The Experts below are selected from a list of 261 Experts worldwide ranked by ideXlab platform
Andrew S Levey - One of the best experts on this subject based on the ideXlab platform.
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Measured and estimated glomerular Filtration Rate: current status and future directions
Nature Reviews Nephrology, 2020Co-Authors: Andrew S Levey, Tom Greene, Josef Coresh, Hocine Tighiouart, Lesley A. InkerAbstract:Evaluation of glomerular Filtration Rate (GFR) is central to the assessment of kidney function in medical practice, research and public health. Measured GFR (mGFR) remains the reference standard, but the past 20 years have seen major advances in estimated GFR (eGFR). Both eGFR and mGFR are associated with error compared with true GFR. eGFR is now recommended by clinical practice guidelines, regulatory agencies and public health agencies for the initial evaluation of GFR, with measured GFR (mGFR) typically considered an important confirmatory test, depending on how accuRate the assessment of GFR needs to be for application to the clinical, research or public health setting. Our approach is to use initial and confirmatory tests as needed to develop a final assessment of true GFR. We suggest that GFR evaluation might be improved by more complete implementation of current recommendations and by further research to improve the accuracy of mGFR and eGFR. The authors of this Perspectives article describe the physiological and statistical principles underlying measured glomerular Filtration Rate (mGFR) and estimated glomerular Filtration Rate (eGFR). They discuss their limitations, the circumstances under which mGFR and eGFR should be used, and approaches to improve these methodologies.
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a new equation to estimate glomerular Filtration Rate
Annals of Internal Medicine, 2009Co-Authors: Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul W Eggers, Frederick Van Lente, Tom GreeneAbstract:The Modification of Diet in Renal Disease (MDRD) Study equation underestimates glomerular Filtration Rate (GFR) in patients with mild kidney disease. Levey and associates therefore developed and va...
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assessing kidney function measured and estimated glomerular Filtration Rate
The New England Journal of Medicine, 2006Co-Authors: Lesley A Stevens, Tom Greene, Josef Coresh, Andrew S LeveyAbstract:In the coming years, estimates of the glomerular Filtration Rate (GFR) may replace the measurement of serum creatinine as the primary tool for the assessment of kidney function. Indeed, many clinical laboratories already report estimated GFR values whenever serum creatinine is measured. This review considers current methods of measuring GFR and GFR-estimating equations and their strengths and weaknesses as applied to chronic kidney disease.
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clinical implications of estimating equations for glomerular Filtration Rate
Annals of Internal Medicine, 2004Co-Authors: Lesley A Stevens, Andrew S LeveyAbstract:Estimating equations that accuRately calculate glomerular Filtration Rate (GFR) in patients with chronic kidney disease and normal renal function are potentially important for early detection of di...
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estimating the prevalence of low glomerular Filtration Rate requires attention to the creatinine assay calibration
Journal of The American Society of Nephrology, 2002Co-Authors: Josef Coresh, Garabed Eknoyan, Andrew S LeveyAbstract:To the Editor: In the May issue of JASN , Clase et al . ([1][1]) report a much higher estimate of the prevalence of low glomerular Filtration Rate (GFR) than recently published in the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines, “
Lesley A Stevens - One of the best experts on this subject based on the ideXlab platform.
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a new equation to estimate glomerular Filtration Rate
Annals of Internal Medicine, 2009Co-Authors: Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul W Eggers, Frederick Van Lente, Tom GreeneAbstract:The Modification of Diet in Renal Disease (MDRD) Study equation underestimates glomerular Filtration Rate (GFR) in patients with mild kidney disease. Levey and associates therefore developed and va...
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serum cystatin c as a marker of glomerular Filtration Rate
Current Opinion in Nephrology and Hypertension, 2006Co-Authors: Magdalena Madero, Mark J Sarnak, Lesley A StevensAbstract:Purpose of reviewGlomerular Filtration Rate is widely accepted as the best overall measure of kidney function. Currently available methods to estimate glomerular Filtration Rate have strengths and limitations. Cystatin C is a novel endogenous Filtration marker being considered as a potential replace
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assessing kidney function measured and estimated glomerular Filtration Rate
The New England Journal of Medicine, 2006Co-Authors: Lesley A Stevens, Tom Greene, Josef Coresh, Andrew S LeveyAbstract:In the coming years, estimates of the glomerular Filtration Rate (GFR) may replace the measurement of serum creatinine as the primary tool for the assessment of kidney function. Indeed, many clinical laboratories already report estimated GFR values whenever serum creatinine is measured. This review considers current methods of measuring GFR and GFR-estimating equations and their strengths and weaknesses as applied to chronic kidney disease.
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clinical implications of estimating equations for glomerular Filtration Rate
Annals of Internal Medicine, 2004Co-Authors: Lesley A Stevens, Andrew S LeveyAbstract:Estimating equations that accuRately calculate glomerular Filtration Rate (GFR) in patients with chronic kidney disease and normal renal function are potentially important for early detection of di...
Andrew D Rule - One of the best experts on this subject based on the ideXlab platform.
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single nephron glomerular Filtration Rate in healthy adults
The New England Journal of Medicine, 2017Co-Authors: Aleksandar Denic, Richard J. Glassock, Jerry Mathew, Lilach O Lerman, John C Lieske, Joseph J Larson, Mariam P Alexander, Emilio D Poggio, Andrew D RuleAbstract:BackgroundThe glomerular Filtration Rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown. MethodsWe identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a computed tomographic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement of the GFR during donor evaluation and who underwent a kidney biopsy at donation. The mean single-nephron GFR was calculated as the GFR divided by the number of nephrons (calculated as the cortical volume of both kidneys as assessed on CT times the biopsy-determined glomerular density). Demographic and clinical characteristics and biopsy findings were correlated with the single-nephron GFR. ResultsA total of 58% of the donors were women, and the mean (±SD) age of the donors was 44±12 years. The mean GFR w...
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using serum creatinine to estimate glomerular Filtration Rate accuracy in good health and in chronic kidney disease
Annals of Internal Medicine, 2004Co-Authors: Andrew D Rule, Timothy S Larson, Erik J Bergstralh, Jeff Slezak, Steven J Jacobsen, Fernando G CosioAbstract:The Modification of Diet in Renal Disease equation for glomerular Filtration Rate (GFR) substantially underestimates GFR in healthy persons. A new equation developed with patients with chronic kidn...
Tom Greene - One of the best experts on this subject based on the ideXlab platform.
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Measured and estimated glomerular Filtration Rate: current status and future directions
Nature Reviews Nephrology, 2020Co-Authors: Andrew S Levey, Tom Greene, Josef Coresh, Hocine Tighiouart, Lesley A. InkerAbstract:Evaluation of glomerular Filtration Rate (GFR) is central to the assessment of kidney function in medical practice, research and public health. Measured GFR (mGFR) remains the reference standard, but the past 20 years have seen major advances in estimated GFR (eGFR). Both eGFR and mGFR are associated with error compared with true GFR. eGFR is now recommended by clinical practice guidelines, regulatory agencies and public health agencies for the initial evaluation of GFR, with measured GFR (mGFR) typically considered an important confirmatory test, depending on how accuRate the assessment of GFR needs to be for application to the clinical, research or public health setting. Our approach is to use initial and confirmatory tests as needed to develop a final assessment of true GFR. We suggest that GFR evaluation might be improved by more complete implementation of current recommendations and by further research to improve the accuracy of mGFR and eGFR. The authors of this Perspectives article describe the physiological and statistical principles underlying measured glomerular Filtration Rate (mGFR) and estimated glomerular Filtration Rate (eGFR). They discuss their limitations, the circumstances under which mGFR and eGFR should be used, and approaches to improve these methodologies.
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a new equation to estimate glomerular Filtration Rate
Annals of Internal Medicine, 2009Co-Authors: Andrew S Levey, Lesley A Stevens, Christopher H Schmid, Yaping Zhang, Alejandro F Castro, Harold I Feldman, John W Kusek, Paul W Eggers, Frederick Van Lente, Tom GreeneAbstract:The Modification of Diet in Renal Disease (MDRD) Study equation underestimates glomerular Filtration Rate (GFR) in patients with mild kidney disease. Levey and associates therefore developed and va...
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assessing kidney function measured and estimated glomerular Filtration Rate
The New England Journal of Medicine, 2006Co-Authors: Lesley A Stevens, Tom Greene, Josef Coresh, Andrew S LeveyAbstract:In the coming years, estimates of the glomerular Filtration Rate (GFR) may replace the measurement of serum creatinine as the primary tool for the assessment of kidney function. Indeed, many clinical laboratories already report estimated GFR values whenever serum creatinine is measured. This review considers current methods of measuring GFR and GFR-estimating equations and their strengths and weaknesses as applied to chronic kidney disease.
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a more accuRate method to estimate glomerular Filtration Rate from serum creatinine a new prediction equation
Annals of Internal Medicine, 1999Co-Authors: Andrew S Levey, Tom Greene, Juan P Bosch, Julia B Lewis, Nancy Rogers, David RothAbstract:The serum creatinine concentration is widely used as an index of renal function, but this measure is affected by factors other than the glomerular Filtration Rate (GFR). This study examined an equa...
Mark J Sarnak - One of the best experts on this subject based on the ideXlab platform.
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serum cystatin c as a marker of glomerular Filtration Rate
Current Opinion in Nephrology and Hypertension, 2006Co-Authors: Magdalena Madero, Mark J Sarnak, Lesley A StevensAbstract:Purpose of reviewGlomerular Filtration Rate is widely accepted as the best overall measure of kidney function. Currently available methods to estimate glomerular Filtration Rate have strengths and limitations. Cystatin C is a novel endogenous Filtration marker being considered as a potential replace
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prediction equations to estimate glomerular Filtration Rate an update
Current Opinion in Nephrology and Hypertension, 2001Co-Authors: Guruprasad Manjunath, Mark J Sarnak, Andrew S LeveyAbstract:: The level of glomerular Filtration Rate can be estimated from the serum creatinine concentration and other easily measured patient variables from prediction equations developed using multivariable regression techniques. Recently, a new equation has been developed from the Modification of Diet in Renal Disease study, which is more accuRate than other equations and more accuRate than measurement of creatinine clearance. The authors recommend using prediction equations in clinical practice to estimate the level of glomerular Filtration Rate.