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D.k.v. Prasad - One of the best experts on this subject based on the ideXlab platform.
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association of GABRA6 1519 t c rs3219151 and synapsin ii rs37733634 gene polymorphisms with the development of idiopathic generalized epilepsy
Epilepsy Research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, Akka Jyothy, Surya T Prabha, Anjana MunshiAbstract:Summary The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABA A and GABA B receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of ‘CC' genotype and ‘C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ 2 =26; p vs T, χ 2 =24.7; p G in Syn II gene was also found to be significantly associated with the disease when compared to controls [GG vs AA, χ 2 =64.52; p vs. A, χ 2 =65.78; p χ 2 =36.6, p C and Syn II (rs37733634) A>G polymorphisms are important risk factors for the development of IGE in the South Indian population from Andhra Pradesh. The gene–gene interaction studies demonstrated significant interactive effects of these two loci in the development of the disease.
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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Epilepsy research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, T. Surya Prabha, Akka Jyothy, Anjana MunshiAbstract:The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABAA and GABAB receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of 'CC' genotype and 'C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ2=26; p
Anjana Munshi - One of the best experts on this subject based on the ideXlab platform.
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association of GABRA6 1519 t c rs3219151 and synapsin ii rs37733634 gene polymorphisms with the development of idiopathic generalized epilepsy
Epilepsy Research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, Akka Jyothy, Surya T Prabha, Anjana MunshiAbstract:Summary The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABA A and GABA B receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of ‘CC' genotype and ‘C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ 2 =26; p vs T, χ 2 =24.7; p G in Syn II gene was also found to be significantly associated with the disease when compared to controls [GG vs AA, χ 2 =64.52; p vs. A, χ 2 =65.78; p χ 2 =36.6, p C and Syn II (rs37733634) A>G polymorphisms are important risk factors for the development of IGE in the South Indian population from Andhra Pradesh. The gene–gene interaction studies demonstrated significant interactive effects of these two loci in the development of the disease.
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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Epilepsy research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, T. Surya Prabha, Akka Jyothy, Anjana MunshiAbstract:The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABAA and GABAB receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of 'CC' genotype and 'C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ2=26; p
Uzma Shaheen - One of the best experts on this subject based on the ideXlab platform.
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association of GABRA6 1519 t c rs3219151 and synapsin ii rs37733634 gene polymorphisms with the development of idiopathic generalized epilepsy
Epilepsy Research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, Akka Jyothy, Surya T Prabha, Anjana MunshiAbstract:Summary The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABA A and GABA B receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of ‘CC' genotype and ‘C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ 2 =26; p vs T, χ 2 =24.7; p G in Syn II gene was also found to be significantly associated with the disease when compared to controls [GG vs AA, χ 2 =64.52; p vs. A, χ 2 =65.78; p χ 2 =36.6, p C and Syn II (rs37733634) A>G polymorphisms are important risk factors for the development of IGE in the South Indian population from Andhra Pradesh. The gene–gene interaction studies demonstrated significant interactive effects of these two loci in the development of the disease.
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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Epilepsy research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, T. Surya Prabha, Akka Jyothy, Anjana MunshiAbstract:The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABAA and GABAB receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of 'CC' genotype and 'C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ2=26; p
Akka Jyothy - One of the best experts on this subject based on the ideXlab platform.
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association of GABRA6 1519 t c rs3219151 and synapsin ii rs37733634 gene polymorphisms with the development of idiopathic generalized epilepsy
Epilepsy Research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, Akka Jyothy, Surya T Prabha, Anjana MunshiAbstract:Summary The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABA A and GABA B receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of ‘CC' genotype and ‘C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ 2 =26; p vs T, χ 2 =24.7; p G in Syn II gene was also found to be significantly associated with the disease when compared to controls [GG vs AA, χ 2 =64.52; p vs. A, χ 2 =65.78; p χ 2 =36.6, p C and Syn II (rs37733634) A>G polymorphisms are important risk factors for the development of IGE in the South Indian population from Andhra Pradesh. The gene–gene interaction studies demonstrated significant interactive effects of these two loci in the development of the disease.
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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Epilepsy research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, T. Surya Prabha, Akka Jyothy, Anjana MunshiAbstract:The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABAA and GABAB receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of 'CC' genotype and 'C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ2=26; p
U Satyanarayana - One of the best experts on this subject based on the ideXlab platform.
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association of GABRA6 1519 t c rs3219151 and synapsin ii rs37733634 gene polymorphisms with the development of idiopathic generalized epilepsy
Epilepsy Research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, Akka Jyothy, Surya T Prabha, Anjana MunshiAbstract:Summary The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABA A and GABA B receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of ‘CC' genotype and ‘C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ 2 =26; p vs T, χ 2 =24.7; p G in Syn II gene was also found to be significantly associated with the disease when compared to controls [GG vs AA, χ 2 =64.52; p vs. A, χ 2 =65.78; p χ 2 =36.6, p C and Syn II (rs37733634) A>G polymorphisms are important risk factors for the development of IGE in the South Indian population from Andhra Pradesh. The gene–gene interaction studies demonstrated significant interactive effects of these two loci in the development of the disease.
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Association of GABRA6 1519 T>C (rs3219151) and Synapsin II (rs37733634) gene polymorphisms with the development of idiopathic generalized epilepsy.
Epilepsy research, 2014Co-Authors: D.k.v. Prasad, Uzma Shaheen, U Satyanarayana, T. Surya Prabha, Akka Jyothy, Anjana MunshiAbstract:The idiopathic generalized epilepsy (IGE) is a neurological disorder which accounts for approximately 30% of all epilepsy cases. Patients identified with IGE syndromes have pharmacoresponsive epilepsies without abnormal neurological symptoms, structural brain lesions and are of unknown origin. A genetic etiology to IGEs has been proposed. Gamma amino butyric acid (GABA), a major inhibitory neurotransmitter acts by binding to transmembrane GABAA and GABAB receptors of both pre- and postsynaptic neurons. Synapsin II (SynII), a neuron specific phosphoprotein plays a major role in synaptogenesis and neurotransmitter release. The present study was carried out with an aim to evaluate the association of GABRA6 (rs3219151) T>C and Syn II (rs37733634) A>G gene polymorphisms with IGE. Molecular analysis revealed that the frequency of 'CC' genotype and 'C'allele of GABRA6 (rs3219151) T>C gene polymorphism was significantly higher in IGE patients compared to healthy controls [CC vs. TT, χ2=26; p
