The Experts below are selected from a list of 42516 Experts worldwide ranked by ideXlab platform

Ricardo G Hahn - One of the best experts on this subject based on the ideXlab platform.

  • BRIEF REPORT Meningomyelocele: Early Detection Using 3- Dimensional Ultrasound Imaging in the Family Medicine Center
    2015
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent struc-tures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first tri-mester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis. (J Am Board Fam Med 2010;23:270–272.

  • meningomyelocele early detection using 3 dimensional ultrasound imaging in the family medicine center
    Journal of the American Board of Family Medicine, 2010
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent structures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first trimester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis.

Christopher P Forest - One of the best experts on this subject based on the ideXlab platform.

  • BRIEF REPORT Meningomyelocele: Early Detection Using 3- Dimensional Ultrasound Imaging in the Family Medicine Center
    2015
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent struc-tures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first tri-mester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis. (J Am Board Fam Med 2010;23:270–272.

  • meningomyelocele early detection using 3 dimensional ultrasound imaging in the family medicine center
    Journal of the American Board of Family Medicine, 2010
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent structures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first trimester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis.

Petros V. Anagnostopoulos - One of the best experts on this subject based on the ideXlab platform.

  • a humanized mouse model generated using surplus neonatal Tissue
    Stem cell reports, 2018
    Co-Authors: Matthew E. Brown, Ying Zhou, Brian E. Mcintosh, Ian G. Norman, Hannah E. Lou, Mitch Biermann, Jeremy A. Sullivan, Timothy J. Kamp, James A. Thomson, Petros V. Anagnostopoulos
    Abstract:

    Summary Here, we describe the NeoThy humanized mouse model created using non-Fetal human Tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). Conventional humanized mouse models are made by engrafting human Fetal thymus and HSCs into immunocompromised mice. These mice harbor functional human T cells that have matured in the presence of human self-peptides and human leukocyte antigen molecules. Neonatal thymus Tissue is more abundant and developmentally mature and allows for creation of up to ∼50-fold more mice per donor compared with Fetal Tissue models. The NeoThy has equivalent frequencies of engrafted human immune cells compared with Fetal Tissue humanized mice and exhibits T cell function in assays of ex vivo cell proliferation, interferon γ secretion, and in vivo graft infiltration. The NeoThy model may provide significant advantages for induced pluripotent stem cell immunogenicity studies, while bypassing the requirement for Fetal Tissue.

  • A Humanized Mouse Model Generated Using Surplus Neonatal Tissue
    Elsevier, 2018
    Co-Authors: Matthew E. Brown, Ying Zhou, Brian E. Mcintosh, Ian G. Norman, Hannah E. Lou, Mitch Biermann, Jeremy A. Sullivan, Timothy J. Kamp, James A. Thomson, Petros V. Anagnostopoulos
    Abstract:

    Summary: Here, we describe the NeoThy humanized mouse model created using non-Fetal human Tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs). Conventional humanized mouse models are made by engrafting human Fetal thymus and HSCs into immunocompromised mice. These mice harbor functional human T cells that have matured in the presence of human self-peptides and human leukocyte antigen molecules. Neonatal thymus Tissue is more abundant and developmentally mature and allows for creation of up to ∼50-fold more mice per donor compared with Fetal Tissue models. The NeoThy has equivalent frequencies of engrafted human immune cells compared with Fetal Tissue humanized mice and exhibits T cell function in assays of ex vivo cell proliferation, interferon γ secretion, and in vivo graft infiltration. The NeoThy model may provide significant advantages for induced pluripotent stem cell immunogenicity studies, while bypassing the requirement for Fetal Tissue. : Corresponding author William Burlingham and colleagues created a humanized mouse model called the NeoThy. The NeoThy uses human neonatal, rather than Fetal, Tissue sources for generating a human immune system within immunocompromised mouse hosts. NeoThy mice are an attractive alternative to conventional humanized mouse models, as they enable robust and reproducible iPSC immunogenicity experiments in vivo. Keywords: NeoThy, humanized mouse, iPSC, PSC, immunogenicity, transplantation, immunology, hematopoietic stem cells, induced pluripotent stem cells, thymu

Darenie Goodman - One of the best experts on this subject based on the ideXlab platform.

  • BRIEF REPORT Meningomyelocele: Early Detection Using 3- Dimensional Ultrasound Imaging in the Family Medicine Center
    2015
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent struc-tures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first tri-mester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis. (J Am Board Fam Med 2010;23:270–272.

  • meningomyelocele early detection using 3 dimensional ultrasound imaging in the family medicine center
    Journal of the American Board of Family Medicine, 2010
    Co-Authors: Christopher P Forest, Darenie Goodman, Ricardo G Hahn
    Abstract:

    A young primigravida presented to the family medicine clinic 7 weeks pregnant. Standard 2-dimensional ultrasound at 9 weeks revealed a grossly abnormal posterior brain and 2 adjacent sonolucent structures: 2 yolk sacs versus a yolk sac and cyst. Imaging by 3-dimensional ultrasound distinguished these structures, revealing a caudal cyst with continuity of Fetal Tissue consistent with a meningomyelocele. To date there is no documentation in the literature of a meningomyelocele diagnosed during the first trimester of pregnancy. Identification of neural tube defects early in pregnancy offers increased options to the mother and may impact long-term Fetal prognosis.

Xuejun Wen - One of the best experts on this subject based on the ideXlab platform.

  • Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain.
    Biomaterials, 2016
    Co-Authors: Stephany Y. Tzeng, Xiaoyan Liu, Markus Tammia, Yu Hao Cheng, Andrew Rolfe, Dong Sun, Ning Zhang, Jordan J. Green, Xuejun Wen
    Abstract:

    Strategies to enhance survival and direct the differentiation of stem cells in vivo following transplantation in Tissue repair site are critical to realizing the potential of stem cell-based therapies. Here we demonstrated an effective approach to promote neuronal differentiation and maturation of human Fetal Tissue-derived neural stem cells (hNSCs) in a brain lesion site of a rat traumatic brain injury model using biodegradable nanoparticle-mediated transfection method to deliver key transcriptional factor neurogenin-2 to hNSCs when transplanted with a tailored hyaluronic acid (HA) hydrogel, generating larger number of more mature neurons engrafted to the host brain Tissue than non-transfected cells. The nanoparticle-mediated transcription activation method together with an HA hydrogel delivery matrix provides a translatable approach for stem cell-based regenerative therapy.