The Experts below are selected from a list of 60 Experts worldwide ranked by ideXlab platform

Margaret L Bauman - One of the best experts on this subject based on the ideXlab platform.

  • regional alterations in purkinje cell density in patients with autism
    PLOS ONE, 2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Katelyn Gail Enzer, Thomas L Kemper, Margaret L Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV–VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p<0.05). Lobule X demonstrated a trend towards lower PC density in only the males with autism (p = 0.05). Brain weight, a correlate of tissue volume, was found to significantly contribute to the lower lobule X PC density observed in males with autism, but not to the finding of lower PC density in crus I & II. Therefore, lower crus I & II PC density in autism is more likely due to a lower number of PCs. The PC density in lobule X was found to correlate with the ADI-R measure of the patient's use of social eye contact (R2 = −0.75, p = 0.012). These findings support the hypothesis that abnormal PC density may contribute to selected clinical features of the autism phenotype.

Birgitte Bo Andersen - One of the best experts on this subject based on the ideXlab platform.

  • reduction of purkinje cell volume in cerebellum of alcoholics
    Brain Research, 2004
    Co-Authors: Birgitte Bo Andersen
    Abstract:

    It is generally believed that chronic alcohol consumption results in cerebellar atrophy and Purkinje cell loss, especially in the anterior vermal region. A post-mortem stereological design was applied to cerebella from 10 chronic male alcoholics (mean age 45.5 years) with a minimum of 10 years of severe addiction and 10 male controls (mean age 42.5 years). All alcoholics had pathoanatomical evidence of alcohol abuse but no clinical signs of Wernicke's encephalopathy. Cerebellum was divided into five different areas: the anterior and posterior Lobe, the anterior and posterior vermis, and the Flocculonodular Lobe. The total cortex and white matter volume, the cerebellar surface area, the total Purkinje and granule cell number and density, and the mean volume of Purkinje cells and their cell nuclei were measured in all five regions using stereological methods. The volume of the granular layer was increased by 13% with an increase in layer thickness by 17% possibly due to oedema. Globally, the mean volume of the Purkinje cell perikaryon was decreased by 24% with a decrease in the volume of Purkinje cell nuclei by 16%. The increase of the granular layer and the decrease of Purkinje cell size resulted in a 21% global reduction of Purkinje cell density without a concomitant loss of neurons. No significant regional or global cortical and white matter atrophy was found in cerebella from alcoholics compared to controls.

Jerry Skefos - One of the best experts on this subject based on the ideXlab platform.

  • regional alterations in purkinje cell density in patients with autism
    PLOS ONE, 2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Katelyn Gail Enzer, Thomas L Kemper, Margaret L Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV–VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p<0.05). Lobule X demonstrated a trend towards lower PC density in only the males with autism (p = 0.05). Brain weight, a correlate of tissue volume, was found to significantly contribute to the lower lobule X PC density observed in males with autism, but not to the finding of lower PC density in crus I & II. Therefore, lower crus I & II PC density in autism is more likely due to a lower number of PCs. The PC density in lobule X was found to correlate with the ADI-R measure of the patient's use of social eye contact (R2 = −0.75, p = 0.012). These findings support the hypothesis that abnormal PC density may contribute to selected clinical features of the autism phenotype.

  • Cerebellar Regions Investigated.
    2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    This flatmap diagram displays the four cerebellar regions of interest for our stereological assay. Hemispheric lobules IV–VI (in yellow) are bordered by the preculminate and superior posterior fissures, lateral to the fourth ventricle. Crus I (in blue) is the region bordered by the superior posterior and horizontal fissures. Crus II (in green) is bordered by the horizontal and ansoparamedian fissures. Lobule X, the Flocculonodular Lobe (in orange), is bordered by the posterolateral fissure. This image is an adaptation of the diagram by Larsell, 1958 [80].

  • Regional alterations in purkinje cell density in patients with autism.
    Public Library of Science (PLoS), 2026
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV-VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p

Jarrod Holiday - One of the best experts on this subject based on the ideXlab platform.

  • regional alterations in purkinje cell density in patients with autism
    PLOS ONE, 2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Katelyn Gail Enzer, Thomas L Kemper, Margaret L Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV–VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p<0.05). Lobule X demonstrated a trend towards lower PC density in only the males with autism (p = 0.05). Brain weight, a correlate of tissue volume, was found to significantly contribute to the lower lobule X PC density observed in males with autism, but not to the finding of lower PC density in crus I & II. Therefore, lower crus I & II PC density in autism is more likely due to a lower number of PCs. The PC density in lobule X was found to correlate with the ADI-R measure of the patient's use of social eye contact (R2 = −0.75, p = 0.012). These findings support the hypothesis that abnormal PC density may contribute to selected clinical features of the autism phenotype.

  • Cerebellar Regions Investigated.
    2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    This flatmap diagram displays the four cerebellar regions of interest for our stereological assay. Hemispheric lobules IV–VI (in yellow) are bordered by the preculminate and superior posterior fissures, lateral to the fourth ventricle. Crus I (in blue) is the region bordered by the superior posterior and horizontal fissures. Crus II (in green) is bordered by the horizontal and ansoparamedian fissures. Lobule X, the Flocculonodular Lobe (in orange), is bordered by the posterolateral fissure. This image is an adaptation of the diagram by Larsell, 1958 [80].

  • Regional alterations in purkinje cell density in patients with autism.
    Public Library of Science (PLoS), 2026
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV-VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p

Tarik Yuce - One of the best experts on this subject based on the ideXlab platform.

  • regional alterations in purkinje cell density in patients with autism
    PLOS ONE, 2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Katelyn Gail Enzer, Thomas L Kemper, Margaret L Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV–VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p<0.05). Lobule X demonstrated a trend towards lower PC density in only the males with autism (p = 0.05). Brain weight, a correlate of tissue volume, was found to significantly contribute to the lower lobule X PC density observed in males with autism, but not to the finding of lower PC density in crus I & II. Therefore, lower crus I & II PC density in autism is more likely due to a lower number of PCs. The PC density in lobule X was found to correlate with the ADI-R measure of the patient's use of social eye contact (R2 = −0.75, p = 0.012). These findings support the hypothesis that abnormal PC density may contribute to selected clinical features of the autism phenotype.

  • Cerebellar Regions Investigated.
    2014
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    This flatmap diagram displays the four cerebellar regions of interest for our stereological assay. Hemispheric lobules IV–VI (in yellow) are bordered by the preculminate and superior posterior fissures, lateral to the fourth ventricle. Crus I (in blue) is the region bordered by the superior posterior and horizontal fissures. Crus II (in green) is bordered by the horizontal and ansoparamedian fissures. Lobule X, the Flocculonodular Lobe (in orange), is bordered by the posterolateral fissure. This image is an adaptation of the diagram by Larsell, 1958 [80].

  • Regional alterations in purkinje cell density in patients with autism.
    Public Library of Science (PLoS), 2026
    Co-Authors: Jerry Skefos, Christopher Cummings, Katelyn Enzer, Jarrod Holiday, Katrina Weed, Ezra Levy, Tarik Yuce, Thomas Kemper, Margaret Bauman
    Abstract:

    Neuropathological studies, using a variety of techniques, have reported a decrease in Purkinje cell (PC) density in the cerebellum in autism. We have used a systematic sampling technique that significantly reduces experimenter bias and variance to estimate PC densities in the postmortem brains of eight clinically well-documented individuals with autism, and eight age- and gender-matched controls. Four cerebellar regions were analyzed: a sensorimotor area comprised of hemispheric lobules IV-VI, crus I & II of the posterior Lobe, and lobule X of the Flocculonodular Lobe. Overall PC density was thus estimated using data from all three cerebellar Lobes and was found to be lower in the cases with autism as compared to controls, an effect that was most prominent in crus I and II (p