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Zoran Duric - One of the best experts on this subject based on the ideXlab platform.

  • a method of detecting and tracking irises and Eyelids in video
    Pattern Recognition, 2002
    Co-Authors: S. Sirohey, Azriel Rosenfeld, Zoran Duric
    Abstract:

    Abstract We locate the eye corners, Eyelids, and irises in every frame of an image sequence, and analyze the movements of the irises and Eyelids to determine changes in gaze direction and blinking, respectively. Using simple models for the motions of the head and eyes, we determine the head-independent motions of the irises and Eyelids by stabilizing for the head motion. The head-independent motions of the irises can be used to determine behaviors like saccades and smooth pursuit. Tracking the upper eyelid and using the distance between its apex and the center of the iris, we detect instances of eye closure during blinking. In experiments on two short image sequences, in one of which the subject was wearing glasses, we successfully located the irises in every frame in which the eyes were fully or partially open, and successfully located the Eyelids 80% of the time. When motion information in the form of normal flow was used, the irises were successfully tracked in every frame in which the eyes were fully or partially open, and the Eyelids were successfully located and tracked 90% of the time.

  • A method of detecting and tracking irises and Eyelids in video
    Pattern Recognition, 2002
    Co-Authors: S. Sirohey, Amir Rosenfeld, Zoran Duric
    Abstract:

    We locate the eye corners, Eyelids, and irises in every frame of an image sequence, and analyze the movements of the irises and Eyelids to determine changes in gaze direction and blinking, respectively. Using simple models for the motions of the head and eyes, we determine the head-independent motions of the irises and Eyelids by stabilizing for the head motion. The head-independent motions of the irises can be used to determine behaviors like saccades and smooth pursuit. Tracking the upper eyelid and using the distance between its apex and the center of the iris, we detect instances of eye closure during blinking. In experiments on two short image sequences, in one of which the subject was wearing glasses, we successfully located the irises in every frame in which the eyes were fully or partially open, and successfully located the Eyelids 80% of the time. When motion information in the form of normal flow was used, the irises were successfully tracked in every frame in which the eyes were fully or partially open, and the Eyelids were successfully located and tracked 90% of the time. © 2002 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.

Timothy D. Spector - One of the best experts on this subject based on the ideXlab platform.

  • intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, H Martino A Neumann, Timothy D. Spector
    Abstract:

    Importance Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. Objective To study nongenetic and genetic risk factors for sagging Eyelids. Design Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. Setting and Participants The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. Main Outcomes and Measures Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). Results Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 ( P  = 1.7 × 10 −8 ). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. Conclusions and Relevance This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids.

  • Intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, H. A.martino Neumann, Fan Liu, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, Timothy D. Spector
    Abstract:

    IMPORTANCE: Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. OBJECTIVE: To study nongenetic and genetic risk factors for sagging Eyelids. DESIGN: Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. SETTING AND PARTICIPANTS: The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. MAIN OUTCOMES AND MEASURES: Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). RESULTS: Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 (P = 1.7 × 10-8). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. CONCLUSIONS AND RELEVANCE: This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids. Copyright 2014 American Medical Association. All rights reserved.

Veronique Bataille - One of the best experts on this subject based on the ideXlab platform.

  • intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, H Martino A Neumann, Timothy D. Spector
    Abstract:

    Importance Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. Objective To study nongenetic and genetic risk factors for sagging Eyelids. Design Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. Setting and Participants The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. Main Outcomes and Measures Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). Results Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 ( P  = 1.7 × 10 −8 ). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. Conclusions and Relevance This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids.

  • Intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, H. A.martino Neumann, Fan Liu, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, Timothy D. Spector
    Abstract:

    IMPORTANCE: Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. OBJECTIVE: To study nongenetic and genetic risk factors for sagging Eyelids. DESIGN: Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. SETTING AND PARTICIPANTS: The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. MAIN OUTCOMES AND MEASURES: Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). RESULTS: Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 (P = 1.7 × 10-8). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. CONCLUSIONS AND RELEVANCE: This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids. Copyright 2014 American Medical Association. All rights reserved.

Isabel Bleyen - One of the best experts on this subject based on the ideXlab platform.

  • intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, H Martino A Neumann, Timothy D. Spector
    Abstract:

    Importance Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. Objective To study nongenetic and genetic risk factors for sagging Eyelids. Design Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. Setting and Participants The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. Main Outcomes and Measures Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). Results Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 ( P  = 1.7 × 10 −8 ). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. Conclusions and Relevance This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids.

  • Intrinsic and extrinsic risk factors for sagging Eyelids
    JAMA Dermatology, 2014
    Co-Authors: Leonie C Jacobs, Isabel Bleyen, H. A.martino Neumann, Fan Liu, David A Gunn, Caroline C. W. Klaver, Veronique Bataille, Albert Hofman, Andre G Uitterlinden, Timothy D. Spector
    Abstract:

    IMPORTANCE: Sagging Eyelids, or dermatochalasis, are a frequent concern in older adults. It is considered a feature of skin aging, but risk factors other than aging are largely unknown. OBJECTIVE: To study nongenetic and genetic risk factors for sagging Eyelids. DESIGN: Upper eyelid sagging was graded in 4 categories of severity using digital photographs. Dermatochalasis was defined as the eyelid hanging over the eyelashes. Age, sex, skin color, tanning ability, hormonal status in women, current smoking, body mass index, and sun protection behavior were analyzed in a multivariable multinomial logistic regression model. Genetic predisposition was assessed using heritability analysis and a genome-wide association study. SETTING AND PARTICIPANTS: The study was performed in 2 independent population-based cohorts. The Rotterdam Study included older adults from one district in Rotterdam, the Netherlands, and the UK Adult Twin Registry (TwinsUK) included twins from all over the United Kingdom. Participants were 5578 unrelated Dutch Europeans (mean age, 67.1 years; 44.0% male) from the Rotterdam Study and 2186 twins (mean age, 53.1 years; 10.4% male) from the TwinsUK. MAIN OUTCOMES AND MEASURES: Sagging eyelid severity levels, ranging from 1 (normal control) to 4 (severe sagging). RESULTS: Among 5578 individuals from the Rotterdam Study, 17.8% showed dermatochalasis (moderate and severe sagging Eyelids). Significant and independent risk factors for sagging Eyelids included age, male sex, lighter skin color, and higher body mass index. In addition, current smoking was borderline significantly associated. Heritability of sagging Eyelids was estimated to be 61% among 1052 twin pairs from the TwinsUK (15.6% showed dermatochalasis). A meta-analysis of genome-wide association study results from 5578 Rotterdam Study and 1053 TwinsUK participants showed a genome-wide significant recessive protective effect of the C allele of rs11876749 (P = 1.7 × 10-8). This variant is located close to TGIF1 (an inducer of transforming growth factor β), which is a known gene associated with skin aging. CONCLUSIONS AND RELEVANCE: This is the first observational study to date demonstrating that other risk factors (male sex, genetic variants, lighter skin color, high body mass index, and possibly current smoking) in addition to aging are involved in the origin of sagging Eyelids. Copyright 2014 American Medical Association. All rights reserved.

  • the wies procedure for management of trichiasis or cicatricial entropion of either upper or lower Eyelids
    British Journal of Ophthalmology, 2009
    Co-Authors: Isabel Bleyen, Peter J Dolman
    Abstract:

    Aim: To report the efficacy of the Wies procedure (transverse blepharotomy and marginal rotation) in the management of trichiasis or cicatricial entropion of the upper or lower eyelid. Methods: A retrospective chart review was performed of all cases of Wies eyelid rotations supervised or performed by one surgeon for cicatricial entropion or trichiasis of the upper or lower Eyelids over a 16-year period to assess the indications, success rate and complications of the procedure. Where follow-up was less than 6 months, telephone interviews were conducted to assess patient satisfaction with the surgery. Patients not meeting these criteria were excluded from the final analysis. Success was defined as no recurrence of the entropion or trichiasis and/or patient satisfaction at least 6 months postoperatively. Statistical analysis was performed using a χ2 test. Results: 126 Eyelids (77 upper lids, 49 lower lids) were identified in 89 patients (53 single eyelid, 33 multiple Eyelids) who underwent a Wies procedure with a minimum follow-up period of 6 months. The mean follow-up period was 67 months (range 6–188 months). The overall success rate was 85%. 13 Eyelids (10%) developed complications. 18 Eyelids (14%) developed recurrences that required a second procedure. 10 of these second procedures were repeat Wies procedures, one of which was followed by electrolysis. All of these second Wies procedures were successful. Conclusions: The Wies procedure (transverse blepharotomy and marginal rotation) is reasonably successful in managing trichiasis and cicatricial entropion of either upper or lower Eyelids.

S. Sirohey - One of the best experts on this subject based on the ideXlab platform.

  • a method of detecting and tracking irises and Eyelids in video
    Pattern Recognition, 2002
    Co-Authors: S. Sirohey, Azriel Rosenfeld, Zoran Duric
    Abstract:

    Abstract We locate the eye corners, Eyelids, and irises in every frame of an image sequence, and analyze the movements of the irises and Eyelids to determine changes in gaze direction and blinking, respectively. Using simple models for the motions of the head and eyes, we determine the head-independent motions of the irises and Eyelids by stabilizing for the head motion. The head-independent motions of the irises can be used to determine behaviors like saccades and smooth pursuit. Tracking the upper eyelid and using the distance between its apex and the center of the iris, we detect instances of eye closure during blinking. In experiments on two short image sequences, in one of which the subject was wearing glasses, we successfully located the irises in every frame in which the eyes were fully or partially open, and successfully located the Eyelids 80% of the time. When motion information in the form of normal flow was used, the irises were successfully tracked in every frame in which the eyes were fully or partially open, and the Eyelids were successfully located and tracked 90% of the time.

  • A method of detecting and tracking irises and Eyelids in video
    Pattern Recognition, 2002
    Co-Authors: S. Sirohey, Amir Rosenfeld, Zoran Duric
    Abstract:

    We locate the eye corners, Eyelids, and irises in every frame of an image sequence, and analyze the movements of the irises and Eyelids to determine changes in gaze direction and blinking, respectively. Using simple models for the motions of the head and eyes, we determine the head-independent motions of the irises and Eyelids by stabilizing for the head motion. The head-independent motions of the irises can be used to determine behaviors like saccades and smooth pursuit. Tracking the upper eyelid and using the distance between its apex and the center of the iris, we detect instances of eye closure during blinking. In experiments on two short image sequences, in one of which the subject was wearing glasses, we successfully located the irises in every frame in which the eyes were fully or partially open, and successfully located the Eyelids 80% of the time. When motion information in the form of normal flow was used, the irises were successfully tracked in every frame in which the eyes were fully or partially open, and the Eyelids were successfully located and tracked 90% of the time. © 2002 Pattern Recognition Society. Published by Elsevier Science Ltd. All rights reserved.