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Salomón Menjón - One of the best experts on this subject based on the ideXlab platform.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ < 3. The present study reports the levels of tumour necrosis factor‐α (TNF‐α), interleukin‐1 (IL‐1), and interleukin‐6 (IL‐6) in the Breast cyst fluid of women with gross cystic Disease and analyses the relationship between the intracystic concentration of these cytokines, sex steroid hormones, and the K+/Na+ ratio. The concentration of these cytokines, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEA‐S), and 17‐OH‐progesterone were determined in the Breast cyst fluid of 54 women with gross cystic Disease. No significant differences were found in the cystic levels of IL‐1 between cysts with intracystic K+/Na+ < 3 and > 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • tumour necrosis factor α and interleukin 1 and 6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast cancer research and treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

Alfonso J. Herruzo - One of the best experts on this subject based on the ideXlab platform.

  • tumour necrosis factor α and interleukin 1 and 6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast cancer research and treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • CA 125, CA 15.3, CA 27.29, CEA, β-hCG and α-fetoprotein levels in cyst fluid of Breast macrocysts
    International Journal of Gynecology & Obstetrics, 1995
    Co-Authors: L Martínez, N. Blanco, F. Peran, Jose Antonio Castilla, Alfonso J. Herruzo
    Abstract:

    Abstract Objective: To determine the tumoral markers CA 125, CA 15.3, CA 27.29, CEA, β-hCG and α-fetoprotein in serum and Breast cystic fluid in women with Fibrocystic Breast Disease. Methods: The study comprised 50 women diagnosed with Fibrocystic Breast Disease but without Breast macrocysts, and 60 women with macrocysts. Results: Significantly higher levels of CA 125, CA 27.29, β-hCG and CEA were observed in the cyst fluid than in the serum of the same patients. According to their K + Na + quotient we found that when K + Na + was K + Na + was >3, only CA 27.29 and β-hCG levels were significantly higher. Comparing cyst fluid marker levels with respect to the K + Na + ratio, the only difference observed was in CA 125 which was significantly greater when K + Na + was K + Na + quotient. Conclusion: These results suggest that CA 125 could be used as a marker to identify cyst type.

  • Thyroid hormones in Fibrocystic Breast Disease.
    European journal of endocrinology, 1995
    Co-Authors: Luis Martínez, Jose Antonio Castilla, Teresa Gil, Jorge Molina, Jose L. Alarcón, Cristina Marcos, Alfonso J. Herruzo
    Abstract:

    This study was undertaken to evaluate the role of thyroid hormones in Fibrocystic Breast Disease. The concentrations of thyroid-stimulating hormone (TSH), thyroxine (T 4 ), free T 4 and free triiodothyronine (T 3 ) were determined in serum of 50 women with Fibrocystic Breast Disease without macrocysts (cysts of over 3 mm diameter) and in the serum and Breast cyst fluid (BCF) of 60 women with Fibrocystic Breast Disease and macrocysts. Possible relationships between thyroid hormones and estradiol, dehydroepiandrosterone sulfate, testosterone, progesterone and 17-hydroxyprogesterone in the BCF also were analyzed. Serum thyroid hormone levels did not differ between the two groups. Free T 3 levels were higher in BCF than in serum (p < 0.001), whereas T 4 , free T 4 and TSH concentrations were lower in BCF as compared to serum (p < 0.001). Cysts were divided according to their K + /Na + ratio because a ratio above 3 represents a predictor of malignant transformation. Free T 3 concentrations were higher in BCF than in serum, in both low K + /Na + cysts and in cysts with a K + /Na + ratio above 3 ; those cysts with a high K + /Na + ratio had the highest free T 3 concentration. Free T 3 in cysts correlated positively to the K + /Na + ratio (r = 0.831 ; p < 0.001). Multiple linear regression analysis demonstrated that the concentration of free T 3 in BCF was predicted statistically by the positive regression coefficient for the estradiol concentration. No candidate variable was included in the model to predict concentrations of TSH, free T 4 or T 4 in BCF. These data suggest an important role of free T 3 in the physiology of Fibrocystic Breast Disease.

  • Intracystic lipidic profile in Fibrocystic Breast Disease
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1994
    Co-Authors: L Martínez, J.a. Castilla, T. Gil, J. Molina, M. A. Diaz, J. Mozas, Alfonso J. Herruzo
    Abstract:

    This study was designed to investigate the lipidic profile of Fibrocystic Breast Disease. The study entailed measuring total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and triglyceride levels in the serum of 50 women with Fibrocystic Breast Disease without macrocysts, and in the serum and Breast cyst fluid of 60 women with Fibrocystic Breast Disease and macrocysts. The relationships between the lipids analyzed in the cyst fluid and intracystic estradiol, progesterone, dehydroepiandrosterone sulfate, testosterone and 17α-hydroxyprogesterone were studied. No differences were found for serum lipid levels between the two groups of patients. The levels of total cholesterol and HDL-C were found to be significantly higher, and the levels of triglycerides and VLDL- C significantly lower in Breast cyst fluid compared to serum. In cysts with high potassium concentrations, we found a higher concentration of...

Eleftherios P Diamandis - One of the best experts on this subject based on the ideXlab platform.

  • prostate specific antigen molecular forms in Breast cyst fluid and serum of women with Fibrocystic Breast Disease
    Journal of Clinical Laboratory Analysis, 1999
    Co-Authors: Gudrun H Borchert, Maurizia Giai, R Roagna, R Ponzone, Luca Sgro, He Yu, George Tomlinson, Eleftherios P Diamandis
    Abstract:

    We have analyzed matched serum and Breast cyst fluid samples for total PSA from 148 patients with Fibrocystic Breast Disease. We have also determined the molecular forms of PSA (free PSA and PSA bound to α1-antichymotrypsin) in 78 Breast cyst fluid samples. We found that total PSA can be detected in all cyst fluids and in about 75% of female sera. The median total PSA concentration in Breast cyst fluid (bcf) is about 30 times higher than the median in the corresponding sera. Breast cyst fluid and serum PSA are not correlated with each other. Total serum PSA is inversely associated with patient age but the inverse association between bcf PSA and age is weak. Lower total PSA in bcf was seen in women who Breast feed, and higher bcf PSA is associated with multiple cysts. Type I cysts (with a high K+/Na+ ratio) tend to have higher total PSA than Type II cysts. All but three of the fractionated cyst fluids (75/78; 96%) had free PSA as the predominant molecular form. The most consistent finding of our study was the positive association between the cyst fluid K+/Na+ ratio and the free to bound PSA ratio. This association was confirmed by Spearman correlation as well as by Wilcoxon and chi-square analysis. Secretory/apocrine cysts (Type I) tend to have more total PSA and proportionally more free PSA than transudative/flattened cysts (Type II). J. Clin. Lab. Anal. 13:75–81, 1999. © 1999 Wiley-Liss, Inc.

  • Prostate specific antigen molecular forms in Breast cyst fluid and serum of women with Fibrocystic Breast Disease.
    Journal of clinical laboratory analysis, 1999
    Co-Authors: Gudrun H Borchert, Maurizia Giai, R Roagna, R Ponzone, Luca Sgro, George Tomlinson, Eleftherios P Diamandis
    Abstract:

    We have analyzed matched serum and Breast cyst fluid samples for total PSA from 148 patients with Fibrocystic Breast Disease. We have also determined the molecular forms of PSA (free PSA and PSA bound to alpha1-antichymotrypsin) in 78 Breast cyst fluid samples. We found that total PSA can be detected in all cyst fluids and in about 75% of female sera. The median total PSA concentration in Breast cyst fluid (bcf) is about 30 times higher than the median in the corresponding sera. Breast cyst fluid and serum PSA are not correlated with each other. Total serum PSA is inversely associated with patient age but the inverse association between bcf PSA and age is weak. Lower total PSA in bcf was seen in women who Breast feed, and higher bcf PSA is associated with multiple cysts. Type I cysts (with a high K+/ Na+ ratio) tend to have higher total PSA than Type II cysts. All but three of the fractionated cyst fluids (75/78; 96%) had free PSA as the predominant molecular form. The most consistent finding of our study was the positive association between the cyst fluid K+/Na+ ratio and the free to bound PSA ratio. This association was confirmed by Spearman correlation as well as by Wilcoxon and chi-square analysis. Secretory/apocrine cysts (Type I) tend to have more total PSA and proportionally more free PSA than transudative/flattened cysts (Type II).

Jose Antonio Castilla - One of the best experts on this subject based on the ideXlab platform.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ < 3. The present study reports the levels of tumour necrosis factor‐α (TNF‐α), interleukin‐1 (IL‐1), and interleukin‐6 (IL‐6) in the Breast cyst fluid of women with gross cystic Disease and analyses the relationship between the intracystic concentration of these cytokines, sex steroid hormones, and the K+/Na+ ratio. The concentration of these cytokines, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEA‐S), and 17‐OH‐progesterone were determined in the Breast cyst fluid of 54 women with gross cystic Disease. No significant differences were found in the cystic levels of IL‐1 between cysts with intracystic K+/Na+ < 3 and > 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • tumour necrosis factor α and interleukin 1 and 6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast cancer research and treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • CA 125, CA 15.3, CA 27.29, CEA, β-hCG and α-fetoprotein levels in cyst fluid of Breast macrocysts
    International Journal of Gynecology & Obstetrics, 1995
    Co-Authors: L Martínez, N. Blanco, F. Peran, Jose Antonio Castilla, Alfonso J. Herruzo
    Abstract:

    Abstract Objective: To determine the tumoral markers CA 125, CA 15.3, CA 27.29, CEA, β-hCG and α-fetoprotein in serum and Breast cystic fluid in women with Fibrocystic Breast Disease. Methods: The study comprised 50 women diagnosed with Fibrocystic Breast Disease but without Breast macrocysts, and 60 women with macrocysts. Results: Significantly higher levels of CA 125, CA 27.29, β-hCG and CEA were observed in the cyst fluid than in the serum of the same patients. According to their K + Na + quotient we found that when K + Na + was K + Na + was >3, only CA 27.29 and β-hCG levels were significantly higher. Comparing cyst fluid marker levels with respect to the K + Na + ratio, the only difference observed was in CA 125 which was significantly greater when K + Na + was K + Na + quotient. Conclusion: These results suggest that CA 125 could be used as a marker to identify cyst type.

  • Thyroid hormones in Fibrocystic Breast Disease.
    European journal of endocrinology, 1995
    Co-Authors: Luis Martínez, Jose Antonio Castilla, Teresa Gil, Jorge Molina, Jose L. Alarcón, Cristina Marcos, Alfonso J. Herruzo
    Abstract:

    This study was undertaken to evaluate the role of thyroid hormones in Fibrocystic Breast Disease. The concentrations of thyroid-stimulating hormone (TSH), thyroxine (T 4 ), free T 4 and free triiodothyronine (T 3 ) were determined in serum of 50 women with Fibrocystic Breast Disease without macrocysts (cysts of over 3 mm diameter) and in the serum and Breast cyst fluid (BCF) of 60 women with Fibrocystic Breast Disease and macrocysts. Possible relationships between thyroid hormones and estradiol, dehydroepiandrosterone sulfate, testosterone, progesterone and 17-hydroxyprogesterone in the BCF also were analyzed. Serum thyroid hormone levels did not differ between the two groups. Free T 3 levels were higher in BCF than in serum (p < 0.001), whereas T 4 , free T 4 and TSH concentrations were lower in BCF as compared to serum (p < 0.001). Cysts were divided according to their K + /Na + ratio because a ratio above 3 represents a predictor of malignant transformation. Free T 3 concentrations were higher in BCF than in serum, in both low K + /Na + cysts and in cysts with a K + /Na + ratio above 3 ; those cysts with a high K + /Na + ratio had the highest free T 3 concentration. Free T 3 in cysts correlated positively to the K + /Na + ratio (r = 0.831 ; p < 0.001). Multiple linear regression analysis demonstrated that the concentration of free T 3 in BCF was predicted statistically by the positive regression coefficient for the estradiol concentration. No candidate variable was included in the model to predict concentrations of TSH, free T 4 or T 4 in BCF. These data suggest an important role of free T 3 in the physiology of Fibrocystic Breast Disease.

Cristina Marcos - One of the best experts on this subject based on the ideXlab platform.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ < 3. The present study reports the levels of tumour necrosis factor‐α (TNF‐α), interleukin‐1 (IL‐1), and interleukin‐6 (IL‐6) in the Breast cyst fluid of women with gross cystic Disease and analyses the relationship between the intracystic concentration of these cytokines, sex steroid hormones, and the K+/Na+ ratio. The concentration of these cytokines, estradiol, testosterone, dehydroepiandrosterone sulfate (DHEA‐S), and 17‐OH‐progesterone were determined in the Breast cyst fluid of 54 women with gross cystic Disease. No significant differences were found in the cystic levels of IL‐1 between cysts with intracystic K+/Na+ < 3 and > 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • tumour necrosis factor α and interleukin 1 and 6 in Fibrocystic Breast Disease
    Breast Cancer Research and Treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • Tumour necrosis factor‐α and interleukin‐1 and ‐6 in Fibrocystic Breast Disease
    Breast cancer research and treatment, 1999
    Co-Authors: Alfonso J. Herruzo, Jose Antonio Castilla, Cristina Marcos, Angel Ramírez, Salomón Menjón
    Abstract:

    The risk of developing Breast cancer is higher in women presenting gross cystic Disease (cysts > 3 mm in diameter) of the Breast with intracystic K+/Na+ > 3 as compared with K+/Na+ 3. However, in cysts with intracystic K+/Na+ > 3 we found a lower concentration of IL‐6 and TNF‐α than in those with intracystic K+/Na+ < 3.Stepwise multiple linear regression analysis demonstrated that the concentration of IL‐6 in Breast cyst fluid was predicted statistically by a negative regression coefficient for the concentration of estradiol and DHEA‐S, and by a positive regression coefficient for the concentration of TNF‐α. The concentration of TNF‐α in Breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of IL‐6, and by a negative regression coefficient for the concentration of estradiol. No candidate variable was included in the model to predict concentrations of IL‐1 in Breast cyst fluid. Our results indicate that IL‐6 and TNF‐α could have a local ‘protector’ role in gross cystic Disease, and that they could be used as a marker to identify cyst type.

  • Thyroid hormones in Fibrocystic Breast Disease.
    European journal of endocrinology, 1995
    Co-Authors: Luis Martínez, Jose Antonio Castilla, Teresa Gil, Jorge Molina, Jose L. Alarcón, Cristina Marcos, Alfonso J. Herruzo
    Abstract:

    This study was undertaken to evaluate the role of thyroid hormones in Fibrocystic Breast Disease. The concentrations of thyroid-stimulating hormone (TSH), thyroxine (T 4 ), free T 4 and free triiodothyronine (T 3 ) were determined in serum of 50 women with Fibrocystic Breast Disease without macrocysts (cysts of over 3 mm diameter) and in the serum and Breast cyst fluid (BCF) of 60 women with Fibrocystic Breast Disease and macrocysts. Possible relationships between thyroid hormones and estradiol, dehydroepiandrosterone sulfate, testosterone, progesterone and 17-hydroxyprogesterone in the BCF also were analyzed. Serum thyroid hormone levels did not differ between the two groups. Free T 3 levels were higher in BCF than in serum (p < 0.001), whereas T 4 , free T 4 and TSH concentrations were lower in BCF as compared to serum (p < 0.001). Cysts were divided according to their K + /Na + ratio because a ratio above 3 represents a predictor of malignant transformation. Free T 3 concentrations were higher in BCF than in serum, in both low K + /Na + cysts and in cysts with a K + /Na + ratio above 3 ; those cysts with a high K + /Na + ratio had the highest free T 3 concentration. Free T 3 in cysts correlated positively to the K + /Na + ratio (r = 0.831 ; p < 0.001). Multiple linear regression analysis demonstrated that the concentration of free T 3 in BCF was predicted statistically by the positive regression coefficient for the estradiol concentration. No candidate variable was included in the model to predict concentrations of TSH, free T 4 or T 4 in BCF. These data suggest an important role of free T 3 in the physiology of Fibrocystic Breast Disease.