The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
F Aubin - One of the best experts on this subject based on the ideXlab platform.
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spectrum of cross photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen associated photoallergies to non benzophenone containing molecules
Contact Dermatitis, 2003Co-Authors: E Durbize, M Vigan, E Puzenat, P Girardin, B Adessi, P H Desprez, Ph Humbert, R Laurent, F AubinAbstract:: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2.5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales de dermatologie et de venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, F Aubin, P Desprez, R LaurentAbstract:Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances. Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations. Nine tested patients had positive reactions to the irradiated tests with no expected allergens: Fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case). The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.
M Vigan - One of the best experts on this subject based on the ideXlab platform.
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spectrum of cross photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen associated photoallergies to non benzophenone containing molecules
Contact Dermatitis, 2003Co-Authors: E Durbize, M Vigan, E Puzenat, P Girardin, B Adessi, P H Desprez, Ph Humbert, R Laurent, F AubinAbstract:: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2.5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales De Dermatologie Et De Venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, François Aubin, René LaurentAbstract:Introduction. Les photoallergies au ketoprofene et les reactions croisees avec les substances contenant le noyau diphenylcetone (oxybenzone, acide tiaprofenique, fenofibrate) sont bien connues. Nous rapportons des cas de photoreactions avec des substances qui ne contiennent pas a priori ce noyau. Malades et methodes. II s'agissait d'une etude retrospective entre juin 1998 et juillet 2000 et prospective entre aout 2000 et janvier 2001. Nous avons teste systematiquement par photopatch tests les malades qui nous etaient adresses pour photoallergie au Ketum®. Ces malades etaient testes avec le Ketum®, le ketoprofene, l'oxybenzone, l'acide tiaprofenique, le fenofibrate, mais aussi la chlorphenesine, la batterie « filtres solaires » et toute la batterie des photobiologistes sauf le « lichen mix » et la benzocaine. Les tests etaient poses en double a Jo, la moitie etait irradiee a J 1 en UVA, les temoins restant couverts. La lecture avait lieu a J 3 et J 4 en utilisant le score de l'ICDRG. Resultats. Onze malades photoallergiques au ketoprofene ont ete testes. Neuf avaient une photosensibilisation associee a des substances qui ne contenaient pas a priori le noyau diphenylcetone: Fenticlor (9 cas), salicylanide halogene (4 cas), dibenzoylmethane (3 cas), cinnamate (1 cas). Discussion. Le mecanisme de ces photosensibilisations multiples est discute: reaction croisee a un metabolisme, stereoisomerie... Ces observations confirment la necessite de tester la batterie « filtres solaires » et la batterie standard des photobiologistes en cas de photoallergie au ketoprofene.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales de dermatologie et de venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, F Aubin, P Desprez, R LaurentAbstract:Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances. Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations. Nine tested patients had positive reactions to the irradiated tests with no expected allergens: Fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case). The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.
R Laurent - One of the best experts on this subject based on the ideXlab platform.
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spectrum of cross photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen associated photoallergies to non benzophenone containing molecules
Contact Dermatitis, 2003Co-Authors: E Durbize, M Vigan, E Puzenat, P Girardin, B Adessi, P H Desprez, Ph Humbert, R Laurent, F AubinAbstract:: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2.5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales de dermatologie et de venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, F Aubin, P Desprez, R LaurentAbstract:Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances. Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations. Nine tested patients had positive reactions to the irradiated tests with no expected allergens: Fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case). The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.
B Adessi - One of the best experts on this subject based on the ideXlab platform.
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spectrum of cross photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen associated photoallergies to non benzophenone containing molecules
Contact Dermatitis, 2003Co-Authors: E Durbize, M Vigan, E Puzenat, P Girardin, B Adessi, P H Desprez, Ph Humbert, R Laurent, F AubinAbstract:: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2.5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales De Dermatologie Et De Venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, François Aubin, René LaurentAbstract:Introduction. Les photoallergies au ketoprofene et les reactions croisees avec les substances contenant le noyau diphenylcetone (oxybenzone, acide tiaprofenique, fenofibrate) sont bien connues. Nous rapportons des cas de photoreactions avec des substances qui ne contiennent pas a priori ce noyau. Malades et methodes. II s'agissait d'une etude retrospective entre juin 1998 et juillet 2000 et prospective entre aout 2000 et janvier 2001. Nous avons teste systematiquement par photopatch tests les malades qui nous etaient adresses pour photoallergie au Ketum®. Ces malades etaient testes avec le Ketum®, le ketoprofene, l'oxybenzone, l'acide tiaprofenique, le fenofibrate, mais aussi la chlorphenesine, la batterie « filtres solaires » et toute la batterie des photobiologistes sauf le « lichen mix » et la benzocaine. Les tests etaient poses en double a Jo, la moitie etait irradiee a J 1 en UVA, les temoins restant couverts. La lecture avait lieu a J 3 et J 4 en utilisant le score de l'ICDRG. Resultats. Onze malades photoallergiques au ketoprofene ont ete testes. Neuf avaient une photosensibilisation associee a des substances qui ne contenaient pas a priori le noyau diphenylcetone: Fenticlor (9 cas), salicylanide halogene (4 cas), dibenzoylmethane (3 cas), cinnamate (1 cas). Discussion. Le mecanisme de ces photosensibilisations multiples est discute: reaction croisee a un metabolisme, stereoisomerie... Ces observations confirment la necessite de tester la batterie « filtres solaires » et la batterie standard des photobiologistes en cas de photoallergie au ketoprofene.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales de dermatologie et de venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, F Aubin, P Desprez, R LaurentAbstract:Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances. Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations. Nine tested patients had positive reactions to the irradiated tests with no expected allergens: Fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case). The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.
P Girardin - One of the best experts on this subject based on the ideXlab platform.
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spectrum of cross photosensitization in 18 consecutive patients with contact photoallergy to ketoprofen associated photoallergies to non benzophenone containing molecules
Contact Dermatitis, 2003Co-Authors: E Durbize, M Vigan, E Puzenat, P Girardin, B Adessi, P H Desprez, Ph Humbert, R Laurent, F AubinAbstract:: Contact photoallergy to ketoprofen gels has been widely reported, and cross-sensitivity reactions with other compounds, such as tiaprofenic acid, fenofibrate and benzophenones, are well known. However, positive photopatch tests to other different non-benzophenone-related compounds have recently been observed. We report the results of photopatch testing in patients with contact photoallergy to ketoprofen and discuss the spectrum of cross-sensitization to ketoprofen. 18 consecutive patients with a history of photocontact dermatitis from ketoprofen were investigated. Patch and photopatch tests were performed. As expected, we observed positive photopatch tests to Ketum* gel and ketoprofen 2.5% in petrolatum in all patients (100%). However, it was remarkable to note positive photopatch tests to other unexpected and non-relevant allergens, including fentichlor (67%), tetrachlorosalicylanilide (28%), triclosan (17%), tribromsalan (11%) and bithionol (11%), with no clinical relevance. Interestingly, these agents belong to the family of halogenated salicylanilides and related compounds, which have been forbidden in Europe since the 1970s. Our results raise the question of hyper-photosusceptibility to non-relevant allergens induced by photosensitivity to ketoprofen. The mechanism may involve the high photoreactivity induced by the association of a benzene ring with an oxygen group.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales De Dermatologie Et De Venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, François Aubin, René LaurentAbstract:Introduction. Les photoallergies au ketoprofene et les reactions croisees avec les substances contenant le noyau diphenylcetone (oxybenzone, acide tiaprofenique, fenofibrate) sont bien connues. Nous rapportons des cas de photoreactions avec des substances qui ne contiennent pas a priori ce noyau. Malades et methodes. II s'agissait d'une etude retrospective entre juin 1998 et juillet 2000 et prospective entre aout 2000 et janvier 2001. Nous avons teste systematiquement par photopatch tests les malades qui nous etaient adresses pour photoallergie au Ketum®. Ces malades etaient testes avec le Ketum®, le ketoprofene, l'oxybenzone, l'acide tiaprofenique, le fenofibrate, mais aussi la chlorphenesine, la batterie « filtres solaires » et toute la batterie des photobiologistes sauf le « lichen mix » et la benzocaine. Les tests etaient poses en double a Jo, la moitie etait irradiee a J 1 en UVA, les temoins restant couverts. La lecture avait lieu a J 3 et J 4 en utilisant le score de l'ICDRG. Resultats. Onze malades photoallergiques au ketoprofene ont ete testes. Neuf avaient une photosensibilisation associee a des substances qui ne contenaient pas a priori le noyau diphenylcetone: Fenticlor (9 cas), salicylanide halogene (4 cas), dibenzoylmethane (3 cas), cinnamate (1 cas). Discussion. Le mecanisme de ces photosensibilisations multiples est discute: reaction croisee a un metabolisme, stereoisomerie... Ces observations confirment la necessite de tester la batterie « filtres solaires » et la batterie standard des photobiologistes en cas de photoallergie au ketoprofene.
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Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)
Annales de dermatologie et de venereologie, 2002Co-Authors: M Vigan, P Girardin, B Adessi, F Aubin, P Desprez, R LaurentAbstract:Photoallergy to ketoprofen and cross reactivity of ketoprofen with diphenylketones are well known; here are some cases of photoreaction to ketoprofen and unusual substances. Eleven photoallergic to ketoprofen patients were photo patch tested with Ketum(R), ketoprofen, oxybenzone, tiaprofenic acid, fenofibrate, and also chlorphenesin, sunscreen series, and photobiologists series (without lichen mix and benzocaine). We performed tests at day 0, we irradiated them with UVA at day 2, and control series remained closed. We performed readings at day 3 and 4 according to ICDRG's recommendations. Nine tested patients had positive reactions to the irradiated tests with no expected allergens: Fenticlor (9 cases), halogenated salicylanilides (4 cases), dibenzoylmethane (3 cases) and cinnamate (1 case). The mechanism of these unusual photosensitizations is discussed. These cases show that it is important to test sunscreen series and photobiologists series in patients photoallergic to ketoprofen.