 0.0182). Other adverse effects were observed at similar rates for both combinations. This study demonstrated that the IOP-reducing effects of DTFC and BTFC in patients with POAG are similar. The side-effect profile of BTFC is similar to that of DTFC. Lower occurrence of a Burning sensation may improve patient compliance in the BTFC group.
Gokhan Gulkilik - One of the best experts on this subject based on the ideXlab platform.
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Comparison of fixed combinations of dorzolamide/timolol and brimonidine/timolol in patients with primary open-angle glaucoma
International Ophthalmology, 2011Co-Authors: Gokhan Gulkilik, Mahmut OdabasıAbstract:To compare the short-term effectiveness and ocular side-effects of fixed combinations of dorzolamide/timolol (DTFC) and brimonidine/timolol (BTFC) in patients with primary open-angle glaucoma (POAG). Forty-two Eyes of 42 patients newly diagnosed with primary open-angle glaucoma were assessed prospectively. One of the two Eyes was chosen randomly and treated with DTFC (2 × 1) for 4 weeks. The treatment was then stopped to allow a 4-week wash-out period. Following the wash-out period, the same Eye was treated with BTFC (2 × 1) for 4 weeks. Intraocular pressure (IOP) values were measured before and after each treatment at 0800, 1,200 and 1,600 h. Tear function test results and ocular side-effects were also recorded. The mean baseline IOP values for DTFC and BTFC were 24.1 ± 1.8 and 24.6 ± 2.4 mmHg, respectively. The mean IOP values after 4 weeks of treatment with DTFC or BTFC were 17.1 ± 2.9 and 16.9 ± 2.5 mmHg, respectively. Both medications reduced IOP values significantly ( P = 0.0000). The effectiveness of both medications was similar ( P = 0.7363). Both combinations significantly reduced the amount of tear secretion and tear break-up time ( P = 0.0000). Eye Burning was more common with DTFC than with BTFC ( P = 0.0182). Other adverse effects were observed at similar rates for both combinations. This study demonstrated that the IOP-reducing effects of DTFC and BTFC in patients with POAG are similar. The side-effect profile of BTFC is similar to that of DTFC. Lower occurrence of a Burning sensation may improve patient compliance in the BTFC group.
Waldemar Gottardi - One of the best experts on this subject based on the ideXlab platform.
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Tolerance of N-Chlorotaurine, an Endogenous Antimicrobial Agent, in the Rabbit and Human Eye— A Phase I Clinical Study
Journal of Ocular Pharmacology and Therapeutics, 1998Co-Authors: Markus Nagl, Bruno Miller, F. Daxecker, Hanno Ulmer, Waldemar GottardiAbstract:ABSTRACT N-chlorotaurine (NCT), an essential weak oxidative N-chloro compound produced by stimulated human leukocytes, shows bactericidal, fungicidal, virucidal and vermicidal efficacy. A double-blind, randomized and placebo controlled study was done to evaluate the tolerance of the aqueous NCT solution by application to rabbit and human conjunctiva. In six rabbits treated with 1% and 3% NCT regimen for nine days no ocular and behaviour changes could be observed. In a pilot study with two volunteers, treatment with 2.8% NCT for five days caused a self-limited conjunctival injection of one subject, while 1% NCT was well tolerated. Subsequently, eight healthy volunteers participated in a phase I clinical study. One percent NCT was applied for five days and was well tolerated by all subjects except for minimal Eye Burning after the application. Because of these positive results, usage of the antimicrobial agent NCT in ophthalmology is suggested.
Mohammadi Mohammad Javad - One of the best experts on this subject based on the ideXlab platform.
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Cardiopulmonary Mortalities and Chronic Obstructive Pulmonary Disease Attributed to Ozone Air Pollution
Archives of Hygiene Sciences, 2013Co-Authors: Goudarzi Gholamreza, Zallaghi Elahe, Neissi Abdolkazem, Ahmadi Ankali Kambiz, Saki Azadeh, Babaei Ali Akbar, Alavi Nadali, Mohammadi Mohammad JavadAbstract:Ba c k g roun d & Aims of the Study: Ozone is a summer pollutant which can cause respiratory complications, Eye Burning sensation and failure of immune defense against infectious diseases. Ahvaz city (southwestern Iran) is one of the seven polluted Iranian metropolises. In this study we examined the health impacts of ozone pollution in Ahvaz city during years 2010 and 2011. Materials & Methods: The health effects of ozone pollution in Ahvaz estimated by determining mortality and morbidity, and incidence of diseases attributed to the ozone, i.e. , cardiopulmonary mortalities and chronic obstructive pulmonary disease (COPD) using Air Quality Model. Ozone data were taken from Ahvaz Department of Environment (ADoE). Conversion between volumetric and gravimetric units (correction of temperature and pressure), coding, processing (averaging) and filtering were implemented. Results: Sum of accumulative cases of mortalities attributed to ozone was 358 cases in 2010 and 276 cases in 2011. Cardiovascular and respiratory mortality attributed to ozone were 118 and 31 persons, respectively; which revealed a considerable reduction compared to those values in 2010. Number of cases for hospital admissions due to COPD was 35 in 2011, while it was 45 cases in 2010. The concentration of ozone in 2011 was lower than that of 2010 and this is why both mortalities and morbidities of 2011 attributed to ozone pollutant had decreased when compared to those values of 2010. Conclusions: Mortality and morbidity attributed to ozone concentrations in 2011 were lower than those of 2010. The most important reason was less concentration in ground level ozone of 2011 than that of 2010 in Ahvaz city air.
Marie A. De Perio - One of the best experts on this subject based on the ideXlab platform.
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Respiratory and Ocular Symptoms Among Employees of an Indoor Waterpark Resort - Ohio, 2016.
Morbidity and Mortality Weekly Report, 2017Co-Authors: Sophia Chiu, Nancy Clark Burton, Kevin H. Dunn, Marie A. De PerioAbstract:: In July 2015, a municipal health department in Ohio received complaints of respiratory and ocular symptoms from patrons of an indoor waterpark resort. In response, the health department conducted an online survey in August 2015 through which 19 (68%) patron and employee respondents reported Eye Burning, nose irritation, difficulty breathing, and vomiting. On August 11, 2015, the health department requested a health hazard evaluation by CDC's National Institute for Occupational Safety and Health to characterize the prevalence of symptoms among employees and determine the etiology of work-related symptoms. In January 2016, CDC investigators performed a cross-sectional epidemiologic study, environmental sampling, and ventilation system assessment (1). Findings suggested that chlorine disinfection byproducts and environmental conditions contributed to a higher prevalence of work-related respiratory and ocular symptoms among employees in the waterpark compared with employees in other resort areas. Recommendations included servicing the ventilation system, changing work practices to decrease the amount of disinfection byproduct precursors, and responding promptly to employee reports of symptoms.
