The Experts below are selected from a list of 148173 Experts worldwide ranked by ideXlab platform
Reinhard Vehring - One of the best experts on this subject based on the ideXlab platform.
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use of a fundamental approach to spray drying Formulation Design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach.
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Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Abouzar Shamsaddini-shahrbabak, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach. Methods Formulation Design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the Design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two Formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. Results The Design targets were met. The Formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both Formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Conclusions Theoretical models were applied to successfully achieve complex Formulations with Design challenges a priori . No further iterations to the Design process were required.
Alireza Kaboorani - One of the best experts on this subject based on the ideXlab platform.
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characterizing water sorption and diffusion properties of wood plastic composites as a function of Formulation Design
Construction and Building Materials, 2017Co-Authors: Alireza KabooraniAbstract:Abstract In this study, the water sorption and diffusion properties of wood/plastic composites (WPCs) as a function of Formulation Design were investigated. Composites with different amounts of wood, coupling agent and high density polyethylene (HDPE) were produced by profile extrusion method. The time required to reach saturation point, moisture contents at saturation point, diffusion coefficients and thickness swelling were measured for all composites. The results showed that the response of WPCs towards water exposure is heavily dependent on Formulation Design. The time required to reach saturation point varied between four weeks and 84 weeks. Such a big difference reflected magnitude of Formulation Design on water resistance of WPCs. Composites with large particles demonstrated weak performance towards water. Any increase in wood content led to an increase in water absorption. Coupling agent reduced water absorption. Diffusion coefficients and thickness swelling were also affected by wood and coupling agent contents, and wood particle size. The highest diffusion coefficients and thickness swelling were found in composites with high wood contents and large particles. Studying the water sorption process in WPCs showed that the process follows kinetics and mechanisms described by Fick’s law.
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Characterizing water sorption and diffusion properties of wood/plastic composites as a function of Formulation Design
Construction and Building Materials, 2017Co-Authors: Alireza KabooraniAbstract:Abstract In this study, the water sorption and diffusion properties of wood/plastic composites (WPCs) as a function of Formulation Design were investigated. Composites with different amounts of wood, coupling agent and high density polyethylene (HDPE) were produced by profile extrusion method. The time required to reach saturation point, moisture contents at saturation point, diffusion coefficients and thickness swelling were measured for all composites. The results showed that the response of WPCs towards water exposure is heavily dependent on Formulation Design. The time required to reach saturation point varied between four weeks and 84 weeks. Such a big difference reflected magnitude of Formulation Design on water resistance of WPCs. Composites with large particles demonstrated weak performance towards water. Any increase in wood content led to an increase in water absorption. Coupling agent reduced water absorption. Diffusion coefficients and thickness swelling were also affected by wood and coupling agent contents, and wood particle size. The highest diffusion coefficients and thickness swelling were found in composites with high wood contents and large particles. Studying the water sorption process in WPCs showed that the process follows kinetics and mechanisms described by Fick’s law.
James W Ivey - One of the best experts on this subject based on the ideXlab platform.
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use of a fundamental approach to spray drying Formulation Design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach.
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Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Abouzar Shamsaddini-shahrbabak, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach. Methods Formulation Design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the Design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two Formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. Results The Design targets were met. The Formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both Formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Conclusions Theoretical models were applied to successfully achieve complex Formulations with Design challenges a priori . No further iterations to the Design process were required.
Emadeddin Javaheri - One of the best experts on this subject based on the ideXlab platform.
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use of a fundamental approach to spray drying Formulation Design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach.
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Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Abouzar Shamsaddini-shahrbabak, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach. Methods Formulation Design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the Design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two Formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. Results The Design targets were met. The Formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both Formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Conclusions Theoretical models were applied to successfully achieve complex Formulations with Design challenges a priori . No further iterations to the Design process were required.
Mohammed A Boraey - One of the best experts on this subject based on the ideXlab platform.
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use of a fundamental approach to spray drying Formulation Design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach.
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Use of a Fundamental Approach to Spray-Drying Formulation Design to Facilitate the Development of Multi-Component Dry Powder Aerosols for Respiratory Drug Delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Abouzar Shamsaddini-shahrbabak, Reinhard VehringAbstract:Purpose A fundamental approach incorporating current theoretical models into aerosol Formulation Design potentially reduces experimental work for complex Formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model Formulation for this approach. Methods Formulation Design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the Design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two Formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. Results The Design targets were met. The Formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both Formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Conclusions Theoretical models were applied to successfully achieve complex Formulations with Design challenges a priori . No further iterations to the Design process were required.