The Experts below are selected from a list of 28434 Experts worldwide ranked by ideXlab platform
Yutaka Atomi - One of the best experts on this subject based on the ideXlab platform.
-
Longterm effects of endoscopic sphincterotomy on Gall Bladder motility
Gut, 1996Co-Authors: M. Sugiyama, Yutaka AtomiAbstract:BACKGROUND: Some of patients with an intact Gall Bladder develop acute cholecystitis or have Gall Bladder stone formation after endoscopic sphincterotomy. Endoscopic sphincterotomy may affect Gall Bladder motility. AIMS: To prospectively evaluate longterm effect of endoscopic sphincterotomy on Gall Bladder motility. PATIENTS: Thirty two patients with an intact Gall Bladder (15 with and 17 without Gall Bladder stones) who underwent endoscopic sphincterotomy for choledocholithiasis. METHODS: Gall Bladder function was examined before and at from seven days to five years after sphincterotomy. Gall Bladder volume, at fasting and after caerulein administration, was determined by ultrasonography. RESULTS: After endoscopic sphincterotomy, the enlarged orifice remained patent during a five year follow up period. One patient with Gall Bladder stones subsequently developed acute cholecystitis, the remaining being asymptomatic. In the patients before sphincterotomy, particularly in those with Gall Bladder stones, the Gall Bladder showed larger fasting volume and lower caerulein stimulated maximum contraction than normal controls. Throughout five years after sphincterotomy, fasting volume of the Gall Bladder decreased and its maximum contraction increased, regardless of Gall Bladder stones; significantly different from the values before sphincterotomy (p < 0.05). CONCLUSIONS: Endoscopic sphincterotomy decreases fasting volume of the Gall Bladder and increases its contraction ability for a long period. These changes may rather decrease the risk of future acute cholecystitis or Gall stone formation.
-
Longterm effects of endoscopic sphincterotomy on Gall Bladder motility
Gut, 1996Co-Authors: M. Sugiyama, Yutaka AtomiAbstract:BACKGROUND: Some of patients with an intact Gall Bladder develop acute cholecystitis or have Gall Bladder stone formation after endoscopic sphincterotomy. Endoscopic sphincterotomy may affect Gall Bladder motility. AIMS: To prospectively evaluate longterm effect of endoscopic sphincterotomy on Gall Bladder motility. PATIENTS: Thirty two patients with an intact Gall Bladder (15 with and 17 without Gall Bladder stones) who underwent endoscopic sphincterotomy for choledocholithiasis. METHODS: Gall Bladder function was examined before and at from seven days to five years after sphincterotomy. Gall Bladder volume, at fasting and after caerulein administration, was determined by ultrasonography. RESULTS: After endoscopic sphincterotomy, the enlarged orifice remained patent during a five year follow up period. One patient with Gall Bladder stones subsequently developed acute cholecystitis, the remaining being asymptomatic. In the patients before sphincterotomy, particularly in those with Gall Bladder stones, the Gall Bladder showed larger fasting volume and lower caerulein stimulated maximum contraction than normal controls. Throughout five years after sphincterotomy, fasting volume of the Gall Bladder decreased and its maximum contraction increased, regardless of Gall Bladder stones; significantly different from the values before sphincterotomy (p < 0.05). CONCLUSIONS: Endoscopic sphincterotomy decreases fasting volume of the Gall Bladder and increases its contraction ability for a long period. These changes may rather decrease the risk of future acute cholecystitis or Gall stone formation.
M. Sugiyama - One of the best experts on this subject based on the ideXlab platform.
-
Longterm effects of endoscopic sphincterotomy on Gall Bladder motility
Gut, 1996Co-Authors: M. Sugiyama, Yutaka AtomiAbstract:BACKGROUND: Some of patients with an intact Gall Bladder develop acute cholecystitis or have Gall Bladder stone formation after endoscopic sphincterotomy. Endoscopic sphincterotomy may affect Gall Bladder motility. AIMS: To prospectively evaluate longterm effect of endoscopic sphincterotomy on Gall Bladder motility. PATIENTS: Thirty two patients with an intact Gall Bladder (15 with and 17 without Gall Bladder stones) who underwent endoscopic sphincterotomy for choledocholithiasis. METHODS: Gall Bladder function was examined before and at from seven days to five years after sphincterotomy. Gall Bladder volume, at fasting and after caerulein administration, was determined by ultrasonography. RESULTS: After endoscopic sphincterotomy, the enlarged orifice remained patent during a five year follow up period. One patient with Gall Bladder stones subsequently developed acute cholecystitis, the remaining being asymptomatic. In the patients before sphincterotomy, particularly in those with Gall Bladder stones, the Gall Bladder showed larger fasting volume and lower caerulein stimulated maximum contraction than normal controls. Throughout five years after sphincterotomy, fasting volume of the Gall Bladder decreased and its maximum contraction increased, regardless of Gall Bladder stones; significantly different from the values before sphincterotomy (p < 0.05). CONCLUSIONS: Endoscopic sphincterotomy decreases fasting volume of the Gall Bladder and increases its contraction ability for a long period. These changes may rather decrease the risk of future acute cholecystitis or Gall stone formation.
-
Longterm effects of endoscopic sphincterotomy on Gall Bladder motility
Gut, 1996Co-Authors: M. Sugiyama, Yutaka AtomiAbstract:BACKGROUND: Some of patients with an intact Gall Bladder develop acute cholecystitis or have Gall Bladder stone formation after endoscopic sphincterotomy. Endoscopic sphincterotomy may affect Gall Bladder motility. AIMS: To prospectively evaluate longterm effect of endoscopic sphincterotomy on Gall Bladder motility. PATIENTS: Thirty two patients with an intact Gall Bladder (15 with and 17 without Gall Bladder stones) who underwent endoscopic sphincterotomy for choledocholithiasis. METHODS: Gall Bladder function was examined before and at from seven days to five years after sphincterotomy. Gall Bladder volume, at fasting and after caerulein administration, was determined by ultrasonography. RESULTS: After endoscopic sphincterotomy, the enlarged orifice remained patent during a five year follow up period. One patient with Gall Bladder stones subsequently developed acute cholecystitis, the remaining being asymptomatic. In the patients before sphincterotomy, particularly in those with Gall Bladder stones, the Gall Bladder showed larger fasting volume and lower caerulein stimulated maximum contraction than normal controls. Throughout five years after sphincterotomy, fasting volume of the Gall Bladder decreased and its maximum contraction increased, regardless of Gall Bladder stones; significantly different from the values before sphincterotomy (p < 0.05). CONCLUSIONS: Endoscopic sphincterotomy decreases fasting volume of the Gall Bladder and increases its contraction ability for a long period. These changes may rather decrease the risk of future acute cholecystitis or Gall stone formation.
Radha K. Dhiman - One of the best experts on this subject based on the ideXlab platform.
-
Gall Bladder motility after endoscopic sphincterotomy
Gut, 1998Co-Authors: Barjesh Chander Sharma, Kartar Singh, Radha K. DhimanAbstract:Editor,—We read with interest the article by Sugiyama and Atomi ( Gut 1996; 39 :856–9) on the effect of endoscopic sphincterotomy (ES) on Gall Bladder motility. These authors have proved conclusively that ES causes a significant improvement in Gall Bladder motility in humans. We have assessed Gall Bladder motility in patients who underwent ES for common bile duct (CBD) stones and compared these with patients with Gall Bladder calculi but without CBD stones. We found significantly lower fasting and residual Gall Bladder volumes in the patients who had undergone ES, indicating reduced filling after ES.1 However, the ejection fraction and the rate constant of Gall Bladder emptying in these patients was increased significantly, suggesting increased Gall Bladder emptying. In another study2 we found a significant decrease in fasting volume (mean (SD) 18.3 (8.5) v 13.9 (7.3) ml), residual volume (12.0 (8.0) v 4.4 (3.2) ml) and an increase in the ejection fraction (54.3 (9.8) v 83.5 (5.4)) after ES, suggesting decreased stasis and increased Gall Bladder emptying. In Sugiyama and Atomi’s this study, all patients in whom Gall Bladder motility was assessed before ES had CBD stones; all stones were extracted before … Dr Sugiyama.
R Ison - One of the best experts on this subject based on the ideXlab platform.
-
effects of various food ingredients on Gall Bladder emptying
European Journal of Clinical Nutrition, 2013Co-Authors: Luca Marciani, Eleanor F Cox, Caroline L Hoad, John J Totman, Carolyn Costigan, Gulzar Singh, V Shepherd, L Chalkley, M Robinson, R IsonAbstract:Background/objectives: The emptying of the Gall Bladder in response to feeding is pivotal for the digestion of fat, but the role of various food ingredients in contracting the Gall Bladder postprandially is not well understood. We hypothesized that different food ingredients, when consumed, will have a different effect on stimulating Gall Bladder emptying. To investigate this we designed two randomized, investigator-blind, cross-over studies in healthy subjects using magnetic resonance imaging (MRI) to measure Gall Bladder volumes serially and non-invasively. Subjects/methods: Study 1: exploratory study evaluating the effects of 10 different food ingredients on Gall Bladder emptying in eight healthy subjects. The choice of ingredients varied from common items like coffee, tea and milk to actives like curcumin and potato protease inhibitor. Study 2: mechanistic study investigating the cholecystokinin (CCK) dose response to the best performer ingredient from Study 1 in 21 healthy subjects four ways. Results: The largest Gall Bladder volume change in Study 1 was observed with fat, which therefore became the dose-response ingredient in Study 2, where the maximum % Gall Bladder volume change correlated well with CCK. Conclusions: These serial test-retest studies showed that the fasted Gall Bladder volume varied remarkably between individuals and that individual day-to-day variability had wide coefficients of variation. Improved knowledge of how to stimulate bile release using food ingredients will be useful to improve in vitro–in vivo correlation of bioavailability testing of hydrophobic drugs. It could improve performance of cholesterol-lowering plant stanol and sterol products and possibly aid understanding of some cholesterol Gallstone disease.
Barjesh Chander Sharma - One of the best experts on this subject based on the ideXlab platform.
-
Gall Bladder motility after endoscopic sphincterotomy
Gut, 1998Co-Authors: Barjesh Chander Sharma, Kartar Singh, Radha K. DhimanAbstract:Editor,—We read with interest the article by Sugiyama and Atomi ( Gut 1996; 39 :856–9) on the effect of endoscopic sphincterotomy (ES) on Gall Bladder motility. These authors have proved conclusively that ES causes a significant improvement in Gall Bladder motility in humans. We have assessed Gall Bladder motility in patients who underwent ES for common bile duct (CBD) stones and compared these with patients with Gall Bladder calculi but without CBD stones. We found significantly lower fasting and residual Gall Bladder volumes in the patients who had undergone ES, indicating reduced filling after ES.1 However, the ejection fraction and the rate constant of Gall Bladder emptying in these patients was increased significantly, suggesting increased Gall Bladder emptying. In another study2 we found a significant decrease in fasting volume (mean (SD) 18.3 (8.5) v 13.9 (7.3) ml), residual volume (12.0 (8.0) v 4.4 (3.2) ml) and an increase in the ejection fraction (54.3 (9.8) v 83.5 (5.4)) after ES, suggesting decreased stasis and increased Gall Bladder emptying. In Sugiyama and Atomi’s this study, all patients in whom Gall Bladder motility was assessed before ES had CBD stones; all stones were extracted before … Dr Sugiyama.
