The Experts below are selected from a list of 279 Experts worldwide ranked by ideXlab platform
Cristina Solomon - One of the best experts on this subject based on the ideXlab platform.
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transfusion in trauma thromboelastometry guided coagulation factor concentrate based therapy versus standard Fresh Frozen Plasma based therapy
Critical Care, 2011Co-Authors: Herbert Schochl, Ulrike Nienaber, Marc Maegele, Gerald Hochleitner, Florian Primavesi, Beatrice Steitz, Christian Arndt, Alexander A Hanke, Wolfgang G Voelckel, Cristina SolomonAbstract:Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with Fresh Frozen Plasma (FFP)-based haemostatic therapy.
Kevin D Mullen - One of the best experts on this subject based on the ideXlab platform.
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role of Fresh Frozen Plasma infusion in correction of coagulopathy of chronic liver disease a dual phase study
The American Journal of Gastroenterology, 2003Co-Authors: Wael Youssef, Fernando Salazar, Srinivasan Dasarathy, Timothy Beddow, Kevin D MullenAbstract:OBJECTIVE: Fresh Frozen Plasma infusions are commonly used to correct the prolonged prothrombin time in patients with advanced chronic liver disease. The aim of this study was to establish how frequently this treatment is effective in correcting this coagulopathy. METHODS: A split retrospective-prospective study design was employed. In the retrospective series, 80 patients were identified with prolongation of the prothrombin time who received Fresh Frozen Plasma infusions. In the prospective arm, 20 patients were included. All patients had confirmed chronic liver disease and showed no response to vitamin K injections. None of the patients had evidence of disseminated intravascular coagulation. The indications for infusion of Fresh Frozen Plasma, number of units administered, complications, and percentage of patients who corrected their prothrombin time to less than 3 s longer than control time were recorded. RESULTS: The majority of patients (75%) received 2-4 units of Fresh Frozen Plasma. The mean prothrombin time was numerically improved by the infusion of 2-6 units of Fresh Frozen Plasma. However, using correction to less than 3 s longer than control time as an endpoint, only 12.5% of the retrospective and 10% of the prospective study groups respectively had correction of their coagulopathy. Only one complication of infusion of Plasma was noted during the course of the study. CONCLUSIONS: Our results reiterate previous observations made more than 45 yr ago, that Fresh Frozen Plasma infusions using the number of units commonly employed in clinical practice infrequently correct the coagulopathy of patients with chronic liver disease. Higher volumes (6 or more units) may be more effective but are rarely employed.
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role of Fresh Frozen Plasma infusion in correction of coagulopathy of chronic liver disease a dual phase study
The American Journal of Gastroenterology, 2003Co-Authors: Wael Youssef, Fernando Salazar, Srinivasan Dasarathy, Timothy Beddow, Kevin D MullenAbstract:Role of Fresh Frozen Plasma Infusion in Correction of Coagulopathy of Chronic Liver Disease: A Dual Phase Study
Herbert Schochl - One of the best experts on this subject based on the ideXlab platform.
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transfusion in trauma thromboelastometry guided coagulation factor concentrate based therapy versus standard Fresh Frozen Plasma based therapy
Critical Care, 2011Co-Authors: Herbert Schochl, Ulrike Nienaber, Marc Maegele, Gerald Hochleitner, Florian Primavesi, Beatrice Steitz, Christian Arndt, Alexander A Hanke, Wolfgang G Voelckel, Cristina SolomonAbstract:Introduction Thromboelastometry (TEM)-guided haemostatic therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in trauma patients may reduce the need for transfusion of red blood cells (RBC) or platelet concentrate, compared with Fresh Frozen Plasma (FFP)-based haemostatic therapy.
Bruce D Spiess - One of the best experts on this subject based on the ideXlab platform.
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treating heparin resistance with antithrombin or Fresh Frozen Plasma
The Annals of Thoracic Surgery, 2008Co-Authors: Bruce D SpiessAbstract:Heparin resistance occurs in up to 22% of patients undergoing cardiac surgery requiring cardiopulmonary bypass and it is associated with decreased levels of antithrombin. Treatment options for heparin resistance include administration of antithrombin or Fresh Frozen Plasma. A systematic review revealed no clinical trials directly comparing antithrombin with Fresh Frozen Plasma as heparin resistance treatment during cardiopulmonary bypass. Thus, the aim of this review is to discuss the limited number of published reports assessing antithrombin or Fresh Frozen Plasma in managing heparin resistance and to present emerging data regarding Fresh Frozen Plasma safety issues and practical considerations for antithrombin treatment in patients with heparin resistance undergoing cardiopulmonary bypass.
Mark Crowther - One of the best experts on this subject based on the ideXlab platform.
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Fresh Frozen Plasma transfusion in critically ill patients
Critical Care Medicine, 2007Co-Authors: Francois Lauzier, Deborah J Cook, Lauren E Griffith, Julia Upton, Mark CrowtherAbstract:Objectives:Although guidelines for Fresh Frozen Plasma (FFP) use have been published, many transfusions are considered inappropriate. Current guidelines suggest few circumstances in which FFP transfusion to critically ill patients is warranted. The objectives of this study were to evaluate the consi
