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Jean-pierre Timmermans - One of the best experts on this subject based on the ideXlab platform.
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Johan Van Swieten, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Jean-pierre TimmermansAbstract:Alzheimer’s disease (AD) is characterized by deposition of -amyloid (A) in diffuse and senile plaques, and variably in vessels. Mutations in the A-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular A deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric A analyses, we demonstrated that in contrast to other familial AD cases with predominant brain A42, Flemish AD patients predominantly deposit A40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semithin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and A facilitate progressive A deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD. (Am J Pathol 2002, 161:507–520)
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Johan Van Swieten, Jean-pierre TimmermansAbstract:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular Abeta deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric Abeta analyses, we demonstrated that in contrast to other familial AD cases with predominant brain Abeta42, Flemish AD patients predominantly deposit Abeta40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semi-thin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and Abeta facilitate progressive Abeta deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD.
Karon F Cook - One of the best experts on this subject based on the ideXlab platform.
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the dutch Flemish promis physical function item bank exhibited strong psychometric properties in patients with chronic pain
Journal of Clinical Epidemiology, 2017Co-Authors: Martine H P Crins, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Caroline B Terwee, Thomas Klausch, Jaap Van LeeuwenAbstract:Abstract Objective The objective of this study was to assess the psychometric properties of the Dutch–Flemish Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function item bank in Dutch patients with chronic pain. Study Design and Setting A bank of 121 items was administered to 1,247 Dutch patients with chronic pain. Unidimensionality was assessed by fitting a one-factor confirmatory factor analysis and evaluating resulting fit statistics. Items were calibrated with the graded response model and its fit was evaluated. Cross-cultural validity was assessed by testing items for differential item functioning (DIF) based on language (Dutch vs. English). Construct validity was evaluated by calculation correlations between scores on the Dutch–Flemish PROMIS Physical Function measure and scores on generic and disease-specific measures. Results Results supported the Dutch–Flemish PROMIS Physical Function item bank's unidimensionality (Comparative Fit Index = 0.976, Tucker Lewis Index = 0.976) and model fit. Item thresholds targeted a wide range of physical function construct (threshold-parameters range: −4.2 to 5.6). Cross-cultural validity was good as four items only showed DIF for language and their impact on item scores was minimal. Physical Function scores were strongly associated with scores on all other measures (all correlations ≤ −0.60 as expected). Conclusion The Dutch–Flemish PROMIS Physical Function item bank exhibited good psychometric properties. Development of a computer adaptive test based on the large bank is warranted.
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validation of the dutch Flemish promis fatigue item bank in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, 2016Co-Authors: Martine H P Crins, Rene Westhovens, David Cella, Caroline B Terwee, D Van Schaardenburg, Nam Smits, J Joly, Patrick Verschueren, Kristien Van Der Elst, Karon F CookAbstract:Background In the assessment of patients with rheumatoid arthritis (RA) it is important to measure fatigue. The National Institutes of Health9s Patient-Reported Outcomes Measurement Information System (PROMIS) initiative developed an item bank for measuring fatigue. This item bank was translated into Dutch-Flemish language according to the FACIT methodology. Objectives The aim of current study was to validate the Dutch-Flemish translation of the PROMIS Fatigue item bank (DF-PROMIS-Fatigue) in Dutch and Flemish RA patients. This is the first validation study of the PROMIS Fatigue item bank in RA patients. Methods 2030 RA patients (1370 Dutch and 660 Flemish RA patients) completed a paper-and-pencil or web-based survey, including the full DF-PROMIS-Fatigue (95 items, 5-point Likert scale). One-factor confirmatory factor analysis assessed unidimensionality. Item response theory (IRT) models evaluated the item characteristics of the item bank, to facilitate future development of a computer adaptive test (CAT). A graded item response model (GRM) was fitted and construct validity was studied. Ordinal regression models evaluated Differential Item Functioning (DIF) for e.g. language (Dutch-Flemish vs. English and Dutch vs. Flemish), to analyse cross-cultural validity. Results The analyses support unidimensionality of the DF-PROMIS-Fatigue (CFI=0.996 and TLI=0.996). Only 45 out of 4465 (1%) item pairs were marked as possibly locally dependent. The data of the item bank fit the GRM, and showed good coverage across the fatigue continuum (threshold-parameters ranged from -3.8 to 5.8). The item bank showed good cross-cultural validity: none of the DF-PROMIS-Fatigue items showed DIF between Dutch and Flemish language. Furthermore, the item bank showed good reliability (Cronbach9s alpha=0.993). Analyses of construct validity are in progress and will be presented at the conference. Conclusions The results indicate that the items of the DF-PROMIS-Fatigue fit a GRM. The DF-PROMIS-Fatigue can be used to develop a CAT for measuring fatigue in Dutch and Flemish RA patients. Disclosure of Interest None declared
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calibration of the dutch Flemish promis pain behavior item bank in patients with chronic pain
European Journal of Pain, 2016Co-Authors: Martine H P Crins, L D Roorda, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Jaap Van Leeuwen, Maarten BoersAbstract:Background The aims of the current study were to calibrate the item parameters of the Dutch-Flemish PROMIS Pain Behavior item bank using a sample of Dutch patients with chronic pain and to evaluate cross-cultural validity between the Dutch-Flemish and the US PROMIS Pain Behavior item banks. Furthermore, reliability and construct validity of the Dutch-Flemish PROMIS Pain Behavior item bank were evaluated. Methods The 39 items in the bank were completed by 1042 Dutch patients with chronic pain. To evaluate unidimensionality, a one-factor confirmatory factor analysis (CFA) was performed. A graded response model (GRM) was used to calibrate the items. To evaluate cross-cultural validity, Differential item functioning (DIF) for language (Dutch vs. English) was evaluated. Reliability of the item bank was also examined and construct validity was studied using several legacy instruments, e.g. the Roland Morris Disability Questionnaire. Results CFA supported the unidimensionality of the Dutch-Flemish PROMIS Pain Behavior item bank (CFI = 0.960, TLI = 0.958), the data also fit the GRM, and demonstrated good coverage across the pain behavior construct (threshold parameters range: −3.42 to 3.54). Analysis showed good cross-cultural validity (only six DIF items), reliability (Cronbach's α = 0.95) and construct validity (all correlations ≥0.53). Conclusions The Dutch-Flemish PROMIS Pain Behavior item bank was found to have good cross-cultural validity, reliability and construct validity. The development of the Dutch-Flemish PROMIS Pain Behavior item bank will serve as the basis for Dutch-Flemish PROMIS short forms and computer adaptive testing (CAT).
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calibration and validation of the dutch Flemish promis pain interference item bank in patients with chronic pain
PLOS ONE, 2015Co-Authors: Martine H P Crins, L D Roorda, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Jaap Van Leeuwen, Maarten BoersAbstract:The Dutch-Flemish PROMIS Group translated the adult PROMIS Pain Interference item bank into Dutch-Flemish. The aims of the current study were to calibrate the parameters of these items using an item response theory (IRT) model, to evaluate the cross-cultural validity of the Dutch-Flemish translations compared to the original English items, and to evaluate their reliability and construct validity. The 40 items in the bank were completed by 1085 Dutch chronic pain patients. Before calibrating the items, IRT model assumptions were evaluated using confirmatory factor analysis (CFA). Items were calibrated using the graded response model (GRM), an IRT model appropriate for items with more than two response options. To evaluate cross-cultural validity, differential item functioning (DIF) for language (Dutch vs. English) was examined. Reliability was evaluated based on standard errors and Cronbach’s alpha. To evaluate construct validity correlations with scores on legacy instruments (e.g., the Disabilities of the Arm, Shoulder and Hand Questionnaire) were calculated. Unidimensionality of the Dutch-Flemish PROMIS Pain Interference item bank was supported by CFA tests of model fit (CFI = 0.986, TLI = 0.986). Furthermore, the data fit the GRM and showed good coverage across the pain interference continuum (threshold-parameters range: -3.04 to 3.44). The Dutch-Flemish PROMIS Pain Interference item bank has good cross-cultural validity (only two out of 40 items showing DIF), good reliability (Cronbach’s alpha = 0.98), and good construct validity (Pearson correlations between 0.62 and 0.75). A computer adaptive test (CAT) and Dutch-Flemish PROMIS short forms of the Dutch-Flemish PROMIS Pain Interference item bank can now be developed.
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thu0599 validation of the dutch Flemish promis pain behavior and pain interference item banks in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, 2015Co-Authors: Martine H P Crins, Niels Smits, Rene Westhovens, David Cella, Caroline B Terwee, D Van Schaardenburg, J Joly, Patrick Verschueren, Kristien Van Der Elst, Karon F CookAbstract:Background In the assessment of patients with rheumatoid arthritis (RA) it is important to measure pain behavior and pain interference. The National Institutes of Health9s Patient-Reported Outcomes Measurement Information System (PROMIS) initiative developed item banks for measuring pain behavior and pain interference. These PROMIS item banks were translated into Dutch-Flemish language according to the FACIT methodology. Objectives The aim of current study was to validate the Dutch-Flemish translation of the PROMIS Pain Behavior (DF-PROMIS-PB) and Pain Interference (DF-PROMIS-PI) item banks in Dutch and Flemish RA patients. Methods 826 Dutch and 618 Flemish RA patients completed a paper-and-pencil or web-based survey, including the full DF-PROMIS-PB (39 items, 6-point Likert scale) and DF-PROMIS-PI (40 items, 5-point Likert scale). One-factor confirmatory factor analysis assessed unidimensionality. Item response theory (IRT) models evaluated the item characteristics of the two item banks, to facilitate future development of computer adaptive tests (CAT). A graded item response model (GRM) was fitted and construct validity was studied. Ordinal regression models evaluated Differential Item Functioning (DIF) for e.g. language (Dutch-Flemish vs. English and Dutch vs. Flemish), to analyse cross-cultural validity. Results Current analyses support unidimensionality of the DF-PROMIS-PB and DF-PROMIS-PI (CFI=0.975;0.997 respectively and TLI=0.974;0.997 respectively). The first factor accounted for 49% (DF-PROMIS-PB) respectively 81% (DF-PROMIS-PI) of the questionnaire variance. Thirteen out of 741 (1.8%) DF-PROMIS-PB item pairs and 20 out of 780 (2.6%) DF-PROMIS-PI item pairs were marked as possibly locally dependent. The data of the two item banks fit the GRM, and showed good coverage across the pain behavior and pain interference continuum. Further analyses of the DF-PROMIS-PB and the DF-PROMIS-PI are in progress and will be presented at the conference. Conclusions The first results indicate that the items of the DF-PROMIS-PB and the DF-PROMIS-PI fit a GRM and demonstrate good coverage across the range of the pain behavior and pain interference domain. The interim conclusion is that the DF-PROMIS-PB and DF-PROMIS-PI can be used to develop a CAT for measuring pain behavior and pain interference in Dutch and Flemish RA patients. Disclosure of Interest None declared
Samir Kumarsingh - One of the best experts on this subject based on the ideXlab platform.
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Johan Van Swieten, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Jean-pierre TimmermansAbstract:Alzheimer’s disease (AD) is characterized by deposition of -amyloid (A) in diffuse and senile plaques, and variably in vessels. Mutations in the A-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular A deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric A analyses, we demonstrated that in contrast to other familial AD cases with predominant brain A42, Flemish AD patients predominantly deposit A40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semithin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and A facilitate progressive A deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD. (Am J Pathol 2002, 161:507–520)
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Johan Van Swieten, Jean-pierre TimmermansAbstract:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular Abeta deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric Abeta analyses, we demonstrated that in contrast to other familial AD cases with predominant brain Abeta42, Flemish AD patients predominantly deposit Abeta40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semi-thin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and Abeta facilitate progressive Abeta deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD.
Martine H P Crins - One of the best experts on this subject based on the ideXlab platform.
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the dutch Flemish promis physical function item bank exhibited strong psychometric properties in patients with chronic pain
Journal of Clinical Epidemiology, 2017Co-Authors: Martine H P Crins, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Caroline B Terwee, Thomas Klausch, Jaap Van LeeuwenAbstract:Abstract Objective The objective of this study was to assess the psychometric properties of the Dutch–Flemish Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function item bank in Dutch patients with chronic pain. Study Design and Setting A bank of 121 items was administered to 1,247 Dutch patients with chronic pain. Unidimensionality was assessed by fitting a one-factor confirmatory factor analysis and evaluating resulting fit statistics. Items were calibrated with the graded response model and its fit was evaluated. Cross-cultural validity was assessed by testing items for differential item functioning (DIF) based on language (Dutch vs. English). Construct validity was evaluated by calculation correlations between scores on the Dutch–Flemish PROMIS Physical Function measure and scores on generic and disease-specific measures. Results Results supported the Dutch–Flemish PROMIS Physical Function item bank's unidimensionality (Comparative Fit Index = 0.976, Tucker Lewis Index = 0.976) and model fit. Item thresholds targeted a wide range of physical function construct (threshold-parameters range: −4.2 to 5.6). Cross-cultural validity was good as four items only showed DIF for language and their impact on item scores was minimal. Physical Function scores were strongly associated with scores on all other measures (all correlations ≤ −0.60 as expected). Conclusion The Dutch–Flemish PROMIS Physical Function item bank exhibited good psychometric properties. Development of a computer adaptive test based on the large bank is warranted.
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validation of the dutch Flemish promis fatigue item bank in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, 2016Co-Authors: Martine H P Crins, Rene Westhovens, David Cella, Caroline B Terwee, D Van Schaardenburg, Nam Smits, J Joly, Patrick Verschueren, Kristien Van Der Elst, Karon F CookAbstract:Background In the assessment of patients with rheumatoid arthritis (RA) it is important to measure fatigue. The National Institutes of Health9s Patient-Reported Outcomes Measurement Information System (PROMIS) initiative developed an item bank for measuring fatigue. This item bank was translated into Dutch-Flemish language according to the FACIT methodology. Objectives The aim of current study was to validate the Dutch-Flemish translation of the PROMIS Fatigue item bank (DF-PROMIS-Fatigue) in Dutch and Flemish RA patients. This is the first validation study of the PROMIS Fatigue item bank in RA patients. Methods 2030 RA patients (1370 Dutch and 660 Flemish RA patients) completed a paper-and-pencil or web-based survey, including the full DF-PROMIS-Fatigue (95 items, 5-point Likert scale). One-factor confirmatory factor analysis assessed unidimensionality. Item response theory (IRT) models evaluated the item characteristics of the item bank, to facilitate future development of a computer adaptive test (CAT). A graded item response model (GRM) was fitted and construct validity was studied. Ordinal regression models evaluated Differential Item Functioning (DIF) for e.g. language (Dutch-Flemish vs. English and Dutch vs. Flemish), to analyse cross-cultural validity. Results The analyses support unidimensionality of the DF-PROMIS-Fatigue (CFI=0.996 and TLI=0.996). Only 45 out of 4465 (1%) item pairs were marked as possibly locally dependent. The data of the item bank fit the GRM, and showed good coverage across the fatigue continuum (threshold-parameters ranged from -3.8 to 5.8). The item bank showed good cross-cultural validity: none of the DF-PROMIS-Fatigue items showed DIF between Dutch and Flemish language. Furthermore, the item bank showed good reliability (Cronbach9s alpha=0.993). Analyses of construct validity are in progress and will be presented at the conference. Conclusions The results indicate that the items of the DF-PROMIS-Fatigue fit a GRM. The DF-PROMIS-Fatigue can be used to develop a CAT for measuring fatigue in Dutch and Flemish RA patients. Disclosure of Interest None declared
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calibration of the dutch Flemish promis pain behavior item bank in patients with chronic pain
European Journal of Pain, 2016Co-Authors: Martine H P Crins, L D Roorda, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Jaap Van Leeuwen, Maarten BoersAbstract:Background The aims of the current study were to calibrate the item parameters of the Dutch-Flemish PROMIS Pain Behavior item bank using a sample of Dutch patients with chronic pain and to evaluate cross-cultural validity between the Dutch-Flemish and the US PROMIS Pain Behavior item banks. Furthermore, reliability and construct validity of the Dutch-Flemish PROMIS Pain Behavior item bank were evaluated. Methods The 39 items in the bank were completed by 1042 Dutch patients with chronic pain. To evaluate unidimensionality, a one-factor confirmatory factor analysis (CFA) was performed. A graded response model (GRM) was used to calibrate the items. To evaluate cross-cultural validity, Differential item functioning (DIF) for language (Dutch vs. English) was evaluated. Reliability of the item bank was also examined and construct validity was studied using several legacy instruments, e.g. the Roland Morris Disability Questionnaire. Results CFA supported the unidimensionality of the Dutch-Flemish PROMIS Pain Behavior item bank (CFI = 0.960, TLI = 0.958), the data also fit the GRM, and demonstrated good coverage across the pain behavior construct (threshold parameters range: −3.42 to 3.54). Analysis showed good cross-cultural validity (only six DIF items), reliability (Cronbach's α = 0.95) and construct validity (all correlations ≥0.53). Conclusions The Dutch-Flemish PROMIS Pain Behavior item bank was found to have good cross-cultural validity, reliability and construct validity. The development of the Dutch-Flemish PROMIS Pain Behavior item bank will serve as the basis for Dutch-Flemish PROMIS short forms and computer adaptive testing (CAT).
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calibration and validation of the dutch Flemish promis pain interference item bank in patients with chronic pain
PLOS ONE, 2015Co-Authors: Martine H P Crins, L D Roorda, Niels Smits, Henrica C W De Vet, Rene Westhovens, David Cella, Karon F Cook, Dennis A Revicki, Jaap Van Leeuwen, Maarten BoersAbstract:The Dutch-Flemish PROMIS Group translated the adult PROMIS Pain Interference item bank into Dutch-Flemish. The aims of the current study were to calibrate the parameters of these items using an item response theory (IRT) model, to evaluate the cross-cultural validity of the Dutch-Flemish translations compared to the original English items, and to evaluate their reliability and construct validity. The 40 items in the bank were completed by 1085 Dutch chronic pain patients. Before calibrating the items, IRT model assumptions were evaluated using confirmatory factor analysis (CFA). Items were calibrated using the graded response model (GRM), an IRT model appropriate for items with more than two response options. To evaluate cross-cultural validity, differential item functioning (DIF) for language (Dutch vs. English) was examined. Reliability was evaluated based on standard errors and Cronbach’s alpha. To evaluate construct validity correlations with scores on legacy instruments (e.g., the Disabilities of the Arm, Shoulder and Hand Questionnaire) were calculated. Unidimensionality of the Dutch-Flemish PROMIS Pain Interference item bank was supported by CFA tests of model fit (CFI = 0.986, TLI = 0.986). Furthermore, the data fit the GRM and showed good coverage across the pain interference continuum (threshold-parameters range: -3.04 to 3.44). The Dutch-Flemish PROMIS Pain Interference item bank has good cross-cultural validity (only two out of 40 items showing DIF), good reliability (Cronbach’s alpha = 0.98), and good construct validity (Pearson correlations between 0.62 and 0.75). A computer adaptive test (CAT) and Dutch-Flemish PROMIS short forms of the Dutch-Flemish PROMIS Pain Interference item bank can now be developed.
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thu0599 validation of the dutch Flemish promis pain behavior and pain interference item banks in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, 2015Co-Authors: Martine H P Crins, Niels Smits, Rene Westhovens, David Cella, Caroline B Terwee, D Van Schaardenburg, J Joly, Patrick Verschueren, Kristien Van Der Elst, Karon F CookAbstract:Background In the assessment of patients with rheumatoid arthritis (RA) it is important to measure pain behavior and pain interference. The National Institutes of Health9s Patient-Reported Outcomes Measurement Information System (PROMIS) initiative developed item banks for measuring pain behavior and pain interference. These PROMIS item banks were translated into Dutch-Flemish language according to the FACIT methodology. Objectives The aim of current study was to validate the Dutch-Flemish translation of the PROMIS Pain Behavior (DF-PROMIS-PB) and Pain Interference (DF-PROMIS-PI) item banks in Dutch and Flemish RA patients. Methods 826 Dutch and 618 Flemish RA patients completed a paper-and-pencil or web-based survey, including the full DF-PROMIS-PB (39 items, 6-point Likert scale) and DF-PROMIS-PI (40 items, 5-point Likert scale). One-factor confirmatory factor analysis assessed unidimensionality. Item response theory (IRT) models evaluated the item characteristics of the two item banks, to facilitate future development of computer adaptive tests (CAT). A graded item response model (GRM) was fitted and construct validity was studied. Ordinal regression models evaluated Differential Item Functioning (DIF) for e.g. language (Dutch-Flemish vs. English and Dutch vs. Flemish), to analyse cross-cultural validity. Results Current analyses support unidimensionality of the DF-PROMIS-PB and DF-PROMIS-PI (CFI=0.975;0.997 respectively and TLI=0.974;0.997 respectively). The first factor accounted for 49% (DF-PROMIS-PB) respectively 81% (DF-PROMIS-PI) of the questionnaire variance. Thirteen out of 741 (1.8%) DF-PROMIS-PB item pairs and 20 out of 780 (2.6%) DF-PROMIS-PI item pairs were marked as possibly locally dependent. The data of the two item banks fit the GRM, and showed good coverage across the pain behavior and pain interference continuum. Further analyses of the DF-PROMIS-PB and the DF-PROMIS-PI are in progress and will be presented at the conference. Conclusions The first results indicate that the items of the DF-PROMIS-PB and the DF-PROMIS-PI fit a GRM and demonstrate good coverage across the range of the pain behavior and pain interference domain. The interim conclusion is that the DF-PROMIS-PB and DF-PROMIS-PI can be used to develop a CAT for measuring pain behavior and pain interference in Dutch and Flemish RA patients. Disclosure of Interest None declared
Johan M. Kros - One of the best experts on this subject based on the ideXlab platform.
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Johan Van Swieten, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Jean-pierre TimmermansAbstract:Alzheimer’s disease (AD) is characterized by deposition of -amyloid (A) in diffuse and senile plaques, and variably in vessels. Mutations in the A-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular A deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric A analyses, we demonstrated that in contrast to other familial AD cases with predominant brain A42, Flemish AD patients predominantly deposit A40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semithin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and A facilitate progressive A deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD. (Am J Pathol 2002, 161:507–520)
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dense core senile plaques in the Flemish variant of alzheimer s disease are vasocentric
American Journal of Pathology, 2002Co-Authors: Samir Kumarsingh, Ursula Lubke, Sally Serneels, Kristl Vennekens, Johan M. Kros, Rong Wang, Patrick Cras, Chantal Ceuterick, Johan Van Swieten, Jean-pierre TimmermansAbstract:Alzheimer's disease (AD) is characterized by deposition of beta-amyloid (Abeta) in diffuse and senile plaques, and variably in vessels. Mutations in the Abeta-encoding region of the amyloid precursor protein (APP) gene are frequently associated with very severe forms of vascular Abeta deposition, sometimes also accompanied by AD pathology. We earlier described a Flemish APP (A692G) mutation causing a form of early-onset AD with a prominent cerebral amyloid angiopathy and unusually large senile plaque cores. The pathogenic basis of Flemish AD is unknown. By image and mass spectrometric Abeta analyses, we demonstrated that in contrast to other familial AD cases with predominant brain Abeta42, Flemish AD patients predominantly deposit Abeta40. On serial histological section analysis we further showed that the neuritic senile plaques in APP692 brains were centered on vessels. Of a total of 2400 senile plaque cores studied from various brain regions from three patients, 68% enclosed a vessel, whereas the remainder were associated with vascular walls. These observations were confirmed by electron microscopy coupled with examination of serial semi-thin plastic sections, as well as three-dimensional observations by confocal microscopy. Diffuse plaques did not associate with vessels, or with neuritic or inflammatory pathology. Together with earlier in vitro data on APP692, our analyses suggest that the altered biological properties of the Flemish APP and Abeta facilitate progressive Abeta deposition in vascular walls that in addition to causing strokes, initiates formation of dense-core senile plaques in the Flemish variant of AD.
