The Experts below are selected from a list of 21 Experts worldwide ranked by ideXlab platform
Frits Gmeligmeyling - One of the best experts on this subject based on the ideXlab platform.
-
skewed distribution of igg Fc Receptor IIa cd32 polymorphism is associated with renal disease in systemic lupus erythematosus patients
Arthritis & Rheumatism, 1995Co-Authors: Ashley J Duits, Cees G M Kallenberg, Hendrika Bootsma, Ronald H W M Derksen, P E Spronk, L Kater, Peter J A Capel, Nomdo A C Westerdaal, Gerrit T H Spierenburg, Frits GmeligmeylingAbstract:Objective. Fc gamma Receptors of class IIa (Fc gamma RIIa) occur in 2 allelic forms, with either a low (IIa-R131) or a high (IIa-H131) affinity for complexed IgG2 and IgG3. This polymorphism might have implications for the handling of immune complexes. Therefore, we determined the distribution of the Fc gamma RIIa allotypes in patients with systemic lupus erythematosus (SLE), with or without a history of lupus nephritis. Methods. We studied 95 unrelated white European patients with SLE, as defined by the American College of Rheumatology criteria, 50 of whom had a history of lupus nephritis, and 69 healthy white European control subjects. Fc gamma RIIa allotypes were determined by immunophenotyping of blood monocytes. Results. It was found that lupus nephritis was significantly associated with the ''low affinity'' Fc gamma RIIa R/R131 allotype and with the R131 allele, compared with healthy controls. No significant association was found upon comparison of groups with and without nephritis. Conclusion. SLE patients with a history of lupus nephritis have an abnormal distribution of Fc gamma RIIa allotypes. Fc gamma RIIa may well play a role in the pathogenesis of lupus nephritis, since IIa-R/R131 SLE patients seem to have a higher incidence of developing this complication.
J. G. J. Van De Winkel - One of the best experts on this subject based on the ideXlab platform.
-
Human immunoglobulin G (IgG) Fc Receptor IIa (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils
Infection and immunity, 1995Co-Authors: Lieke A. M. Sanders, Robert G. Feldman, M. M. Voorhorst-ogink, M. De Haas, Ger T. Rijkers, P. J. A. Capel, Ben J.m. Zegers, J. G. J. Van De WinkelAbstract:Human immunoglobulin G (IgG) Fc Receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc Receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides. The two genetically determined structurally different allotypes of human Fc gamma RIIa, the products of the Fc gamma RIIa-R131 and IIa-H131 alleles, have functionally different reactivities with human IgG2. In humans, the Fc gamma RIIa-H131 allotype is known to interact efficiently with complexed human IgG2, whereas the IIa-H131 allotype does so only poorly. This polymorphism may therefore have implications for IgG2-mediated phagocytosis of encapsulated bacteria and susceptibility to bacterial infections. Phagocytosis of IgG2-opsonized bacteria by homozygous Fc gamma RIIa-R/R131, heterozygous IIa-H/R131, and homozygous IIa-H/H131 polymorphonuclear cells (PMN) was compared. A higher phagocytic capacity of IgG2-opsonized group B type III streptococci by PMN of homozygous H/H131 individuals compared with PMN from homozygous R/R131 individuals was observed (P = 0.001), while heterozygous IIa-H/R131 PMN showed intermediate phagocytosis. In this model system, IgG2-mediated phagocytosis was independent of the Fc gamma RIIIb-NA1/NA2 allelic polymorphism.
Ashley J Duits - One of the best experts on this subject based on the ideXlab platform.
-
skewed distribution of igg Fc Receptor IIa cd32 polymorphism is associated with renal disease in systemic lupus erythematosus patients
Arthritis & Rheumatism, 1995Co-Authors: Ashley J Duits, Cees G M Kallenberg, Hendrika Bootsma, Ronald H W M Derksen, P E Spronk, L Kater, Peter J A Capel, Nomdo A C Westerdaal, Gerrit T H Spierenburg, Frits GmeligmeylingAbstract:Objective. Fc gamma Receptors of class IIa (Fc gamma RIIa) occur in 2 allelic forms, with either a low (IIa-R131) or a high (IIa-H131) affinity for complexed IgG2 and IgG3. This polymorphism might have implications for the handling of immune complexes. Therefore, we determined the distribution of the Fc gamma RIIa allotypes in patients with systemic lupus erythematosus (SLE), with or without a history of lupus nephritis. Methods. We studied 95 unrelated white European patients with SLE, as defined by the American College of Rheumatology criteria, 50 of whom had a history of lupus nephritis, and 69 healthy white European control subjects. Fc gamma RIIa allotypes were determined by immunophenotyping of blood monocytes. Results. It was found that lupus nephritis was significantly associated with the ''low affinity'' Fc gamma RIIa R/R131 allotype and with the R131 allele, compared with healthy controls. No significant association was found upon comparison of groups with and without nephritis. Conclusion. SLE patients with a history of lupus nephritis have an abnormal distribution of Fc gamma RIIa allotypes. Fc gamma RIIa may well play a role in the pathogenesis of lupus nephritis, since IIa-R/R131 SLE patients seem to have a higher incidence of developing this complication.
Lieke A. M. Sanders - One of the best experts on this subject based on the ideXlab platform.
-
Human immunoglobulin G (IgG) Fc Receptor IIa (CD32) polymorphism and IgG2-mediated bacterial phagocytosis by neutrophils
Infection and immunity, 1995Co-Authors: Lieke A. M. Sanders, Robert G. Feldman, M. M. Voorhorst-ogink, M. De Haas, Ger T. Rijkers, P. J. A. Capel, Ben J.m. Zegers, J. G. J. Van De WinkelAbstract:Human immunoglobulin G (IgG) Fc Receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc Receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides. The two genetically determined structurally different allotypes of human Fc gamma RIIa, the products of the Fc gamma RIIa-R131 and IIa-H131 alleles, have functionally different reactivities with human IgG2. In humans, the Fc gamma RIIa-H131 allotype is known to interact efficiently with complexed human IgG2, whereas the IIa-H131 allotype does so only poorly. This polymorphism may therefore have implications for IgG2-mediated phagocytosis of encapsulated bacteria and susceptibility to bacterial infections. Phagocytosis of IgG2-opsonized bacteria by homozygous Fc gamma RIIa-R/R131, heterozygous IIa-H/R131, and homozygous IIa-H/H131 polymorphonuclear cells (PMN) was compared. A higher phagocytic capacity of IgG2-opsonized group B type III streptococci by PMN of homozygous H/H131 individuals compared with PMN from homozygous R/R131 individuals was observed (P = 0.001), while heterozygous IIa-H/R131 PMN showed intermediate phagocytosis. In this model system, IgG2-mediated phagocytosis was independent of the Fc gamma RIIIb-NA1/NA2 allelic polymorphism.
P E Spronk - One of the best experts on this subject based on the ideXlab platform.
-
skewed distribution of igg Fc Receptor IIa cd32 polymorphism is associated with renal disease in systemic lupus erythematosus patients
Arthritis & Rheumatism, 1995Co-Authors: Ashley J Duits, Cees G M Kallenberg, Hendrika Bootsma, Ronald H W M Derksen, P E Spronk, L Kater, Peter J A Capel, Nomdo A C Westerdaal, Gerrit T H Spierenburg, Frits GmeligmeylingAbstract:Objective. Fc gamma Receptors of class IIa (Fc gamma RIIa) occur in 2 allelic forms, with either a low (IIa-R131) or a high (IIa-H131) affinity for complexed IgG2 and IgG3. This polymorphism might have implications for the handling of immune complexes. Therefore, we determined the distribution of the Fc gamma RIIa allotypes in patients with systemic lupus erythematosus (SLE), with or without a history of lupus nephritis. Methods. We studied 95 unrelated white European patients with SLE, as defined by the American College of Rheumatology criteria, 50 of whom had a history of lupus nephritis, and 69 healthy white European control subjects. Fc gamma RIIa allotypes were determined by immunophenotyping of blood monocytes. Results. It was found that lupus nephritis was significantly associated with the ''low affinity'' Fc gamma RIIa R/R131 allotype and with the R131 allele, compared with healthy controls. No significant association was found upon comparison of groups with and without nephritis. Conclusion. SLE patients with a history of lupus nephritis have an abnormal distribution of Fc gamma RIIa allotypes. Fc gamma RIIa may well play a role in the pathogenesis of lupus nephritis, since IIa-R/R131 SLE patients seem to have a higher incidence of developing this complication.
