The Experts below are selected from a list of 3630 Experts worldwide ranked by ideXlab platform
Jan Albrecht - One of the best experts on this subject based on the ideXlab platform.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 microM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 muM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by approximately 12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 microM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain Research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Abstract Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 μM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to ∼29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 μM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by ∼12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 μM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
Wojciech Hilgier - One of the best experts on this subject based on the ideXlab platform.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 microM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 muM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by approximately 12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 microM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain Research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Abstract Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 μM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to ∼29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 μM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by ∼12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 μM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
G. Singh - One of the best experts on this subject based on the ideXlab platform.
-
(.+‐.)‐2‐Amino‐2‐thiazoline‐4‐ethanoic Acid. A Novel, Specific GABAA Receptor Agonist.
ChemInform, 2010Co-Authors: Malcolm M. Campbell, S. J. Mickel, G. SinghAbstract:Abstract Intramolecular Michael cyclization led directly to-amino-2-thiazoline-4-ethanoic acid, a new and potent member of the limited group of specific GABA A Receptor Agonists.
-
2 amino 2 thiazoline 4 ethanoic acid a novel specific GABAA Receptor Agonist
ChemInform, 1993Co-Authors: Malcolm M. Campbell, S. J. Mickel, G. SinghAbstract:Abstract Intramolecular Michael cyclization led directly to-amino-2-thiazoline-4-ethanoic acid, a new and potent member of the limited group of specific GABA A Receptor Agonists.
-
(±)-2-amino-2-thiazoline-4-ethanoic acid; a novel, specific GABAA Receptor Agonist
Bioorganic & Medicinal Chemistry Letters, 1991Co-Authors: Malcolm M. Campbell, S. J. Mickel, G. SinghAbstract:Abstract Intramolecular Michael cyclization led directly to-amino-2-thiazoline-4-ethanoic acid, a new and potent member of the limited group of specific GABA A Receptor Agonists.
Simo S Oja - One of the best experts on this subject based on the ideXlab platform.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 microM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 muM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by approximately 12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 microM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain Research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Abstract Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 μM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to ∼29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 μM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by ∼12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 μM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
Pirjo Saransaari - One of the best experts on this subject based on the ideXlab platform.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 microM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 muM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by approximately 12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 microM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
-
Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine Receptors.
Brain Research, 2005Co-Authors: Wojciech Hilgier, Simo S Oja, Pirjo Saransaari, Jan AlbrechtAbstract:Abstract Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA Receptor antAgonist bicuculline or a glycine Receptor antAgonist strychnine (100 μM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to ∼29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antAgonists or of 100 μM picrotoxin, which is an antAgonist of both GABAA and Gly Receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by ∼12% upon coinfusion of a GABAA Receptor Agonist muscimol (100 μM). The results suggest that stimulation of both GABAA and glycine Receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
