The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Tae-ho Park - One of the best experts on this subject based on the ideXlab platform.
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effect of fixed dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia mrs roze multicenter randomized study of Rosuvastatin and Ezetimibe
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
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Effect of fixed‐dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of Rosuvastatin and Ezetimibe)
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
Kyung Jin Kim - One of the best experts on this subject based on the ideXlab platform.
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effect of fixed dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia mrs roze multicenter randomized study of Rosuvastatin and Ezetimibe
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
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Effect of fixed‐dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of Rosuvastatin and Ezetimibe)
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
Sang-hyun Kim - One of the best experts on this subject based on the ideXlab platform.
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effect of fixed dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia mrs roze multicenter randomized study of Rosuvastatin and Ezetimibe
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
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Effect of fixed‐dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of Rosuvastatin and Ezetimibe)
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
Young Won Yoon - One of the best experts on this subject based on the ideXlab platform.
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effect of fixed dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia mrs roze multicenter randomized study of Rosuvastatin and Ezetimibe
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
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Effect of fixed‐dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of Rosuvastatin and Ezetimibe)
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
Seung-woon Rha - One of the best experts on this subject based on the ideXlab platform.
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effect of fixed dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia mrs roze multicenter randomized study of Rosuvastatin and Ezetimibe
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
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Effect of fixed‐dose combinations of Ezetimibe Plus Rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of Rosuvastatin and Ezetimibe)
Cardiovascular Therapeutics, 2016Co-Authors: Kyung Jin Kim, Sang-hyun Kim, Young Won Yoon, Seung-woon Rha, Soon Jun Hong, Choong Hwan Kwak, Weon Kim, Chang-wook Nam, Moo Yong Rhee, Tae-ho ParkAbstract:SummaryAim We aimed to compare the effects of fixed-dose combinations of Ezetimibe Plus Rosuvastatin to Rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis of patients with diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight-week randomized double-blind phase III study evaluated the safety and efficacy of fixed-dose combinations of Ezetimibe 10 mg Plus Rosuvastatin, compared with Rosuvastatin alone in patients with primary hypercholesterolemia. Four hundred and seven patients with primary hypercholesterolemia who required lipid-lowering treatment according to the ATP III guideline were randomized to one of the following six treatments for 8 weeks: fixed-dose combinations with Ezetimibe 10 mg daily Plus Rosuvastatin (5, 10, or 20 mg daily) or Rosuvastatin alone (5, 10, or 20 mg daily). Results Fixed-dose combination of Ezetimibe Plus Rosuvastatin significantly reduced LDL cholesterol, total cholesterol, and triglyceride levels compared with Rosuvastatin alone. Depending on the Rosuvastatin dose, these fixed-dose combinations of Ezetimibe Plus Rosuvastatin provided LDL cholesterol, total cholesterol, and triglyceride reductions of 56%–63%, 37%–43%, and 19%–24%, respectively. Moreover, the effect of combination treatment on cholesterol levels was more pronounced in patients with DM or MetS than in non-DM or non-MetS patients, respectively, whereas the effect of Rosuvastatin alone did not differ between DM vs non-DM or MetS vs non-MetS patients. Conclusion Fixed-dose combinations of Ezetimibe and Rosuvastatin provided significantly superior efficacy to Rosuvastatin alone in lowering LDL cholesterol, total cholesterol, and triglyceride levels. Moreover, the reduction rate was greater in patients with DM or MetS.
