The Experts below are selected from a list of 491196 Experts worldwide ranked by ideXlab platform
Reinhard Vehring - One of the best experts on this subject based on the ideXlab platform.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: Susan Hoe, James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach. Formulation design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. The design targets were met. The formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.
James W Ivey - One of the best experts on this subject based on the ideXlab platform.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: Susan Hoe, James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach. Formulation design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. The design targets were met. The formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.
Emadeddin Javaheri - One of the best experts on this subject based on the ideXlab platform.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: Susan Hoe, James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach. Formulation design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. The design targets were met. The formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.
Abouzar Shamsaddinishahrbabak - One of the best experts on this subject based on the ideXlab platform.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: Susan Hoe, James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach. Formulation design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. The design targets were met. The formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.
Mohammed A Boraey - One of the best experts on this subject based on the ideXlab platform.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:Purpose A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach.
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use of a Fundamental Approach to spray drying formulation design to facilitate the development of multi component dry powder aerosols for respiratory drug delivery
Pharmaceutical Research, 2014Co-Authors: Susan Hoe, James W Ivey, Mohammed A Boraey, Abouzar Shamsaddinishahrbabak, Emadeddin Javaheri, Sadaf Matinkhoo, Warren H Finlay, Reinhard VehringAbstract:A Fundamental Approach incorporating current theoretical models into aerosol formulation design potentially reduces experimental work for complex formulations. A D-amino acid mixture containing D-Leucine (D-Leu), D-Methionine, D-Tryptophan, and D-Tyrosine was selected as a model formulation for this Approach. Formulation design targets were set, with the aim of producing a highly dispersible D-amino acid aerosol. Particle formation theory and a spray dryer process model were applied with boundary conditions to the design targets, resulting in a priori predictions of particle morphology and necessary spray dryer process parameters. Two formulations containing 60% w/w trehalose, 30% w/w D-Leu, and 10% w/w remaining D-amino acids were manufactured. The design targets were met. The formulations had rugose and hollow particles, caused by deformation of a crystalline D-Leu shell while trehalose remained amorphous, as predicted by particle formation theory. D-Leu acts as a dispersibility enhancer, ensuring that both formulations: 1) delivered over 40% of the loaded dose into the in vitro lung region, and 2) achieved desired values of lung airway surface liquid concentrations based on lung deposition simulations. Theoretical models were applied to successfully achieve complex formulations with design challenges a priori. No further iterations to the design process were required.
