GABRB1

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Chongde Lin - One of the best experts on this subject based on the ideXlab platform.

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    article i nfo Article history: Accepted 25 August 2014 Available online 2 September 2014 The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships be- tween the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, ge-

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships between the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, genetic, and behavioral data from 316 healthy Chinese adults (including 187 females and 129 males), and examined associations between GABRB1 variants, thalamus volume, and intelligence (measured by the Wechsler Adult Intelligence Scale Revised). After controlling for intracranial volume, sex, and age, GABRB1 genetic polymorphism at the SNP rs7435958 had the strongest association with thalamus volume (p = 0.002 and 0.00008 for left and right thalamus volumes, respectively), with GG homozygotes having smaller bilateral thalamus volumes than the other genotypes. Furthermore, there were positive correlations between bilateral thalamus volumes and intelligence, especially for GABRB1 rs7435958 GG female homozygotes (r's = 0.31 and 0.29, p < 0.01, for the correlations of intelligence with left and right thalamus volumes, respectively). This study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence. Future studies of the thalamus-intelligence associations should consider genetic factors as potential moderators.

Bi Zhu - One of the best experts on this subject based on the ideXlab platform.

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    article i nfo Article history: Accepted 25 August 2014 Available online 2 September 2014 The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships be- tween the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, ge-

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships between the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, genetic, and behavioral data from 316 healthy Chinese adults (including 187 females and 129 males), and examined associations between GABRB1 variants, thalamus volume, and intelligence (measured by the Wechsler Adult Intelligence Scale Revised). After controlling for intracranial volume, sex, and age, GABRB1 genetic polymorphism at the SNP rs7435958 had the strongest association with thalamus volume (p = 0.002 and 0.00008 for left and right thalamus volumes, respectively), with GG homozygotes having smaller bilateral thalamus volumes than the other genotypes. Furthermore, there were positive correlations between bilateral thalamus volumes and intelligence, especially for GABRB1 rs7435958 GG female homozygotes (r's = 0.31 and 0.29, p < 0.01, for the correlations of intelligence with left and right thalamus volumes, respectively). This study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence. Future studies of the thalamus-intelligence associations should consider genetic factors as potential moderators.

Chuansheng Chen - One of the best experts on this subject based on the ideXlab platform.

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    article i nfo Article history: Accepted 25 August 2014 Available online 2 September 2014 The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships be- tween the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, ge-

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships between the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, genetic, and behavioral data from 316 healthy Chinese adults (including 187 females and 129 males), and examined associations between GABRB1 variants, thalamus volume, and intelligence (measured by the Wechsler Adult Intelligence Scale Revised). After controlling for intracranial volume, sex, and age, GABRB1 genetic polymorphism at the SNP rs7435958 had the strongest association with thalamus volume (p = 0.002 and 0.00008 for left and right thalamus volumes, respectively), with GG homozygotes having smaller bilateral thalamus volumes than the other genotypes. Furthermore, there were positive correlations between bilateral thalamus volumes and intelligence, especially for GABRB1 rs7435958 GG female homozygotes (r's = 0.31 and 0.29, p < 0.01, for the correlations of intelligence with left and right thalamus volumes, respectively). This study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence. Future studies of the thalamus-intelligence associations should consider genetic factors as potential moderators.

Robert K Moyzis - One of the best experts on this subject based on the ideXlab platform.

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    article i nfo Article history: Accepted 25 August 2014 Available online 2 September 2014 The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships be- tween the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, ge-

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships between the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, genetic, and behavioral data from 316 healthy Chinese adults (including 187 females and 129 males), and examined associations between GABRB1 variants, thalamus volume, and intelligence (measured by the Wechsler Adult Intelligence Scale Revised). After controlling for intracranial volume, sex, and age, GABRB1 genetic polymorphism at the SNP rs7435958 had the strongest association with thalamus volume (p = 0.002 and 0.00008 for left and right thalamus volumes, respectively), with GG homozygotes having smaller bilateral thalamus volumes than the other genotypes. Furthermore, there were positive correlations between bilateral thalamus volumes and intelligence, especially for GABRB1 rs7435958 GG female homozygotes (r's = 0.31 and 0.29, p < 0.01, for the correlations of intelligence with left and right thalamus volumes, respectively). This study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence. Future studies of the thalamus-intelligence associations should consider genetic factors as potential moderators.

Gui Xue - One of the best experts on this subject based on the ideXlab platform.

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    article i nfo Article history: Accepted 25 August 2014 Available online 2 September 2014 The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships be- tween the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, ge-

  • The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence.
    NeuroImage, 2014
    Co-Authors: Bi Zhu, Chuansheng Chen, Gui Xue, Xuemei Lei, Robert K Moyzis, Qi Dong, Chongde Lin
    Abstract:

    The GABRB1 gene encodes the beta 1 subunit of the gamma-aminobutyric acid A receptor (GABA A receptor), which is responsible for mediating inhibitory neurotransmission in the thalamus. Potential relationships between the GABRB1 gene, thalamus volume, and intelligence have been suggested by previous clinical studies, but have not been directly examined among nonclinical samples. The current study collected structural MRI, genetic, and behavioral data from 316 healthy Chinese adults (including 187 females and 129 males), and examined associations between GABRB1 variants, thalamus volume, and intelligence (measured by the Wechsler Adult Intelligence Scale Revised). After controlling for intracranial volume, sex, and age, GABRB1 genetic polymorphism at the SNP rs7435958 had the strongest association with thalamus volume (p = 0.002 and 0.00008 for left and right thalamus volumes, respectively), with GG homozygotes having smaller bilateral thalamus volumes than the other genotypes. Furthermore, there were positive correlations between bilateral thalamus volumes and intelligence, especially for GABRB1 rs7435958 GG female homozygotes (r's = 0.31 and 0.29, p < 0.01, for the correlations of intelligence with left and right thalamus volumes, respectively). This study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence. Future studies of the thalamus-intelligence associations should consider genetic factors as potential moderators.