The Experts below are selected from a list of 14913 Experts worldwide ranked by ideXlab platform
Yanis Boumber - One of the best experts on this subject based on the ideXlab platform.
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an improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion
BMC Cancer, 2019Co-Authors: Alexander Y Deneka, Louis F Chai, Colin Kanach, Tim N. Beck, Priya Johal, Yanis Boumber, Nicolas J AlvarezAbstract:Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a Foam delivery system designed to more effectively coat the pleural cavity. C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) Control, Foam Control (F), talc slurry (TS, 2 mg/g) or talc Foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined. The TF group had significantly better survival than the TS group (21 vs 13.5 days, p 0.05). This report describes using a novel talc Foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc Foam from animal models into clinical trials.
Tim N. Beck - One of the best experts on this subject based on the ideXlab platform.
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an improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion
BMC Cancer, 2019Co-Authors: Alexander Y Deneka, Louis F Chai, Colin Kanach, Tim N. Beck, Priya Johal, Yanis Boumber, Nicolas J AlvarezAbstract:Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a Foam delivery system designed to more effectively coat the pleural cavity. C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) Control, Foam Control (F), talc slurry (TS, 2 mg/g) or talc Foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined. The TF group had significantly better survival than the TS group (21 vs 13.5 days, p 0.05). This report describes using a novel talc Foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc Foam from animal models into clinical trials.
Alexander Y Deneka - One of the best experts on this subject based on the ideXlab platform.
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an improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion
BMC Cancer, 2019Co-Authors: Alexander Y Deneka, Louis F Chai, Colin Kanach, Tim N. Beck, Priya Johal, Yanis Boumber, Nicolas J AlvarezAbstract:Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a Foam delivery system designed to more effectively coat the pleural cavity. C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) Control, Foam Control (F), talc slurry (TS, 2 mg/g) or talc Foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined. The TF group had significantly better survival than the TS group (21 vs 13.5 days, p 0.05). This report describes using a novel talc Foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc Foam from animal models into clinical trials.
Xuwei Long - One of the best experts on this subject based on the ideXlab platform.
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recent progress towards industrial rhamnolipids fermentation process optimization and Foam Control
Bioresource Technology, 2020Co-Authors: Jingjing Jiang, Qin Meng, Xuwei LongAbstract:The global market for rhamnolipids production holds great promise, and is in need of an economically viable mass-production scheme. Accordingly, several strategies have been employed to improve the efficiency of rhamnolipid production in the past few decades. Currently, rhamnolipids can be produced by Pseudomonas aeruginosa at a high yield (over 70 g/L) when vegetable oil is used as the carbon source under optimized fed-batch cultivations. However, severe Foaming during rhamnolipid fermentation inhibits scaling-up and production efficiency. Stop valve was found to effective break the extremely stable rhamnolipids Foams during fermentation, and production efficiency of rhamnolipids was highly improved, while its scale-up mechanism needs further study. In addition, the combination of both chemical and mechanical approaches is likely to be more efficiently resolving the Foam problem existed in rhamnolipids fermentation than either chemical or mechanical methods alone.
Slavka Tcholakova - One of the best experts on this subject based on the ideXlab platform.
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mechanistic understanding of the modes of action of Foam Control agents
Advances in Colloid and Interface Science, 2014Co-Authors: Nikolai D. Denkov, Krastanka G. Marinova, Slavka TcholakovaAbstract:In this paper we present briefly our current understanding of the modes of action of Foam Control agents (often termed "deFoamers" or "antiFoams"). After summarizing the background knowledge, reviewed in previous articles, the focus of the presentation is shifted to the antiFoam studies from the last decade. The new experimental results, obtained by various research groups, are reviewed briefly to reveal the main mechanisms of antiFoam action and the related key factors, governing the efficiency of the Foam Control agents. The role of the entry, spreading and bridging coefficients, of the entry barrier of the antiFoam entities, and of the dynamics of surfactant adsorption is specifically discussed.
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model studies of the effect of silica hydrophobicity on the efficiency of mixed oil silica antiFoams
Langmuir, 2002Co-Authors: Krastanka G. Marinova, Slavka Tcholakova, Nikolai D. Denkov, Martial DeruelleAbstract:Mixtures of poly(dimethylsiloxane) oil and hydrophobized silica are used for Foam Control and are termed antiFoam compounds or mixed oil−silica antiFoams. In a previous study, we found experimentally a well-pronounced maximum in the antiFoam efficiency at a certain optimal silica hydrophobicity. The reasons for this peculiar dependence are studied in the present paper by performing two series of experiments. First, compounds of silica and oil are prepared under different conditions (with and without heating and/or stirring) and the antiFoam efficiency of these compounds is compared by Foam tests. Second, several characteristics of the studied compounds, such as viscosity, entry barrier, and thickness of the layer of spreading oil, are measured, and their contribution to the compound performance is analyzed. The results show that the optimal hydrophobicity of the silica particles is related to a minimum in the entry barrier (measured by the film trapping technique), which determines how easily the compound...