The Experts below are selected from a list of 96 Experts worldwide ranked by ideXlab platform
Mamoru Yamaguchi - One of the best experts on this subject based on the ideXlab platform.
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Tubular aggregates observed in spindle Muscle fiber of horse lumbrical Muscle
Acta Neuropathologica, 2001Co-Authors: Wuthichai Klomkleaw, Yoshinori Kasashima, Ataru Kobayashi, Geraldine Fuller, Masahiro Morimoto, Tetsuya Nakade, Makoto Muto, Robert L. Hamlin, Mamoru YamaguchiAbstract:Tubular aggregates (TAs) originate from the sarcoplasmic reticulum (SR) and form polymorphic double (or single) -walled structures in cross section. TAs are involved in various human skeletal Muscle disorders including periodic paralysis, congenital myasthenic syndromes, inflammatory myopathies, and malignant hyperthermias. Horse lumbrical Muscle (LM) is a slender Fusiform Muscle that shows varying degrees of regression due to its limited activity in the limb. Double-walled TAs were found in degenerating spindle fibers and with a range of 80–116 nm (average 92 nm, n =135) for outer layer and 50–78 nm (average 59 nm, n =135) for the inner layer. TAs exhibit degradation of myofibrillar proteins, disruption of mitochondria with cristae lost, glycogen accumulation, electron-dense metabolic products, blebbing appearance of sarcolemma, and presence of various vacuoles. LM fibers also show a similarly degenerative state. The disassembly of the SR structure probably produces a large accumulation of SR proteins which remain as molecules without being further degraded and which could aggregate to form the orderly structure of TAs. We believe that TA formation may be an adaptation to store unbalanced extra proteins by forming ordered aggregates in degeneration caused by stress in cells.
Vishal Manohar Rao Salve - One of the best experts on this subject based on the ideXlab platform.
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Incidence of the third head of biceps brachii in population of Andhra Pradesh
National Journal of Clinical Anatomy, 2020Co-Authors: Vishal Manohar Rao Salve, Chandaka Swathi PoornimaAbstract:Abstract Background and aims : The biceps brachii is a large Fusiform Muscle in the flexor compartment of the arm. In terms of the number and morphology of its head, the biceps brachii Muscle is one of the most variable Muscles in human body. The present study explores the importance of such variations. Materials and methods: The upper limbs of embalmed human cadavers (fixed in 10 % formaldehyde solution) were included in present study. Total 36 (72 upper limbs) cadavers were studied by dissection. Results: Among the 72 superior extremities studied, six (8.33%) arms were found to have a three- headed biceps brachii Muscles. The variation was present in the left arm of four males and one female. The variation was present in the right arm of one male. Conclusion : Presence of third head of biceps brachii Muscle might increase its kinematics. Supernumerary heads of biceps brachii Muscle may become significant in pre-operative procedure and during surgery of upper limb.
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A third head of the biceps brachii and coexisting fused higher origin of brachioradialis
International Journal of Anatomical Variations, 2020Co-Authors: Anita S. Fating, Vishal Manohar Rao SalveAbstract:The biceps brachii is a large Fusiform Muscle in the flexor compartment of the arm. Brachioradialis is the most superficial Muscle of the forearm. It has been reported that in 10% cases the third head of biceps brachii may arise from the supero-medial part of the brachialis and is attached to the bicipital apponeurosis. The presence of the third head is important for academic and clinical purpose. During routine dissection of a middle aged male cadaver at the Dr. PSIMS & RF, Gannavaram (INDIA); third head of biceps brachii and fused higher origin of brachioradialis were found in the left upper limb. The third head of biceps brachii arose from superomedial part of brachialis. Brachioradialis had higher additional origin beside its usual origin from proximal 2/3 of the lateral supracondylar crest of humerus. A variation in the heads of the biceps brachii Muscle has already been reported to cause compression of surrounding neurovascular structures.
Gujaria Ij - One of the best experts on this subject based on the ideXlab platform.
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A case of third head of biceps brachii Muscle and fused higher origin of brachioradialis
2020Co-Authors: Gujaria IjAbstract:The biceps brachii is a large Fusiform Muscle in the flexor compartment of the arm. During routine dissection of the left upper limb, a third head of biceps brachii which arose from superomedial part of brachialis and fused higher origin of brachioradialis was found. Brachioradialis had higher additional origin besides its usual origin. A variation in the heads of the biceps brachii Muscle has been reported to compress the surrounding neurovascular structures.
Wuthichai Klomkleaw - One of the best experts on this subject based on the ideXlab platform.
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Tubular aggregates observed in spindle Muscle fiber of horse lumbrical Muscle
Acta Neuropathologica, 2001Co-Authors: Wuthichai Klomkleaw, Yoshinori Kasashima, Ataru Kobayashi, Geraldine Fuller, Masahiro Morimoto, Tetsuya Nakade, Makoto Muto, Robert L. Hamlin, Mamoru YamaguchiAbstract:Tubular aggregates (TAs) originate from the sarcoplasmic reticulum (SR) and form polymorphic double (or single) -walled structures in cross section. TAs are involved in various human skeletal Muscle disorders including periodic paralysis, congenital myasthenic syndromes, inflammatory myopathies, and malignant hyperthermias. Horse lumbrical Muscle (LM) is a slender Fusiform Muscle that shows varying degrees of regression due to its limited activity in the limb. Double-walled TAs were found in degenerating spindle fibers and with a range of 80–116 nm (average 92 nm, n =135) for outer layer and 50–78 nm (average 59 nm, n =135) for the inner layer. TAs exhibit degradation of myofibrillar proteins, disruption of mitochondria with cristae lost, glycogen accumulation, electron-dense metabolic products, blebbing appearance of sarcolemma, and presence of various vacuoles. LM fibers also show a similarly degenerative state. The disassembly of the SR structure probably produces a large accumulation of SR proteins which remain as molecules without being further degraded and which could aggregate to form the orderly structure of TAs. We believe that TA formation may be an adaptation to store unbalanced extra proteins by forming ordered aggregates in degeneration caused by stress in cells.
Amber R. Deslauriers - One of the best experts on this subject based on the ideXlab platform.
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Regional heterogeneity in Muscle fiber strain: the role of fiber architecture.
Frontiers in Physiology, 2014Co-Authors: Emanuel Azizi, Amber R. DeslauriersAbstract:The force, mechanical work and power produced by Muscle fibers are profoundly affected by the length changes they undergo during a contraction. These length changes are in turn affected by the spatial orientation of Muscle fibers within a Muscle (fiber architecture). Therefore any heterogeneity in fiber architecture within a single Muscle has the potential to cause spatial variation in fiber strain. Here we examine how the architectural variation within a pennate Muscle and within a Fusiform Muscle can result in regional fiber strain heterogeneity. We combine simple geometric models with empirical measures of fiber strain to better understand the effect of architecture on fiber strain heterogeneity. We show that variation in pennation angle throughout a Muscle can result in differences in fiber strain with higher strains being observed at lower angles of pennation. We also show that in Fusiform Muscles, the outer/superficial fibers of the Muscle experience lower strains than central fibers. These results show that regional variation in mechanical output of Muscle fibers can arise solely from architectural features of the Muscle without the presence of any spatial variation in motor recruitment.
