The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Daniel Henrion - One of the best experts on this subject based on the ideXlab platform.
-
involvement of rhoa rho kinase pathway in myogenic tone in the rabbit Facial Vein
Hypertension, 2005Co-Authors: Caroline Dubroca, Bernard I Levy, Laurent Loufrani, Daniel HenrionAbstract:Myogenic tone (MT), a fundamental stretch-sensitive vasoconstrictor property of resistance arteries and Veins, is a key determinant of local blood flow regulation. We evaluated the pathways involved in MT development. The role of the RhoA/Rho kinase, p38 MAP kinase, and HSP27 in MT was investigated in the rabbit Facial Vein (RFV), previously shown to possess MT at a pressure level equivalent to 20 mm Hg. Venous MT is poorly understood, although venous diseases affect a large proportion of the population. Stretched RFV are characterized by a temperature-sensitive MT, which is normal at 39°C but fails to develop at 33°C. This allows for the discrimination of the pathways involved in MT from the multiple pathways activated by stretch. Isolated RFV segments were mounted in organ baths and stretched. Temperature was then set at 33°C or 39°C. MT was associated to the translocation of RhoA to the plasma membrane and the Rho kinase inhibitor Y27632 decreased stretch-induced MT by 93.1±4.9%. MT was also associated to an increase in p38 (131.0±12.5% at 39°C versus 100% at 33°C) and HSP27 phosphorylation (196.1±13.3% versus 100%), and the p38 MAP kinase inhibitor SB203580 decreased MT by 36.5±8.1%. (39°C, compared with RFV stretched at 33°C). Finally, phosphorylation of p38 was blocked by Y27632 and HSP27 phosphorylation was inhibited by SB203580 and Y27632. Thus, MT and the associated p38 and HSP27 phosphorylation seem to depend on RhoA/Rho kinase activation in stretch RFV.
-
Involvement of RhoA/Rho Kinase Pathway in Myogenic Tone in the Rabbit Facial Vein
Hypertension, 2005Co-Authors: Caroline Dubroca, Bernard I Levy, Laurent Loufrani, Daniel HenrionAbstract:Myogenic tone (MT), a fundamental stretch-sensitive vasoconstrictor property of resistance arteries and Veins, is a key determinant of local blood flow regulation. We evaluated the pathways involved in MT development. The role of the RhoA/Rho kinase, p38 MAP kinase, and HSP27 in MT was investigated in the rabbit Facial Vein (RFV), previously shown to possess MT at a pressure level equivalent to 20 mm Hg. Venous MT is poorly understood, although venous diseases affect a large proportion of the population. Stretched RFV are characterized by a temperature-sensitive MT, which is normal at 39°C but fails to develop at 33°C. This allows for the discrimination of the pathways involved in MT from the multiple pathways activated by stretch. Isolated RFV segments were mounted in organ baths and stretched. Temperature was then set at 33°C or 39°C. MT was associated to the translocation of RhoA to the plasma membrane and the Rho kinase inhibitor Y27632 decreased stretch-induced MT by 93.1±4.9%. MT was also associated to an increase in p38 (131.0±12.5% at 39°C versus 100% at 33°C) and HSP27 phosphorylation (196.1±13.3% versus 100%), and the p38 MAP kinase inhibitor SB203580 decreased MT by 36.5±8.1%. (39°C, compared with RFV stretched at 33°C). Finally, phosphorylation of p38 was blocked by Y27632 and HSP27 phosphorylation was inhibited by SB203580 and Y27632. Thus, MT and the associated p38 and HSP27 phosphorylation seem to depend on RhoA/Rho kinase activation in stretch RFV.
-
small changes in extracellular sodium influence myogenic tone in rabbit Facial Vein by changing its sensitivity to calcium
Life Sciences, 1997Co-Authors: Daniel Henrion, Ismail Laher, John A BevanAbstract:Extracellular Na+ concentration ([Na+]e) significantly effects the regulation of myogenic tone in isolated blood vessels. We examined the effect of small changes in [Na+]e on simultaneous changes in stretchactivated myogenic tone in rabbit Facial Vein and 45Ca2+ unidirectional influx and net uptake. Decreasing [Na+]e from 150 to 120 mmoll augmented myogenic tone (control: 3.15 ± 0.27 mN, n = 22) by 89 ± 29%, while raising [Na+]e to 165 mmoll attenuated myogenic tone to 80 ± 2% of control. Changes in myogenic tone induced by alterations in [Na+]e were not accompanied by proportional changes in 45Ca2+ net uptake. 45Ca2+ unidirectional influx per unit of wall force (10.2 ± 1.0 pmolmg per mN force, n = 22, control) was decreased to 6.1 ± 0.6 pmolmg per mN (n = 20, P < 0.05) and increased to 21.0 ± 2.5 pmolmg per mN (n = 14, P < 0.05) when [Na+]e was 120 or 165 mmoll, respectively, suggesting that decreasing [Na+]e is related to an increased sensitivity to calcium. We conclude that, in the rabbit Facial Vein, the sensitivity of myogenic tone to changes in [Na+]e may reflect changes in the sensitivity of smooth muscle to Ca2+ through a change in mechanoreceptor sensitivity.
-
intraluminal flow preferentially increases net sodium uptake in the rabbit Facial Vein
Journal of Vascular Research, 1995Co-Authors: Daniel Henrion, John A BevanAbstract:The infusion of physiological salt solution into the lumen of ring segments of the isolated rabbit Facial Vein induces an increase in vessel wall tone. Changes in 22Na+ and
-
myogenic tone of rabbit Facial Vein and posterior cerebral artery is influenced by changes in extracellular sodium
American Journal of Physiology-heart and Circulatory Physiology, 1994Co-Authors: Daniel Henrion, Ismail Laher, A Klaasen, John A BevanAbstract:We examined the effect of small changes in extracellular Na+ concentration ([Na+]e) on myogenic tone (MT) in isometrically mounted ring segments of the rabbit Facial Vein and in pressurized cannulated posterior cerebral artery segments. Decreasing [Na+]e from 150 to 120 mM in the Vein increased MT by 24%, and raising [Na+]e to 165 mM attenuated it by 30%. In pressurized posterior cerebral arteries, decreasing [Na+]e to 120 mM reduced the intraluminal diameter by 12%, whereas increasing [Na+]e to 165 mM increased it by 17%. MT was inhibited by amiloride [50% inhibitory concentration (IC50) = 17 +/- 6 microM], an inhibitor of Na(+)-H+ exchange. Diisothiocyanatostilbene sulfonic acid, a Na(+)-Cl(-)-HCO3- cotransporter blocker, inhibited MT with an IC50 of 4.4 +/- 0.65 microM. Ouabain increased MT [50% effective concentration (EC50) = 0.10 +/- 0.04 microM] as did the reintroduction of HCO3- (EC50 5.0 +/- 1.5 mM). Our study suggests that MT in the rabbit posterior cerebral artery and rabbit Facial Vein is modulated by changes in [Na+]e. This effect is independent of the method used to register changes in wall force. The sensitivity of the tone to changes in [Na+]e and the independence of vessel diameter at different pressures at various [Na+]e may reflect changes in the sensitivity of smooth muscle stretch or mechanoreceptors to [Na+]e.
Fengchi Chang - One of the best experts on this subject based on the ideXlab platform.
-
anatomic variation of Facial Vein in carotid cavernous fistula and trans Facial Vein embolization
World Neurosurgery, 2015Co-Authors: Fengchi Chang, Michael Muhuo Teng, Tawei TingAbstract:Objective Trans–Facial Vein (FV) embolization via the internal jugular Vein is an alternative approach to embolization of carotid cavernous fistulas (CCFs). The purpose of this study is to report the anatomic variation of FVs and our experience of trans-FV embolization of CCFs. Methods Over 6 years, 26 patients (12 men and 14 women; age range 27–72 years old) with CCFs underwent trans-FV embolization because of anterior drainage of fistulas. We retrospectively analyzed angioarchitecture of the CCFs focusing on the anatomic variations of FVs and angiographic and clinical outcomes after embolization. Results FVs drained to the internal jugular Vein in 10 (38%) cases; FVs unexpectedly emptied into the external jugular Vein in 16 (62%) cases. All FVs entered into the internal jugular Vein at the level of the hyoid bone. In cases with fistulas to the FV and EJV, the termination of FVs was variable including superior ( n = 5), inferior ( n = 1), or at the level of the hyoid bone ( n = 10). Successful microcatheterization via different insertions of FVs to jugular Veins was achieved in all cases. One patient had a small residual fistula, and 2 patients had fistula recurrence. Temporary impairment of cranial nerve III or VI occurred in 4 patients. The mean clinical follow-up time was 18 months. Conclusions Trans-FV embolization is an effective and safe method to manage CCFs with anterior drainage. However, anatomic variations of the FV exist, and a careful work-up of fistula venous drainage before trans-FV embolization is essential to reduce erroneous attempts, procedure time, and periprocedural risk.
-
Anatomic Variation of Facial Vein in Carotid-Cavernous Fistula and Trans–Facial Vein Embolization
World Neurosurgery, 2015Co-Authors: Fengchi Chang, Michael Muhuo Teng, Tawei TingAbstract:Objective Trans–Facial Vein (FV) embolization via the internal jugular Vein is an alternative approach to embolization of carotid cavernous fistulas (CCFs). The purpose of this study is to report the anatomic variation of FVs and our experience of trans-FV embolization of CCFs. Methods Over 6 years, 26 patients (12 men and 14 women; age range 27–72 years old) with CCFs underwent trans-FV embolization because of anterior drainage of fistulas. We retrospectively analyzed angioarchitecture of the CCFs focusing on the anatomic variations of FVs and angiographic and clinical outcomes after embolization. Results FVs drained to the internal jugular Vein in 10 (38%) cases; FVs unexpectedly emptied into the external jugular Vein in 16 (62%) cases. All FVs entered into the internal jugular Vein at the level of the hyoid bone. In cases with fistulas to the FV and EJV, the termination of FVs was variable including superior ( n = 5), inferior ( n = 1), or at the level of the hyoid bone ( n = 10). Successful microcatheterization via different insertions of FVs to jugular Veins was achieved in all cases. One patient had a small residual fistula, and 2 patients had fistula recurrence. Temporary impairment of cranial nerve III or VI occurred in 4 patients. The mean clinical follow-up time was 18 months. Conclusions Trans-FV embolization is an effective and safe method to manage CCFs with anterior drainage. However, anatomic variations of the FV exist, and a careful work-up of fistula venous drainage before trans-FV embolization is essential to reduce erroneous attempts, procedure time, and periprocedural risk.
Alessandro Pedicelli - One of the best experts on this subject based on the ideXlab platform.
-
embolization of dural arteriovenous fistula of the cavernous sinus through percutaneous ultrasound guided puncture of the Facial Vein
World Neurosurgery, 2017Co-Authors: Andrea Alexandre, Emiliano Visconti, Emilio Lozupone, Francesco Dargento, Alessandro PedicelliAbstract:Background The goal of dural arteriovenous fistula of the cavernous sinus treated with coils through ultrasound-guided access to the Facial Vein is to interrupt the fistulous communications and decrease the pressure in the cavernous sinus and consequently in the ophthalmic Veins. The traditional approach in the treatment of these fistulae is transvenous endovascular occlusion of the cavernous sinus. Transvenous embolization has been proven to be safe and can provide complete and permanent occlusion of the fistula in a single session. The most commonly used venous pathway is the inferior petrosal sinus, but, if it is inaccessible, then, the superior ophthalmic Vein is considered; nonetheless, it can require a surgical exposure. Other pathways include the transfemoral transFacial Vein. An arterial approach is considered usually when venous approach pathways fail. Arterial occlusion of feeders supplying the fistula is associated with a greater risk of embolic complications. Case Description We report a case of dural arteriovenous fistula of the cavernous sinus treated with coils through ultrasound-guided access to the Facial Vein. Conclusions We propose an alternative pathway when the conventional transvenous approach through the inferior petrosal sinus is excluded. An ultrasound-guided Facial Vein approach can be considered as a direct and safe alternative to reach the cavernous sinus and obtain exclusion of the fistula.
Remy Van Effenterre - One of the best experts on this subject based on the ideXlab platform.
-
cavernous sinus dural fistulae treated by transvenous approach through the Facial Vein report of seven cases and review of the literature
American Journal of Neuroradiology, 2003Co-Authors: A Biondi, Dan Milea, C Cognard, Giuseppe Ricciardi, F Bonneville, Remy Van EffenterreAbstract:BACKGROUND AND PURPOSE: Dural Carotid Cavernous Fistulas (CCFs) can be treated by transarterial and/or transvenous endovascular techniques. The venous route usually goes through the internal jugular Vein (IJV) and the inferior petrosal sinus (IPS) up to the pathologic shunts of the cavernous sinus. In case a thrombosed IPS, catheterization through the obstructed sinus is not always possible and a puncture of the superior ophthalmic Vein (SOV) can be performed often after a surgical approach. We report our results in the endovascular transvenous treatment of dural CCFs through the Facial Vein (retrograde catheterization of the IJV, Facial Vein, angular Vein, SOV, and cavernous sinus). METHODS: A retrospective study of seven patients with a dural CCF treated with transvenous embolization via the Facial Vein was performed. In five patients, the IPS was thrombosed. In one patient, the IPS was patent, but there was not communication between the cavernous sinus compartment in which the CCF shunts were located and the IPS itself. In the only patient with the CCF draining through permeable IPS, the transvenous route through the IPS permitted the occlusion of the posterior CCF shunts and a second session was performed through the Facial Vein in order to occlude the shunts of the anterior compartment of the cavernous sinus. The other six patients underwent one embolization session only. RESULTS: In all seven cases, it was possible to navigate through the tortuous junction of the angular Vein and the SOV. In one patient with a thrombosed SOV, the venous procedure was interrupted because the catheterization through the occluded SOV failed. In the other six patients, after transvenous catheterization of the cavernous sinus via the Facial Vein, placement of coils resulted in complete occlusion of the dural CCF with clinical cure in four patients and improvement in two. CONCLUSION: In the endovasular treatment of the dural CCFs, the transfemoral approach via the Facial Vein provides a valuable alternative to other transvenous routes. Catheterization of the cavernous sinus via the Facial Vein is usually successful. Although this technique requires caution, it allows a safe and effective treatment of these lesions.
Tawei Ting - One of the best experts on this subject based on the ideXlab platform.
-
anatomic variation of Facial Vein in carotid cavernous fistula and trans Facial Vein embolization
World Neurosurgery, 2015Co-Authors: Fengchi Chang, Michael Muhuo Teng, Tawei TingAbstract:Objective Trans–Facial Vein (FV) embolization via the internal jugular Vein is an alternative approach to embolization of carotid cavernous fistulas (CCFs). The purpose of this study is to report the anatomic variation of FVs and our experience of trans-FV embolization of CCFs. Methods Over 6 years, 26 patients (12 men and 14 women; age range 27–72 years old) with CCFs underwent trans-FV embolization because of anterior drainage of fistulas. We retrospectively analyzed angioarchitecture of the CCFs focusing on the anatomic variations of FVs and angiographic and clinical outcomes after embolization. Results FVs drained to the internal jugular Vein in 10 (38%) cases; FVs unexpectedly emptied into the external jugular Vein in 16 (62%) cases. All FVs entered into the internal jugular Vein at the level of the hyoid bone. In cases with fistulas to the FV and EJV, the termination of FVs was variable including superior ( n = 5), inferior ( n = 1), or at the level of the hyoid bone ( n = 10). Successful microcatheterization via different insertions of FVs to jugular Veins was achieved in all cases. One patient had a small residual fistula, and 2 patients had fistula recurrence. Temporary impairment of cranial nerve III or VI occurred in 4 patients. The mean clinical follow-up time was 18 months. Conclusions Trans-FV embolization is an effective and safe method to manage CCFs with anterior drainage. However, anatomic variations of the FV exist, and a careful work-up of fistula venous drainage before trans-FV embolization is essential to reduce erroneous attempts, procedure time, and periprocedural risk.
-
Anatomic Variation of Facial Vein in Carotid-Cavernous Fistula and Trans–Facial Vein Embolization
World Neurosurgery, 2015Co-Authors: Fengchi Chang, Michael Muhuo Teng, Tawei TingAbstract:Objective Trans–Facial Vein (FV) embolization via the internal jugular Vein is an alternative approach to embolization of carotid cavernous fistulas (CCFs). The purpose of this study is to report the anatomic variation of FVs and our experience of trans-FV embolization of CCFs. Methods Over 6 years, 26 patients (12 men and 14 women; age range 27–72 years old) with CCFs underwent trans-FV embolization because of anterior drainage of fistulas. We retrospectively analyzed angioarchitecture of the CCFs focusing on the anatomic variations of FVs and angiographic and clinical outcomes after embolization. Results FVs drained to the internal jugular Vein in 10 (38%) cases; FVs unexpectedly emptied into the external jugular Vein in 16 (62%) cases. All FVs entered into the internal jugular Vein at the level of the hyoid bone. In cases with fistulas to the FV and EJV, the termination of FVs was variable including superior ( n = 5), inferior ( n = 1), or at the level of the hyoid bone ( n = 10). Successful microcatheterization via different insertions of FVs to jugular Veins was achieved in all cases. One patient had a small residual fistula, and 2 patients had fistula recurrence. Temporary impairment of cranial nerve III or VI occurred in 4 patients. The mean clinical follow-up time was 18 months. Conclusions Trans-FV embolization is an effective and safe method to manage CCFs with anterior drainage. However, anatomic variations of the FV exist, and a careful work-up of fistula venous drainage before trans-FV embolization is essential to reduce erroneous attempts, procedure time, and periprocedural risk.
