The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Leora Witkowski - One of the best experts on this subject based on the ideXlab platform.
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abstract 3422 the influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary hypercalcemic type
Cancer Research, 2016Co-Authors: Leora Witkowski, Emmanouil Saloustros, Catherine Goudie, Pilar Ramos, Anthony N Karnezis, Talia Boshari, P Pautier, Michel Longy, James A Knost, Glenn W MccluggageAbstract:Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian tumor diagnosed in women below the age of 40. While it is uncommon, with only ∼500 cases reported, it is an extremely aggressive tumor, with long term survival rates of Citation Format: Leora Witkowski, Catherine Goudie, Pilar Ramos, Anthony N. Karnezis, Talia Boshari, Patricia Pautier, Michel Longy, James A. Knost, Emmanouil Saloustros, W Glenn McCluggage, Martin Hasselblatt, William P. Hendricks, David Huntsman, Douglas A. Levine, Jeffrey Trent, William D. Foulkes. The influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary, hypercalcemic type. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3422.
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germline and somatic smarca4 mutations characterize small cell carcinoma of the ovary hypercalcemic type
Nature Genetics, 2014Co-Authors: Leora Witkowski, Jian Carrotzhang, Steffen Albrecht, Somayyeh Fahiminiya, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Javad Nadaf, Barbara RiveraAbstract:William Foulkes and colleagues identify germline inactivating mutations in familial cases of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Through additional analysis of non-familial tumors, the authors find that nearly 100% of tumors carry SMARCA4 mutations and 38 of 40 lack protein expression, implicating SMARCA4 loss as the major cause of SCCOHT.
Glenn W Mccluggage - One of the best experts on this subject based on the ideXlab platform.
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abstract 3422 the influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary hypercalcemic type
Cancer Research, 2016Co-Authors: Leora Witkowski, Emmanouil Saloustros, Catherine Goudie, Pilar Ramos, Anthony N Karnezis, Talia Boshari, P Pautier, Michel Longy, James A Knost, Glenn W MccluggageAbstract:Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian tumor diagnosed in women below the age of 40. While it is uncommon, with only ∼500 cases reported, it is an extremely aggressive tumor, with long term survival rates of Citation Format: Leora Witkowski, Catherine Goudie, Pilar Ramos, Anthony N. Karnezis, Talia Boshari, Patricia Pautier, Michel Longy, James A. Knost, Emmanouil Saloustros, W Glenn McCluggage, Martin Hasselblatt, William P. Hendricks, David Huntsman, Douglas A. Levine, Jeffrey Trent, William D. Foulkes. The influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary, hypercalcemic type. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3422.
Emmanouil Saloustros - One of the best experts on this subject based on the ideXlab platform.
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abstract 3422 the influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary hypercalcemic type
Cancer Research, 2016Co-Authors: Leora Witkowski, Emmanouil Saloustros, Catherine Goudie, Pilar Ramos, Anthony N Karnezis, Talia Boshari, P Pautier, Michel Longy, James A Knost, Glenn W MccluggageAbstract:Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is the most common undifferentiated ovarian tumor diagnosed in women below the age of 40. While it is uncommon, with only ∼500 cases reported, it is an extremely aggressive tumor, with long term survival rates of Citation Format: Leora Witkowski, Catherine Goudie, Pilar Ramos, Anthony N. Karnezis, Talia Boshari, Patricia Pautier, Michel Longy, James A. Knost, Emmanouil Saloustros, W Glenn McCluggage, Martin Hasselblatt, William P. Hendricks, David Huntsman, Douglas A. Levine, Jeffrey Trent, William D. Foulkes. The influence of genetic and clinical factors on the outcome following a diagnosis of small cell carcinoma of the ovary, hypercalcemic type. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3422.
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germline and somatic smarca4 mutations characterize small cell carcinoma of the ovary hypercalcemic type
Nature Genetics, 2014Co-Authors: Leora Witkowski, Jian Carrotzhang, Steffen Albrecht, Somayyeh Fahiminiya, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Javad Nadaf, Barbara RiveraAbstract:William Foulkes and colleagues identify germline inactivating mutations in familial cases of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Through additional analysis of non-familial tumors, the authors find that nearly 100% of tumors carry SMARCA4 mutations and 38 of 40 lack protein expression, implicating SMARCA4 loss as the major cause of SCCOHT.
Barbara Rivera - One of the best experts on this subject based on the ideXlab platform.
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germline and somatic smarca4 mutations characterize small cell carcinoma of the ovary hypercalcemic type
Nature Genetics, 2014Co-Authors: Leora Witkowski, Jian Carrotzhang, Steffen Albrecht, Somayyeh Fahiminiya, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Javad Nadaf, Barbara RiveraAbstract:William Foulkes and colleagues identify germline inactivating mutations in familial cases of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Through additional analysis of non-familial tumors, the authors find that nearly 100% of tumors carry SMARCA4 mutations and 38 of 40 lack protein expression, implicating SMARCA4 loss as the major cause of SCCOHT.
Christian Ikenmeyer - One of the best experts on this subject based on the ideXlab platform.
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on geometric complexity theory multiplicity obstructions are stronger than occurrence obstructions
arXiv: Computational Complexity, 2019Co-Authors: Julian Dorfler, Christian Ikenmeyer, Greta PanovaAbstract:Geometric Complexity Theory as initiated by Mulmuley and Sohoni in two papers (SIAM J Comput 2001, 2008) aims to separate algebraic complexity classes via representation theoretic multiplicities in coordinate rings of specific group varieties. The papers also conjecture that the vanishing behavior of these multiplicities would be sufficient to separate complexity classes (so-called occurrence obstructions). The existence of such strong occurrence obstructions has been recently disproven in 2016 in two successive papers, Ikenmeyer-Panova (Adv. Math.) and Burgisser-Ikenmeyer-Panova (J. AMS). This raises the question whether separating group varieties via representation theoretic multiplicities is stronger than separating them via occurrences. This paper provides for the first time a setting where separating with multiplicities can be achieved, while the separation with occurrences is provably impossible. Our setting is surprisingly simple and natural: We study the variety of products of homogeneous linear forms (the so-called Chow variety) and the variety of polynomials of bounded border Waring rank (i.e. a higher secant variety of the Veronese variety). As a side result we prove a slight generalization of Hermite's reciprocity theorem, which proves Foulkes' conjecture for a new infinite family of cases.
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on geometric complexity theory multiplicity obstructions are stronger than occurrence obstructions
International Colloquium on Automata Languages and Programming, 2019Co-Authors: Julian Dorfler, Christian Ikenmeyer, Greta PanovaAbstract:Geometric Complexity Theory as initiated by Mulmuley and Sohoni in two papers (SIAM J Comput 2001, 2008) aims to separate algebraic complexity classes via representation theoretic multiplicities in coordinate rings of specific group varieties. We provide the first toy setting in which a separation can be achieved for a family of polynomials via these multiplicities. Mulmuley and Sohoni's papers also conjecture that the vanishing behavior of multiplicities would be sufficient to separate complexity classes (so-called occurrence obstructions). The existence of such strong occurrence obstructions has been recently disproven in 2016 in two successive papers, Ikenmeyer-Panova (Adv. Math.) and Burgisser-Ikenmeyer-Panova (J. AMS). This raises the question whether separating group varieties via representation theoretic multiplicities is stronger than separating them via occurrences. We provide first finite settings where a separation via multiplicities can be achieved, while the separation via occurrences is provably impossible. These settings are surprisingly simple and natural: We study the variety of products of homogeneous linear forms (the so-called Chow variety) and the variety of polynomials of bounded border Waring rank (i.e. a higher secant variety of the Veronese variety). As a side result we prove a slight generalization of Hermite's reciprocity theorem, which proves Foulkes' conjecture for a new infinite family of cases.
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symmetrizing tableaux and the 5th case of the Foulkes conjecture
Journal of Symbolic Computation, 2017Co-Authors: Manwai Cheung, Christian Ikenmeyer, Sevak MkrtchyanAbstract:Abstract The Foulkes conjecture states that the multiplicities in the plethysm Sym a ( Sym b V ) are at most as large as the multiplicities in the plethysm Sym b ( Sym a V ) for all a ≤ b . This conjecture has been known to be true for a ≤ 4 . The main result of this paper is its verification for a = 5 . This is achieved by performing a combinatorial calculation on a computer and using a propagation theorem of Tom McKay from 2008. Moreover, we obtain a complete representation theoretic decomposition of the vanishing ideal of the 5th Chow variety in degree 5, we show that there are no degree 5 equations for the 6th Chow variety, and we also find some representation theoretic degree 6 equations for the 6th Chow variety.
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on mckay s propagation theorem for the Foulkes conjecture
arXiv: Representation Theory, 2015Co-Authors: Christian IkenmeyerAbstract:We translate the main theorem in Tom McKay's paper "On plethysm conjectures of Stanley and Foulkes" (J. Alg. 319, 2008, pp. 2050-2071) to the language of weight spaces and projections onto invariant spaces of tensors, which makes its proof short and elegant.