The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Christopher J Brigham - One of the best experts on this subject based on the ideXlab platform.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
S Abdel-aleem - One of the best experts on this subject based on the ideXlab platform.
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Free Fatty Acid Metabolism during myocardial ischemia and reperfusion.
Molecular and cellular biochemistry, 1997Co-Authors: S C Hendrickson, J D St Louis, J E Lowe, S Abdel-aleemAbstract:Long chain free Fatty Acids (FFA) are the preferred metabolic substrates of myocardium under aerobic conditions. However, under ischemic conditions long chain FFA have been shown to be harmful both clinically and experimentally. Serum levels of free Fatty Acids frequently are elevated in patients with myocardial ischemia. The proposed mechanisms of the detrimental effects of free Fatty Acids include: (1) accumulation of toxic intermediates of Fatty Acid Metabolism, such as long chain acyl-CoA thioesters and long chain acylcarnitines, (2) inhibition of glucose utilization, particularly glycolysis, during ischemia and/or reperfusion, and (3) uncoupling of oxidative Metabolism from electron transfer. The relative importance of these mechanisms remains controversial. The primary site of FFA-induced injury appears to be the sarcolemmal and intracellular membranes and their associated enzymes. Inhibitors of free Fatty Acid Metabolism have been shown experimentally to decrease the size of myocardial infarction and lessen postischemic cardiac dysfunction in animal models of regional and global ischemia. The mechanism by which FFA inhibitors improve cardiac function in the postischemic heart is controversial. Whether the effects are dependent on decreased levels of long chain intermediates and/or enhancement of glucose utilization is under investigation. Manipulation of myocardial Fatty Acid Metabolism may prove beneficial in the treatment of myocardial ischemia, particularly during situations of controlled ischemia and reperfusion, such as percutaneous transluminal coronary angioplasty and coronary artery bypass grafting.
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Free Fatty Acid Metabolism during myocardial ischemia and reperfusion
Molecular and Cellular Biochemistry, 1997Co-Authors: S C Hendrickson, J D St Louis, J E Lowe, S Abdel-aleemAbstract:Long chain free Fatty Acids (FFA) are the preferred metabolic substrates of myocardium under aerobic conditions. However, under ischemic conditions long chain FFA have been shown to be harmful both clinically and experimentally. Serum levels of free Fatty Acids frequently are elevated in patients with myocardial ischemia. The proposed mechanisms of the detrimental effects of free Fatty Acids include: (1) accumulation of toxic intermediates of Fatty Acid Metabolism, such as long chain acyl-CoA thioesters and long chain acylcarnitines, (2) inhibition of glucose utilization, particularly glycolysis, during ischemia and/or reperfusion, and (3) uncoupling of oxidative Metabolism from electron transfer. The relative importance of these mechanisms remains controversial. The primary site of FFA-induced injury appears to be the sarcolemmal and intracellular membranes and their associated enzymes. Inhibitors of free Fatty Acid Metabolism have been shown experimentally to decrease the size of myocardial infarction and lessen postischemic cardiac dysfunction in animal models of regional and global ischemia. The mechanism by which FFA inhibitors improve cardiac function in the postischemic heart is controversial. Whether the effects are dependent on decreased levels of long chain intermediates and/or enhancement of glucose utilization is under investigation. Manipulation of myocardial Fatty Acid Metabolism may prove beneficial in the treatment of myocardial ischemia, particularly during situations of controlled ischemia and reperfusion, such as percutaneous transluminal coronary angioplasty and coronary artery bypass grafting. (Mol Cell Biochem 166: 85-94, 1997)
Sebastian L. Riedel - One of the best experts on this subject based on the ideXlab platform.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
Jingnan Lu - One of the best experts on this subject based on the ideXlab platform.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
Ulf Stahl - One of the best experts on this subject based on the ideXlab platform.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
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Lipid and Fatty Acid Metabolism in Ralstonia eutropha: relevance for the biotechnological production of value-added products
Applied Microbiology and Biotechnology, 2014Co-Authors: Sebastian L. Riedel, Jingnan Lu, Ulf Stahl, Christopher J BrighamAbstract:Lipid and Fatty Acid Metabolism has been well studied in model microbial organisms like Escherichia coli and Bacillus subtilis . The major precursor of Fatty Acid biosynthesis is also the major product of Fatty Acid degradation (β-oxidation), acetyl-CoA, which is a key metabolite for all organisms. Controlling carbon flux to Fatty Acid biosynthesis and from β-oxidation allows for the biosynthesis of natural products of biotechnological importance. Ralstonia eutropha can utilize acetyl-CoA from Fatty Acid Metabolism to produce intracellular polyhydroxyalkanoate (PHA). R. eutropha can also be engineered to utilize Fatty Acid Metabolism intermediates to produce different PHA precursors. Metabolism of lipids and Fatty Acids can be rerouted to convert carbon into other value-added compounds like biofuels. This review discusses the lipid and Fatty Acid metabolic pathways in R. eutropha and how they can be used to construct reagents for the biosynthesis of products of industrial importance. Specifically, how the use of lipids or Fatty Acids as the sole carbon source in R. eutropha cultures adds value to these biotechnological products will be discussed here.
