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Dennis P. Han - One of the best experts on this subject based on the ideXlab platform.

  • Postoperative Fibrin Formation and visual outcome after pars plana vitrectomy.
    Retina (Philadelphia Pa.), 1994
    Co-Authors: Dennis P. Han, Glenn J. Jaffe, Gary W. Abrams, Q. Wang, Ashley Hartz, T. G. Murray, H. C. Boldt, Everton L. Arrindell, E. Coe, William F. Mieler
    Abstract:

    PURPOSE: To determine whether postvitrectomy Fibrin Formation was associated with visual outcome, a prospective study of patients undergoing pars plana vitrectomy was performed. METHODS: In 121 patients undergoing vitrectomy at the Medical College of Wisconsin between July 1986 and April 1989, the association of Fibrin Formation and other perioperative factors with visual outcome was evaluated by univariate and multivariate regression analysis. Poor visual outcome was defined as visual acuity worse than 5/200. RESULTS: After a median follow-up period of 23 months (range 6 to 51 months), patients with severe Fibrin Formation experienced a higher rate of poor visual outcome (19 of 26 patients, 73%) than patients with little or no Fibrin Formation (23 of 95 patients, 24%; P < 0.0001, univariate analysis). After adjusting for a variety of factors with multivariate regression analysis, Fibrin Formation was not significantly predictive of final visual outcome. CONCLUSIONS: Factors associated with postvitrectomy Fibrin Formation may affect visual outcome more than Fibrin Formation itself.

  • Risk factors for postvitrectomy Fibrin Formation.
    American journal of ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Daniel M. Schwartz, Dennis P. Han, Mark Gottlieb, Arthur J. Hartz, Daniel Mccarty, William F. Mieler, Gary W. Abrams
    Abstract:

    We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular Fibrin Formation and the association of a variety of preoperative and intraoperative variables with the Formation of severe postvitrectomy Fibrin. Overall, 62 (32%) patients developed postvitrectomy Fibrin; 25 (13%) had mild Fibrin Formation, 13 (6.5%) had moderate Fibrin Formation, and 24 (12.4%) had severe Fibrin Formation. By logistic multivariate analysis, preoperative factors that were independently predictive of severe Fibrin Formation included severe flare (P = .004), the presence of a previously placed scleral buckle (P = .001), and poor preoperative visual acuity (P = .007). Anterior epiretinal membrane dissection was the only intraoperative factor that was independently associated with an increased Fibrin risk (P = .0003). A risk score derived from the multivariate analysis effectively categorized patients according to their likelihood of developing severe postvitrectomy Fibrin. Results of this study may be useful in designing prophylactic interventions to decrease postvitrectomy Fibrin Formation.

  • Tissue plasminogen activator for postvitrectomy Fibrin Formation.
    Ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Gary W. Abrams, George A. Williams, Dennis P. Han
    Abstract:

    Abstract The authors injected 25,ug of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular Fibrin Formation that developed after vitrectomy surgery for complicated cases of proliferative vitreoretinopathy (PVR) (13 eyes), diabetic traction retinal detachment (TRD) (7 eyes), or endophthalmitis (3 eyes). Tissue plasminogen activator injected an average (± standard deviation) of 73 ± 63 hours after vitrectomy surgery resulted in complete Fibrinolysis in 21 of 23 eyes and partial Fibrinolysis in one eye. The mean time to Fibrin resolution was 3.0 ± 1.0 hours. Four eyes required repeat tPA injection for recurrent Fibrin Formation; repeat injection resulted in complete Fibrinolysis in each case. The mean followup duration after tPA administration was 6 months. At the final follow-up examination, the retina was totally attached in 18 of 23 eyes and was partially attached in 2. Visual acuity improved in 12 eyes (52%); it was at least 20/400 in 8. Complications of tPA injection included hyphema (2 patients) and corneal stromal thickening (2 patients). Mild, transient, periocular pain that was easily managed with non-narcotic analgesia developed in three patients.

Glenn J. Jaffe - One of the best experts on this subject based on the ideXlab platform.

  • Postoperative Fibrin Formation and visual outcome after pars plana vitrectomy.
    Retina (Philadelphia Pa.), 1994
    Co-Authors: Dennis P. Han, Glenn J. Jaffe, Gary W. Abrams, Q. Wang, Ashley Hartz, T. G. Murray, H. C. Boldt, Everton L. Arrindell, E. Coe, William F. Mieler
    Abstract:

    PURPOSE: To determine whether postvitrectomy Fibrin Formation was associated with visual outcome, a prospective study of patients undergoing pars plana vitrectomy was performed. METHODS: In 121 patients undergoing vitrectomy at the Medical College of Wisconsin between July 1986 and April 1989, the association of Fibrin Formation and other perioperative factors with visual outcome was evaluated by univariate and multivariate regression analysis. Poor visual outcome was defined as visual acuity worse than 5/200. RESULTS: After a median follow-up period of 23 months (range 6 to 51 months), patients with severe Fibrin Formation experienced a higher rate of poor visual outcome (19 of 26 patients, 73%) than patients with little or no Fibrin Formation (23 of 95 patients, 24%; P < 0.0001, univariate analysis). After adjusting for a variety of factors with multivariate regression analysis, Fibrin Formation was not significantly predictive of final visual outcome. CONCLUSIONS: Factors associated with postvitrectomy Fibrin Formation may affect visual outcome more than Fibrin Formation itself.

  • Risk factors for postvitrectomy Fibrin Formation.
    American journal of ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Daniel M. Schwartz, Dennis P. Han, Mark Gottlieb, Arthur J. Hartz, Daniel Mccarty, William F. Mieler, Gary W. Abrams
    Abstract:

    We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular Fibrin Formation and the association of a variety of preoperative and intraoperative variables with the Formation of severe postvitrectomy Fibrin. Overall, 62 (32%) patients developed postvitrectomy Fibrin; 25 (13%) had mild Fibrin Formation, 13 (6.5%) had moderate Fibrin Formation, and 24 (12.4%) had severe Fibrin Formation. By logistic multivariate analysis, preoperative factors that were independently predictive of severe Fibrin Formation included severe flare (P = .004), the presence of a previously placed scleral buckle (P = .001), and poor preoperative visual acuity (P = .007). Anterior epiretinal membrane dissection was the only intraoperative factor that was independently associated with an increased Fibrin risk (P = .0003). A risk score derived from the multivariate analysis effectively categorized patients according to their likelihood of developing severe postvitrectomy Fibrin. Results of this study may be useful in designing prophylactic interventions to decrease postvitrectomy Fibrin Formation.

  • Tissue plasminogen activator for postvitrectomy Fibrin Formation.
    Ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Gary W. Abrams, George A. Williams, Dennis P. Han
    Abstract:

    Abstract The authors injected 25,ug of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular Fibrin Formation that developed after vitrectomy surgery for complicated cases of proliferative vitreoretinopathy (PVR) (13 eyes), diabetic traction retinal detachment (TRD) (7 eyes), or endophthalmitis (3 eyes). Tissue plasminogen activator injected an average (± standard deviation) of 73 ± 63 hours after vitrectomy surgery resulted in complete Fibrinolysis in 21 of 23 eyes and partial Fibrinolysis in one eye. The mean time to Fibrin resolution was 3.0 ± 1.0 hours. Four eyes required repeat tPA injection for recurrent Fibrin Formation; repeat injection resulted in complete Fibrinolysis in each case. The mean followup duration after tPA administration was 6 months. At the final follow-up examination, the retina was totally attached in 18 of 23 eyes and was partially attached in 2. Visual acuity improved in 12 eyes (52%); it was at least 20/400 in 8. Complications of tPA injection included hyphema (2 patients) and corneal stromal thickening (2 patients). Mild, transient, periocular pain that was easily managed with non-narcotic analgesia developed in three patients.

Gary W. Abrams - One of the best experts on this subject based on the ideXlab platform.

  • Postoperative Fibrin Formation and visual outcome after pars plana vitrectomy.
    Retina (Philadelphia Pa.), 1994
    Co-Authors: Dennis P. Han, Glenn J. Jaffe, Gary W. Abrams, Q. Wang, Ashley Hartz, T. G. Murray, H. C. Boldt, Everton L. Arrindell, E. Coe, William F. Mieler
    Abstract:

    PURPOSE: To determine whether postvitrectomy Fibrin Formation was associated with visual outcome, a prospective study of patients undergoing pars plana vitrectomy was performed. METHODS: In 121 patients undergoing vitrectomy at the Medical College of Wisconsin between July 1986 and April 1989, the association of Fibrin Formation and other perioperative factors with visual outcome was evaluated by univariate and multivariate regression analysis. Poor visual outcome was defined as visual acuity worse than 5/200. RESULTS: After a median follow-up period of 23 months (range 6 to 51 months), patients with severe Fibrin Formation experienced a higher rate of poor visual outcome (19 of 26 patients, 73%) than patients with little or no Fibrin Formation (23 of 95 patients, 24%; P < 0.0001, univariate analysis). After adjusting for a variety of factors with multivariate regression analysis, Fibrin Formation was not significantly predictive of final visual outcome. CONCLUSIONS: Factors associated with postvitrectomy Fibrin Formation may affect visual outcome more than Fibrin Formation itself.

  • Risk factors for postvitrectomy Fibrin Formation.
    American journal of ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Daniel M. Schwartz, Dennis P. Han, Mark Gottlieb, Arthur J. Hartz, Daniel Mccarty, William F. Mieler, Gary W. Abrams
    Abstract:

    We prospectively studied 194 patients undergoing vitrectomy between July 1988 and April 1989 to determine the incidence of postvitrectomy intraocular Fibrin Formation and the association of a variety of preoperative and intraoperative variables with the Formation of severe postvitrectomy Fibrin. Overall, 62 (32%) patients developed postvitrectomy Fibrin; 25 (13%) had mild Fibrin Formation, 13 (6.5%) had moderate Fibrin Formation, and 24 (12.4%) had severe Fibrin Formation. By logistic multivariate analysis, preoperative factors that were independently predictive of severe Fibrin Formation included severe flare (P = .004), the presence of a previously placed scleral buckle (P = .001), and poor preoperative visual acuity (P = .007). Anterior epiretinal membrane dissection was the only intraoperative factor that was independently associated with an increased Fibrin risk (P = .0003). A risk score derived from the multivariate analysis effectively categorized patients according to their likelihood of developing severe postvitrectomy Fibrin. Results of this study may be useful in designing prophylactic interventions to decrease postvitrectomy Fibrin Formation.

  • Tissue plasminogen activator for postvitrectomy Fibrin Formation.
    Ophthalmology, 1990
    Co-Authors: Glenn J. Jaffe, Gary W. Abrams, George A. Williams, Dennis P. Han
    Abstract:

    Abstract The authors injected 25,ug of recombinant tissue plasminogen activator (tPA) into the anterior chamber or vitreous cavity of 23 eyes of 22 patients with severe intraocular Fibrin Formation that developed after vitrectomy surgery for complicated cases of proliferative vitreoretinopathy (PVR) (13 eyes), diabetic traction retinal detachment (TRD) (7 eyes), or endophthalmitis (3 eyes). Tissue plasminogen activator injected an average (± standard deviation) of 73 ± 63 hours after vitrectomy surgery resulted in complete Fibrinolysis in 21 of 23 eyes and partial Fibrinolysis in one eye. The mean time to Fibrin resolution was 3.0 ± 1.0 hours. Four eyes required repeat tPA injection for recurrent Fibrin Formation; repeat injection resulted in complete Fibrinolysis in each case. The mean followup duration after tPA administration was 6 months. At the final follow-up examination, the retina was totally attached in 18 of 23 eyes and was partially attached in 2. Visual acuity improved in 12 eyes (52%); it was at least 20/400 in 8. Complications of tPA injection included hyphema (2 patients) and corneal stromal thickening (2 patients). Mild, transient, periocular pain that was easily managed with non-narcotic analgesia developed in three patients.

Håkan Wallén - One of the best experts on this subject based on the ideXlab platform.

  • Impaired Fibrinolytic capacity and increased Fibrin Formation associate with myocardial infarction.
    Thrombosis and haemostasis, 2012
    Co-Authors: Karin Leander, Margareta Blombäck, Håkan Wallén
    Abstract:

    We assessed whether abnormality of haemostasis measured by a newly developed global method is associated with risk of a first myocardial infarction (MI). The global markers Coagulation activation profile (Cp), Fibrinolysis activation profile (Fp) and sum of Fibrin optical density over time (Fibrin OD- sum) were determined in plasma from 800 MI cases and 1,123 controls included in the Stockholm Heart Epidemiology Program. Clot lysis time (CLT) was also determined based on raw data of Fibrin OD from the global assay. Odds ratios (OR) of MI with 95% confidence intervals (CI) were calculated using logistic regression. A Fp value 90th percentile value in controls) the adjusted OR of MI was 2.62 (95% CI 1.87–3.66) and for a high Fibrin OD-sum value (>90th percentile in controls) it was 1.86 (95% CI 1.37–2.53). A high Cp value was not significantly associated with MI. In conclusion, we found that abnormal haemostasis in platelet-poor plasma, reflected either as an attenuated Fibrinolytic capacity or the resulting increase of Fibrin Formation, was associated with increased MI risk.

  • Is Fibrin Formation and thrombin generation increased during and after an acute coronary syndrome
    Thrombosis research, 2011
    Co-Authors: Mika Skeppholm, Margareta Blombäck, Anders Kallner, Karin Malmqvist, Håkan Wallén
    Abstract:

    Abstract Introduction and methods In order to study coagulation and Fibrinolysis in acute coronary syndrome (ACS) we used a recently developed assay, called OH-index, which provides simultaneous measurements of Fibrin Formation and Fibrinolysis (Fibrin degradation) in the patients´ plasma. We also investigated thrombin generation using the calibrated automated thrombogram (CAT), and assessed thrombin generation in vivo by measuring F1 + 2 plasma concentrations. In addition, to better characterize the patients we also assessed markers of inflammation and endothelial function. Eighty-seven ACS patients were sampled at admission, within 24 hours during treatment with low molecular weight heparin (LMH), and 6 months later; 65 healthy controls were also sampled. Results As assessed by OH-index Fibrin Formation was slightly depressed at admission, profoundly depressed during LMH treatment and comparable to controls at 6 months, whereas Fibrin degradation was elevated, particularly during LMH treatment. F1 + 2 levels decreased during LMH treatment but did not deviate significantly from controls at admission or in convalescence. CAT data showed that peak thrombin was higher at admission and after 6 months compared to controls, whereas the endogenous thrombin potential only tended to be elevated. Both variables were strongly reduced during LMH treatment. Patients had elevated levels of markers of inflammation and endothelial function as expected. Conclusion ACS-patients have an increased capacity to generate thrombin and an enhanced capacity to degrade Fibrin in the acute phase. Increased thrombin generation persists also 6 months after the event.

  • a global assay of haemostasis which uses recombinant tissue factor and tissue type plasminogen activator to measure the rate of Fibrin Formation and Fibrin degradation in plasma
    Thrombosis and Haemostasis, 2007
    Co-Authors: Kun Zhu, Margareta Blombäck, Mika Skeppholm, Nils Egberg, Jenny Vedin, Jan Svensson, Håkan Wallén
    Abstract:

    The global assay of Overall Haemostasis Potential we previously described has been refined.The coagulation cascade in plateletpoor plasma is triggered by adding a minimal dose of recombinant tissue factor together with purified phospholipids and calcium; Fibrinolysis is initiated by adding recombinant tissue type-plasminogen activator in a concentration similar to what can be obtained during thrombolysis. Numerical differentials of optical densities reflecting rates of Fibrin Formation and degradation are calculated by a new software, and the Coagulation Profile (Cp) and the Fibrinolysis Profile (Fp) are determined. The combined effect of these counteractive systems is expressed as a ratio of Cp to Fp, called the Overall Haemostasis Index. Commercially available coagulant-deficient patient plasma samples and plasma with various amounts of added PAI-1 are examined; changes of Fibrin turbidity demonstrate that this assay can determine Cp and Fp in a physiologically relevant way. Increased Cp and decreased Fp in prothrombotic patients, as well as expected effects of heparin or a thrombin inhibitor on Cp and Fp, suggest that our method can detect hypercoagulability and assist in monitoring antithrombotic treatment. Ongoing studies will show whether this simple assay can be of value in clinical routine.

B Dick - One of the best experts on this subject based on the ideXlab platform.

  • Recombinant tissue plasminogen activator in cases with Fibrin Formation after cataract surgery: a prospective randomised multicentre study
    The British journal of ophthalmology, 1998
    Co-Authors: A Heiligenhaus, B Steinmetz, R Lapuente, P Krallmann, C Althaus, W K Steinkamp, B Dick
    Abstract:

    Aims—This study investigated the eVect of tissue plasminogen activator (tPA) in patients with severe intracameral Fibrin after extracapsular cataract extraction or phacoemulsification with posterior chamber intraocular lens implantation. Methods—A randomised prospective multicentre study was carried out in 86 patients with intraocular Fibrin Formation 2‐8 days after cataract surgery. While the first group (n=41) received only antiinflammatory drugs, a single anterior chamber injection of tPA (10 µg) as an additional treatment to the standard was given in the second group (n=44). On days 1, 2, 14, and 90 after randomisation, the visual acuities, slit lamp findings, and intraocular pressures were documented in standardised protocols. EYcacy of treatment was judged by the rate of Fibrinolysis (primary objective), the frequency of synechiae, and central capsular fibrosis (secondary objectives). Results—The incidence and quantity of intraocular Fibrin were significantly lower in the patients treated with tPA than in the control group (p