The Experts below are selected from a list of 105636 Experts worldwide ranked by ideXlab platform
Tomonori Segawa - One of the best experts on this subject based on the ideXlab platform.
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prevention of no reFlow slow Flow Phenomenon during rotational atherectomy a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil
American Heart Journal, 2007Co-Authors: Hitoshi Matsuo, Sachiro Watanabe, Takatomo Watanabe, Shunichiro Warita, Tai Kojima, Takeshi Hirose, Makoto Iwama, Koji Ono, Haruki Takahashi, Tomonori SegawaAbstract:Background The potential exists for microcirculatory impairment during rotational coronary atherectomy (RA) due to embolization of plaque debris, platelet aggregation, or vasospasm. This prospective randomized pilot study aimed to confirm favorable effects of nicorandil during RA compared with verapamil. Methods We randomly assigned 200 patients with 219 coronary lesions planned to undergo RA with intracoronary infusion of nicorandil cocktail (100 patients, 109 lesions), which contained nicorandil 24 mg, nitroglycerin 5 mg, and heparin 10000 U in 1000 mL saline, or verapamil cocktail (100 patients, 110 lesions), which contained verapamil 10 mg instead of nicorandil. Drug cocktails were infused through a 4F Teflon sheath of the rotablator system during RA. The primary end point was incidence of no-reFlow/slow-Flow Phenomenon; secondary end points were those of continuous ST elevation, Q-wave myocardial infarction (MI), and non–Q-wave MI. Results Group baseline and coronary angiographic characteristics were similar. Rotational atherectomy was performed successfully, and no patients died or required emergency coronary artery bypass grafting. Incidence of no-reFlow/slow-Flow Phenomenon was significantly lower in the nicorandil group (nicorandil 5/109 lesions, verapamil 13/110 lesions, P P P Conclusion Our findings suggest that continuous intracoronary infusion of nicorandil during RA prevents acute periprocedural complications. Nicorandil should be used as adjunctive treatment during RA.
Satoru Iwasaki - One of the best experts on this subject based on the ideXlab platform.
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Magnetic resonance plaque imaging to predict the occurrence of the slow-Flow Phenomenon in carotid artery stenting procedures
Neuroradiology, 2010Co-Authors: Masahiko Sakamoto, Toshiaki Taoka, Hiroyuki Nakagawa, Katsutoshi Takayama, Takeshi Wada, Kaoru Myouchin, Toshiaki Akashi, Toshiteru Miyasaka, Akio Fukusumi, Satoru IwasakiAbstract:Introduction The purpose is to investigate the feasibility of magnetic resonance (MR) plaque imaging in predicting the arterial Flow impairment (slow-Flow Phenomenon) during carotid artery stenting (CAS) using a filter-type protection device. Methods Thirty-one carotid artery stenotic lesions in 30 patients (28 men and two women; mean age, 71.8 years) were evaluated by MR plaque imaging with black blood T1- and T2-weighted and time-of-flight sequences before CAS. Main plaque components were classified as vulnerable (intraplaque hemorrhage and lipid-rich/necrotic core) or stable (fibrous tissue and dense calcification) from the signal pattern. The plaque classification was statistically compared with the occurrence of slow-Flow Phenomenon. Results The slow-Flow Phenomenon was observed in ten CAS procedures (five Flow arrests and five Flow reductions). Flow arrests consisted of four vulnerable and one stable plaque, and Flow reductions consisted of four vulnerable and one stable plaque. The slow-Flow Phenomenon occurred significantly ( P
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Magnetic resonance plaque imaging to predict the occurrence of the slow-Flow Phenomenon in carotid artery stenting procedures
Neuroradiology, 2009Co-Authors: Masahiko Sakamoto, Toshiaki Taoka, Hiroyuki Nakagawa, Katsutoshi Takayama, Takeshi Wada, Kaoru Myouchin, Toshiaki Akashi, Toshiteru Miyasaka, Akio Fukusumi, Satoru IwasakiAbstract:Introduction The purpose is to investigate the feasibility of magnetic resonance (MR) plaque imaging in predicting the arterial Flow impairment (slow-Flow Phenomenon) during carotid artery stenting (CAS) using a filter-type protection device.
Khosrow Hosseini - One of the best experts on this subject based on the ideXlab platform.
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Computational investigation on the effects of rib on the slug Flow Phenomenon; using OpenFOAM
International Journal of Modern Physics C, 2019Co-Authors: Behrouz Aghebatie, Khosrow HosseiniAbstract:Slug Flow is a two-phase fluid Flow pattern, characterized by a series of liquid slugs dispersed by relatively large air bubbles. Air bubbles produced and trapped during the slug Flow Phenomenon conduct to interruption in Flow which induces pressure and velocity fluctuations. These effects have destructive circumstances in conduits and conveyance structures. This paper deals with studying numerically two-phase Flows using computational fluid dynamic (CFD) techniques performed in OpenFOAM (an open source software) by interFoam solver. Most of the previous concerning studies on slug Flow were performed in micro-channels with small scales in which the expansion of the air bubbles was negligible. By contrast, we investigated the systems with large pressure drops which conduct to abrupt increases on the volume of air phase. The slug Flow Phenomenon could be created by introducing air and water with different velocities at inlet of a culvert with air to water velocity ratio varied from 1.1 to 34. First, this study focused on temporal and spatial variations of pressure and velocity along the culvert. After that, by dimensional analysis, the nondimensional parameters influencing the slug Flow Phenomenon are extracted and analyzed. Finally, different strategies for reducing the destructive effects of slug Flow, including the shape and location of ribs, are evaluated and the best strategy is proposed.
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Computational investigation on the effects of rib on the slug Flow Phenomenon; using OpenFOAM
International Journal of Modern Physics C, 2019Co-Authors: Behrouz Aghebatie, Khosrow HosseiniAbstract:Slug Flow is a two-phase fluid Flow pattern, characterized by a series of liquid slugs dispersed by relatively large air bubbles. Air bubbles produced and trapped during the slug Flow Phenomenon co...
Massimo Fineschi - One of the best experts on this subject based on the ideXlab platform.
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The coronary slow Flow Phenomenon: A new cardiac “Y” syndrome?
Clinical Hemorheology and Microcirculation, 2008Co-Authors: Maria Cristina Leone, Tommaso Gori, Massimo FineschiAbstract:The coronary slow Flow Phenomenon (CSFP) is an angiographic finding that is characterised by delayed progression of the contrast medium during coronary angiography. The mechanism of this Phenomenon remains unknown. In the present paper, we revise the current evidence regarding this Phenomenon and discuss recent findings from our group reporting increased resting resistances in patients with the CSFP. We report that these patients had preserved blood Flow responses to the intracoronary infusion of the vasodilator papaverine, demonstrating that the CSFP is not necessarily associated with an abnormal coronary Flow reserve. Based on these findings and on the review of the current literature, we concur with the concept proposed by Beltrame et al. that the CSFP should be considered a separate clinical entity. Further studies are necessary to describe the clinical characteristics, including the prognosis, of these patients and to identify potential treatments.
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the coronary slow Flow Phenomenon a new cardiac y syndrome
Clinical Hemorheology and Microcirculation, 2008Co-Authors: Maria Cristina Leone, Tommaso Gori, Massimo FineschiAbstract:The coronary slow Flow Phenomenon (CSFP) is an angiographic finding that is characterised by delayed progression of the contrast medium during coronary angiography. The mechanism of this Phenomenon remains unknown. In the present paper, we revise the current evidence regarding this Phenomenon and discuss recent findings from our group reporting increased resting resistances in patients with the CSFP. We report that these patients had preserved blood Flow responses to the intracoronary infusion of the vasodilator papaverine, demonstrating that the CSFP is not necessarily associated with an abnormal coronary Flow reserve. Based on these findings and on the review of the current literature, we concur with the concept proposed by Beltrame et al. that the CSFP should be considered a separate clinical entity. Further studies are necessary to describe the clinical characteristics, including the prognosis, of these patients and to identify potential treatments.
Hitoshi Matsuo - One of the best experts on this subject based on the ideXlab platform.
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prevention of no reFlow slow Flow Phenomenon during rotational atherectomy a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil
American Heart Journal, 2007Co-Authors: Hitoshi Matsuo, Sachiro Watanabe, Takatomo Watanabe, Shunichiro Warita, Tai Kojima, Takeshi Hirose, Makoto Iwama, Koji Ono, Haruki Takahashi, Tomonori SegawaAbstract:Background The potential exists for microcirculatory impairment during rotational coronary atherectomy (RA) due to embolization of plaque debris, platelet aggregation, or vasospasm. This prospective randomized pilot study aimed to confirm favorable effects of nicorandil during RA compared with verapamil. Methods We randomly assigned 200 patients with 219 coronary lesions planned to undergo RA with intracoronary infusion of nicorandil cocktail (100 patients, 109 lesions), which contained nicorandil 24 mg, nitroglycerin 5 mg, and heparin 10000 U in 1000 mL saline, or verapamil cocktail (100 patients, 110 lesions), which contained verapamil 10 mg instead of nicorandil. Drug cocktails were infused through a 4F Teflon sheath of the rotablator system during RA. The primary end point was incidence of no-reFlow/slow-Flow Phenomenon; secondary end points were those of continuous ST elevation, Q-wave myocardial infarction (MI), and non–Q-wave MI. Results Group baseline and coronary angiographic characteristics were similar. Rotational atherectomy was performed successfully, and no patients died or required emergency coronary artery bypass grafting. Incidence of no-reFlow/slow-Flow Phenomenon was significantly lower in the nicorandil group (nicorandil 5/109 lesions, verapamil 13/110 lesions, P P P Conclusion Our findings suggest that continuous intracoronary infusion of nicorandil during RA prevents acute periprocedural complications. Nicorandil should be used as adjunctive treatment during RA.