Framycetin

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W. Hauke - One of the best experts on this subject based on the ideXlab platform.

H. Knothe - One of the best experts on this subject based on the ideXlab platform.

A. K. Dorle - One of the best experts on this subject based on the ideXlab platform.

  • Wound Healing Activity Of Durva Ghrita
    Indian Journal of Pharmaceutical Sciences, 2003
    Co-Authors: M. S. Charde, Suniket V. Fulzele, P.m Satturwar, A. K. Dorle
    Abstract:

    Durva ghrita is herbal formulation containing Cynodon dactylon and Cow's ghee as its main constituents. In the present study Durva ghrita was evaluated for its wound healing property by incision and excision wound models in male Wistar rats. Treatment with Durva ghrita alone promoted wound contraction and reduced the time for closure showing healing potential comparable to Framycetin sulphate cream 1% w/w. Histopathological studies shows proliferation of epithelial tissue, angiogenesis and fibrosis due to treatment with Durva ghrita. The present study demonstrates wound healing potential of the test formulation.

  • Wound Healing Activity Of Chandanadi Yamak In Rats
    Indian Journal of Pharmaceutical Sciences, 2003
    Co-Authors: Suniket V. Fulzele, P.m Satturwar, S. B. Joshi, A. K. Dorle
    Abstract:

    Panchagavya is a term used in Ayurveda to describe the five important bovine products, milk, curd, ghee, urine and dung. Several formulations based on panchagavya are reported in Ayurvedic texts. One such formulation, Chandanadi Yamak was tested in the present study for its topical wound healing activity. Studies were conducted in male Wistar rats. Two wound models, incision wounds for tensile strength and excision wounds for wound contraction were employed along with histopathological evaluation. The application of the test formulation alone promoted wound contraction and reduced the time for wound closure showing healing potential comparable to marketed Framycetin sulphate cream (1% w/w).The histological studies reveal complete healing with the test formulation showing good keratinization, epithelialization, fibrosis and angiogenesis. The present study demonstrates the wound healing potential of the test formulation.

  • Study of the topical wound healing activity of darvhi ghrita
    Indian drugs, 2003
    Co-Authors: M. S. Charde, Suniket V. Fulzele, P.m Satturwar, A. K. Dorle
    Abstract:

    Darvhi ghrita is a herbal formulation containing cow's ghee and Berberis aristata as its main constituents. It is being tested in present study for its topical wound healing activity. The activity was studied in male wistar rats. In this study two wound models were studied viz. Incision wounds (for tensile strength) and Excision wound (To quantify wound contraction with histopathological evaluation). Treatment with Darvhi ghrita alone promoted wound contraction and reduced the time for closure showing good healing potential compared to marketed Framycetin sulphate cream (FSC) 1% w/w. The Histopathological studies reveal complete healing with test formulation showing better epithelization, fibrosis and angiogenesis. The present study demonstrates wound healing potential of test formulation.

  • Wound healing activity of Hingvadya ghrita in rats
    Indian drugs, 2002
    Co-Authors: Suniket V. Fulzele, P.m Satturwar, S. B. Joshi, A. K. Dorle
    Abstract:

    The present study aims to evaluate the wound healing activity of a polyherbal formulation Hingvadya ghrita in rats. Incision wounds for tensile strength and excision wounds for wound contraction along with the histopathological examination of the regenerated tissue were employed to investigate the wound healing potential. Topical application of the test formulation alone promoted the tensile strength (incision wounds) and wound contraction (excision wounds) showing healing potential comparable to Framycetin sulphate cream (1% w/w). Histological examination reveal good keratinization, epithelization, fibrosis and collagenation indicative of the wound healing potential of Hingvadya ghrita. The present study thus offers a valuable insight into the claimed wound healing potential of the test formulation.

Kl Bairy - One of the best experts on this subject based on the ideXlab platform.

  • COMPARATIVE EFFECT OF SODIUM FUSIDATE, Framycetin SULPHATE ON EXPERIMENTALLY INDUCED BURN WOUND HEALING Research Article
    2011
    Co-Authors: Kl Bairy, Avinash M Holla, Pawan Kumar, Satish Kumar
    Abstract:

    Topical antibiotics like Sodium fusidate, Framycetin are used to treat burn wounds. But whether they influence healing of wounds is not known. The aim of the experiment to compare the effect of Sodium fusidate, Framycetin of Apex Laboratories Chennai, with that of available market preparations on experimentally induced burn wound healing in Wistar rats. Partial thickness burn wounds was inflicted, on Wistar rats under ketamine (50mg/kg/i.p), by pouring hot molten wax at 80 ◦ C into a metal cylinder of 300 mm 2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI and VII received topical creams of Sodium fusidate A, Sodium fusidate B, Fucidic acid, Framycetin A, Framycetin B, and Framycetin respectively, twice a day for 21 days or till complete healing whichever was earlier. Sodium fusidate B and Framycetin A significantly decreased the duration of epithelialisation and increased % of wound contraction in comparison to the control group. This was confirmed by histopathology studies. Sodium fusidate and Framycetin possess significant wound healing properties.

  • Comparative effect of Sodium fusidate, Framycetin and Calcium mupirocin on experimentally induced burn wound healing
    2010
    Co-Authors: Kl Bairy, Avinash M Holla, Pawan Kumar, Veena Nayak, M Satish Kumar, Sachidananda Adiga, Rajesh C Subramanya, Br Chandrashekhar, Bharti Chogtu
    Abstract:

    Topical antibiotics like sodium fusidate, Framycetin and calcium mupirocin are used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: to compare the effect of sodium fusidate, Framycetin and calcium mupirocin of Apex Laboratories Chennai, on experimentally induced burn wound healing in male Wistar rats and compare with available market preparation namely, Fucidin cream 2% (ranbaxy), T Bact cream (GSK) & Soframycin cream (Sanofi-aventis). Method: Partial thickness burn wounds was inflicted, on Wistar rats under pentobarbitone anesthesia (30mg/kg/i.p), by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group 1 did not receive any drug and served as control group. Group 2, 3, 4, 5, 6, 7 received sodium fusidate, Framycetin, calcium mupirocin, Fucidin 2% (ranbaxy), T Bact (GSK) and So-framycin (Sanofi-aventis) creams topically respectively twice daily for 21 days or till complete healing whichever was earlier. Results: Sodium fusidate significantly decreased the duration of epithelialization increased wound contraction in comparison to the control group. This was confirmed by histopathology studies. Conclusion: Sodium fusidate possess significant wound heal-ing properties.

M. A. Singara Charya - One of the best experts on this subject based on the ideXlab platform.

  • Studies on wound healing potential of red pigment isolated from marine Bacterium Vibrio sp.
    Elsevier, 2019
    Co-Authors: Pabba Shiva Krishna, S. Sudha, Fahad A. Al-dhabaan, Reddy Shetty Prakasham, Ashok K. Reddy, M. A. Singara Charya
    Abstract:

    Wounds are common clinical entities of life which may be subacute or acute. Wound healing is a complex biochemical process where the cell structures are restored to normalcy, which depend on cell proliferation and migration, basically fibroblast cell. The present investigation was undertaken to evaluate the healing efficacy of red pigment isolated from marine isolate Vibrio sps on experimental wounds in albino rats. The red pigment was applied topically, twice daily for 14 days. Treatment with Framycetin ointment was used as reference control. The red pigment treated group showed faster reduction in wound area in comparison with control and Framycetin ointment treated groups. In conclusion, red pigment possesses significant healing potential in wounds and has a positive influence on the different phases of wound repair. Keywords: Pigments, Marine microbes, Vibrio sps, Wound healing, Anti bacteria

  • Studies on wound healing potential of red pigment isolated from marine Bacterium Vibrio sp.
    Saudi Journal of Biological Sciences, 2017
    Co-Authors: Pabba Shiva Krishna, S. Sudha, K. Ashok Reddy, Fahad A. Al-dhabaan, Meher, Reddy Shetty Prakasham, M. A. Singara Charya
    Abstract:

    Wounds are common clinical entities of life which may be subacute or acute. Wound healing is a complex biochemical process where the cell structures are restored to normalcy, which depend on cell proliferation and migration, basically fibroblast cell. The present investigation was undertaken to evaluate the healing efficacy of red pigment isolated from marine isolate Vibrio sps on experimental wounds in albino rats. The red pigment was applied topically, twice daily for 14 days. Treatment with Framycetin ointment was used as reference control. The red pigment treated group showed faster reduction in wound area in comparison with control and Framycetin ointment treated groups. In conclusion, red pigment possesses significant healing potential in wounds and has a positive influence on the different phases of wound repair.