The Experts below are selected from a list of 13284 Experts worldwide ranked by ideXlab platform

Ekrem Kalkan - One of the best experts on this subject based on the ideXlab platform.

  • preparation of scrap tire rubber Fiber silica fume mixtures for Modification of clayey soils
    Applied Clay Science, 2013
    Co-Authors: Ekrem Kalkan
    Abstract:

    Abstract This experimental work was performed to investigate the influence of silica fume–scrap tire rubber Fiber mixture inclusion on the geotechnical properties of clayey soils. The natural and modified clayey soil samples were subjected to the unconfined compression, the shear box, the odometer and the falling-head permeability tests after compaction at optimum moisture content. The results of experimental research indicated that silica fume, Fiber and silica fume–Fiber mixture Modification enhanced both the unconfined compression strength and strength parameters. Although, the Fiber Modification increased in the hydraulic conductivity, it decreased in the swelling pressure. It was observed also that the silica fume and silica fume–Fiber Modification decreased both the hydraulic conductivity and swelling pressure. Consequently, it is concluded that the silica fume–Fiber mixture materials can be successfully used for the Modifications of clayey soils in the geotechnical applications.

  • Preparation of scrap tire rubber Fiber–silica fume mixtures for Modification of clayey soils
    Applied Clay Science, 2013
    Co-Authors: Ekrem Kalkan
    Abstract:

    Abstract This experimental work was performed to investigate the influence of silica fume–scrap tire rubber Fiber mixture inclusion on the geotechnical properties of clayey soils. The natural and modified clayey soil samples were subjected to the unconfined compression, the shear box, the odometer and the falling-head permeability tests after compaction at optimum moisture content. The results of experimental research indicated that silica fume, Fiber and silica fume–Fiber mixture Modification enhanced both the unconfined compression strength and strength parameters. Although, the Fiber Modification increased in the hydraulic conductivity, it decreased in the swelling pressure. It was observed also that the silica fume and silica fume–Fiber Modification decreased both the hydraulic conductivity and swelling pressure. Consequently, it is concluded that the silica fume–Fiber mixture materials can be successfully used for the Modifications of clayey soils in the geotechnical applications.

Man Jiang - One of the best experts on this subject based on the ideXlab platform.

  • effects of the wollastonite Fiber Modification on the sliding wear behavior of the uhmwpe composites
    Wear, 2003
    Co-Authors: Jin Tong, Man Jiang
    Abstract:

    Abstract The effects of wollastonite Fiber additions and, particularly, the surface Modification of the wollastonite Fibers, on the sliding wear behavior of the ultra-high molecular weight polyethylene (UHMWPE) composites were investigated. Needle-shaped wollastonite Fibers had an average aspect ratio of 15:1. The UHMWPE had a molecular weight of about 2.5 millions. The composites were prepared by first cold-pressing, then sintering and hot-pressing. A grey cast iron was used as the counterface on a block-on-ring tester. The sliding velocity during sliding tests was 0.53 m/s. The results showed that the sliding friction coefficient of the UHMWPE composites increased with the Fiber content increased. The wear resistance of the UHMWPE composite was the highest when the wollastonite Fiber content was about 10 wt.% and was decreased as the applied normal load was increased. It was found that the silane Modification, titanate Modification, and silane–titanate combined Modification of the wollastonite Fibers improved the wear resistance, tensile strength, and impact resistance of the UHMWPE composites as well. The examination of the worn surfaces of the composites by scanning electron microscopy showed that the plastic deformation, plowing and cutting were the main wear mechanisms of the composite and there existed the strain fatigue wear and the abrasive wear features for the composites containing the wollastonite Fibers without surface Modification and at the higher normal load.

  • effects of the wollastonite Fiber Modification on the sliding wear behavior of the uhmwpe composites
    Wear, 2003
    Co-Authors: Jin Tong, Man Jiang
    Abstract:

    Abstract The effects of wollastonite Fiber additions and, particularly, the surface Modification of the wollastonite Fibers, on the sliding wear behavior of the ultra-high molecular weight polyethylene (UHMWPE) composites were investigated. Needle-shaped wollastonite Fibers had an average aspect ratio of 15:1. The UHMWPE had a molecular weight of about 2.5 millions. The composites were prepared by first cold-pressing, then sintering and hot-pressing. A grey cast iron was used as the counterface on a block-on-ring tester. The sliding velocity during sliding tests was 0.53 m/s. The results showed that the sliding friction coefficient of the UHMWPE composites increased with the Fiber content increased. The wear resistance of the UHMWPE composite was the highest when the wollastonite Fiber content was about 10 wt.% and was decreased as the applied normal load was increased. It was found that the silane Modification, titanate Modification, and silane–titanate combined Modification of the wollastonite Fibers improved the wear resistance, tensile strength, and impact resistance of the UHMWPE composites as well. The examination of the worn surfaces of the composites by scanning electron microscopy showed that the plastic deformation, plowing and cutting were the main wear mechanisms of the composite and there existed the strain fatigue wear and the abrasive wear features for the composites containing the wollastonite Fibers without surface Modification and at the higher normal load.

Jin Tong - One of the best experts on this subject based on the ideXlab platform.

  • effects of the wollastonite Fiber Modification on the sliding wear behavior of the uhmwpe composites
    Wear, 2003
    Co-Authors: Jin Tong, Man Jiang
    Abstract:

    Abstract The effects of wollastonite Fiber additions and, particularly, the surface Modification of the wollastonite Fibers, on the sliding wear behavior of the ultra-high molecular weight polyethylene (UHMWPE) composites were investigated. Needle-shaped wollastonite Fibers had an average aspect ratio of 15:1. The UHMWPE had a molecular weight of about 2.5 millions. The composites were prepared by first cold-pressing, then sintering and hot-pressing. A grey cast iron was used as the counterface on a block-on-ring tester. The sliding velocity during sliding tests was 0.53 m/s. The results showed that the sliding friction coefficient of the UHMWPE composites increased with the Fiber content increased. The wear resistance of the UHMWPE composite was the highest when the wollastonite Fiber content was about 10 wt.% and was decreased as the applied normal load was increased. It was found that the silane Modification, titanate Modification, and silane–titanate combined Modification of the wollastonite Fibers improved the wear resistance, tensile strength, and impact resistance of the UHMWPE composites as well. The examination of the worn surfaces of the composites by scanning electron microscopy showed that the plastic deformation, plowing and cutting were the main wear mechanisms of the composite and there existed the strain fatigue wear and the abrasive wear features for the composites containing the wollastonite Fibers without surface Modification and at the higher normal load.

  • effects of the wollastonite Fiber Modification on the sliding wear behavior of the uhmwpe composites
    Wear, 2003
    Co-Authors: Jin Tong, Man Jiang
    Abstract:

    Abstract The effects of wollastonite Fiber additions and, particularly, the surface Modification of the wollastonite Fibers, on the sliding wear behavior of the ultra-high molecular weight polyethylene (UHMWPE) composites were investigated. Needle-shaped wollastonite Fibers had an average aspect ratio of 15:1. The UHMWPE had a molecular weight of about 2.5 millions. The composites were prepared by first cold-pressing, then sintering and hot-pressing. A grey cast iron was used as the counterface on a block-on-ring tester. The sliding velocity during sliding tests was 0.53 m/s. The results showed that the sliding friction coefficient of the UHMWPE composites increased with the Fiber content increased. The wear resistance of the UHMWPE composite was the highest when the wollastonite Fiber content was about 10 wt.% and was decreased as the applied normal load was increased. It was found that the silane Modification, titanate Modification, and silane–titanate combined Modification of the wollastonite Fibers improved the wear resistance, tensile strength, and impact resistance of the UHMWPE composites as well. The examination of the worn surfaces of the composites by scanning electron microscopy showed that the plastic deformation, plowing and cutting were the main wear mechanisms of the composite and there existed the strain fatigue wear and the abrasive wear features for the composites containing the wollastonite Fibers without surface Modification and at the higher normal load.

Maciej S. Lesniak - One of the best experts on this subject based on the ideXlab platform.

  • Enhanced transduction and replication of RGD-Fiber modified adenovirus in primary T cells.
    PloS one, 2011
    Co-Authors: Sadhak Sengupta, Ilya V. Ulasov, Bart Thaci, Atique U. Ahmed, Maciej S. Lesniak
    Abstract:

    Background Adenoviruses are often used as vehicles to mediate gene delivery for therapeutic purposes, but their research scope in hematological cells remains limited due to a narrow choice of host cells that express the adenoviral receptor (CAR). T cells, which are attractive targets for gene therapy of numerous diseases, remain resistant to adenoviral infection because of the absence of CAR expression. Here, we demonstrate that this resistance can be overcome when murine or human T cells are transduced with an adenovirus incorporating the RGD-Fiber Modification (Ad-RGD). Methodology/Principal Finding A luciferase-expressing replication-deficient Ad-RGD infected 3-fold higher number of activated primary T cells than an adenovirus lacking the RGD-Fiber Modification in vitro. Infection with replication-competent Ad-RGD virus also caused increased cell cycling, higher E1A copy number and enriched hexon antigen expression in both human and murine T cells. Transduction with oncolytic Ad-RGD also resulted in higher titers of progeny virus and enhanced the killing of T cells. In vivo, 35–45% of splenic T cells were transduced by Ad-RGD. Conclusions Collectively, our results prove that a Fiber modified Ad-RGD successfully transduces and replicates in primary T cells of both murine and human origin.

Sadhak Sengupta - One of the best experts on this subject based on the ideXlab platform.

  • Enhanced transduction and replication of RGD-Fiber modified adenovirus in primary T cells.
    PloS one, 2011
    Co-Authors: Sadhak Sengupta, Ilya V. Ulasov, Bart Thaci, Atique U. Ahmed, Maciej S. Lesniak
    Abstract:

    Background Adenoviruses are often used as vehicles to mediate gene delivery for therapeutic purposes, but their research scope in hematological cells remains limited due to a narrow choice of host cells that express the adenoviral receptor (CAR). T cells, which are attractive targets for gene therapy of numerous diseases, remain resistant to adenoviral infection because of the absence of CAR expression. Here, we demonstrate that this resistance can be overcome when murine or human T cells are transduced with an adenovirus incorporating the RGD-Fiber Modification (Ad-RGD). Methodology/Principal Finding A luciferase-expressing replication-deficient Ad-RGD infected 3-fold higher number of activated primary T cells than an adenovirus lacking the RGD-Fiber Modification in vitro. Infection with replication-competent Ad-RGD virus also caused increased cell cycling, higher E1A copy number and enriched hexon antigen expression in both human and murine T cells. Transduction with oncolytic Ad-RGD also resulted in higher titers of progeny virus and enhanced the killing of T cells. In vivo, 35–45% of splenic T cells were transduced by Ad-RGD. Conclusions Collectively, our results prove that a Fiber modified Ad-RGD successfully transduces and replicates in primary T cells of both murine and human origin.