The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
David Morrison - One of the best experts on this subject based on the ideXlab platform.
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immediate maxillofacial prosthodontic rehabilitation after radical mid Face Tumor resection
Journal of Prosthodontics, 1997Co-Authors: Ansgar C Cheng, David MorrisonAbstract:: Mid-facial surgical defects can adversely affect a patient's esthetics and psychological well-being. Fabrication of a definitive mid-facial prosthesis can be a time-consuming procedure. It is crucial to minimize the time between the Tumor resection and initial prosthetic rehabilitation. This article describes a method for rapid fabrication of a transitional facial prosthesis for mid-facial defects.
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Immediate Maxillofacial Prosthodontic Rehabilitation After Radical Mid‐Face Tumor Resection
Journal of Prosthodontics, 1997Co-Authors: Ansgar C Cheng, David MorrisonAbstract:: Mid-facial surgical defects can adversely affect a patient's esthetics and psychological well-being. Fabrication of a definitive mid-facial prosthesis can be a time-consuming procedure. It is crucial to minimize the time between the Tumor resection and initial prosthetic rehabilitation. This article describes a method for rapid fabrication of a transitional facial prosthesis for mid-facial defects.
Ansgar C Cheng - One of the best experts on this subject based on the ideXlab platform.
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immediate maxillofacial prosthodontic rehabilitation after radical mid Face Tumor resection
Journal of Prosthodontics, 1997Co-Authors: Ansgar C Cheng, David MorrisonAbstract:: Mid-facial surgical defects can adversely affect a patient's esthetics and psychological well-being. Fabrication of a definitive mid-facial prosthesis can be a time-consuming procedure. It is crucial to minimize the time between the Tumor resection and initial prosthetic rehabilitation. This article describes a method for rapid fabrication of a transitional facial prosthesis for mid-facial defects.
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Immediate Maxillofacial Prosthodontic Rehabilitation After Radical Mid‐Face Tumor Resection
Journal of Prosthodontics, 1997Co-Authors: Ansgar C Cheng, David MorrisonAbstract:: Mid-facial surgical defects can adversely affect a patient's esthetics and psychological well-being. Fabrication of a definitive mid-facial prosthesis can be a time-consuming procedure. It is crucial to minimize the time between the Tumor resection and initial prosthetic rehabilitation. This article describes a method for rapid fabrication of a transitional facial prosthesis for mid-facial defects.
Celine Naveaux - One of the best experts on this subject based on the ideXlab platform.
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Reliability of Tumor-infiltrating lymphocyte and tertiary lymphoid structure assessment in human breast cancer
Modern Pathology, 2017Co-Authors: Laurence Buisseret, Christine Desmedt, Soizic Garaud, Marco Fornili, Xiaoxiao Wang, Gert Van Den Eyden, Alexandre De Wind, Sebastien Duquenne, Anais Boisson, Celine NaveauxAbstract:The presence of Tumor-infiltrating lymphocytes (TIL), reflecting host immune activity, is frequently correlated with better clinical outcomes, particularly in HER2-positive and triple-negative breast cancer. Recent findings suggest that organization of immune infiltrates in tertiary lymphoid structures also has a beneficial effect on survival. This study investigated inter- and intra-observer variation in TIL assessment using conventional hematoxylin-eosin versus immunohistochemical staining to identify immune cells. Global, intraTumoral, and stromal TIL, as well as tertiary lymphoid structures were scored independently by experienced pathologists on full-Face Tumor sections ( n =124). The fidelity of scoring infiltrates in core biopsies compared to surgical specimens, and pathological assessment compared to quantitative digital analysis was also evaluated. The inter-observer concordance correlation coefficient was 0.80 for global, 0.72 for intraTumoral, and 0.71 for stromal TIL, while the intra-observer concordance correlation coefficient was 0.90 for global, 0.77 for intraTumoral, and 0.89 for stromal TIL using immunohistochemical stains. Correlations were lower with hematoxylin-eosin stains, particularly for intraTumoral TIL, while global scores had the highest concordance correlation coefficients. Our study concluded that tertiary lymphoid structures are accurately and consistently scored using immunohistochemical but not hematoxylin-eosin stains. A strong association was observed between TIL in core biopsies and surgical samples ( R ^2=0.74) but this did not extend to tertiary lymphoid structures ( R ^2=0.26). TIL scored by pathologists and digital analysis were correlated but our analysis reveals a constant bias between these methods. These data challenge current criteria for TIL and tertiary lymphoid structure assessment in breast cancer and recommend that how pathologists evaluate immune infiltrates be reexamined for future studies.
Debra T. Auguste - One of the best experts on this subject based on the ideXlab platform.
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A Drug‐Delivery Vehicle Combining the Targeting and Thermal Ablation of HER2+ Breast‐Cancer Cells with Triggered Drug Release
Angewandte Chemie, 2013Co-Authors: Debra T. AugusteAbstract:Breast cancer is the second leading cause of cancer-related deaths in women, surpassed only by lung cancer. [1] Current clinical therapies target the estrogen receptor (ER) and human epidermal growth factor receptor-2 (HER2) to reduce cancer-cell proliferation. These methods are often used in conjunction with surgery, chemotherapy, and/or radiation in efforts to eradicate the disease. However, 25 % of patients Face Tumor recurrence and resistance within 5 years after treatment. [2] Ideally, the initial treatment would supply a robust, broad-spectrum therapy to eliminate all cancer
Laurence Buisseret - One of the best experts on this subject based on the ideXlab platform.
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Reliability of Tumor-infiltrating lymphocyte and tertiary lymphoid structure assessment in human breast cancer
Modern Pathology, 2017Co-Authors: Laurence Buisseret, Christine Desmedt, Soizic Garaud, Marco Fornili, Xiaoxiao Wang, Gert Van Den Eyden, Alexandre De Wind, Sebastien Duquenne, Anais Boisson, Celine NaveauxAbstract:The presence of Tumor-infiltrating lymphocytes (TIL), reflecting host immune activity, is frequently correlated with better clinical outcomes, particularly in HER2-positive and triple-negative breast cancer. Recent findings suggest that organization of immune infiltrates in tertiary lymphoid structures also has a beneficial effect on survival. This study investigated inter- and intra-observer variation in TIL assessment using conventional hematoxylin-eosin versus immunohistochemical staining to identify immune cells. Global, intraTumoral, and stromal TIL, as well as tertiary lymphoid structures were scored independently by experienced pathologists on full-Face Tumor sections ( n =124). The fidelity of scoring infiltrates in core biopsies compared to surgical specimens, and pathological assessment compared to quantitative digital analysis was also evaluated. The inter-observer concordance correlation coefficient was 0.80 for global, 0.72 for intraTumoral, and 0.71 for stromal TIL, while the intra-observer concordance correlation coefficient was 0.90 for global, 0.77 for intraTumoral, and 0.89 for stromal TIL using immunohistochemical stains. Correlations were lower with hematoxylin-eosin stains, particularly for intraTumoral TIL, while global scores had the highest concordance correlation coefficients. Our study concluded that tertiary lymphoid structures are accurately and consistently scored using immunohistochemical but not hematoxylin-eosin stains. A strong association was observed between TIL in core biopsies and surgical samples ( R ^2=0.74) but this did not extend to tertiary lymphoid structures ( R ^2=0.26). TIL scored by pathologists and digital analysis were correlated but our analysis reveals a constant bias between these methods. These data challenge current criteria for TIL and tertiary lymphoid structure assessment in breast cancer and recommend that how pathologists evaluate immune infiltrates be reexamined for future studies.
