The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
W. Ventura - One of the best experts on this subject based on the ideXlab platform.
-
Fungal Endocarditis evidence in the world literature 1965 1995
Clinical Infectious Diseases, 2001Co-Authors: Michael Ellis, A. Sandridge, W. Greer, H Alabdely, W. VenturaAbstract:We analyzed 270 cases of Fungal Endocarditis (FE) that occurred over 30 years. Vascular lines, non-cardiac surgery, immunocompromise and injection drug abuse are increasing risk factors. Delayed or mistaken diagnosis (82% of patients), long duration of symptoms before hospitalization (mean +/- standard deviation, 32+/-39 days) and extracardiac manifestations were characteristic. From 1988 onwards, 72% of patients were diagnosed preoperatively, compared with 43% before 1988 (P=.0001). The fungi most commonly isolated were Candida albicans (24% of patients), non-albicans species of Candida (24%), Apergillus species (24%), and Histoplasma species (6%); recently-emerged fungi accounted for 25% of cases. The mortality rate was 72%. Survival rates were better among patients who received combined surgical-antiFungal treatment, were infected with Candida, and had univalvular involvement. Improvement in the survival rate (from or =4 years while on prophylactic antiFungal therapy.
-
Fungal Endocarditis: Evidence in the World Literature, 1965–1995
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000Co-Authors: Michael Ellis, H. Al-abdely, A. Sandridge, W. Greer, W. VenturaAbstract:We analyzed 270 cases of Fungal Endocarditis (FE) that occurred over 30 years. Vascular lines, non-cardiac surgery, immunocompromise and injection drug abuse are increasing risk factors. Delayed or mistaken diagnosis (82% of patients), long duration of symptoms before hospitalization (mean +/- standard deviation, 32+/-39 days) and extracardiac manifestations were characteristic. From 1988 onwards, 72% of patients were diagnosed preoperatively, compared with 43% before 1988 (P=.0001). The fungi most commonly isolated were Candida albicans (24% of patients), non-albicans species of Candida (24%), Apergillus species (24%), and Histoplasma species (6%); recently-emerged fungi accounted for 25% of cases. The mortality rate was 72%. Survival rates were better among patients who received combined surgical-antiFungal treatment, were infected with Candida, and had univalvular involvement. Improvement in the survival rate (from or =4 years while on prophylactic antiFungal therapy.
Michael Ellis - One of the best experts on this subject based on the ideXlab platform.
-
Fungal Endocarditis evidence in the world literature 1965 1995
Clinical Infectious Diseases, 2001Co-Authors: Michael Ellis, A. Sandridge, W. Greer, H Alabdely, W. VenturaAbstract:We analyzed 270 cases of Fungal Endocarditis (FE) that occurred over 30 years. Vascular lines, non-cardiac surgery, immunocompromise and injection drug abuse are increasing risk factors. Delayed or mistaken diagnosis (82% of patients), long duration of symptoms before hospitalization (mean +/- standard deviation, 32+/-39 days) and extracardiac manifestations were characteristic. From 1988 onwards, 72% of patients were diagnosed preoperatively, compared with 43% before 1988 (P=.0001). The fungi most commonly isolated were Candida albicans (24% of patients), non-albicans species of Candida (24%), Apergillus species (24%), and Histoplasma species (6%); recently-emerged fungi accounted for 25% of cases. The mortality rate was 72%. Survival rates were better among patients who received combined surgical-antiFungal treatment, were infected with Candida, and had univalvular involvement. Improvement in the survival rate (from or =4 years while on prophylactic antiFungal therapy.
-
Fungal Endocarditis: Evidence in the World Literature, 1965–1995
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2000Co-Authors: Michael Ellis, H. Al-abdely, A. Sandridge, W. Greer, W. VenturaAbstract:We analyzed 270 cases of Fungal Endocarditis (FE) that occurred over 30 years. Vascular lines, non-cardiac surgery, immunocompromise and injection drug abuse are increasing risk factors. Delayed or mistaken diagnosis (82% of patients), long duration of symptoms before hospitalization (mean +/- standard deviation, 32+/-39 days) and extracardiac manifestations were characteristic. From 1988 onwards, 72% of patients were diagnosed preoperatively, compared with 43% before 1988 (P=.0001). The fungi most commonly isolated were Candida albicans (24% of patients), non-albicans species of Candida (24%), Apergillus species (24%), and Histoplasma species (6%); recently-emerged fungi accounted for 25% of cases. The mortality rate was 72%. Survival rates were better among patients who received combined surgical-antiFungal treatment, were infected with Candida, and had univalvular involvement. Improvement in the survival rate (from or =4 years while on prophylactic antiFungal therapy.
Ko M Zelj - One of the best experts on this subject based on the ideXlab platform.
-
a case of recurrent candida parapsilosis prosthetic valve Endocarditis cure by medical treatment alone
Journal of Infection, 1997Co-Authors: T Lejkozupanc, Ko M ZeljAbstract:A patient with recurrent Fungal Endocarditis on prosthetic mitral valve is presented. Candida parapsilosis was the causative agent. The patient was treated medically with conventional amphotericin during the first episode. When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects. Treatment was continued with amphotericin B colloidal dispersion, followed by fluconazole for 8 months. The patient is healthy 16 months after discontinuation of fluconazole. Medical treatment of Fungal Endocarditis on prosthetic valves can be successful in selected cases.
Kjell Alestig - One of the best experts on this subject based on the ideXlab platform.
-
Fungal Endocarditis — a report on seven cases and a brief review
Infection, 1996Co-Authors: Harriet Hogevik, Kjell AlestigAbstract:Candida Endocarditis is an unusual but severe complication of systemic infection caused byCandida albicans and occasionally by other Fungal species. We describe seven cases that occurred during a period of 20 years in western Sweden. In four cases infections were located on prosthetic valves and in three cases native valves were involved. Three patients died of the disease in the acute phase. A definite diagnosis was established in one of four survivors. This patient had an aortic valve Endocarditis and a saddle embolisation and was treated with immediate surgery, followed by intensive treatment with liposomal amphotericin B + flucytosine. Fungal Endocarditis is still a serious disease with a high mortality and whenever the diagnosis is suspected, antiFungal therapy must be started and transesophageal sonography should be performed to visualize vegetations. Immediate surgery should be considered.
-
Fungal Endocarditis a report on seven cases and a brief review
Infection, 1996Co-Authors: Harriet Hogevik, Kjell AlestigAbstract:Candida Endocarditis is an unusual but severe complication of systemic infection caused byCandida albicans and occasionally by other Fungal species. We describe seven cases that occurred during a period of 20 years in western Sweden. In four cases infections were located on prosthetic valves and in three cases native valves were involved. Three patients died of the disease in the acute phase. A definite diagnosis was established in one of four survivors. This patient had an aortic valve Endocarditis and a saddle embolisation and was treated with immediate surgery, followed by intensive treatment with liposomal amphotericin B + flucytosine. Fungal Endocarditis is still a serious disease with a high mortality and whenever the diagnosis is suspected, antiFungal therapy must be started and transesophageal sonography should be performed to visualize vegetations. Immediate surgery should be considered.
-
Fungal Endocarditis — a report on seven cases and a brief review
Infection, 1996Co-Authors: Harriet Hogevik, Kjell AlestigAbstract:Die Candida -Endokarditis ist eine seltene, aber schwere Komplikation einer systemischen Infektion durch Candida albicans und gelegentlich auch durch andere Pilzspezies. Wir berichten über sieben Fälle, die in einem Zeitraum von 20 Jahren in Westschweden beobachtet wurden. In vier Fällen waren Klappenprothesen und in drei Fällen natürliche Klappen betroffen. Drei Patienten starben in der akuten Phase an der Krankheit. Bei einem der vier überlebenden Patienten konnte die Diagnose eindeutig gesichert werden. Dieser Patient hatte eine Aortenklappenendokarditis und einen reitenden Embolus. Er wurde sofort operiert und hochdosiert mit liposomalem Amphotericin B und mit Flucytosin behandelt. Die Pilzendokarditis ist nach wie vor eine ernste, mit hoher Letalität belastete Krankheit. Die antimykotische Therapie muß bereits beim ersten Verdacht begonnen werden. Um Vegetationen nachzuweisen, sollte die transösophageale Sonographie durchgeführt werden. Ein sofortiges chirurgisches Eingreifen ist zu erwägen. Candida Endocarditis is an unusual but severe complication of systemic infection caused by Candida albicans and occasionally by other Fungal species. We describe seven cases that occurred during a period of 20 years in western Sweden. In four cases infections were located on prosthetic valves and in three cases native valves were involved. Three patients died of the disease in the acute phase. A definite diagnosis was established in one of four survivors. This patient had an aortic valve Endocarditis and a saddle embolisation and was treated with immediate surgery, followed by intensive treatment with liposomal amphotericin B + flucytosine. Fungal Endocarditis is still a serious disease with a high mortality and whenever the diagnosis is suspected, antiFungal therapy must be started and transesophageal sonography should be performed to visualize vegetations. Immediate surgery should be considered.
Niloo M. Edwards - One of the best experts on this subject based on the ideXlab platform.
-
Aortoventricular Dissociation and Refractory Fungal Endocarditis Caused by a Rare Pathogen Lichtheimia: A Surgical and Medical Management Strategy.
The Annals of thoracic surgery, 2017Co-Authors: Christopher M. Terrien, Niloo M. EdwardsAbstract:We report a rare case of prosthetic valve Fungal Endocarditis caused by Lichtheimia, a subspecies of the order Mucorales. The patient experienced complicated prosthetic valve Endocarditis less than 2 months after uneventful coronary artery bypass grafting (CABG) and 2 aortic valve replacements. Ultimately surgical management required aortic root replacement and lifelong antimicrobial agents. We believe this is the first case of Fungal Endocarditis caused by Lichtheimia.
