The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform
David Lodge - One of the best experts on this subject based on the ideXlab platform.
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the effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats
Neuroscience Letters, 2001Co-Authors: Jason Katner, Smriti Iyengar, David LodgeAbstract:Abstract The aim of this study was to investigate the reason for the contradictory results following surgical sympathectomy on increased tactile sensitivity in spinal nerve ligated rats. For this purpose, firstly the results of L5 spinal nerve ligation alone and both L5 and L6 (L5/6) spinal nerve ligation were compared in Sprague–Dawley rats. Secondly, the difference in tactile sensitivity between the plantar surface (the middle glabrous area on the foot pads of the hind paw) and on the Toe (the proximal half of the third and Fourth Toe of the hind paw) after the spinal nerve injury was studied. Third, we divided the L5 spinal nerve ligated rats into two groups, (i.e. low and high threshold groups) based on the degree of tactile sensitivity and investigated the effect of surgical lumbar sympathectomy (L2–L5) on tactile sensitivity in both the plantar and Toe areas. The results show that the tactile sensitivities of L5 spinal nerve ligated rats and L5/6 spinal nerve ligated rats were not different. However, tactile sensitivities of the plantar surface were less than those of Toe area suggesting that the response from Toe is a better indicator of neuropathic pain. Surgical sympathectomy reduced the response from only the Toe area and only in the low threshold group. These results suggest that the reason for the contradictory results of surgical sympathectomy in spinal nerve ligation models is, at least in part, the difference in the degree of mechanical allodynia in each study.
Jin Mo Chung - One of the best experts on this subject based on the ideXlab platform.
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the effect of lumbar sympathectomy in the spinal nerve ligation model of neuropathic pain
The Journal of Pain, 2001Co-Authors: Soon Kwon Park, Kyungsoon Chung, Jin Mo ChungAbstract:To evaluate the sympathetic dependency of pain behaviors in an animal model of neuropathic pain, the effect of surgical sympathectomy on the mechanical sensitivity of the hindpaw was examined in rats with L5 spinal nerve ligation. Mechanical sensitivity was determined by measuring foot withdrawal thresholds to mechanical stimulation with von Frey filaments applied to the base of the third or Fourth Toe. Tight ligation of the segmental L5 spinal nerve led to the development of mechanical hypersensitivity in the hindpaw. The effects of 2 different procedures of surgical lumbar sympathectomy on mechanical hypersensitivity were compared, limited (resection of sympathetic chain/ganglia L2 to L4 segments) and extensive (resection of L2 to L6 segments) sympathectomies. Mechanical hypersensitivity produced by L5 spinal nerve ligation was partially but significantly reduced by both sympathectomy procedures. In a separate group of rats, the L5 spinal nerve was ligated while irritating the neighboring L4 spinal nerve. This procedure produced a lesser degree of mechanical hypersensitivity, and subsequent sympathectomy had no effect on these animals. These data suggest that sympathectomy is effective in this model only when the animals show severe mechanical hypersensitivity. © 2001 by the American Pain Society
Rudiger Krauspe - One of the best experts on this subject based on the ideXlab platform.
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the ruiz mora procedure a surgical treatment of the cock up deformity of the fifth Toe
Foot and Ankle Surgery, 1998Co-Authors: J L Visposeara, V Ettl, Rudiger KrauspeAbstract:A fixed rotational deformity of the fifth Toe combined with subluxation/dislocation of the fifth metatarsophalangeal joint is also known as the cock-up deformity. If the Toe cannot be accommodated by wide or extra-depth shoes surgery may be indicated. Surgical treatment requires adequate bony decompression. Complete excision of the proximal phalanx combined with tightened plantar skin closure after elliptical plantar skin excision, the Ruiz-Mora procedure, provides good relief of symptoms. We reviewed 18 patients with 22 procedures, operated on between 1986 and 1996. Two patients with two procedures had post-traumatic foot deformities and because of the different underlying aetiology and pathology of their deformity were excluded from the study. There were 10 women and eight men, and four patients had bilateral operations. The average age at surgery was 38 years. Follow-up examination was possible for 17 cases. These patients were followed for an average of 6.6 years. After surgery there was no recurrence of deformity. Subjectively, all of the examined patients had complete relief of pain. Three recurrences of a simultaneously surgically treated hammer Toe deformity of the Fourth Toe with a corn on the dorsal aspect of this Toe were observed. In two cases a floppy fifth Toe, and in another two cases some problems with excessive shortening, were noted. The use of a partial syndactylization between the Fourth and fifth Toe or a skin incision placed near to interdigital space should be considered to avoid the excessive shortening and the development of a floppy fifth Toe.
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the ruiz mora procedure a surgical the cock up deformity of the fifth Toe treatment of
1998Co-Authors: Rudiger KrauspeAbstract:Summary A fixed rotational deformity of the fifth Toe combined with subluxation/dislocation of the fifth metatarsophalangeal joint is also known as the cock-up deformity. If the Toe cannot be accommodated by wide or extra-depth shoes surgery may be indicated. Surgical treatment requires adequate bony decompression. Complete excision of the proximal phalanx combined with tightened plantar skin closure after elliptical plantar skin excision, the Ruiz-Mora procedure, provides good relief of symptoms. We reviewed 18 patients with 22 procedures, operated on between 1986 and 1996. Two patients with two procedures had post-traumatic foot deformities and because of the different underlying aetiology and pathology of their deformity were excluded from the study. There were 10 women and eight men, and four patients had bilateral operations. The average age at surgery was 38 years. Follow-up examination was possible for 17 cases. These patients were followed for an average of 6.6 years. After surgery there was no recurrence of deformity. Subjectively, all of the examined patients had complete relief of pain. Three recurrences of a simultaneously surgically treated hammer Toe deformity of the Fourth Toe with a corn on the dorsal aspect of this Toe were observed. In two cases a floppy fifth Toe, and in another two cases some problems with excessive shortening, were noted. The use of a partial syndactylization between the Fourth and fifth Toe or a skin incision placed near to interdigital space should be considered to avoid the excessive shortening and the development of a floppy fifth Toe.
Jason Katner - One of the best experts on this subject based on the ideXlab platform.
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the effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats
Neuroscience Letters, 2001Co-Authors: Jason Katner, Smriti Iyengar, David LodgeAbstract:Abstract The aim of this study was to investigate the reason for the contradictory results following surgical sympathectomy on increased tactile sensitivity in spinal nerve ligated rats. For this purpose, firstly the results of L5 spinal nerve ligation alone and both L5 and L6 (L5/6) spinal nerve ligation were compared in Sprague–Dawley rats. Secondly, the difference in tactile sensitivity between the plantar surface (the middle glabrous area on the foot pads of the hind paw) and on the Toe (the proximal half of the third and Fourth Toe of the hind paw) after the spinal nerve injury was studied. Third, we divided the L5 spinal nerve ligated rats into two groups, (i.e. low and high threshold groups) based on the degree of tactile sensitivity and investigated the effect of surgical lumbar sympathectomy (L2–L5) on tactile sensitivity in both the plantar and Toe areas. The results show that the tactile sensitivities of L5 spinal nerve ligated rats and L5/6 spinal nerve ligated rats were not different. However, tactile sensitivities of the plantar surface were less than those of Toe area suggesting that the response from Toe is a better indicator of neuropathic pain. Surgical sympathectomy reduced the response from only the Toe area and only in the low threshold group. These results suggest that the reason for the contradictory results of surgical sympathectomy in spinal nerve ligation models is, at least in part, the difference in the degree of mechanical allodynia in each study.
Soon Kwon Park - One of the best experts on this subject based on the ideXlab platform.
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the effect of lumbar sympathectomy in the spinal nerve ligation model of neuropathic pain
The Journal of Pain, 2001Co-Authors: Soon Kwon Park, Kyungsoon Chung, Jin Mo ChungAbstract:To evaluate the sympathetic dependency of pain behaviors in an animal model of neuropathic pain, the effect of surgical sympathectomy on the mechanical sensitivity of the hindpaw was examined in rats with L5 spinal nerve ligation. Mechanical sensitivity was determined by measuring foot withdrawal thresholds to mechanical stimulation with von Frey filaments applied to the base of the third or Fourth Toe. Tight ligation of the segmental L5 spinal nerve led to the development of mechanical hypersensitivity in the hindpaw. The effects of 2 different procedures of surgical lumbar sympathectomy on mechanical hypersensitivity were compared, limited (resection of sympathetic chain/ganglia L2 to L4 segments) and extensive (resection of L2 to L6 segments) sympathectomies. Mechanical hypersensitivity produced by L5 spinal nerve ligation was partially but significantly reduced by both sympathectomy procedures. In a separate group of rats, the L5 spinal nerve was ligated while irritating the neighboring L4 spinal nerve. This procedure produced a lesser degree of mechanical hypersensitivity, and subsequent sympathectomy had no effect on these animals. These data suggest that sympathectomy is effective in this model only when the animals show severe mechanical hypersensitivity. © 2001 by the American Pain Society
