The Experts below are selected from a list of 435 Experts worldwide ranked by ideXlab platform
Yoon-jung Shon - One of the best experts on this subject based on the ideXlab platform.
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Ménétrier’s Disease as a Gastrointestinal Manifestation of Active Cytomegalovirus Infection in a 22-Month-Old Boy: A Case Report with a Review of the Literature of Korean Pediatric Cases
Hoon Jai Chun, 2018Co-Authors: Jeana Hong, Seungkoo Lee, Yoon-jung ShonAbstract:Ménétrier’s disease (MD), which is characterized by hypertrophic gastric folds and Foveolar Cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder. However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient’s age or immune status
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Ménétrier's Disease as a Gastrointestinal Manifestation of Active Cytomegalovirus Infection in a 22-Month-Old Boy: A Case Report with a Review of the Literature of Korean Pediatric Cases.
Clinical endoscopy, 2017Co-Authors: Jeana Hong, Seungkoo Lee, Yoon-jung ShonAbstract:Menetrier's disease (MD), which is characterized by hypertrophic gastric folds and Foveolar Cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder. However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient's age or immune status.
Gordon G. Forstner - One of the best experts on this subject based on the ideXlab platform.
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The pathogenesis of duodenal gastric metaplasia: the role of local goblet Cell transformation
Gut, 2000Co-Authors: R. Shaoul, P. Marcon, Y Okada, Ernest Cutz, Gordon G. ForstnerAbstract:BACKGROUND AND AIMS—Gastric metaplasia is frequently seen in biopsies of the duodenal cap, particularly when inflamed or ulcerated. In its initial manifestation small patches of gastric Foveolar Cells appear near the tip of a villus. These Cells contain periodic acid-Schiff (PAS) positive neutral mucins in contrast with the alcian blue (AB) positive acidic mucins within duodenal goblet Cells. Previous investigations have suggested that these PAS positive Cells originate either in Brunner's gland ducts or at the base of duodenal crypts and migrate in distinct streams to the upper villus. To investigate the origin of gastric metaplasia in superficial patches, we used the PAS/AB stain to distinguish between neutral and acidic mucins and in addition specific antibodies to immunolocalise Foveolar Cell mucin MUC5AC, the Foveolar Cell secretory product, gastric trefoil factor (TFF1), the mature goblet Cell mucin MUC2, and MUC2 core antigen. RESULTS—Cells in focal patches of gastric metaplasia contained secretory granules of both gastric and goblet Cell phenotypes. MUC5AC and TFF1 were present as expected in gastric Foveolar Cells but in addition, MUC2 core antigen, normally present only in the Golgi of intestinal goblet Cells, was expressed in secretory granules. Goblet Cells in the vicinity of metaplastic patches also expressed both gastric and intestinal antigens. MUC5AC/MUC2 containing goblet Cells were most common near the villus tip but were also seen at the base of crypts. Where crypts and Brunner's gland ducts merged they were always seen on the crypt side of the junction. Goblet Cells were the only Cells to express gastric antigens in these areas. In advanced metaplastic lesions, dual phenotype goblet Cells were less evident and fewer Cells expressed intestinal mucin antigens. CONCLUSIONS—We suggest that goblet Cells that express both intestinal and gastric antigens may represent local precursors of gastric metaplasia undergoing a transition to Foveolar-like Cells of mixed phenotype at the site of early metaplastic patches. As metaplasia becomes more widespread, a more pure gastric phenotype emerges. This progression is likely to be controlled by local inflammatory signals. Keywords: gastric metaplasia; goblet Cells; mucin
Masae Tatematsu - One of the best experts on this subject based on the ideXlab platform.
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Cellular differentiation status of epithelial polyps of the colorectum: the gastric Foveolar Cell-type in hyperplastic polyps.
Histopathology, 2003Co-Authors: Masahiko Koike, Ken Ichi Inada, Hayao Nakanishi, A Matsuura, Shigeo Nakamura, Masae TatematsuAbstract:Aims: The ‘metaplastic’ polyp of the colorectum, a synonym for the hyperplastic polyp, was named based only on features of the crypt epithelium. It is considered non-neoplastic, but the precise Cellular differentiation status remains to be proven. Methods and results: Forty-eight hyperplastic polyps, 12 serrated adenomas, 45 tubular adenomas and five juvenile polyps were studied for their phenotypic expression using gastric (Foveolar or pyloric gland Cell), small intestinal (goblet Cell), and colonic (goblet Cell) Cellular markers by immunohistochemical and mucin histochemical techniques. Gastric Foveolar Cell-type differentiation was significantly expressed in hyperplastic polyps, while colonic differentiation was also consistently preserved. Neither gastric pyloric-type nor small intestinal differentiation was observed. The same Cell differentiation status as hyperplastic polyps was observed in serrated adenomas but not in tubular adenomas or juvenile polyps. Conclusions: A large proportion of hyperplastic polyps are composed of hybrid epithelium, with bidirectional differentiation to both gastric Foveolar and colonic epithelial Cells in the same crypt. Therefore hyperplastic polyps might be interpreted as the outcome of abnormal Cell differentiation of stem Cells. The same phenotypic expression suggests that hyperplastic polyps and serrated adenomas share the same Cell lineage.
U. Zanetto - One of the best experts on this subject based on the ideXlab platform.
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13. Helicobacter heilmanii related gastritis in humans: presentation of 2 new cases with PCR confirmation and review of the literature
Pathology, 2012Co-Authors: D.k. Jothimani, S.y. Chan, A J Lawson, R.j. Owen, P.g. Wilson, M.v. Lewis, U. ZanettoAbstract:We present two cases of Helicobacter heilmannii (Hh) associated gastritis. A 37-year-old lady presented with 4 weeks history of dysphagia and dyspepsia. Gastroscopy showed 3–4 small punched out erosions with raised edges in the antrum. Her Campylobacter-like organism (CLO) test was positive. Biopsies showed chronic gastritis with numerous Gram-negative bacteria that were corkscrew shaped, larger and longer compared to H. pylori. The characteristic features were suggestive of Hh and this was subsequently confirmed by polymerase chain reaction (PCR). The histology also showed florid lymphoid infiltration suspicious of a low grade B Cell lymphoma. She was successfully treated with H. pylori eradication treatment. Subsequent biopsies showed chronic active gastritis with milder lymphoid infiltration. An 82-year-old man had 10 years history of intermittent epigastric discomfort. Gastroscopy showed antral gastritis and patchy duodenitis. His CLO test was positive. The histology showed antral Foveolar Cell hyperplasia, moderate mixed inflammatory infiltrate and many spiral organisms morphologically consistent with Hh. This was confirmed by PCR on formalin fixed, paraffin embedded tissue. He received H. pylori eradication treatment but was lost to follow up. Discussion Hh gastritis is rare and is generally considered as zoonosis from pet animals. The presence of unusual lymphocy-tereaction with the tendency to invade the Foveolar lumen are distinctive features of Hh chronic gastritis. The morphology of the bacteria is characteristic. Serology, CLO test and immuno-histochemistry cannot distinguish between the Helicobacter species.
Jeana Hong - One of the best experts on this subject based on the ideXlab platform.
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Ménétrier’s Disease as a Gastrointestinal Manifestation of Active Cytomegalovirus Infection in a 22-Month-Old Boy: A Case Report with a Review of the Literature of Korean Pediatric Cases
Hoon Jai Chun, 2018Co-Authors: Jeana Hong, Seungkoo Lee, Yoon-jung ShonAbstract:Ménétrier’s disease (MD), which is characterized by hypertrophic gastric folds and Foveolar Cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder. However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient’s age or immune status
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Ménétrier's Disease as a Gastrointestinal Manifestation of Active Cytomegalovirus Infection in a 22-Month-Old Boy: A Case Report with a Review of the Literature of Korean Pediatric Cases.
Clinical endoscopy, 2017Co-Authors: Jeana Hong, Seungkoo Lee, Yoon-jung ShonAbstract:Menetrier's disease (MD), which is characterized by hypertrophic gastric folds and Foveolar Cell hyperplasia, is the most common gastrointestinal (GI) cause of protein-losing enteropathy (PLE). The clinical course of MD in childhood differs from that in adults and has often been reported to be associated with cytomegalovirus (CMV) infection. We present a case of a previously healthy 22-month-old boy presenting with PLE, who was initially suspected to have an eosinophilic GI disorder. However, he was eventually confirmed, by detection of CMV DNA using polymerase chain reaction (PCR) with gastric tissue, to have MD associated with an active CMV infection. We suggest that endoscopic and pathological evaluation is necessary for the differential diagnosis of MD. In addition, CMV DNA detection using PCR analysis of biopsy tissue is recommended to confirm the etiologic agent of MD regardless of the patient's age or immune status.
