The Experts below are selected from a list of 41142 Experts worldwide ranked by ideXlab platform
Timothee Jacquesson - One of the best experts on this subject based on the ideXlab platform.
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diffusion tensor imaging tractography detecting isolated oculomotor nerve Damage after traumatic brain injury
World Neurosurgery, 2017Co-Authors: Timothee Jacquesson, Carole Frindel, Francois CottonAbstract:A 24-year-old woman was hit by a bus and suffered an isolated complete oculomotor nerve palsy. Computed tomography scan did not show a skull base fracture. T2*-weighted magnetic resonance imaging revealed petechial cerebral hemorrhages sparing the brainstem. T2 constructive interference in steady state suggested a partial sectioning of the left oculomotor nerve just before entering the superior orbital fissure. Diffusion tensor imaging Fiber tractography confirmed a sharp arrest of the left oculomotor nerve. This recent imaging technique could be of interest to assess white Fiber Damage and help make a diagnosis or prognosis.
Francois Cotton - One of the best experts on this subject based on the ideXlab platform.
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diffusion tensor imaging tractography detecting isolated oculomotor nerve Damage after traumatic brain injury
World Neurosurgery, 2017Co-Authors: Timothee Jacquesson, Carole Frindel, Francois CottonAbstract:A 24-year-old woman was hit by a bus and suffered an isolated complete oculomotor nerve palsy. Computed tomography scan did not show a skull base fracture. T2*-weighted magnetic resonance imaging revealed petechial cerebral hemorrhages sparing the brainstem. T2 constructive interference in steady state suggested a partial sectioning of the left oculomotor nerve just before entering the superior orbital fissure. Diffusion tensor imaging Fiber tractography confirmed a sharp arrest of the left oculomotor nerve. This recent imaging technique could be of interest to assess white Fiber Damage and help make a diagnosis or prognosis.
Rayaz A Malik - One of the best experts on this subject based on the ideXlab platform.
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natural history of corneal nerve morphology in mild neuropathy associated with type 1 diabetes development of a potential measure of diabetic peripheral neuropathy
Investigative Ophthalmology & Visual Science, 2014Co-Authors: Cirous Dehghani, Nicola Pritchard, Katie Edwards, Rayaz A Malik, Dimitrios Vagenas, Anthony W RussellAbstract:To investigate longitudinal changes of subbasal nerve plexus (SNP) morphology and its relationship with conventional measures of neuropathy in individuals with diabetes. A cohort of 147 individuals with type 1 diabetes and 60 age-balanced controls underwent detailed assessment of clinical and metabolic factors, neurologic deficits, quantitative sensory testing, nerve conduction studies, and corneal confocal microscopy at baseline and four subsequent annual visits. The SNP parameters included corneal nerve Fiber density (CNFD), branch density (CNBD), and Fiber length (CNFL), and were quantified using a fully automated algorithm. Linear mixed models were fitted to examine the changes in corneal nerve parameters over time. At baseline, 27% of the participants had mild diabetic neuropathy. All SNP parameters were significantly lower in the neuropathy group compared with controls (P This study demonstrates dynamic small Fiber Damage at the SNP, thus providing justification for our ongoing efforts to establish corneal nerve morphology as an appropriate adjunct to conventional measures of diabetic peripheral neuropathy.
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comparing skin biopsy with corneal confocal microscopy diagnostic yield of nerve Fiber density conference abstract
Diabetologia: clinical and experimental diabetes and metabolism, 2010Co-Authors: Cristian Quattrini, Andrew J M Boulton, Mitra Tavakoli, Panagiotis A Kallinikos, Nathan Efron, Andrew G Marshall, Rayaz A MalikAbstract:Background and aims: The assessment of intra-epidermal nerve Fiber density (IENFD) in skin biopsies and corneal nerve Fiber density (CNFD) using corneal confocal microscopy (CCM) provides promising techniques to detect small nerve Fiber Damage in patients with peripheral neuropathy. To help define the clinical utility of each of these techniques in patients with diabetic neuropathy we have assessed sensitivity and specificity of IENFD and CNFD in predicting the following: 1) diabetic polyneuropathy (DPN); 2) risk of foot ulceration (RFU); 3) initial small Fiber neuropathy (iSFN); 4) severe small Fiber neuropathy (sSFN)...
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surrogate markers of small Fiber Damage in human diabetic neuropathy
Diabetes, 2007Co-Authors: Cristian Quattrini, Maria Jeziorska, Andrew Marshall, Andrew J M Boulton, Mitra Tavakoli, Panagiotis A Kallinikos, Solomon Tesfaye, Joanne Finnigan, Nathan Efron, Rayaz A MalikAbstract:Surrogate markers of diabetic neuropathy are being actively sought to facilitate the diagnosis, measure the progression, and assess the benefits of therapeutic intervention in patients with diabetic neuropathy. We have quantified small nerve Fiber pathological changes using the technique of intraepidermal nerve Fiber (IENF) assessment and the novel in vivo technique of corneal confocal microscopy (CCM). Fifty-four diabetic patients stratified for neuropathy, using neurological evaluation, neurophysiology, and quantitative sensory testing, and 15 control subjects were studied. They underwent a punch skin biopsy to quantify IENFs and CCM to quantify corneal nerve Fibers. IENF density (IENFD), branch density, and branch length showed a progressive reduction with increasing severity of neuropathy, which was significant in patients with mild, moderate, and severe neuropathy. CCM also showed a progressive reduction in corneal nerve Fiber density (CNFD) and branch density, but the latter was significantly reduced even in diabetic patients without neuropathy. Both IENFD and CNFD correlated significantly with cold detection and heat as pain thresholds. Intraepidermal and corneal nerve Fiber lengths were reduced in patients with painful compared with painless diabetic neuropathy. Both IENF and CCM assessment accurately quantify small nerve Fiber Damage in diabetic patients. However, CCM quantifies small Fiber Damage rapidly and noninvasively and detects earlier stages of nerve Damage compared with IENF pathology. This may make it an ideal technique to accurately diagnose and assess progression of human diabetic neuropathy.
Carole Frindel - One of the best experts on this subject based on the ideXlab platform.
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diffusion tensor imaging tractography detecting isolated oculomotor nerve Damage after traumatic brain injury
World Neurosurgery, 2017Co-Authors: Timothee Jacquesson, Carole Frindel, Francois CottonAbstract:A 24-year-old woman was hit by a bus and suffered an isolated complete oculomotor nerve palsy. Computed tomography scan did not show a skull base fracture. T2*-weighted magnetic resonance imaging revealed petechial cerebral hemorrhages sparing the brainstem. T2 constructive interference in steady state suggested a partial sectioning of the left oculomotor nerve just before entering the superior orbital fissure. Diffusion tensor imaging Fiber tractography confirmed a sharp arrest of the left oculomotor nerve. This recent imaging technique could be of interest to assess white Fiber Damage and help make a diagnosis or prognosis.
Bo Tao - One of the best experts on this subject based on the ideXlab platform.
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the effect of impactor shape on the low velocity impact behavior of hybrid corrugated core sandwich structures
Composites Part B-engineering, 2017Co-Authors: Jingxi Liu, De Xie, Bo TaoAbstract:Abstract Corrugated core sandwich structures are fabricated with carbon Fiber reinforced polymer (CFRP) face sheets and aluminum alloy cores. This lightweight design concept enables sandwich structures to maximize their specific bending stiffness/strength and improve their energy absorption capability. A combined experimental and numerical study is performed to investigate the effect of impactor shape on low-velocity impact behavior. Low-velocity impact tests are conducted to study the impact resistance when impacted by conical, hemispherical and flat impactors. A user subroutine VUMAT is developed to model the CFRP face sheet behavior, in which a progressive Damage model based on the Hashin failure criteria and Yeh delamination failure criteria is implemented in ABAQUS/Explicit. Reasonably good agreement is achieved when comparing impact force, absorbed energy, and failure modes between experimental measurements and numerical predictions. These studies reveal that Damage, consisting of Fiber Damage, matrix Damage and delamination of the face sheets as well as buckling of core members, depends on the impactor shape, impact energy and impact location. The investigations provide some insight into the failure mechanisms in this hybrid sandwich structure under low-velocity impact loading, which could be used in the development of novel lightweight multifunctional structures.