The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform

Turgut Tufan - One of the best experts on this subject based on the ideXlab platform.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis Akut apandisit tanisinda serum fibrinojen düzeyinin değeri
    2012
    Co-Authors: Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    BACKGROUND The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. METHODS This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. RESULTS During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x10 9 /L and for Alvarado score at 7. CONCLUSION The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2012
    Co-Authors: Oner Mentes, Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    Background The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. Methods This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. Results During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x109/L and for Alvarado score at 7. Conclusion The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.

H Gadner - One of the best experts on this subject based on the ideXlab platform.

  • Sinusvenenthrombose unter L-Asparaginase-Therapie
    Klinische Padiatrie, 1994
    Co-Authors: U Schulz, G Mann, A Zoubek, H Gadner
    Abstract:

    Changes in the coagulation system due to steroids and asparaginase during treatment for acute lymphoblastic leukemia (ALL) are well known side effects and may cause bleeding or thrombosis. We report the case history of a 7-year old girl who developed thrombosis of the sinus sagittalis superior during ALL-treatment. Diagnosis was made by computed tomography and magnetic resonance imaging after the child became symptomatic with seizure. Until this event the girl had been treated already for two weeks with prednisone and E. coli-asparaginase (4 infusions). This medication caused distinct hypoFibrinogenemia (Fibrinogen 53 mg/dl), prothrombin time expressed as percent of normal values of 58% was also pathological, activated partial thromboplastin time of 35 sec, antithrombin III 120% and thrombocyte count 178 G/l were in normal range. We were not successful in the attempt to adjust the imbalance in the coagulation system by transfusion of fresh frozen plasma (FFP)--seizure happened during FFP-infusion, Fibrinogen Blood Level could be elevated only slightly. Our patient stayed consequently asymptomatic, the clinical recovery was confirmed radiologically.

  • Venous thrombosis of cranial sinuses in asparaginase therapy. A case report
    Klinische Padiatrie, 1994
    Co-Authors: U Schulz, G Mann, A Zoubek, H Gadner
    Abstract:

    Changes in the coagulation system due to steroids and asparaginase during treatment for acute lymphoblastic leukemia (ALL) are well known side effects and may cause bleeding or thrombosis. We report the case history of a 7-year old girl who developed thrombosis of the sinus sagittalis superior during ALL-treatment. Diagnosis was made by computed tomography and magnetic resonance imaging after the child became symptomatic with seizure. Until this event the girl had been treated already for two weeks with prednisone and E. coli-asparaginase (4 infusions). This medication caused distinct hypoFibrinogenemia (Fibrinogen 53 mg/dl), prothrombin time expressed as percent of normal values of 58% was also pathological, activated partial thromboplastin time of 35 sec, antithrombin III 120% and thrombocyte count 178 G/l were in normal range. We were not successful in the attempt to adjust the imbalance in the coagulation system by transfusion of fresh frozen plasma (FFP)--seizure happened during FFP-infusion, Fibrinogen Blood Level could be elevated only slightly. Our patient stayed consequently asymptomatic, the clinical recovery was confirmed radiologically.

Mehmet Eryilmaz - One of the best experts on this subject based on the ideXlab platform.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis Akut apandisit tanisinda serum fibrinojen düzeyinin değeri
    2012
    Co-Authors: Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    BACKGROUND The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. METHODS This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. RESULTS During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x10 9 /L and for Alvarado score at 7. CONCLUSION The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2012
    Co-Authors: Oner Mentes, Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    Background The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. Methods This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. Results During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x109/L and for Alvarado score at 7. Conclusion The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.

U Schulz - One of the best experts on this subject based on the ideXlab platform.

  • Sinusvenenthrombose unter L-Asparaginase-Therapie
    Klinische Padiatrie, 1994
    Co-Authors: U Schulz, G Mann, A Zoubek, H Gadner
    Abstract:

    Changes in the coagulation system due to steroids and asparaginase during treatment for acute lymphoblastic leukemia (ALL) are well known side effects and may cause bleeding or thrombosis. We report the case history of a 7-year old girl who developed thrombosis of the sinus sagittalis superior during ALL-treatment. Diagnosis was made by computed tomography and magnetic resonance imaging after the child became symptomatic with seizure. Until this event the girl had been treated already for two weeks with prednisone and E. coli-asparaginase (4 infusions). This medication caused distinct hypoFibrinogenemia (Fibrinogen 53 mg/dl), prothrombin time expressed as percent of normal values of 58% was also pathological, activated partial thromboplastin time of 35 sec, antithrombin III 120% and thrombocyte count 178 G/l were in normal range. We were not successful in the attempt to adjust the imbalance in the coagulation system by transfusion of fresh frozen plasma (FFP)--seizure happened during FFP-infusion, Fibrinogen Blood Level could be elevated only slightly. Our patient stayed consequently asymptomatic, the clinical recovery was confirmed radiologically.

  • Venous thrombosis of cranial sinuses in asparaginase therapy. A case report
    Klinische Padiatrie, 1994
    Co-Authors: U Schulz, G Mann, A Zoubek, H Gadner
    Abstract:

    Changes in the coagulation system due to steroids and asparaginase during treatment for acute lymphoblastic leukemia (ALL) are well known side effects and may cause bleeding or thrombosis. We report the case history of a 7-year old girl who developed thrombosis of the sinus sagittalis superior during ALL-treatment. Diagnosis was made by computed tomography and magnetic resonance imaging after the child became symptomatic with seizure. Until this event the girl had been treated already for two weeks with prednisone and E. coli-asparaginase (4 infusions). This medication caused distinct hypoFibrinogenemia (Fibrinogen 53 mg/dl), prothrombin time expressed as percent of normal values of 58% was also pathological, activated partial thromboplastin time of 35 sec, antithrombin III 120% and thrombocyte count 178 G/l were in normal range. We were not successful in the attempt to adjust the imbalance in the coagulation system by transfusion of fresh frozen plasma (FFP)--seizure happened during FFP-infusion, Fibrinogen Blood Level could be elevated only slightly. Our patient stayed consequently asymptomatic, the clinical recovery was confirmed radiologically.

Ali Harlak - One of the best experts on this subject based on the ideXlab platform.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis Akut apandisit tanisinda serum fibrinojen düzeyinin değeri
    2012
    Co-Authors: Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    BACKGROUND The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. METHODS This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. RESULTS During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x10 9 /L and for Alvarado score at 7. CONCLUSION The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.

  • The value of serum Fibrinogen Level in the diagnosis of acute appendicitis.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2012
    Co-Authors: Oner Mentes, Mehmet Eryilmaz, Ali Harlak, Erkan Ozturk, Turgut Tufan
    Abstract:

    Background The aim of this study was to investigate the importance of serum Fibrinogen Level in the diagnosis of acute appendicitis. Methods This study was performed on 201 patients who admitted to our clinic. Symptoms, signs, duration of symptoms, and laboratory indicators of appendicitis were recorded, in keeping with the Alvarado score for acute appendicitis. The ultimate diagnosis was based on histopathological results. Serum Fibrinogen Levels were detected before surgery. The sensitivity, specificity, and predictive values of single test and test combinations were calculated at different cut-off Levels. Results During the study period, 201 patients underwent surgery for suspected acute appendicitis. Appendicitis was confirmed in 179 (89%) patients. The mean age was 24.8±7.7 (range, 20-57) years, and 154 (76.6%) patients were male and 47 (23.4%) female. The best diagnostic cut-off point for Fibrinogen was found at 245.5 mg/dl, for white Blood cells (WBC) at 11,900x109/L and for Alvarado score at 7. Conclusion The use of Fibrinogen Blood Level may be a new diagnostic acute-phase reactant in the diagnosis of acute appendicitis. The formulation of a triple test is recommended as criteria in deciding emergency surgery or observation.