The Experts below are selected from a list of 21636 Experts worldwide ranked by ideXlab platform

Julien Dinkel - One of the best experts on this subject based on the ideXlab platform.

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Michael Ingrisch, Olaf Dietrich, Julien Dinkel
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Julien Dinkel, Michael Ingrisch, Olaf Dietrich
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

Thomas Gaass - One of the best experts on this subject based on the ideXlab platform.

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Michael Ingrisch, Olaf Dietrich, Julien Dinkel
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Julien Dinkel, Michael Ingrisch, Olaf Dietrich
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

Michael Ingrisch - One of the best experts on this subject based on the ideXlab platform.

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Michael Ingrisch, Olaf Dietrich, Julien Dinkel
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Julien Dinkel, Michael Ingrisch, Olaf Dietrich
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

Moritz Schneider - One of the best experts on this subject based on the ideXlab platform.

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Michael Ingrisch, Olaf Dietrich, Julien Dinkel
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Julien Dinkel, Michael Ingrisch, Olaf Dietrich
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

Olaf Dietrich - One of the best experts on this subject based on the ideXlab platform.

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Michael Ingrisch, Olaf Dietrich, Julien Dinkel
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine

  • technical note quantitative dynamic contrast enhanced mri of a 3 dimensional artificial capillary network
    Medical Physics, 2017
    Co-Authors: Thomas Gaass, Moritz Schneider, Julien Dinkel, Michael Ingrisch, Olaf Dietrich
    Abstract:

    Purpose: Variability across devices, patients, and time still hinders widespread recognition of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as quantitative biomarker. The purpose of this work was to introduce and characterize a dedicated microchannel phantom as a model for quantitative DCE-MRI measurements. Methods: A perfusable, MR-compatible microchannel network was constructed on the basis of sacrificial melt-spun sugar fibers embedded in a block of epoxy resin. Structural analysis was performed on the basis of light microscopy images before DCE-MRI experiments. During dynamic acquisition the capillary network was perfused with a standard contrast agent injection system. Flow-Dependency, as well as inter- and intrascanner reproducibility of the computed DCE parameters were evaluated using a 3.0T whole-body MRI. Results: Semi-quantitative and quantitative Flow-related parameters exhibited the expected proportionality to the set Flow rate (mean Pearson correlation coefficient: 0.991, P<2.5e-5). The volume fraction was approximately independent from changes of the applied Flow rate through the phantom. Repeatability and reproducibility experiments yielded maximum intrascanner coefficients of variation (CV) of 4.6% for quantitative parameters. All evaluated parameters were well in the range of known invivo results for the applied Flow rates. Conclusion: The constructed phantom enables reproducible, Flow-dependent, contrast-enhanced MR measurements with the potential to facilitate standardization and comparability of DCE-MRI examinations. (C) 2017 American Association of Physicists in Medicine