The Experts below are selected from a list of 109626 Experts worldwide ranked by ideXlab platform
Werner Windischhofer - One of the best experts on this subject based on the ideXlab platform.
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a new type of pharmacological chaperone for gm1 gangliosidosis related human lysosomal β Galactosidase n substituted 5 amino 1 hydroxymethyl cyclopentanetriols
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Michael Schalli, Patrick Weber, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Werner Windischhofer, Stephen G WithersAbstract:Abstract N -Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β- d -Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for G M1 -gangliosidosis-associated lysosomal acid β-Galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
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n substituted 5 amino 1 hydroxymethyl cyclopentanetriols a new family of activity promotors for a gm1 gangliosidosis related human lysosomal β Galactosidase mutant
Carbohydrate Research, 2017Co-Authors: Michael Schalli, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Roland Fischer, Tanja Rappitsch, Werner WindischhoferAbstract:Abstract From 1,2;3,4-di-O-isopropylidene-α-D-galactopyranose, a series of highly functionalized (hydroxymethyl)cyclopentanes was easily available. In line with reports by Reymond and Jager on similar structures, these amine containing basic carbasugars are potent inhibitors of β-D-Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-Galactosidase mutant R201C, thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
Michael Schalli - One of the best experts on this subject based on the ideXlab platform.
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a new type of pharmacological chaperone for gm1 gangliosidosis related human lysosomal β Galactosidase n substituted 5 amino 1 hydroxymethyl cyclopentanetriols
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Michael Schalli, Patrick Weber, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Werner Windischhofer, Stephen G WithersAbstract:Abstract N -Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β- d -Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for G M1 -gangliosidosis-associated lysosomal acid β-Galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
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n substituted 5 amino 1 hydroxymethyl cyclopentanetriols a new family of activity promotors for a gm1 gangliosidosis related human lysosomal β Galactosidase mutant
Carbohydrate Research, 2017Co-Authors: Michael Schalli, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Roland Fischer, Tanja Rappitsch, Werner WindischhoferAbstract:Abstract From 1,2;3,4-di-O-isopropylidene-α-D-galactopyranose, a series of highly functionalized (hydroxymethyl)cyclopentanes was easily available. In line with reports by Reymond and Jager on similar structures, these amine containing basic carbasugars are potent inhibitors of β-D-Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-Galactosidase mutant R201C, thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
Stephen G Withers - One of the best experts on this subject based on the ideXlab platform.
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a new type of pharmacological chaperone for gm1 gangliosidosis related human lysosomal β Galactosidase n substituted 5 amino 1 hydroxymethyl cyclopentanetriols
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Michael Schalli, Patrick Weber, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Werner Windischhofer, Stephen G WithersAbstract:Abstract N -Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β- d -Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for G M1 -gangliosidosis-associated lysosomal acid β-Galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
Marion Tschernutter - One of the best experts on this subject based on the ideXlab platform.
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a new type of pharmacological chaperone for gm1 gangliosidosis related human lysosomal β Galactosidase n substituted 5 amino 1 hydroxymethyl cyclopentanetriols
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Michael Schalli, Patrick Weber, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Werner Windischhofer, Stephen G WithersAbstract:Abstract N -Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β- d -Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for G M1 -gangliosidosis-associated lysosomal acid β-Galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
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n substituted 5 amino 1 hydroxymethyl cyclopentanetriols a new family of activity promotors for a gm1 gangliosidosis related human lysosomal β Galactosidase mutant
Carbohydrate Research, 2017Co-Authors: Michael Schalli, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Roland Fischer, Tanja Rappitsch, Werner WindischhoferAbstract:Abstract From 1,2;3,4-di-O-isopropylidene-α-D-galactopyranose, a series of highly functionalized (hydroxymethyl)cyclopentanes was easily available. In line with reports by Reymond and Jager on similar structures, these amine containing basic carbasugars are potent inhibitors of β-D-Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-Galactosidase mutant R201C, thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
Arnold E Stutz - One of the best experts on this subject based on the ideXlab platform.
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a new type of pharmacological chaperone for gm1 gangliosidosis related human lysosomal β Galactosidase n substituted 5 amino 1 hydroxymethyl cyclopentanetriols
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Michael Schalli, Patrick Weber, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Werner Windischhofer, Stephen G WithersAbstract:Abstract N -Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β- d -Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for G M1 -gangliosidosis-associated lysosomal acid β-Galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.
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n substituted 5 amino 1 hydroxymethyl cyclopentanetriols a new family of activity promotors for a gm1 gangliosidosis related human lysosomal β Galactosidase mutant
Carbohydrate Research, 2017Co-Authors: Michael Schalli, Christina Tysoe, Bettina M Pabst, Martin Thonhofer, Eduard Paschke, Arnold E Stutz, Marion Tschernutter, Roland Fischer, Tanja Rappitsch, Werner WindischhoferAbstract:Abstract From 1,2;3,4-di-O-isopropylidene-α-D-galactopyranose, a series of highly functionalized (hydroxymethyl)cyclopentanes was easily available. In line with reports by Reymond and Jager on similar structures, these amine containing basic carbasugars are potent inhibitors of β-D-Galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-Galactosidase mutant R201C, thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease.