The Experts below are selected from a list of 2607 Experts worldwide ranked by ideXlab platform
Carlos T Moraes - One of the best experts on this subject based on the ideXlab platform.
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mitochondrial methionyl n Formylation affects steady state levels of oxidative phosphorylation complexes and their organization into supercomplexes
Journal of Biological Chemistry, 2018Co-Authors: Tania Arguello, Caroline Kohrer, Uttam L Rajbhandary, Carlos T MoraesAbstract:N-Formylation of the Met-tRNAMet by the nuclearly encoded mitochondrial methionyl-tRNA formyltransferase (MTFMT) has been found to be a key determinant of protein synthesis initiation in mitochondria. In humans, mutations in the MTFMT gene result in Leigh syndrome, a progressive and severe neurometabolic disorder. However, the absolute requirement of Formylation of Met-tRNAMet for protein synthesis in mammalian mitochondria is still debated. Here, we generated a Mtfmt-KO mouse fibroblast cell line and demonstrated that N-Formylation of the first methionine via fMet-tRNAMet by MTFMT is not an absolute requirement for initiation of protein synthesis. However, it differentially affected the efficiency of synthesis of mtDNA-coded polypeptides. Lack of methionine N-Formylation did not compromise the stability of these individual subunits but had a marked effect on the assembly and stability of the OXPHOS complexes I and IV and on their supercomplexes. In summary, N-Formylation is not essential for mitochondrial protein synthesis but is critical for efficient synthesis of several mitochondrially encoded peptides and for OXPHOS complex stability and assembly into supercomplexes.
Krishnacharya G Akamanchi - One of the best experts on this subject based on the ideXlab platform.
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sulfated tungstate catalyzed highly accelerated n Formylation
ChemInform, 2012Co-Authors: Sagar P Pathare, Ravindra V Sawant, Krishnacharya G AkamanchiAbstract:The improved conditions are applied to a broad spectrum of amino compounds to produce the desired formylated products with good to excellent yields within a short time.
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sulfated tungstate catalyzed highly accelerated n Formylation
Tetrahedron Letters, 2012Co-Authors: Sagar P Pathare, Ravindra V Sawant, Krishnacharya G AkamanchiAbstract:Abstract Sulfated tungstate catalyzed, green, rapid, and practical method for N-Formylation of amines using formic acid under solvent-free conditions is described. This method showed improvements over the reported in terms of yield, reaction time, and chemoselectivity.
Tania Arguello - One of the best experts on this subject based on the ideXlab platform.
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mitochondrial methionyl n Formylation affects steady state levels of oxidative phosphorylation complexes and their organization into supercomplexes
Journal of Biological Chemistry, 2018Co-Authors: Tania Arguello, Caroline Kohrer, Uttam L Rajbhandary, Carlos T MoraesAbstract:N-Formylation of the Met-tRNAMet by the nuclearly encoded mitochondrial methionyl-tRNA formyltransferase (MTFMT) has been found to be a key determinant of protein synthesis initiation in mitochondria. In humans, mutations in the MTFMT gene result in Leigh syndrome, a progressive and severe neurometabolic disorder. However, the absolute requirement of Formylation of Met-tRNAMet for protein synthesis in mammalian mitochondria is still debated. Here, we generated a Mtfmt-KO mouse fibroblast cell line and demonstrated that N-Formylation of the first methionine via fMet-tRNAMet by MTFMT is not an absolute requirement for initiation of protein synthesis. However, it differentially affected the efficiency of synthesis of mtDNA-coded polypeptides. Lack of methionine N-Formylation did not compromise the stability of these individual subunits but had a marked effect on the assembly and stability of the OXPHOS complexes I and IV and on their supercomplexes. In summary, N-Formylation is not essential for mitochondrial protein synthesis but is critical for efficient synthesis of several mitochondrially encoded peptides and for OXPHOS complex stability and assembly into supercomplexes.
Ravinder Singh Kuntal - One of the best experts on this subject based on the ideXlab platform.
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comparative study on feed formulation software a short review
International Journal of Research, 2017Co-Authors: Vishal Patil, R Gupta, D Rajendran, Ravinder Singh KuntalAbstract:The paper highlightsthe different feed formulation software’s for least cost formulation of livestock and animals, where the comparison of techniques is donebased on different aspectslike data collection, software used, price, scope and limitations. Feed formulation requires large amount of data about the composition of feeds, environment conditions,and availability of feeds.Development of Software’sfor feed formulations is changing with change in computer. With advancement of technology, the feed formulation can be calculated for ‘n’ number of feed stuff but still Linear Programming is used as base for mathematical modelling, where uses of non-linear programming is very less. Maximum number of feed formulation software’s is developed to select the feeds for formulation within budget of the farmers or dairy industry.
Sagar P Pathare - One of the best experts on this subject based on the ideXlab platform.
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sulfated tungstate catalyzed highly accelerated n Formylation
ChemInform, 2012Co-Authors: Sagar P Pathare, Ravindra V Sawant, Krishnacharya G AkamanchiAbstract:The improved conditions are applied to a broad spectrum of amino compounds to produce the desired formylated products with good to excellent yields within a short time.
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sulfated tungstate catalyzed highly accelerated n Formylation
Tetrahedron Letters, 2012Co-Authors: Sagar P Pathare, Ravindra V Sawant, Krishnacharya G AkamanchiAbstract:Abstract Sulfated tungstate catalyzed, green, rapid, and practical method for N-Formylation of amines using formic acid under solvent-free conditions is described. This method showed improvements over the reported in terms of yield, reaction time, and chemoselectivity.