The Experts below are selected from a list of 16101 Experts worldwide ranked by ideXlab platform
Lourdes Ibáñez - One of the best experts on this subject based on the ideXlab platform.
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Body Composition and Circulating High-Molecular- Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age Breast- Versus Formula-Feeding
2016Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sánchez-infantes, Abel Lopez-bermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mecha-nisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutri-tion. Compared with AGA-BRF infants, SGA-BRF infants had nor
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breast Feeding vs Formula Feeding for infants born small for gestational age divergent effects on fat mass and on circulating igf i and high molecular weight adiponectin in late infancy
The Journal of Clinical Endocrinology and Metabolism, 2013Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, Abel Lopezbermejo, Maria Dolores Gomezroig, Lourdes IbáñezAbstract:Context: Fetal growth restraint, if followed by rapid weight gain, confers risk for adult disease including diabetes. How breast-Feeding may lower such risk is poorly understood. Objective, Study Participants, Intervention, Outcomes: In infants born small-for-gestational-age (SGA), we studied the effects of nutrition in early infancy (breast-Feeding vs Formula-Feeding; BRF vs FOF) on weight partitioning and endocrine markers in late infancy. Body composition (by absorptiometry), fasting glycemia, insulin, IGF-I, and high-molecular-weight (HMW) adiponectin were assessed at 4 and 12 months in BRF controls born appropriate-for-GA (N = 31) and in SGA infants receiving BRF (N = 48) or FOF (N = 51), the latter being randomized to receive a standard Formula (FOF1) or a protein-rich Formula (FOF2). Setting: The study was conducted in a University Hospital. Results: SGA-BRF infants maintained a low fat mass and normal levels of IGF-I and HMW adiponectin. In contrast, SGA-FOF infants normalized their body compositi...
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body composition and circulating high molecular weight adiponectin and igf i in infants born small for gestational age breast versus Formula Feeding
Diabetes, 2012Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sanchezinfantes, Abel Lopezbermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mechanisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutrition. Compared with AGA-BRF infants, SGA-BRF infants had normal HMW adiponectin and IGF-I levels at 4 months, whereas SGA-FOF infants had elevated levels of HMW adiponectin (particularly SGA-FOF1) and IGF-I (particularly SGA-FOF2). In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants. Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including diabetes.
Per T Sangild - One of the best experts on this subject based on the ideXlab platform.
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bovine colostrum before or after Formula Feeding improves systemic immune protection and gut function in newborn preterm pigs
Frontiers in Immunology, 2020Co-Authors: Xiaoyu Pan, Duc Ninh Nguyen, Shuqiang Ren, Arshnee Moodley, Per T SangildAbstract:Objectives: Maternal milk is often absent or in limited supply just after preterm birth. Many preterm infants are therefore fed infant Formula as their first enteral feed despite an increased risk of Feeding intolerance, necrotizing enterocolitis (NEC), and infection. Using preterm pigs as a model for preterm infants, we hypothesized that bovine colostrum given before or after Formula Feeding would alleviate Formula-induced detrimental effects during the first days after preterm birth. Methods: A total of 74 preterm pigs received gradually increasing volumes of Formula (F) or bovine colostrum (C) until day 5, when they were euthanized or transitioned to either C or F for another 4 days, resulting in six groups: C or F until day 5 (C5, F5, n = 11 each), C or F until day 9 (CC, FF n = 12-13 each), C followed by F (CF, n = 14), and F followed by C (FC, n = 13). Results: Systemically, colostrum Feeding stimulated circulating neutrophil recruitment on day 5 (C5 vs. F5, P < 0.05). Relative to initial Formula Feeding, initial colostrum Feeding promoted the development of systemic immune protection as indicated by a decreased T-helper cell population and an increased regulatory T-cell population (CC + CF vs. FC + FF, P < 0.01). In the gut, colostrum Feeding improved intestinal parameters such as villus heights, enzymes, hexose absorption, colonic goblet cell density, and decreased the incidence of severe NEC (27 vs. 64%), diarrhea (16 vs. 49%), and gut permeability on day 5, coupled with lowered expression of LBP, MYD88, IL8, HIF1A, and CASP3 (C5 vs. F5, all P < 0.05). On day 9, the incidence of severe NEC was similarly low across groups (15-21%), but diarrhea resistance and intestinal parameters were further improved by colostrum Feeding, relative to exclusive Formula Feeding (CC, CF, or FC vs. FF, respectively, all P < 0.05). The expression of MYD88 and CASP3 remained downregulated by exclusive colostrum Feeding (CC vs. FF, P < 0.01) and colostrum before or after Formula Feeding down regulated HIF1A and CASP3 expression marginally. Conclusion: Colostrum Feeding ameliorated detrimental effects of Formula Feeding on systemic immunity and gut health in preterm newborns, especially when given immediately after birth.
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bovine colostrum improves intestinal function following Formula induced gut inflammation in preterm pigs
Clinical Nutrition, 2014Co-Authors: Ann Cathrine Findal Stoy, Thomas Thymann, Mette Schmidt, Mette Boye, Bent Borg Jensen, Barbara Stoll, Peter M H Heegaard, Mette Bjerre, Kerstin Skovgaard, Per T SangildAbstract:Summary Background & aims Only few hours of Formula Feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to Formula Feeding after some days of total parenteral nutrition (TPN). Methods After receiving TPN for 2 days, preterm pigs were fed Formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or Formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated. Results NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine. Conclusions Bovine colostrum restores intestinal function after initial Formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.
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similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2013Co-Authors: Michael Ladegaard Jensen, Per T Sangild, Mikkel Lykke, Mette Schmidt, Mette Boye, Bent Borg Jensen, Thomas ThymannAbstract:Preterm birth and Formula Feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant Formula (IF) and human donor milk (HM...
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temporal proteomic analysis of intestine developing necrotizing enterocolitis following enteral Formula Feeding to preterm pigs
Journal of Proteome Research, 2009Co-Authors: Pingping Jiang, Per T Sangild, Waihung Sit, Heidi Hoiyee Ngai, Jayda L Siggers, Jennifer Manfan WanAbstract:Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral Formula Feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.
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Formula Feeding reduces lactose digestive capacity in neonatal pigs
British Journal of Nutrition, 2006Co-Authors: Thomas Thymann, Douglas G Burrin, Kelly A Tappenden, Charlotte R Bjornvad, Soren Krogh Jensen, Per T SangildAbstract:The intestine of newborn pigs develops rapidly during the first days postpartum. We investigated if Feeding milk replacer (infant Formula) as an alternative to colostrum has compromising effects on nutrient digestive function in the neonatal period. Nineteen piglets born at term were assigned to one of four treatments: (1) newborn controls; (2) natural suckling for 24 h; (3) tube-fed Formula for 24 h; (4) tube-fed porcine colostrum for 24 h. All three fed groups showed significant increases in small-intestinal and colonic weights, villous heights and widths, maltase and aminopeptidase A activities, and decreases in dipeptidylpeptidase IV activity, relative to newborn pigs. Following oral boluses of mannitol, lactose or galactose, Formula-fed pigs showed significantly reduced plasma levels of mannitol and galactose compared with colostrum-fed pigs. Activity of intestinal inducible NO synthase and plasma levels of cortisol were significantly increased, whereas intestinal constitutive NO synthase and alpha-tocopherol were decreased in Formula-fed pigs compared with colostrum-fed pigs. Although Formula-fed pigs only showed minor clinical signs of intestinal dysfunction and showed similar intestinal trophic responses just after birth, as those fed colostrum, lactose digestive capacity was markedly reduced. We conclude that Formula-Feeding may exert detrimental effects on intestinal function in neonates. Formula-induced subclinical malfunction of the gut in pigs born at term was associated with altered NO synthase activity and antioxidative capacity.
Francis De Zegher - One of the best experts on this subject based on the ideXlab platform.
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Body Composition and Circulating High-Molecular- Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age Breast- Versus Formula-Feeding
2016Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sánchez-infantes, Abel Lopez-bermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mecha-nisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutri-tion. Compared with AGA-BRF infants, SGA-BRF infants had nor
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breast Feeding vs Formula Feeding for infants born small for gestational age divergent effects on fat mass and on circulating igf i and high molecular weight adiponectin in late infancy
The Journal of Clinical Endocrinology and Metabolism, 2013Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, Abel Lopezbermejo, Maria Dolores Gomezroig, Lourdes IbáñezAbstract:Context: Fetal growth restraint, if followed by rapid weight gain, confers risk for adult disease including diabetes. How breast-Feeding may lower such risk is poorly understood. Objective, Study Participants, Intervention, Outcomes: In infants born small-for-gestational-age (SGA), we studied the effects of nutrition in early infancy (breast-Feeding vs Formula-Feeding; BRF vs FOF) on weight partitioning and endocrine markers in late infancy. Body composition (by absorptiometry), fasting glycemia, insulin, IGF-I, and high-molecular-weight (HMW) adiponectin were assessed at 4 and 12 months in BRF controls born appropriate-for-GA (N = 31) and in SGA infants receiving BRF (N = 48) or FOF (N = 51), the latter being randomized to receive a standard Formula (FOF1) or a protein-rich Formula (FOF2). Setting: The study was conducted in a University Hospital. Results: SGA-BRF infants maintained a low fat mass and normal levels of IGF-I and HMW adiponectin. In contrast, SGA-FOF infants normalized their body compositi...
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body composition and circulating high molecular weight adiponectin and igf i in infants born small for gestational age breast versus Formula Feeding
Diabetes, 2012Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sanchezinfantes, Abel Lopezbermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mechanisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutrition. Compared with AGA-BRF infants, SGA-BRF infants had normal HMW adiponectin and IGF-I levels at 4 months, whereas SGA-FOF infants had elevated levels of HMW adiponectin (particularly SGA-FOF1) and IGF-I (particularly SGA-FOF2). In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants. Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including diabetes.
Marta Diaz - One of the best experts on this subject based on the ideXlab platform.
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Body Composition and Circulating High-Molecular- Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age Breast- Versus Formula-Feeding
2016Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sánchez-infantes, Abel Lopez-bermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mecha-nisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutri-tion. Compared with AGA-BRF infants, SGA-BRF infants had nor
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breast Feeding vs Formula Feeding for infants born small for gestational age divergent effects on fat mass and on circulating igf i and high molecular weight adiponectin in late infancy
The Journal of Clinical Endocrinology and Metabolism, 2013Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, Abel Lopezbermejo, Maria Dolores Gomezroig, Lourdes IbáñezAbstract:Context: Fetal growth restraint, if followed by rapid weight gain, confers risk for adult disease including diabetes. How breast-Feeding may lower such risk is poorly understood. Objective, Study Participants, Intervention, Outcomes: In infants born small-for-gestational-age (SGA), we studied the effects of nutrition in early infancy (breast-Feeding vs Formula-Feeding; BRF vs FOF) on weight partitioning and endocrine markers in late infancy. Body composition (by absorptiometry), fasting glycemia, insulin, IGF-I, and high-molecular-weight (HMW) adiponectin were assessed at 4 and 12 months in BRF controls born appropriate-for-GA (N = 31) and in SGA infants receiving BRF (N = 48) or FOF (N = 51), the latter being randomized to receive a standard Formula (FOF1) or a protein-rich Formula (FOF2). Setting: The study was conducted in a University Hospital. Results: SGA-BRF infants maintained a low fat mass and normal levels of IGF-I and HMW adiponectin. In contrast, SGA-FOF infants normalized their body compositi...
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body composition and circulating high molecular weight adiponectin and igf i in infants born small for gestational age breast versus Formula Feeding
Diabetes, 2012Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sanchezinfantes, Abel Lopezbermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mechanisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutrition. Compared with AGA-BRF infants, SGA-BRF infants had normal HMW adiponectin and IGF-I levels at 4 months, whereas SGA-FOF infants had elevated levels of HMW adiponectin (particularly SGA-FOF1) and IGF-I (particularly SGA-FOF2). In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants. Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including diabetes.
Giorgia Sebastiani - One of the best experts on this subject based on the ideXlab platform.
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Body Composition and Circulating High-Molecular- Weight Adiponectin and IGF-I in Infants Born Small for Gestational Age Breast- Versus Formula-Feeding
2016Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sánchez-infantes, Abel Lopez-bermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mecha-nisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutri-tion. Compared with AGA-BRF infants, SGA-BRF infants had nor
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breast Feeding vs Formula Feeding for infants born small for gestational age divergent effects on fat mass and on circulating igf i and high molecular weight adiponectin in late infancy
The Journal of Clinical Endocrinology and Metabolism, 2013Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, Abel Lopezbermejo, Maria Dolores Gomezroig, Lourdes IbáñezAbstract:Context: Fetal growth restraint, if followed by rapid weight gain, confers risk for adult disease including diabetes. How breast-Feeding may lower such risk is poorly understood. Objective, Study Participants, Intervention, Outcomes: In infants born small-for-gestational-age (SGA), we studied the effects of nutrition in early infancy (breast-Feeding vs Formula-Feeding; BRF vs FOF) on weight partitioning and endocrine markers in late infancy. Body composition (by absorptiometry), fasting glycemia, insulin, IGF-I, and high-molecular-weight (HMW) adiponectin were assessed at 4 and 12 months in BRF controls born appropriate-for-GA (N = 31) and in SGA infants receiving BRF (N = 48) or FOF (N = 51), the latter being randomized to receive a standard Formula (FOF1) or a protein-rich Formula (FOF2). Setting: The study was conducted in a University Hospital. Results: SGA-BRF infants maintained a low fat mass and normal levels of IGF-I and HMW adiponectin. In contrast, SGA-FOF infants normalized their body compositi...
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body composition and circulating high molecular weight adiponectin and igf i in infants born small for gestational age breast versus Formula Feeding
Diabetes, 2012Co-Authors: Francis De Zegher, Giorgia Sebastiani, Marta Diaz, David Sanchezinfantes, Abel Lopezbermejo, Lourdes IbáñezAbstract:Prenatal growth restraint, if followed by postnatal overweight, confers risk for adult disease including diabetes. The mechanisms whereby neonatal nutrition may modulate such risk are poorly understood. We studied the effects of nutrition (breast-Feeding [BRF] vs. Formula-Feeding [FOF]) on weight partitioning and endocrine state (as judged by high-molecular-weight [HMW] adiponectin and IGF-I) of infants born small for gestational age (SGA). Body composition (by absorptiometry), HMW adiponectin, and IGF-I were assessed at birth and 4 months in BRF infants born appropriate for gestational age (AGA; n = 72) and SGA infants receiving BRF (n = 46) or FOF (n = 56), the latter being randomized to receive a standard (FOF1) or protein-rich Formula (FOF2). Compared with AGA-BRF infants, the catchup growth of SGA infants was confined to lean mass, independently of nutrition. Compared with AGA-BRF infants, SGA-BRF infants had normal HMW adiponectin and IGF-I levels at 4 months, whereas SGA-FOF infants had elevated levels of HMW adiponectin (particularly SGA-FOF1) and IGF-I (particularly SGA-FOF2). In conclusion, neonatal nutrition seems to influence endocrinology more readily than body composition of SGA infants. Follow-up will disclose whether the endocrine abnormalities in SGA-FOF infants can serve as early markers of an unfavorable metabolic course and whether they may contribute to design early interventions that prevent subsequent disease, including diabetes.