The Experts below are selected from a list of 8592 Experts worldwide ranked by ideXlab platform

G. Boschetti - One of the best experts on this subject based on the ideXlab platform.

Sumio Hoka - One of the best experts on this subject based on the ideXlab platform.

  • Effect of epidural epinephrine infusion with bupivacaine on labor pain and mother-Fetus Outcome in humans.
    Regional anesthesia and pain medicine, 2000
    Co-Authors: Toshiyuki Okutomi, Junko Mochizuki, Kan Amano, Sumio Hoka
    Abstract:

    Background and Objectives Epinephrine is used with local anesthetics to prolong the duration of epidural analgesia and decrease the peak plasma concentrations of local anesthetics. In the practice of obstetric anesthesia, the utero-placental and fetal effects of epinephrine are controversial issues. We designed a prospective, randomized, and double-blind study to examine the effects of epinephrine infusion on the quality of analgesia and uterine or umbilical blood flows with Doppler ultrasound, as well as the duration of the first or the second stage of labor, and fetal Outcome. Methods Twenty-eight parturients received continuous epidural bupivacaine 0.25% (4 mL/h) combined either with epinephrine (20 μg/h) (n = 13) or without epinephrine (n = 15) for analgesia during labor. If patients requested additional analgesia, an additional bolus of 1% or 1.5% lidocaine (6 to 10 mL) was admimistered. Results The total amount of additional lidocaine was greater in the plain bupivacaine group (130 [0, 280] mg; median [25th, 75th percentile] with P Conclusions A low-dose epidural infusion of epinephrine decreased anesthetic requirements.

Li-jiang Jiang - One of the best experts on this subject based on the ideXlab platform.

  • The study of management mode of gestational diabetes mellitus in Primary hospital
    China Clinical Practical Medicine, 2010
    Co-Authors: Yue-wen Guo, Li-jiang Jiang
    Abstract:

    Objective To study the management mode of gestational diabetes mellitus of our hospital.Methods Using retrospective analysis to study the pregnancies of gestational diabetes mellitus and the following Outcomes of our hospital from January 2005 to December 2008. And compareing with all pregnancies and Outcomes of our hospital in the same period. Results The incidence of gestational diabetes mellitus was 4.74%.Cesarean section 、premature birth and macrosomia rate of gestational diabetes were above the rate of average.But other maternal and child Outcomes with no significant difference between the normal pregnant women. Conclusion Gestational diabetes screening all pregnant women between 24-28 weeks and with gestational diabetes diet control, monitoring of blood glucose and fetal monitoring, timely termination of pregnancies of gestational diabetes mellitus. The pregnancies of gestational diabetes mellitus can get similar maternal and Fetus Outcomes with normal pregnant women. Key words: Gestational diabetes mellitus;  Management;  Complications;  Fetus Outcome

Zhang Jing - One of the best experts on this subject based on the ideXlab platform.

  • Study on Perinatal Fetus Outcome of Severe Pregnancy-induced Hypertension with Fetal Growth Restriction
    Journal of Practical Obstetrics and Gynecology, 2005
    Co-Authors: Zhang Jing
    Abstract:

    Objective: To analyze the relationship of perinatal Fetus Outcome and delivery opportunity in severe PIH with FGR. Methods: We collected 145 cases of severe PIH with FGR, and divided them into six groups according to their gestational week of birth, Group A: 28 weeks to 30 -1 weeks; Group B: 30 weeks to 32 -1 weeks; Group C: 32 weeks to 34 -1 weeks; Group D: 34 weeks to 36 -1 weeks; Group E: 36 weeks to 37 -1 weeks; Group F: 37 weeks to 39 weeks. The results of all perinatal Fetus were retrospectively analyzed. Results: The prevalence of asphyxia neonatorum, hyaline membrane disease, and neonatal death was remarkablely higher in group A, B, C (gestational week between 28 to 34 weeks) than that in group D and E (gestational week 34 to 37)(P0.01), but no difference between group D, E(gestational weeks 34 to 37 -1) and group F(gestational weeks 37 to 39) (P 0.05). The incidence of severe meconium and fetal distress in uterus in group F was higher than that of group D and E (P0.01). Conclusions: To terminate pregnancy in time, we will put emphasis upon gravidas who had gestational age 34 weeks to 37 -1weeks in severe PIH with FGR that is important to decrease neonatal morbidity and mortality.

Sanjay Basak - One of the best experts on this subject based on the ideXlab platform.

  • Regulation of Placentation by Environmental Factors
    Early Nutrition and Lifestyle Factors, 2016
    Co-Authors: Asim K. Duttaroy, Sanjay Basak
    Abstract:

    Changes in the maternal environment can impair fetal growth and development, which may result in increased susceptibility to diseases in postnatal life. The placental nutrient sensing capacity may integrate these perturbations with information from intrinsic nutrient sensing signaling pathways to regulate secretion of hormones and placental nutrients and oxygen transfer. Placental responses to perturbations in the maternal compartment are complex and poorly understood, highlighting an urgent need for further well-designed and mechanistic research in this area. Intervention strategies to alleviate pregnancy complications and prevent fetal programing of adult disease are likely to be the most effective if placental function is targeted. The effect of environment exposure pollutants on placentation is warranted since pregnant mothers are often exposed to these factors during preconception to gestational period. Impaired placentation that ultimately influences Fetus Outcome is the center of many development disorders and contributes as an independent risk factor for the adult chronic diseases. The interaction of genes and the environment that predict the Fetus Outcome was evidenced where birth weight was reduced in babies derived from the women smoked during pregnancy irrespective of their genotypes. While susceptible genotypes in addition to smoking contributed further reduction in the birth weight explained why we need to measure the quantum of changes in genotypes that comes from the lifestyle habit, i.e., smoking or alcohol, etc. during pregnancy (please see Chap. 8). Placental gene expression affects its invasive and functional capacities and thereby the growth of the feto-placental unit. Placental secreted factors that influence the maternal adaptation to pregnancy and, hence, the health of both mother and baby are influenced by the stress factors. Many studies raised the issue that prenatal exposure to environmental pollutants that include air pollutants, food contaminants, and chemicals present in consumer products may contribute additional insult to the early developmental in utero. The biomarker measurements of such conditions by mimicking their effect on placental growth and development and gene expression may provide a new insight into the association between early exposure of these modifiable environmental factors and Fetus Outcome. This chapter will review the subtle effect induced by environmental risk factors exposed to mother during pregnancy which can lead to functional insufficiency in the placenta due to alteration in the gene expression of the functional pathways associated with placentation. Impact of environmental toxins on placental blood flow, vasculature, and angiogenesis of the placenta are also discussed.

  • Maternal Lifestyle Factors and Placentation
    Early Nutrition and Lifestyle Factors, 2016
    Co-Authors: Asim K. Duttaroy, Sanjay Basak
    Abstract:

    Developing nations carry the burden of maternal malnutrition and nutrient deficiencies that ultimately contribute to adverse Fetus Outcome and low birth weight (LBW)-related issues. In developed nation, undernutrition is often restricted to women with eating disorder or lifestyle (smoking/alcohol) habit that increases risk for LBW. In both the cases, placenta is exposed to certain stresses that may affect the placentation. In addition to nutrition, there are several lifestyle factors, such as cigarette smoking, environmental pollution are a global threat that includes pregnant women particularly in developed countries where 15–30 % of pregnant women smoke during pregnancy. It is important to know the effect of maternal smoking, alcohol intake, and exposure to the environmental pollutants on placentation, since pregnant women if exposed to these factors during preconception to gestational life may have consequence on pregnancy Outcome. Impaired placentation that ultimately influences Fetus Outcome is the center of many developmental disorders and contributes as an independent risk factor for the adult chronic diseases. This chapter will review the impact of maternal lifestyle behavior such as alcohol intake, maternal smoking, and environmental toxins on placental blood flow, vasculature, and angiogenesis of the placenta that includes the process of trophoblast growth and development trajectory linked with placentation that ultimately determines Fetus growth and birth Outcome. Specific effect of persistent organic pollutants (POPs) and its metabolites, nicotine, aryl hydrocarbon receptor (AHR) and their ligands on trophoblast metabolism, gene expression, nutrient uptake, and transport of the placenta and trophoblast at early and late gestation is described in this chapter.